Protein Alignment Tl and Il1rapl2

DIOPT Version :9

• Sequence 1: NP_001262995.1
• Gene: Tl / 43222
• FlyBaseID: FBgn0262473
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: NP_109613.1
• Gene: Il1rapl2 / 60367
• MGIID: 1913106
• Length: 686
• Species: Mus musculus
• Alignment Length: 334
• Identity: 76/334 - (22%)
• Similarity: 147/334 - (44%)
• Gaps: 55/334 - (16%)

  Fly   819 LAGFTAALYYKFQTEIKIW-LYAHNLLLW----FVTEEDLDKDKKFDAFISYSHKDQSFI----- 873
            |||...|::......:.:: .|...|:|:    |..:|..|.:|::||::||:..||..:
Mouse   357 LAGGLGAIFLLLILLLVVYKCYNIELMLFYRQRFGGDETTDDNKEYDAYLSYTKVDQDTLDCDNT 421

  Fly   874 --EDY---LVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFI-KSEWAR 932
              |.:   ::|.:......::|.:.|||.:..|...|::.|.|..|||.||||:.::| :..|:.
Mouse   422 EEEQFALEILPDVLEKHYGYKLFIPERDLIPSGTYIEDLTRCVEQSRRLIIVLTPDYILRRGWSI 486

  Fly   933 LEFRAAHRSALNEGRSRIIVIIYSDI-GDVEKLD-EELKAYLKMNTYLKWGDP-------WFWDK 988
            .|..:...:.|..|..::|:|..::: |.|...: |.||..:|:.:.:||..|       .||..
Mouse   487 FELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKHNIKLLSLIKWKGPKSSKLNSKFWKH 551

  Fly   989 LRFALPHRRPVGNIGNGALIKTALKGSTDDKLELIKPSPVTPPLTTPPAEATKNPLVAQLNGVTP 1053
            |.:.:|.::. ..:.:..::.:|.:|...:    ::|   .|.:......||..|..|.|.....
Mouse   552 LVYEMPIKKK-EMLSHCHVLDSAEQGLFGE----LQP---IPSIAMTSTSATMVPSQADLPEFHH 608

  Fly  1054 HQAIMIANGKNGLTNLYTPNG---KSHGNGH---------INGAFIINTNAKQSDVXDWEKAELF 1106
            ..::.:.:...|..:....|.   .|.||.|         :||...:|.:.|:::
Mouse   609 SDSMQMRHCCRGYQHEMPANTLSVPSLGNHHTYCNLPLTLLNGQLPLNNSLKETE---------- 663

  Fly  1107 QFDPDDELL 1115
            :|..::.||
Mouse   664 EFSRNNPLL 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566
		leucine-rich repeat	176..198	CDD:275380
		leucine-rich repeat	199..222	CDD:275380
		LRR_RI	216..542	CDD:238064
		LRR_8	221..281	CDD:290566
		leucine-rich repeat	223..270	CDD:275380
		leucine-rich repeat	271..294	CDD:275380
		leucine-rich repeat	295..320	CDD:275380
		leucine-rich repeat	321..343	CDD:275380
		LRR_8	342..402	CDD:290566
		leucine-rich repeat	344..367	CDD:275380
		leucine-rich repeat	368..391	CDD:275380
		LRR_8	390..450	CDD:290566
		leucine-rich repeat	392..415	CDD:275380
		leucine-rich repeat	416..439	CDD:275380
		leucine-rich repeat	440..474	CDD:275380
		leucine-rich repeat	475..498	CDD:275380
		LRR_8	477..534	CDD:290566
		leucine-rich repeat	499..520	CDD:275380
		leucine-rich repeat	523..552	CDD:275380
		LRRCT	561..619	CDD:214507
		LRRNT	631..667	CDD:214470
		leucine-rich repeat	664..693	CDD:275380
		LRR_8	669..726	CDD:290566
		leucine-rich repeat	694..715	CDD:275380
		leucine-rich repeat	716..737	CDD:275380
		LRRCT	751..800	CDD:214507
		TIR	858..996	CDD:214587	43/157 (27%)
Il1rapl2	NP_109613.1	Ig1_IL1RAPL-1_like	32..133	CDD:143304
		Ig2_IL1R_like	146..237	CDD:319309
		IG_like	250..347	CDD:214653
		TIR	401..559	CDD:214587	43/157 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8062
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860