DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tl and TLR2

DIOPT Version :10

Sequence 1:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster
Sequence 2:NP_003255.2 Gene:TLR2 / 7097 HGNCID:11848 Length:784 Species:Homo sapiens


Alignment Length:879 Identity:201/879 - (22%)
Similarity:354/879 - (40%) Gaps:227/879 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   206 SNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTN 270
            |..|..:|.|:   ...:|.|:|.:|::..::..|.:...::..:.:..|||..:..|.|:.|.:
Human    40 SGSLNSIPSGL---TEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGS 101

  Fly   271 VTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATL-PSRLFANQPELQILRL-------R 327
            :..::||.|...:|....|.....|..:.|:.|  |..|| .:.||::..:|||||:       :
Human   102 LEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGN--PYKTLGETSLFSHLTKLQILRVGNMDTFTK 164

  Fly   328 AELQSLPGDLFEHSTQITNISLGDNLLKTLPA------TLLEHQVNLLSLDLSNNRLTHLPDSLF 386
            .:.:...|..|....:|....|.....|:|.:      .:|..:.::|.|::..: :|...:.|.
Human   165 IQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVD-VTSSVECLE 228

  Fly   387 AHTTNLTDLRLEDNLLTGISGDI-----FSNL----GNLVTLVMSRNRLRTIDSRAF--VSTNGL 440
            ...|:|......: |.||.:..:     |.|:    .:|..::...|::..:....|  .:.||:
Human   229 LRDTDLDTFHFSE-LSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGV 292

  Fly   441 RHLHLDHNDIDLQQPLLDIMLQTQINSPFGYM-HGLLTL----------NLRNNSIIFVYNDWKN 494
            .:.....||..:....::.:...:::.|..|: :.|.||          .:.|:.:..|......
Human   293 GNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQ 357

  Fly   495 TMLQLRELDLSYN-----NISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGY--NNN 552
            .:..|..||||.|     .:.:...|| |:.|...|.:...|     :|..|..  ||..  ..|
Human   358 HLKSLEYLDLSENLMVEEYLKNSACED-AWPSLQTLILRQNH-----LASLEKT--GETLLTLKN 414

  Fly   553 LVHVDLNDN-----PLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIE 612
            |.::|::.|     |..|.    |          |:..:...|.:.|:          ..|....
Human   415 LTNIDISKNSFHSMPETCQ----W----------PEKMKYLNLSSTRI----------HSVTGCI 455

  Fly   613 PQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMELHLEN 677
            |:||.. ||.|::.                     :|..|.||.            ||.||::..
Human   456 PKTLEI-LDVSNNN---------------------LNLFSLNLP------------QLKELYISR 486

  Fly   678 NTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMK 742
            |.|:.||.|:.  ...:..|.::.|.:|:...:||.        |::.|:.|.|           
Human   487 NKLMTLPDASL--LPMLLVLKISRNAITTFSKEQLD--------SFHTLKTLEA----------- 530

  Fly   743 WRSVKLSGNPWMCDCTAKPLLLFTQD-------------NFERIGDRNEMMCVNAEMPTRM---- 790
                  .||.::|.|   ..|.|||:             |:         :|   :.|:.:    
Human   531 ------GGNNFICSC---EFLSFTQEQQALAKVLIDWPANY---------LC---DSPSHVRGQQ 574

  Fly   791 ---VELSTNDIC---PAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKI---WLYAHNLLLW 846
               |.||.:: |   ....|:..||.::|.|||:|......|:|     :|:   ||.|..    
Human   575 VQDVRLSVSE-CHRTALVSGMCCALFLLILLTGVLCHRFHGLWY-----MKMMWAWLQAKR---- 629

  Fly   847 FVTEEDLDKDKK-------FDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIP 904
                    |.:|       :|||:|||.:|..::|:.:|.:||:....|:||:|:||::.|..|.
Human   630 --------KPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWII 686

  Fly   905 ENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDE--- 966
            :||:.|:..|.:|:.|||:||:||||.:.|...:|....:|.....|:|:...| :.:.:.:   
Human   687 DNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPI-EKKAIPQRFC 750

  Fly   967 ELKAYLKMNTYLKWGDPW-------FWDKLRFAL 993
            :|:..:...|||:|  |.       ||..||.|:
Human   751 KLRKIMNTKTYLEW--PMDEAQREGFWVNLRAAI 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TlNP_001262995.1 LRR_8 174..233 CDD:404697 8/26 (31%)
leucine-rich repeat 176..198 CDD:275380
leucine-rich repeat 199..222 CDD:275380 4/15 (27%)
LRR 222..576 CDD:443914 84/401 (21%)
leucine-rich repeat 223..270 CDD:275380 11/46 (24%)
leucine-rich repeat 271..294 CDD:275380 5/22 (23%)
leucine-rich repeat 295..320 CDD:275380 8/25 (32%)
leucine-rich repeat 321..343 CDD:275380 7/28 (25%)
leucine-rich repeat 344..367 CDD:275380 5/28 (18%)
leucine-rich repeat 368..391 CDD:275380 4/22 (18%)
leucine-rich repeat 392..415 CDD:275380 6/31 (19%)
leucine-rich repeat 416..439 CDD:275380 3/24 (13%)
leucine-rich repeat 440..474 CDD:275380 4/34 (12%)
leucine-rich repeat 475..498 CDD:275380 5/32 (16%)
leucine-rich repeat 499..520 CDD:275380 9/25 (36%)
leucine-rich repeat 523..552 CDD:275380 6/30 (20%)
LRRCT 561..619 CDD:214507 11/62 (18%)
LRRNT 631..667 CDD:214470 4/35 (11%)
PPP1R42 <660..752 CDD:455733 19/91 (21%)
leucine-rich repeat 664..693 CDD:275380 9/28 (32%)
leucine-rich repeat 694..715 CDD:275380 5/20 (25%)
leucine-rich repeat 716..737 CDD:275380 4/20 (20%)
LRRCT 751..800 CDD:214507 14/71 (20%)
TIR 858..996 CDD:214587 51/153 (33%)
TLR2NP_003255.2 LRR <39..296 CDD:443914 56/262 (21%)
leucine-rich repeat 54..77 CDD:275378 5/22 (23%)
LRR 1 54..77 5/22 (23%)
leucine-rich repeat 78..101 CDD:275378 6/22 (27%)
LRR 2 78..101 6/22 (27%)
leucine-rich repeat 102..125 CDD:275378 5/22 (23%)
LRR 3 102..125 5/22 (23%)
leucine-rich repeat 126..150 CDD:275378 8/25 (32%)
LRR 4 126..150 8/25 (32%)
LRR 5 151..175 6/23 (26%)
LRR 6 176..199 4/22 (18%)
leucine-rich repeat 176..196 CDD:275380 4/19 (21%)
LRR 7 200..223 4/23 (17%)
LRR 221..>556 CDD:443914 86/431 (20%)
LRR 8 224..250 6/26 (23%)
LRR 9 251..278 4/26 (15%)
LRR 10 279..308 5/28 (18%)
LRR 11 309..337 5/27 (19%)
LRR 12 338..361 2/22 (9%)
leucine-rich repeat 362..388 CDD:275380 9/26 (35%)
LRR 13 362..388 9/26 (35%)
leucine-rich repeat 389..414 CDD:275380 6/31 (19%)
LRR 14 389..414 6/31 (19%)
leucine-rich repeat 415..437 CDD:275380 7/35 (20%)
LRR 15 415..437 7/35 (20%)
leucine-rich repeat 438..478 CDD:275380 13/83 (16%)
LRR 16 438..457 3/28 (11%)
LRR 17 458..478 9/53 (17%)
leucine-rich repeat 479..500 CDD:275380 8/22 (36%)
LRR 18 479..500 8/22 (36%)
leucine-rich repeat 501..524 CDD:275380 6/30 (20%)
LRR 19 501..524 6/30 (20%)
LRRCT 533..586 CDD:214507 13/68 (19%)
TIR 640..784 CDD:214587 50/146 (34%)
ATG16L1-binding motif 761..778 6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

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