DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and RLP13

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_001322432.1	Gene:	RLP13 / 843757	AraportID:	AT1G74170	Length:	1068	Species:	Arabidopsis thaliana

Alignment Length:	980	Identity:	212/980 - (21%)
Similarity:	348/980 - (35%)	Gaps:	314/980 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KAASELALLVIILQLLQWPGSEASFGRDACSEMSIDGLCQCAPIMSEYEIICPANA--------- 60
            ||..||...:|.|...:|..:..|:..|..|:        |...|.   :.|...:
plant    33 KALLELKAFLIPLNAGEWNDNVLSWTNDTKSD--------CCQWMG---VECNRKSGRITNIAFG 86

  Fly    61 -----ENPTFRLT-IQPKDYVQIM----------CNLT----DTTDYQQLPKKLRIGEVDRVQMR 105
                 |||...|: :.|.:.|:.:          |..:    |...|:.|.:...:..:|
plant    87 IGFIIENPLLNLSLLHPFEDVRSLDLSSSRSCEDCGFSGLFDDVEGYKSLSRLRNLEILD----- 146

  Fly   106 RCMLPGHTPIASILDYLGIVSPTTLIFESDNLGMNITRQHLDRLHG---LKRFRFTTRRLTHIPA 167
               |..|....||..:|...:..|.:|.:.|           .:|.   :|.|:
plant   147 ---LSSHRFNNSIFPFLNAATSLTTLFLTYN-----------NMHSPFLVKEFK----------- 186

  Fly   168 NLLTDMRNLSHLELRAN--IEEMPSHLFDDL---ENLESIEFGSNKLRQMPRGIFGKMPKLKQLN 227
                |:.||.||:||.|  ...:|:..::.|   ..||.::...|...............||.|:
plant   187 ----DLTNLEHLDLRGNRFNGSIPTQDYNSLRRFRKLEILDLSDNLFNSRIFPFLNSATSLKSLS 247

  Fly   228 LWSNQLHN-LTKHDFEGATSVLGIDIHDNGIE-QLPHDVFAHLTNVTDINLSANLFRSLP--QGL 288
            ||.|.:.. ....:....|:|..:|:..|... .:|......|..:..::||.|.|.|..  ||.
plant   248 LWGNNMGGPFPAKELRDLTNVELLDLSRNRFNGSIPVRALFALRKLKALDLSDNEFSSSVELQGK 312

  Fly   289 FDHN---------KHLNEVRLMNNR----------------------------VP--LATLPS-- 312
            |...         |::.|::|.||:                            ||  ||.|.|
plant   313 FAKTKPLSGTCPWKNMEELKLSNNKLAGQFPLCLTSLTGLRVLDLSSNQLTGNVPSALANLESLE 377

  Fly   313 ---------------RLFANQPELQILRLRAELQSLPGDLFEHS----TQITNISLGDNLLKTLP 358
                           .|.||..:|::|||.::..||..: ||.|    .|:..|:|....|:.:|
plant   378 YLSLFGNNFEGFFSLGLLANLSKLKVLRLDSQSNSLEVE-FETSWKPKFQLVVIALRSCNLEKVP 441

  Fly   359 ATLLEHQVNLLSLDLSNNRL-THLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMS 422
            ..|| ||.:|..:|||:|:: .:.|..|..:.|.|..|.|::|..|...            |..|
plant   442 HFLL-HQKDLHHVDLSDNQIHGNFPSWLLENNTKLEVLLLQNNSFTSFQ------------LPKS 493

  Fly   423 RNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYM--HGLLTLNLRNNSI 485
            .:.|..::    ||.|...||.|.:                     ||::  | |:.:||
plant   494 AHNLLFLN----VSVNKFNHLFLQN---------------------FGWILPH-LVCVNL----- 527

  Fly   486 IFVYNDWKNTMLQLRELDLSYNNISSLGYEDLAFLSQNRLH----------------VNMTHNKI 534
              .||.::.      .|..|.:|:.|:.:.|   ||.||.|                :.::|||:
plant   528 --AYNGFQG------NLPSSLDNMKSIEFLD---LSHNRFHGKLPRRFLKGCYNLTILKLSHNKL 581

  Fly   535 RRIALPEDV-----------------HLGEGYNN--NLVHVDLNDNPLVCDCTILWFIQLVRGVH 580
            .....||..                 ::|:|:.:  :|..:|:::|.|.  ..|..:|...:|:.
plant   582 SGEVFPEAANFTRLWVMSMDNNLFTGNIGKGFRSLPSLNVLDISNNKLT--GVIPSWIGERQGLF 644

  Fly   581 KPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKA 645
            ..|.|.              |:|||.....:...:.:..||.|.:......|.    ||.:....
plant   645 ALQLSN--------------NMLEGEIPTSLFNISYLQLLDLSSNRLSGDIPP----HVSSIYHG 691

  Fly   646 LVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGY---ESVTSLHLAGNNLTSI 707
            .|:...:.||:.|  :|:. ..:.::.|.|.||.|    |.|.|.:   ::::.|.|.|||.|.
plant   692 AVLLLQNNNLSGV--IPDT-LLLNVIVLDLRNNRL----SGNLPEFINTQNISILLLRGNNFTG- 748

  Fly   708 DVDQLP------TNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDC-----TAKP 761
               |:|      :|:..||:|.|   ..|.::...|:.|.  ..::...:.:..|.     |||.
plant   749 ---QIPHQFCSLSNIQLLDLSNN---KFNGSIPSCLSNTS--FGLRKGDDSYRYDVPSRFGTAKD 805

  Fly   762 LLLFTQ----DNFERIGDRNEMMCVNAEMPTRM---------------VELSTNDI---CPAEKG 804
            .:.|..    |.|..:.:.|..  ...|..|:.               ::||.|::   .|.|.|
plant   806 PVYFESLLMIDEFNMVNETNSQ--TKIEFATKHRYDAYMGGNLKLLFGMDLSENELSGEIPVELG 868

  Fly   805 VFIAL 809
            ..:.|
plant   869 GLVEL 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	18/63 (29%)
		leucine-rich repeat	176..198	CDD:275380	8/26 (31%)
		leucine-rich repeat	199..222	CDD:275380	3/22 (14%)
		LRR_RI	216..542	CDD:238064	96/408 (24%)
		LRR_8	221..281	CDD:290566	15/61 (25%)
		leucine-rich repeat	223..270	CDD:275380	12/48 (25%)
		leucine-rich repeat	271..294	CDD:275380	8/33 (24%)
		leucine-rich repeat	295..320	CDD:275380	13/71 (18%)
		leucine-rich repeat	321..343	CDD:275380	9/25 (36%)
		LRR_8	342..402	CDD:290566	21/60 (35%)
		leucine-rich repeat	344..367	CDD:275380	8/22 (36%)
		leucine-rich repeat	368..391	CDD:275380	7/23 (30%)
		LRR_8	390..450	CDD:290566	15/59 (25%)
		leucine-rich repeat	392..415	CDD:275380	5/22 (23%)
		leucine-rich repeat	416..439	CDD:275380	5/22 (23%)
		leucine-rich repeat	440..474	CDD:275380	5/35 (14%)
		leucine-rich repeat	475..498	CDD:275380	5/22 (23%)
		LRR_8	477..534	CDD:290566	16/72 (22%)
		leucine-rich repeat	499..520	CDD:275380	5/20 (25%)
		leucine-rich repeat	523..552	CDD:275380	10/63 (16%)
		LRRCT	561..619	CDD:214507	11/57 (19%)
		LRRNT	631..667	CDD:214470	8/35 (23%)
		leucine-rich repeat	664..693	CDD:275380	8/31 (26%)
		LRR_8	669..726	CDD:290566	21/65 (32%)
		leucine-rich repeat	694..715	CDD:275380	8/26 (31%)
		leucine-rich repeat	716..737	CDD:275380	5/20 (25%)
		LRRCT	751..800	CDD:214507	13/75 (17%)
		TIR	858..996	CDD:214587
RLP13	NP_001322432.1	LRRNT_2	31..74	CDD:311940	12/51 (24%)
		PLN00113	<101..206	CDD:331614	26/138 (19%)
		leucine-rich repeat	142..165	CDD:275380	6/30 (20%)
		leucine-rich repeat	166..190	CDD:275380	7/49 (14%)
		PLN00113	<180..259	CDD:331614	21/93 (23%)
		leucine-rich repeat	191..218	CDD:275380	8/26 (31%)
		leucine-rich repeat	219..267	CDD:275380	9/47 (19%)
		PLN00113	238..>957	CDD:331614	164/730 (22%)
		leucine-rich repeat	268..292	CDD:275380	5/23 (22%)
		leucine-rich repeat	293..318	CDD:275380	8/24 (33%)
		leucine-rich repeat	319..351	CDD:275380	5/31 (16%)
		leucine-rich repeat	352..375	CDD:275380	5/22 (23%)
		leucine-rich repeat	376..400	CDD:275380	3/23 (13%)
		leucine-rich repeat	450..474	CDD:275380	7/23 (30%)
		leucine-rich repeat	475..521	CDD:275380	16/82 (20%)
		leucine-rich repeat	522..545	CDD:275380	8/35 (23%)
		leucine-rich repeat	546..570	CDD:275380	6/26 (23%)
		leucine-rich repeat	571..594	CDD:275380	5/22 (23%)
		leucine-rich repeat	595..618	CDD:275380	2/22 (9%)
		leucine-rich repeat	619..642	CDD:275380	6/24 (25%)
		leucine-rich repeat	643..666	CDD:275380	6/36 (17%)
		leucine-rich repeat	667..691	CDD:275380	6/27 (22%)
		leucine-rich repeat	713..735	CDD:275380	8/25 (32%)
		leucine-rich repeat	736..757	CDD:275380	8/24 (33%)
		leucine-rich repeat	760..781	CDD:275380	6/23 (26%)
		leucine-rich repeat	849..872	CDD:275380	6/22 (27%)
		leucine-rich repeat	873..896	CDD:275380	1/1 (100%)
		leucine-rich repeat	897..918	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	125	1.000	Inparanoid score	I1937
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050