DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tl and TLR10

DIOPT Version :9

Sequence 1:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster
Sequence 2:NP_001017388.1 Gene:TLR10 / 81793 HGNCID:15634 Length:811 Species:Homo sapiens


Alignment Length:805 Identity:180/805 - (22%)
Similarity:303/805 - (37%) Gaps:239/805 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   369 LSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRA 433
            |..:.||..|..:|..|...||.|.   |..|||..:....|.::..|..|::..||::.:|.:.
Human    30 LMTNCSNMSLRKVPADLTPATTTLD---LSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKT 91

  Fly   434 F----------VSTN-----------GLRHLHLDHNDID-----------------------LQQ 454
            |          :|.|           |||:|.|..||.|                       :|:
Human    92 FEFNKELRYLDLSNNRLKSVTWYLLAGLRYLDLSFNDFDTMPICEEAGNMSHLEILGLSGAKIQK 156

  Fly   455 PLLDIMLQTQINSPF-------GYMHGLL-TLNLRNNSIIFVY--NDW--------KNTMLQLRE 501
            .....:....:|:.|       .|..|.| .||.....|:...  |.|        .:.:|::..
Human   157 SDFQKIAHLHLNTVFLGFRTLPHYEEGSLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTN 221

  Fly   502 LD-----LSY---NNIS--------------SLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVH 544
            :|     :||   .|:|              .|.::||..:.|...|.::.|.:||.:...    
Human   222 IDGKSQFVSYEMQRNLSLENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFG---- 282

  Fly   545 LGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNV-LEGTPV 608
             |:.|        |:.|......|::..|:| ..||    .|.|.::.|::......: :|...:
Human   283 -GKAY--------LDHNSFDYSNTVMRTIKL-EHVH----FRVFYIQQDKIYLLLTKMDIENLTI 333

  Fly   609 RQIEPQTLICP--------LDFSDD-------PRERKCPRGCNCHVRTYDKALVINCHSGN---- 654
            ...:...::.|        |:|:::       .|..:.|     |::|    |::|   ||    
Human   334 SNAQMPHMLFPNYPTKFQYLNFANNILTDELFKRTIQLP-----HLKT----LILN---GNKLET 386

  Fly   655 LTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLT---------SIDVD 710
            |:.|....|   |..|..|.|..|.|......|....|:|.:::|:.|.|:         ||.:.
Human   387 LSLVSCFAN---NTPLEHLDLSQNLLQHKNDENCSWPETVVNMNLSYNKLSDSVFRCLPKSIQIL 448

  Fly   711 QLPTN--------------LTHLDISWN------------HLQMLNATV-------LGFLNRTMK 742
            .|..|              |..|:|::|            .|.:||..:       |.|:....:
Human   449 DLNNNQIQTVPKETIHLMALRELNIAFNFLTDLPGCSHFSRLSVLNIEMNFILSPSLDFVQSCQE 513

  Fly   743 WRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMCV------NAEMP-----TRMVELSTN 796
            .:::....||:.|.|..|        ||.::...:|:|.|      ..|.|     ||:.::..:
Human   514 VKTLNAGRNPFRCTCELK--------NFIQLETYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLH 570

  Fly   797 DICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFV------------- 848
            ::......:.:.:.|::.:.||...|..               .|..|.|::             
Human   571 ELSCNTALLIVTIVVIMLVLGLAVAFCC---------------LHFDLPWYLRMLGQCTQTWHRV 620

  Fly   849 ---TEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRS 910
               |:|.|.::.:|.||||||..|..::::.|:|.||.......:|::|..:..|..|.|||:..
Human   621 RKTTQEQLKRNVRFHAFISYSEHDSLWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIVSF 685

  Fly   911 VADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIG--DVEKLDEELKAYLK 973
            :..|.::|.|||.||:::||...||..||.:..:|....||:|:...|.  .:.....:|||.|:
Human   686 IEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLE 750

  Fly   974 MNTYLKWGDP-----WFWDKLRFAL 993
            ...||:|...     .||..||.|:
Human   751 KKAYLEWPKDRRKCGLFWANLRAAI 775

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TlNP_001262995.1 LRR_8 174..233 CDD:290566
leucine-rich repeat 176..198 CDD:275380
leucine-rich repeat 199..222 CDD:275380
LRR_RI 216..542 CDD:238064 55/256 (21%)
LRR_8 221..281 CDD:290566
leucine-rich repeat 223..270 CDD:275380
leucine-rich repeat 271..294 CDD:275380
leucine-rich repeat 295..320 CDD:275380
leucine-rich repeat 321..343 CDD:275380
LRR_8 342..402 CDD:290566 11/32 (34%)
leucine-rich repeat 344..367 CDD:275380
leucine-rich repeat 368..391 CDD:275380 7/21 (33%)
LRR_8 390..450 CDD:290566 21/80 (26%)
leucine-rich repeat 392..415 CDD:275380 6/22 (27%)
leucine-rich repeat 416..439 CDD:275380 8/43 (19%)
leucine-rich repeat 440..474 CDD:275380 11/63 (17%)
leucine-rich repeat 475..498 CDD:275380 6/33 (18%)
LRR_8 477..534 CDD:290566 17/88 (19%)
leucine-rich repeat 499..520 CDD:275380 8/42 (19%)
leucine-rich repeat 523..552 CDD:275380 6/28 (21%)
LRRCT 561..619 CDD:214507 10/58 (17%)
LRRNT 631..667 CDD:214470 10/39 (26%)
leucine-rich repeat 664..693 CDD:275380 7/28 (25%)
LRR_8 669..726 CDD:290566 19/91 (21%)
leucine-rich repeat 694..715 CDD:275380 7/29 (24%)
leucine-rich repeat 716..737 CDD:275380 8/39 (21%)
LRRCT 751..800 CDD:214507 14/59 (24%)
TIR 858..996 CDD:214587 49/143 (34%)
TLR10NP_001017388.1 LRR 1 24..46 5/15 (33%)
LRR 2 49..70 8/23 (35%)
leucine-rich repeat 50..73 CDD:275378 8/25 (32%)
LRR_8 72..129 CDD:316378 14/56 (25%)
LRR 3 73..94 6/20 (30%)
leucine-rich repeat 74..97 CDD:275378 6/22 (27%)
LRR 4 97..118 2/20 (10%)
leucine-rich repeat 98..112 CDD:275378 2/13 (15%)
leucine-rich repeat 119..143 CDD:275378 7/23 (30%)
LRR 5 119..139 7/19 (37%)
LRR 6 143..166 1/22 (5%)
leucine-rich repeat 144..155 CDD:275378 0/10 (0%)
LRR 289..>522 CDD:227223 49/252 (19%)
LRR 7 296..321 8/29 (28%)
LRR 8 325..348 2/22 (9%)
LRR 9 349..368 2/18 (11%)
leucine-rich repeat 350..373 CDD:275380 4/27 (15%)
LRR 10 373..394 8/27 (30%)
leucine-rich repeat 374..398 CDD:275380 9/33 (27%)
LRR 11 398..419 6/20 (30%)
leucine-rich repeat 399..422 CDD:275380 6/22 (27%)
LRR 12 422..442 4/19 (21%)
leucine-rich repeat 423..444 CDD:275380 4/20 (20%)
LRR 13 444..465 4/20 (20%)
leucine-rich repeat 445..467 CDD:275380 3/21 (14%)
LRR 14 467..488 4/20 (20%)
leucine-rich repeat 468..490 CDD:275380 4/21 (19%)
LRR 15 489..509 5/19 (26%)
leucine-rich repeat 491..513 CDD:275380 4/21 (19%)
LRRCT 522..574 CDD:214507 14/59 (24%)
TIR 633..775 CDD:214587 48/141 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 1 1.000 - - FOG0000239
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24365
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.920

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