DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and TLR2

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_001305716.1	Gene:	TLR2 / 7097	HGNCID:	11848	Length:	784	Species:	Homo sapiens

Alignment Length:	879	Identity:	201/879 - (22%)
Similarity:	354/879 - (40%)	Gaps:	227/879 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 SNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTN 270
            |..|..:|.|:   ...:|.|:|.:|::..::..|.:...::..:.:..|||..:..|.|:.|.:
Human    40 SGSLNSIPSGL---TEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGS 101

  Fly   271 VTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATL-PSRLFANQPELQILRL-------R 327
            :..::||.|...:|....|.....|..:.|:.|  |..|| .:.||::..:|||||:       :
Human   102 LEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGN--PYKTLGETSLFSHLTKLQILRVGNMDTFTK 164

  Fly   328 AELQSLPGDLFEHSTQITNISLGDNLLKTLPA------TLLEHQVNLLSLDLSNNRLTHLPDSLF 386
            .:.:...|..|....:|....|.....|:|.:      .:|..:.::|.|::..: :|...:.|.
Human   165 IQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVD-VTSSVECLE 228

  Fly   387 AHTTNLTDLRLEDNLLTGISGDI-----FSNL----GNLVTLVMSRNRLRTIDSRAF--VSTNGL 440
            ...|:|......: |.||.:..:     |.|:    .:|..::...|::..:....|  .:.||:
Human   229 LRDTDLDTFHFSE-LSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGV 292

  Fly   441 RHLHLDHNDIDLQQPLLDIMLQTQINSPFGYM-HGLLTL----------NLRNNSIIFVYNDWKN 494
            .:.....||..:....::.:...:::.|..|: :.|.||          .:.|:.:..|......
Human   293 GNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQ 357

  Fly   495 TMLQLRELDLSYN-----NISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGY--NNN 552
            .:..|..||||.|     .:.:...|| |:.|...|.:...|     :|..|..  ||..  ..|
Human   358 HLKSLEYLDLSENLMVEEYLKNSACED-AWPSLQTLILRQNH-----LASLEKT--GETLLTLKN 414

  Fly   553 LVHVDLNDN-----PLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIE 612
            |.::|::.|     |..|.    |          |:..:...|.:.|:          ..|....
Human   415 LTNIDISKNSFHSMPETCQ----W----------PEKMKYLNLSSTRI----------HSVTGCI 455

  Fly   613 PQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMELHLEN 677
            |:||.. ||.|::.                     :|..|.||.            ||.||::..
Human   456 PKTLEI-LDVSNNN---------------------LNLFSLNLP------------QLKELYISR 486

  Fly   678 NTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMK 742
            |.|:.||.|:.  ...:..|.::.|.:|:...:||.        |::.|:.|.|
Human   487 NKLMTLPDASL--LPMLLVLKISRNAITTFSKEQLD--------SFHTLKTLEA----------- 530

  Fly   743 WRSVKLSGNPWMCDCTAKPLLLFTQD-------------NFERIGDRNEMMCVNAEMPTRM---- 790
                  .||.::|.|   ..|.|||:             |:         :|   :.|:.:
Human   531 ------GGNNFICSC---EFLSFTQEQQALAKVLIDWPANY---------LC---DSPSHVRGQQ 574

  Fly   791 ---VELSTNDIC---PAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKI---WLYAHNLLLW 846
               |.||.:: |   ....|:..||.::|.|||:|......|:|     :|:   ||.|..
Human   575 VQDVRLSVSE-CHRTALVSGMCCALFLLILLTGVLCHRFHGLWY-----MKMMWAWLQAKR---- 629

  Fly   847 FVTEEDLDKDKK-------FDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIP 904
                    |.:|       :|||:|||.:|..::|:.:|.:||:....|:||:|:||::.|..|.
Human   630 --------KPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWII 686

  Fly   905 ENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDE--- 966
            :||:.|:..|.:|:.|||:||:||||.:.|...:|....:|.....|:|:...| :.:.:.:
Human   687 DNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPI-EKKAIPQRFC 750

  Fly   967 ELKAYLKMNTYLKWGDPW-------FWDKLRFAL 993
            :|:..:...|||:|  |.       ||..||.|:
Human   751 KLRKIMNTKTYLEW--PMDEAQREGFWVNLRAAI 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	8/26 (31%)
		leucine-rich repeat	176..198	CDD:275380
		leucine-rich repeat	199..222	CDD:275380	4/15 (27%)
		LRR_RI	216..542	CDD:238064	74/366 (20%)
		LRR_8	221..281	CDD:290566	14/59 (24%)
		leucine-rich repeat	223..270	CDD:275380	11/46 (24%)
		leucine-rich repeat	271..294	CDD:275380	5/22 (23%)
		leucine-rich repeat	295..320	CDD:275380	8/25 (32%)
		leucine-rich repeat	321..343	CDD:275380	7/28 (25%)
		LRR_8	342..402	CDD:290566	11/65 (17%)
		leucine-rich repeat	344..367	CDD:275380	5/28 (18%)
		leucine-rich repeat	368..391	CDD:275380	4/22 (18%)
		LRR_8	390..450	CDD:290566	13/70 (19%)
		leucine-rich repeat	392..415	CDD:275380	6/31 (19%)
		leucine-rich repeat	416..439	CDD:275380	3/24 (13%)
		leucine-rich repeat	440..474	CDD:275380	4/34 (12%)
		leucine-rich repeat	475..498	CDD:275380	5/32 (16%)
		LRR_8	477..534	CDD:290566	16/71 (23%)
		leucine-rich repeat	499..520	CDD:275380	9/25 (36%)
		leucine-rich repeat	523..552	CDD:275380	6/30 (20%)
		LRRCT	561..619	CDD:214507	11/62 (18%)
		LRRNT	631..667	CDD:214470	4/35 (11%)
		leucine-rich repeat	664..693	CDD:275380	9/28 (32%)
		LRR_8	669..726	CDD:290566	15/56 (27%)
		leucine-rich repeat	694..715	CDD:275380	5/20 (25%)
		leucine-rich repeat	716..737	CDD:275380	4/20 (20%)
		LRRCT	751..800	CDD:214507	14/71 (20%)
		TIR	858..996	CDD:214587	51/153 (33%)
TLR2	NP_001305716.1	PLN00113	<40..>206	CDD:331614	39/170 (23%)
		leucine-rich repeat	54..77	CDD:275380	5/22 (23%)
		LRR 1	54..77		5/22 (23%)
		LRR_8	77..135	CDD:316378	14/59 (24%)
		leucine-rich repeat	78..101	CDD:275380	6/22 (27%)
		LRR 2	78..101		6/22 (27%)
		leucine-rich repeat	102..125	CDD:275380	5/22 (23%)
		LRR 3	102..125		5/22 (23%)
		leucine-rich repeat	126..150	CDD:275380	8/25 (32%)
		LRR 4	126..150		8/25 (32%)
		leucine-rich repeat	151..175	CDD:275380	6/23 (26%)
		LRR 5	151..175		6/23 (26%)
		LRR 6	176..199		4/22 (18%)
		leucine-rich repeat	176..196	CDD:275380	4/19 (21%)
		LRR 7	200..223		4/23 (17%)
		LRR 8	224..250		6/26 (23%)
		LRR 9	251..278		4/26 (15%)
		LRR 10	279..308		5/28 (18%)
		LRR 11	309..337		5/27 (19%)
		NEL	<324..>558	CDD:330839	68/329 (21%)
		LRR 12	338..361		2/22 (9%)
		leucine-rich repeat	362..388	CDD:275380	9/26 (35%)
		LRR 13	362..388		9/26 (35%)
		leucine-rich repeat	389..414	CDD:275380	6/31 (19%)
		LRR 14	389..414		6/31 (19%)
		leucine-rich repeat	415..437	CDD:275380	7/35 (20%)
		LRR 15	415..437		7/35 (20%)
		leucine-rich repeat	438..478	CDD:275380	13/83 (16%)
		LRR 16	438..457		3/28 (11%)
		LRR 17	458..478		9/53 (17%)
		leucine-rich repeat	479..500	CDD:275380	8/22 (36%)
		LRR 18	479..500		8/22 (36%)
		leucine-rich repeat	501..524	CDD:275380	6/30 (20%)
		LRR 19	501..524		6/30 (20%)
		LRRCT	533..586	CDD:214507	13/68 (19%)
		TIR	640..784	CDD:214587	50/146 (34%)
		ATG16L1-binding motif	761..778		6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920