DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tl and kek6

DIOPT Version :9

Sequence 1:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster
Sequence 2:NP_001263151.1 Gene:kek6 / 43729 FlyBaseID:FBgn0039862 Length:843 Species:Drosophila melanogaster


Alignment Length:609 Identity:119/609 - (19%)
Similarity:214/609 - (35%) Gaps:183/609 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    99 VDRVQMRRCMLPGHTPIASILDYLGIVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLT 163
            :||   ||...|...|:..||  |.:|:.|.....|.:...|.|.:.   .:|.|....::.:||
  Fly     5 MDR---RRSRTPRTLPVCWIL--LCLVAWTVADDWSLSCASNCTCKW---TNGKKSAICSSLQLT 61

  Fly   164 HIPANLLTDMR-----------------------NLSHLEL-RANIEEMPSHLFDDLENLESIEF 204
            .||..|.|:::                       ||..:.| ::.::.:....|.:|:.|..|:.
  Fly    62 TIPNTLSTELQVLVLNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDL 126

  Fly   205 GSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLT 269
            ..|||..:.:..|....:|:.|.|..|.|..|..:.|.....:..:|:||..|..:.....|:|.
  Fly   127 SDNKLEMLDKDTFMGNDRLRILYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLN 191

  Fly   270 NVTDINLSANLFRSLPQGLFDHNKHLNEVRL------------------MNNRVPLATL-----P 311
            .:..:||..||..||.:.:|.|..:|..:.|                  :|:|:...:|     |
  Fly   192 LLEFLNLKNNLLESLSEYVFQHMANLKTLSLEENPWQCNCKLRKFRGWYVNSRLSSVSLVCKGPP 256

  Fly   312 SR-----------LFANQPELQILRLRAELQSLP------------GD----------------- 336
            ::           ||...|.::|.. ..|:|::.            ||                 
  Fly   257 AQKDRTWDSVDDELFGCPPRVEIFN-NEEVQNIDIGSNTTFSCLVYGDPLPEVAWELNGKILDND 320

  Fly   337 --LFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLD------LSNNRLTHLPDSLFAHTTNLT 393
              ||| |..|.:..|..||      |:.    |:.|||      ..:|.:..:..::..:.:.:.
  Fly   321 NVLFE-SESIASDKLWSNL------TVF----NVTSLDAGTYACTGSNSIGSMTQNISIYLSEIV 374

  Fly   394 DLRLED--------NLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDI 450
            ...||.        .|:.||.|.:|..:.....:.:.:...|             :|.|.:...:
  Fly   375 QHVLEKTPETFWYFGLIMGIFGTVFLLISISFVVCLCKRTTR-------------QHRHANKAGV 426

  Fly   451 -------DLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNN 508
                   |.::.|||..:.|..|.. |..:|:      :|              |...:.::..:
  Fly   427 KSSVSFNDQEKKLLDSSVTTTTNDR-GDSYGI------DN--------------QPTSIGMNKGD 470

  Fly   509 ISSLGYEDLAFLSQNRLHVNMTHNK----IRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTI 569
            .:.:|:      :|..:|...:|..    :::....:.|..|.|....|:.|  .|:    .|.:
  Fly   471 SAGMGF------NQIEIHAVESHRHGSMLVQQQPQQQQVAGGGGMRQQLMQV--KDS----TCGM 523

  Fly   570 LWFIQLVRG---VHKPQYSRQFKL 590
            :.....:.|   .|..|.|.:|.|
  Fly   524 MSVPTSMAGHAHSHPAQISEEFPL 547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TlNP_001262995.1 LRR_8 174..233 CDD:290566 15/82 (18%)
leucine-rich repeat 176..198 CDD:275380 4/22 (18%)
leucine-rich repeat 199..222 CDD:275380 6/22 (27%)
LRR_RI 216..542 CDD:238064 74/415 (18%)
LRR_8 221..281 CDD:290566 16/59 (27%)
leucine-rich repeat 223..270 CDD:275380 13/46 (28%)
leucine-rich repeat 271..294 CDD:275380 8/22 (36%)
leucine-rich repeat 295..320 CDD:275380 8/58 (14%)
leucine-rich repeat 321..343 CDD:275380 9/52 (17%)
LRR_8 342..402 CDD:290566 12/73 (16%)
leucine-rich repeat 344..367 CDD:275380 5/22 (23%)
leucine-rich repeat 368..391 CDD:275380 4/28 (14%)
LRR_8 390..450 CDD:290566 10/67 (15%)
leucine-rich repeat 392..415 CDD:275380 7/30 (23%)
leucine-rich repeat 416..439 CDD:275380 1/22 (5%)
leucine-rich repeat 440..474 CDD:275380 9/40 (23%)
leucine-rich repeat 475..498 CDD:275380 1/22 (5%)
LRR_8 477..534 CDD:290566 6/60 (10%)
leucine-rich repeat 499..520 CDD:275380 1/20 (5%)
leucine-rich repeat 523..552 CDD:275380 5/32 (16%)
LRRCT 561..619 CDD:214507 7/33 (21%)
LRRNT 631..667 CDD:214470
leucine-rich repeat 664..693 CDD:275380
LRR_8 669..726 CDD:290566
leucine-rich repeat 694..715 CDD:275380
leucine-rich repeat 716..737 CDD:275380
LRRCT 751..800 CDD:214507
TIR 858..996 CDD:214587
kek6NP_001263151.1 leucine-rich repeat 71..96 CDD:275380 0/24 (0%)
LRR_8 96..155 CDD:290566 15/58 (26%)
leucine-rich repeat 97..120 CDD:275380 4/22 (18%)
leucine-rich repeat 121..144 CDD:275380 6/22 (27%)
LRR_4 144..186 CDD:289563 11/41 (27%)
leucine-rich repeat 145..168 CDD:275380 7/22 (32%)
leucine-rich repeat 169..216 CDD:275380 14/46 (30%)
LRRCT 225..274 CDD:214507 6/48 (13%)
Ig 295..367 CDD:143165 16/82 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453727
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.930

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