Protein Alignment Tl and CG7800

DIOPT Version :10

• Sequence 1: NP_001262995.1
• Gene: Tl / 43222
• FlyBaseID: FBgn0262473
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: NP_649770.1
• Gene: CG7800 / 40963
• FlyBaseID: FBgn0037552
• Length: 533
• Species: Drosophila melanogaster
• Alignment Length: 669
• Identity: 140/669 - (20%)
• Similarity: 237/669 - (35%)
• Gaps: 205/669 - (30%)

  Fly   134 SDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHLELRANIEEMPSHLFDDLEN 198
            ||.....:|..|:|...                ..:|..|.||..||               |||
  Fly    39 SDKKATKLTEFHMDSCE----------------KKVLKLMPNLRTLE---------------LEN 72

  Fly   199 LESIEFGSNKLRQMP--------RG--------IFGKMPKLKQLNLWSNQLHNLTKHDFEGATSV 247
            .:|.:|..|.|.|:|        ||        .|.|.|.:|.|.|..|.:..|:...|:|...:
  Fly    73 CDSPDFTMNDLNQLPYLTSLQLRRGNLLGLHDEHFSKWPNMKILMLGGNNITRLSNECFKGLAQL 137

  Fly   248 LGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPS 312
            ..:.:..|||:.||.|||.:|..:..::||.|                          .:.||..
  Fly   138 WLLSLPGNGIQGLPWDVFQNLPELLHLDLSGN--------------------------RIETLHE 176

  Fly   313 RLFANQPELQILRLRAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNR 377
            .:|...|:|::|.|..                       |.|..:..|.|:...||..||:||
  Fly   177 NIFTGVPKLEMLLLNG-----------------------NPLTWIAPTSLKSLSNLRLLDMSN-- 216

  Fly   378 LTHLPDSLF--AHTTNLTDLRLEDNLLTGISG-DIFSNLGNLVTLVMSRNRLRTI---DSRAFVS 436
            ...|||...  |||..|      ||  :|:.. ||   ||::..|...:|.:..|   |..:.:
  Fly   217 CGPLPDLSLPGAHTLIL------DN--SGVQRLDI---LGSVHKLQARKNHITEIKLPDKSSVI- 269

  Fly   437 TNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRE 501
                        ::||...||     |..:.|     .|||                 .|.:|:.
  Fly   270 ------------ELDLHSNLL-----TATDIP-----KLLT-----------------GMWRLQR 295

  Fly   502 LDLSYNNI---SSLGYEDLA--FLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDN 561
            ||||.|.|   ::.|.::.:  |:..|.:::|::.|::.|:.....:..     ..|.|:|.:.|
  Fly   296 LDLSENIIGIYAAAGSDNTSELFILPNLMYMNLSANRLTRLHFDSPIPW-----ERLTHLDASYN 355

  Fly   562 PLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDP 626
            .:.....:        |:     ...|.|::..|..:..|..|.||.:   |...:..:...|:.
  Fly   356 RIYAPAKV--------GI-----DEAFNLQSLHLEGNYINNFELTPWK---PHPSLKEVALYDNK 404

  Fly   627 RERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGY 691
            .:   |:|.. ::..:...:.:|.                 ::..:....|||............
  Fly   405 FQ---PKGYK-NITKFFNEIGVNV-----------------LEKTQYSQSNNTTPTCKPCIPDAR 448

  Fly   692 ESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCD 756
            :..||:....|......|:.| :|.|:....||.|.:::..|..|:|..:..:.::|.|......
  Fly   449 DFPTSISADTNQTIDTKVNPL-SNDTYQWNVWNVLMLVSLIVSLFVNSFLIVKLIRLRGRNQFTQ 512

  Fly   757 CTAKPLL--LFTQDNFERI 773
            .::.|.:  :|:.::.:.|
  Fly   513 SSSVPAIIEMFSNESDDEI 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:404697	22/74 (30%)
		leucine-rich repeat	176..198	CDD:275380	4/21 (19%)
		leucine-rich repeat	199..222	CDD:275380	10/38 (26%)
		LRR	222..576	CDD:443914	81/364 (22%)
		leucine-rich repeat	223..270	CDD:275380	16/46 (35%)
		leucine-rich repeat	271..294	CDD:275380	3/22 (14%)
		leucine-rich repeat	295..320	CDD:275380	3/24 (13%)
		leucine-rich repeat	321..343	CDD:275380	3/21 (14%)
		leucine-rich repeat	344..367	CDD:275380	4/22 (18%)
		leucine-rich repeat	368..391	CDD:275380	11/24 (46%)
		leucine-rich repeat	392..415	CDD:275380	7/23 (30%)
		leucine-rich repeat	416..439	CDD:275380	4/25 (16%)
		leucine-rich repeat	440..474	CDD:275380	6/33 (18%)
		leucine-rich repeat	475..498	CDD:275380	4/22 (18%)
		leucine-rich repeat	499..520	CDD:275380	8/25 (32%)
		leucine-rich repeat	523..552	CDD:275380	4/28 (14%)
		LRRCT	561..619	CDD:214507	10/57 (18%)
		LRRNT	631..667	CDD:214470	3/35 (9%)
		PPP1R42	<660..752	CDD:455733	18/91 (20%)
		leucine-rich repeat	664..693	CDD:275380	3/28 (11%)
		leucine-rich repeat	694..715	CDD:275380	5/20 (25%)
		leucine-rich repeat	716..737	CDD:275380	5/20 (25%)
		LRRCT	751..800	CDD:214507	3/25 (12%)
		TIR	858..996	CDD:214587
CG7800	NP_649770.1	leucine-rich repeat	46..64	CDD:275380	5/33 (15%)
		leucine-rich repeat	65..85	CDD:275380	10/34 (29%)
		LRR	68..482	CDD:443914	122/573 (21%)
		leucine-rich repeat	89..112	CDD:275380	4/22 (18%)
		leucine-rich repeat	113..136	CDD:275380	7/22 (32%)
		leucine-rich repeat	137..160	CDD:275380	9/22 (41%)
		leucine-rich repeat	161..184	CDD:275380	6/48 (13%)
		leucine-rich repeat	185..208	CDD:275380	7/45 (16%)
		leucine-rich repeat	209..246	CDD:275380	18/49 (37%)
		leucine-rich repeat	247..267	CDD:275380	4/19 (21%)
		leucine-rich repeat	268..292	CDD:275380	10/63 (16%)
		leucine-rich repeat	293..322	CDD:275380	9/28 (32%)
		leucine-rich repeat	395..406	CDD:275378	1/10 (10%)