DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and RLP35

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_001319521.1	Gene:	RLP35 / 820279	AraportID:	AT3G11080	Length:	943	Species:	Arabidopsis thaliana

Alignment Length:	1102	Identity:	232/1102 - (21%)
Similarity:	388/1102 - (35%)	Gaps:	376/1102 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 RDACSEMSIDGLCQCAPIMSEYEIICPANAENPTFR--LTIQPKDYVQIMCNLTDTTDYQQLPKK 93
            |..|.....|.|.:   :.:|:||..| ::.:..:|  ..:.|....:...|.:|..:::.:...
plant    35 RHLCLPEQRDALLE---LKNEFEIGKP-SSNDYCYRNNSRVSPHPTTESWRNNSDCCNWEGITCD 95

  Fly    94 LRIGEVDRVQMRRCMLPG--HTPIASILDYLGIVSPTTLIFESDNLG-MNITRQHLDRLHGLKRF 155
            .:.|||..:.:....|.|  |:              .:.:|...||. :::|:..||
plant    96 TKSGEVIELDLSCSWLYGSFHS--------------NSSLFRLQNLRVLDLTQNDLD-------- 138

  Fly   156 RFTTRRLTHIPANLLTDMRNLSHL-ELRANIEE----MPSHLFDDLENLESIEFGSNKLR-QMPR 214
                   ..||:::    .||||| .|..:..:    :||.: ::|..|.|:...||:.. |:|.
plant   139 -------GEIPSSI----GNLSHLTSLHLSYNQFLGLIPSSI-ENLSRLTSLHLSSNQFSGQIPS 191

  Fly   215 GIFGKMPKLKQLNLWSNQ-----------LHNLT-----KHDFEG-ATSVLG--------IDIHD 254
            .| |.:..|..|.|.|||           |.|||     .:||.| ..|.:|        ...::
plant   192 SI-GNLSHLTSLELSSNQFSGQIPSSIGNLSNLTFLSLPSNDFFGQIPSSIGNLARLTYLYLSYN 255

  Fly   255 NGIEQLPHDVFAHLTNVTDINLSAN-LFRSLPQGLFD----------HNKHL----NEVRLMNNR 304
            |.:.::|.. |.:|..:..:.:.:| |..::|..|.:          ||:..    |.:.|::|.
plant   256 NFVGEIPSS-FGNLNQLIVLQVDSNKLSGNVPISLLNLTRLSALLLSHNQFTGTIPNNISLLSNL 319

  Fly   305 VPL--------ATLPSRLFANQPELQILRLRAELQSLPGDL-FEHSTQITNISL----GDNLLKT 356
            :..        .||||.|| |.|.|  :||......|.|.| |.:.:..:|:..    .:|.:.|
plant   320 MDFEASNNAFTGTLPSSLF-NIPPL--IRLDLSDNQLNGTLHFGNISSPSNLQYLIIGSNNFIGT 381

  Fly   357 LPATLLEHQVNLLSLDLS--NNRLTHLPDSLFAHTTNLTDLRLEDNLLTGIS-GDIFSNLGNLVT 418
            :|.: |...|||...|||  |.:...:..|:|:|..:|.||||.....|.|. .||......|.:
plant   382 IPRS-LSRFVNLTLFDLSHLNTQCRPVDFSIFSHLKSLDDLRLSYLTTTTIDLNDILPYFKTLRS 445

  Fly   419 LVMSRNRLRTIDSRAFVSTN----GLRHLHLDHNDI-DLQQPLLDIMLQTQINSPFGYMHGLLTL 478
            |.:|.| |.:..:::.||::    .::.|:|....| |..:     :|:||        |.|..|
plant   446 LDISGN-LVSATNKSSVSSDPPSQSIQSLYLSGCGITDFPE-----ILRTQ--------HELGFL 496

  Fly   479 NLRNNSIIFVYNDWKNTMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDV 543
            ::.||.|......|..|:..|..|:||.|..       ::|.|.::.|      .:..:..|..:
plant   497 DVSNNKIKGQVPGWLWTLPNLFYLNLSNNTF-------ISFESSSKKH------GLSSVRKPSMI 548

  Fly   544 HLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPV 608
            ||....||                                    |..:....:|.         :
plant   549 HLFASNNN------------------------------------FTGKIPSFICG---------L 568

  Fly   609 RQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMEL 673
            |.:.      .||.|::......||   |..:......|:|....||:  ..||.
plant   569 RSLN------TLDLSENNYNGSIPR---CMEKLKSTLFVLNLRQNNLS--GGLPK---------- 612

  Fly   674 HLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLN 738
            |:               :||:.||.: |:||.   |.:||.:|    |.:::|::||.. ...:|
plant   613 HI---------------FESLRSLDV-GHNLL---VGKLPRSL----IRFSNLEVLNVE-SNRIN 653

  Fly   739 RTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFE-----------RIGD--RNEMMCVNAEMPTR- 789
            .|..:         |:...:...:|:...:.|.           ||.|  .|..   |..:||.
plant   654 DTFPF---------WLSSLSKLQVLVLRSNAFHGPIHEATFPELRIIDISHNHF---NGTLPTEY 706

  Fly   790 ------MVELSTNDICPAEK----GVFIALAVVIALTGL-------LAGFTAALY--YKFQTEIK 835
                  |..|..|:....||    |::...::|:...||       |..:||..:  .||:.||.
plant   707 FVKWSAMSSLGKNEDQSNEKYMGSGLYYQDSMVLMNKGLAMELVRILTIYTALDFSGNKFEGEIP 771

  Fly   836 IWLYAHNLLLWFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVG 900
                                            |....:::.||..|.:.             ..|
plant   772 --------------------------------KSIGLLKELLVLNLSNN-------------AFG 791

  Fly   901 GHIPENIMRSVA-DSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKL 964
            ||||.::....| :|    :.:|||.:..|                        |..::||:..|
plant   792 GHIPSSMGNLTALES----LDVSQNKLTGE------------------------IPQELGDLSFL 828

  Fly   965 DEELKAYLKMNTYLKWGDPWFWDKLRFALPHRRPVGNIGNGALIKTALKGSTDDKLELIKPS 1026
                 ||:..:                   |.:..|.:..|...:.....:.::.|.|..||
plant   829 -----AYMNFS-------------------HNQLAGLVPGGTQFRRQNCSAFENNLGLFGPS 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	23/75 (31%)
		leucine-rich repeat	176..198	CDD:275380	8/26 (31%)
		leucine-rich repeat	199..222	CDD:275380	8/23 (35%)
		LRR_RI	216..542	CDD:238064	100/386 (26%)
		LRR_8	221..281	CDD:290566	20/85 (24%)
		leucine-rich repeat	223..270	CDD:275380	19/71 (27%)
		leucine-rich repeat	271..294	CDD:275380	6/33 (18%)
		leucine-rich repeat	295..320	CDD:275380	10/36 (28%)
		leucine-rich repeat	321..343	CDD:275380	7/22 (32%)
		LRR_8	342..402	CDD:290566	20/65 (31%)
		leucine-rich repeat	344..367	CDD:275380	5/26 (19%)
		leucine-rich repeat	368..391	CDD:275380	8/24 (33%)
		LRR_8	390..450	CDD:290566	18/64 (28%)
		leucine-rich repeat	392..415	CDD:275380	9/23 (39%)
		leucine-rich repeat	416..439	CDD:275380	7/26 (27%)
		leucine-rich repeat	440..474	CDD:275380	7/34 (21%)
		leucine-rich repeat	475..498	CDD:275380	7/22 (32%)
		LRR_8	477..534	CDD:290566	14/56 (25%)
		leucine-rich repeat	499..520	CDD:275380	5/20 (25%)
		leucine-rich repeat	523..552	CDD:275380	5/28 (18%)
		LRRCT	561..619	CDD:214507	3/57 (5%)
		LRRNT	631..667	CDD:214470	9/35 (26%)
		leucine-rich repeat	664..693	CDD:275380	1/28 (4%)
		LRR_8	669..726	CDD:290566	13/56 (23%)
		leucine-rich repeat	694..715	CDD:275380	8/20 (40%)
		leucine-rich repeat	716..737	CDD:275380	5/20 (25%)
		LRRCT	751..800	CDD:214507	13/68 (19%)
		TIR	858..996	CDD:214587	21/138 (15%)
RLP35	NP_001319521.1	LRRNT_2	39..95	CDD:311940	10/59 (17%)
		PLN00113	79..>658	CDD:331614	168/735 (23%)
		leucine-rich repeat	103..123	CDD:275380	3/33 (9%)
		leucine-rich repeat	127..150	CDD:275380	8/41 (20%)
		leucine-rich repeat	151..174	CDD:275380	5/23 (22%)
		leucine-rich repeat	175..198	CDD:275380	8/23 (35%)
		leucine-rich repeat	199..222	CDD:275380	7/22 (32%)
		leucine-rich repeat	223..246	CDD:275380	7/22 (32%)
		leucine-rich repeat	247..270	CDD:275380	4/23 (17%)
		leucine-rich repeat	271..294	CDD:275380	4/22 (18%)
		leucine-rich repeat	295..318	CDD:275380	4/22 (18%)
		leucine-rich repeat	319..337	CDD:275380	4/17 (24%)
		leucine-rich repeat	343..367	CDD:275380	7/25 (28%)
		leucine-rich repeat	368..388	CDD:275380	4/20 (20%)
		leucine-rich repeat	392..417	CDD:275380	8/24 (33%)
		leucine-rich repeat	443..469	CDD:275380	7/26 (27%)
		leucine-rich repeat	470..492	CDD:275380	7/34 (21%)
		leucine-rich repeat	493..516	CDD:275380	7/22 (32%)
		leucine-rich repeat	517..541	CDD:275380	8/36 (22%)
		leucine-rich repeat	542..570	CDD:275380	7/72 (10%)
		leucine-rich repeat	571..594	CDD:275380	6/31 (19%)
		leucine-rich repeat	596..617	CDD:275380	7/47 (15%)
		leucine-rich repeat	618..641	CDD:275380	10/30 (33%)
		LRR_8	640..698	CDD:316378	12/67 (18%)
		leucine-rich repeat	642..665	CDD:275380	6/32 (19%)
		leucine-rich repeat	716..803	CDD:275380	24/131 (18%)
		PLN00113	<758..864	CDD:331614	31/202 (15%)
		leucine-rich repeat	804..825	CDD:275380	7/48 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000