DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and tlr4al

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_001315534.1	Gene:	tlr4al / 795671	ZFINID:	ZDB-GENE-090507-2	Length:	816	Species:	Danio rerio

Alignment Length:	956	Identity:	209/956 - (21%)
Similarity:	362/956 - (37%)	Gaps:	313/956 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 RNLSHLELRANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTK 238
            ||||::..|     :||       ::::::|..|.|:.:.:.:|.....|:.|:|  ::.|
Zfish    35 RNLSYIPSR-----IPS-------SVQTLDFSFNDLKWLKKTVFPVFTFLRVLDL--SRCH---- 81

  Fly   239 HDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNN 303
                              |.|:.:|.|.::.|:|.:.|:.|.......|..  |...|..||:..
Zfish    82 ------------------IRQIENDAFYNVKNLTTLFLTGNPIIYFAPGCL--NTLYNLQRLVLV 126

  Fly   304 RVPLATLPSRLFANQPELQILRLRAELQSLPGDLFEHSTQITNISLGDNLLK--TLP---ATLLE 363
            .:.|.:|         :|.|..|               |::..:::|.|.::  |||   :|..:
Zfish   127 DIGLESL---------QLNINNL---------------TKLQELNVGTNYIQSMTLPPFMSTFKD 167

  Fly   364 HQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRT 428
            ..:    |||              |..|::.:|....:       :...:|..:||::|||.|..
Zfish   168 FSL----LDL--------------HANNISIIRTNHTV-------VLREIGKNMTLILSRNPLLH 207

  Fly   429 IDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQ-------IN-----------------SPF 469
            |:..:|      :.:||  .::|::...:....:.|       :|                 |..
Zfish   208 IEPGSF------KGVHL--VELDIRSTFVSFASKKQGLNGLHGLNVTRLMFGMYKDDPKLYPSDL 264

  Fly   470 GYMHGLLTLNLRNNSIIFVYN----DWK----NTMLQLRELDLSYNNISSLGY------EDLAFL 520
            .|..||.:::...   .:.|.    |||    ..|:....:.:....|..:||      ::| :|
Zfish   265 DYFDGLCSIHFYE---AYYYMKERLDWKMNIFRCMINATVVVVKGGVIRVIGYVPFHKIKEL-YL 325

  Fly   521 SQNRL---------HVN------MTHNKIRRIA----LPEDVHLGEGYNNNLVHVDLNDNPLVC- 565
            ...:|         |:.      .|||...::.    :|:           |.:||||.|.:..
Zfish   326 INTQLYTVPGKQLSHIRTLEKFVFTHNSATQVEKFLDMPK-----------LQYVDLNSNQITLQ 379

  Fly   566 DCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERK 630
            .|.    |.::.|.  ||. |...|..:..:.......||....:|        |||.
Zfish   380 SCC----IDVLSGT--PQI-RYLNLSLNPQISLDKGGFEGLESLEI--------LDFH------- 422

  Fly   631 CPRGCNCHVR---------------------TYDKALVIN--CHSG------------------- 653
                   |.:                     :|.....:|  |..|
Zfish   423 -------HTKLLGIGSFTLLSNLKNLRYLDISYSSVTFVNVYCFYGLSSLKVLKMAGNSFQGDVA 480

  Fly   654 -----NLTHVPRLP-------NLH----KNMQ-LMELHLENNTLLRLPSANTPGYESVTSLHLAG 701
                 |||.:..|.       .:|    ||:| |..|:|..|.|:.:.....|..:.:|:.::..
Zfish   481 NYLFNNLTFLEHLDISYCHVIEIHLTSFKNLQRLRHLNLRGNNLMSIDFLTDPNLKQLTTFYVNK 545

  Fly   702 NNLTSIDVD---QLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLL 763
            |::|:|.:|   :||.||:..|:|:                           ||..|.|:....:
Zfish   546 NSITTIPLDILQKLPMNLSEFDLSF---------------------------NPIDCSCSQTDFM 583

  Fly   764 LFTQDNFERIGDRNEMMC--VNAEMPTRMVELSTNDICPAEKGVFIALAV--VIALTGLLAGFTA 824
            |:..:|...:.....::|  ::.....|:.:... |.|..:|.:.|||.|  |:.:..|     :
Zfish   584 LWIINNQRVLKQPENILCKTISPNSDFRVTDFDI-DHCVYKKKLIIALLVFCVVFIVVL-----S 642

  Fly   825 ALYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQ 889
            .|.|:||..::   |...||..:  .....::..:|||:.:|..|::::.:.|:..||:|....|
Zfish   643 ILVYRFQFYLR---YCWILLRGY--RSPGQQECSYDAFVIFSSYDEAWVMNELMENLENGVPPIQ 702

  Fly   890 LCVHERDWLVGGHIPENIM-RSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVI 953
            ||:|.||:..|..|..||: ..:..||:.|:|:||:||.|.|.|.||..|....:.|..:.||:|
Zfish   703 LCLHMRDFQAGKSIASNIIDEGIMGSRKIIVVVSQHFIDSAWCRFEFELAQSRFVVERNANIIII 767

  Fly   954 IYSDIGDVE-KLDEELKAYLKMNTYLKWG-DPW----FWDKLRFAL 993
            |..|:.:.: |....|..:||.||||||. ||.    ||.:||.|:
Zfish   768 ILEDVAERKTKKVLGLHKHLKKNTYLKWSRDPLSNMRFWIRLRKAI 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	14/58 (24%)
		leucine-rich repeat	176..198	CDD:275380	5/21 (24%)
		leucine-rich repeat	199..222	CDD:275380	4/22 (18%)
		LRR_RI	216..542	CDD:238064	70/387 (18%)
		LRR_8	221..281	CDD:290566	12/59 (20%)
		leucine-rich repeat	223..270	CDD:275380	8/46 (17%)
		leucine-rich repeat	271..294	CDD:275380	5/22 (23%)
		leucine-rich repeat	295..320	CDD:275380	5/24 (21%)
		leucine-rich repeat	321..343	CDD:275380	3/21 (14%)
		LRR_8	342..402	CDD:290566	13/64 (20%)
		leucine-rich repeat	344..367	CDD:275380	6/27 (22%)
		leucine-rich repeat	368..391	CDD:275380	4/22 (18%)
		LRR_8	390..450	CDD:290566	13/59 (22%)
		leucine-rich repeat	392..415	CDD:275380	1/22 (5%)
		leucine-rich repeat	416..439	CDD:275380	8/22 (36%)
		leucine-rich repeat	440..474	CDD:275380	7/57 (12%)
		leucine-rich repeat	475..498	CDD:275380	6/30 (20%)
		LRR_8	477..534	CDD:290566	15/85 (18%)
		leucine-rich repeat	499..520	CDD:275380	4/26 (15%)
		leucine-rich repeat	523..552	CDD:275380	6/47 (13%)
		LRRCT	561..619	CDD:214507	11/58 (19%)
		LRRNT	631..667	CDD:214470	10/93 (11%)
		leucine-rich repeat	664..693	CDD:275380	10/33 (30%)
		LRR_8	669..726	CDD:290566	18/60 (30%)
		leucine-rich repeat	694..715	CDD:275380	7/23 (30%)
		leucine-rich repeat	716..737	CDD:275380	3/20 (15%)
		LRRCT	751..800	CDD:214507	9/50 (18%)
		TIR	858..996	CDD:214587	56/143 (39%)
tlr4al	NP_001315534.1	leucine-rich repeat	28..47	CDD:275380	7/23 (30%)
		leucine-rich repeat	48..71	CDD:275380	4/22 (18%)
		LRR_8	72..127	CDD:290566	17/80 (21%)
		leucine-rich repeat	72..95	CDD:275380	8/46 (17%)
		leucine-rich repeat	96..119	CDD:275380	5/24 (21%)
		leucine-rich repeat	120..142	CDD:275380	7/45 (16%)
		leucine-rich repeat	143..168	CDD:275380	6/24 (25%)
		leucine-rich repeat	170..196	CDD:275380	7/50 (14%)
		leucine-rich repeat	321..343	CDD:275380	4/22 (18%)
		LRR_RI	364..>524	CDD:238064	37/199 (19%)
		LRR_8	364..426	CDD:290566	21/101 (21%)
		leucine-rich repeat	366..391	CDD:275380	9/30 (30%)
		leucine-rich repeat	392..415	CDD:275380	4/23 (17%)
		LRR_8	415..475	CDD:290566	9/81 (11%)
		leucine-rich repeat	416..440	CDD:275380	5/45 (11%)
		leucine-rich repeat	441..464	CDD:275380	4/22 (18%)
		leucine-rich repeat	465..489	CDD:275380	2/23 (9%)
		leucine-rich repeat	490..513	CDD:275380	4/22 (18%)
		LRR_4	512..552	CDD:289563	10/39 (26%)
		LRR_8	513..573	CDD:290566	18/86 (21%)
		leucine-rich repeat	514..537	CDD:275380	6/22 (27%)
		leucine-rich repeat	538..562	CDD:275380	7/23 (30%)
		TIR	672..813	CDD:214587	55/140 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7248
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24216
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920