DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tl and TLR5

DIOPT Version :9

Sequence 1:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster
Sequence 2:NP_003259.2 Gene:TLR5 / 7100 HGNCID:11851 Length:858 Species:Homo sapiens


Alignment Length:945 Identity:217/945 - (22%)
Similarity:380/945 - (40%) Gaps:216/945 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   145 HLDRLHG-------------------LKRFRFTTRRLTHIPANLLTDMRNLSHLELRAN-IEEMP 189
            |||.|.|                   :..:||.  .||.:|..|.|..|    |.|..| |..:.
Human     4 HLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFC--NLTQVPQVLNTTER----LLLSFNYIRTVT 62

  Fly   190 SHLFDDLENLESIEFGSNKLRQMPRGI----FGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGI 250
            :..|..||.|:.:|.||   :..|..|    |..:|.|:.|:|.|::::.|....|:|...:..:
Human    63 ASSFPFLEQLQLLELGS---QYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFEL 124

  Fly   251 DIHDNGIEQ--LPHDVFAHLTNVTDINLSANLFRSL---PQGLFDHNKHLNEVRLMNNRVPLATL 310
            .::..|:..  |....|.:|..:|.::||.|..|||   |.  |.....|..:...:|::     
Human   125 RLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPS--FGKLNSLKSIDFSSNQI----- 182

  Fly   311 PSRLFANQPELQILRLRAELQSLPGDLFEHSTQITN-------ISLGD--NLLKTLPATLLEHQV 366
                        .|....||:.|.|......:...|       :..|.  |..:.:...:|:...
Human   183 ------------FLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSG 235

  Fly   367 NLLSLDLSNNRLTHLPDS-----LFAHTT--------NLTD----------------LRLEDNLL 402
            |..::|::.|....:..|     :.||..        |:.|                |.|....:
Human   236 NGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV 300

  Fly   403 TGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINS 467
            ..::..:|..|.:|..|.::.|::..|...||...:.|:.|:|.:|           :|....:|
Human   301 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYN-----------LLGELYSS 354

  Fly   468 PFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNNISSLGY----EDLAFLSQNRL--- 525
            .|..:..:..::|:.|.|..:.:.....:.:|:.|||..|.::::.:    .|: |||.|:|   
Human   355 NFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDI-FLSGNKLVTL 418

  Fly   526 -HVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFK 589
             .:|:|.|.|         ||.|   |.|.::|           ||:|  |:|..|    .:...
Human   419 PKINLTANLI---------HLSE---NRLENLD-----------ILYF--LLRVPH----LQILI 454

  Fly   590 LRTDRL-VCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSG 653
            |..:|. .||.    :.||               |::|...:...|.|.....::..|..:...|
Human   455 LNQNRFSSCSG----DQTP---------------SENPSLEQLFLGENMLQLAWETELCWDVFEG 500

  Fly   654 NLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPG-YESVTSLH---LAGNNLTSIDVDQLPT 714
             |:|            |..|:|.:|.|..||    || :..:|:|.   |..|.||.:..:.||.
Human   501 -LSH------------LQVLYLNHNYLNSLP----PGVFSHLTALRGLSLNSNRLTVLSHNDLPA 548

  Fly   715 NLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLL-LFTQDNFERIGDRNE 778
            ||..||||.|.|...|..|  |::.::    :.::.|.::|:|.....: .....|....|...:
Human   549 NLEILDISRNQLLAPNPDV--FVSLSV----LDITHNKFICECELSTFINWLNHTNVTIAGPPAD 607

  Fly   779 MMCV--NAEMPTRMVELSTNDICPAE---KGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWL 838
            :.||  ::.....:..|||.. |..|   |.:..:|.:|..:|..|...|.....||:....| .
Human   608 IYCVYPDSFSGVSLFSLSTEG-CDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFI-C 670

  Fly   839 YAHNLLLWFV-----TEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLE---HGPQKFQLCVHER 895
            |.....|.|.     ||.|:   .|:||::.:|.||.:::::.|:..|:   ....:|.||..||
Human   671 YKTAQRLVFKDHPQGTEPDM---YKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEER 732

  Fly   896 DWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGD 960
            |::.|.:...||..::.:||:.:.::|::|::..|....|..|....|::..|.:|:::...:..
Human   733 DFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQ 797

  Fly   961 VEKL-DEELKAYLKMNTYLKWGDP-----WFWDKL 989
            .:.: .:.::.:::...||:|.:.     ||..||
Human   798 YQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKL 832

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
TlNP_001262995.1 LRR_8 174..233 CDD:290566 20/63 (32%)
leucine-rich repeat 176..198 CDD:275380 6/22 (27%)
leucine-rich repeat 199..222 CDD:275380 7/26 (27%)
LRR_RI 216..542 CDD:238064 77/380 (20%)
LRR_8 221..281 CDD:290566 16/61 (26%)
leucine-rich repeat 223..270 CDD:275380 11/48 (23%)
leucine-rich repeat 271..294 CDD:275380 9/25 (36%)
leucine-rich repeat 295..320 CDD:275380 2/24 (8%)
leucine-rich repeat 321..343 CDD:275380 5/21 (24%)
LRR_8 342..402 CDD:290566 14/97 (14%)
leucine-rich repeat 344..367 CDD:275380 4/31 (13%)
leucine-rich repeat 368..391 CDD:275380 5/35 (14%)
LRR_8 390..450 CDD:290566 16/83 (19%)
leucine-rich repeat 392..415 CDD:275380 5/38 (13%)
leucine-rich repeat 416..439 CDD:275380 6/22 (27%)
leucine-rich repeat 440..474 CDD:275380 7/33 (21%)
leucine-rich repeat 475..498 CDD:275380 3/22 (14%)
LRR_8 477..534 CDD:290566 17/64 (27%)
leucine-rich repeat 499..520 CDD:275380 6/24 (25%)
leucine-rich repeat 523..552 CDD:275380 9/32 (28%)
LRRCT 561..619 CDD:214507 12/58 (21%)
LRRNT 631..667 CDD:214470 6/35 (17%)
leucine-rich repeat 664..693 CDD:275380 9/29 (31%)
LRR_8 669..726 CDD:290566 24/60 (40%)
leucine-rich repeat 694..715 CDD:275380 8/23 (35%)
leucine-rich repeat 716..737 CDD:275380 9/20 (45%)
LRRCT 751..800 CDD:214507 10/51 (20%)
TIR 858..996 CDD:214587 34/141 (24%)
TLR5NP_003259.2 LRR 1. /evidence=ECO:0000269|PubMed:22173220 45..68 8/26 (31%)
leucine-rich repeat 48..83 CDD:275378 12/41 (29%)
LRR 2. /evidence=ECO:0000269|PubMed:22173220 71..93 7/24 (29%)
PLN00113 90..>581 CDD:331614 131/592 (22%)
LRR 3. /evidence=ECO:0000269|PubMed:22173220 95..117 7/21 (33%)
leucine-rich repeat 97..120 CDD:275380 7/22 (32%)
LRR 4. /evidence=ECO:0000269|PubMed:22173220 120..143 3/22 (14%)
leucine-rich repeat 121..146 CDD:275380 4/24 (17%)
LRR 5. /evidence=ECO:0000269|PubMed:22173220 146..166 8/21 (38%)
leucine-rich repeat 147..171 CDD:275380 9/25 (36%)
LRR 6. /evidence=ECO:0000269|PubMed:22173220 171..192 5/37 (14%)
leucine-rich repeat 172..205 CDD:275380 7/49 (14%)
LRR 7. /evidence=ECO:0000269|PubMed:22173220 197..211 1/13 (8%)
LRR 8. /evidence=ECO:0000269|PubMed:22173220 214..229 2/14 (14%)