DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and CG7800

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_649770.1	Gene:	CG7800 / 40963	FlyBaseID:	FBgn0037552	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	669	Identity:	140/669 - (20%)
Similarity:	237/669 - (35%)	Gaps:	205/669 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 SDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHLELRANIEEMPSHLFDDLEN 198
            ||.....:|..|:|...                ..:|..|.||..||               |||
  Fly    39 SDKKATKLTEFHMDSCE----------------KKVLKLMPNLRTLE---------------LEN 72

  Fly   199 LESIEFGSNKLRQMP--------RG--------IFGKMPKLKQLNLWSNQLHNLTKHDFEGATSV 247
            .:|.:|..|.|.|:|        ||        .|.|.|.:|.|.|..|.:..|:...|:|...:
  Fly    73 CDSPDFTMNDLNQLPYLTSLQLRRGNLLGLHDEHFSKWPNMKILMLGGNNITRLSNECFKGLAQL 137

  Fly   248 LGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPS 312
            ..:.:..|||:.||.|||.:|..:..::||.|                          .:.||..
  Fly   138 WLLSLPGNGIQGLPWDVFQNLPELLHLDLSGN--------------------------RIETLHE 176

  Fly   313 RLFANQPELQILRLRAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNR 377
            .:|...|:|::|.|..                       |.|..:..|.|:...||..||:||
  Fly   177 NIFTGVPKLEMLLLNG-----------------------NPLTWIAPTSLKSLSNLRLLDMSN-- 216

  Fly   378 LTHLPDSLF--AHTTNLTDLRLEDNLLTGISG-DIFSNLGNLVTLVMSRNRLRTI---DSRAFVS 436
            ...|||...  |||..|      ||  :|:.. ||   ||::..|...:|.:..|   |..:.:
  Fly   217 CGPLPDLSLPGAHTLIL------DN--SGVQRLDI---LGSVHKLQARKNHITEIKLPDKSSVI- 269

  Fly   437 TNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRE 501
                        ::||...||     |..:.|     .|||                 .|.:|:.
  Fly   270 ------------ELDLHSNLL-----TATDIP-----KLLT-----------------GMWRLQR 295

  Fly   502 LDLSYNNI---SSLGYEDLA--FLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDN 561
            ||||.|.|   ::.|.::.:  |:..|.:::|::.|::.|:.....:..     ..|.|:|.:.|
  Fly   296 LDLSENIIGIYAAAGSDNTSELFILPNLMYMNLSANRLTRLHFDSPIPW-----ERLTHLDASYN 355

  Fly   562 PLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDP 626
            .:.....:        |:     ...|.|::..|..:..|..|.||.:   |...:..:...|:.
  Fly   356 RIYAPAKV--------GI-----DEAFNLQSLHLEGNYINNFELTPWK---PHPSLKEVALYDNK 404

  Fly   627 RERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGY 691
            .:   |:|.. ::..:...:.:|.                 ::..:....|||............
  Fly   405 FQ---PKGYK-NITKFFNEIGVNV-----------------LEKTQYSQSNNTTPTCKPCIPDAR 448

  Fly   692 ESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCD 756
            :..||:....|......|:.| :|.|:....||.|.:::..|..|:|..:..:.::|.|......
  Fly   449 DFPTSISADTNQTIDTKVNPL-SNDTYQWNVWNVLMLVSLIVSLFVNSFLIVKLIRLRGRNQFTQ 512

  Fly   757 CTAKPLL--LFTQDNFERI 773
            .::.|.:  :|:.::.:.|
  Fly   513 SSSVPAIIEMFSNESDDEI 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	22/74 (30%)
		leucine-rich repeat	176..198	CDD:275380	4/21 (19%)
		leucine-rich repeat	199..222	CDD:275380	10/38 (26%)
		LRR_RI	216..542	CDD:238064	80/336 (24%)
		LRR_8	221..281	CDD:290566	20/59 (34%)
		leucine-rich repeat	223..270	CDD:275380	16/46 (35%)
		leucine-rich repeat	271..294	CDD:275380	3/22 (14%)
		leucine-rich repeat	295..320	CDD:275380	3/24 (13%)
		leucine-rich repeat	321..343	CDD:275380	3/21 (14%)
		LRR_8	342..402	CDD:290566	19/61 (31%)
		leucine-rich repeat	344..367	CDD:275380	4/22 (18%)
		leucine-rich repeat	368..391	CDD:275380	11/24 (46%)
		LRR_8	390..450	CDD:290566	12/63 (19%)
		leucine-rich repeat	392..415	CDD:275380	7/23 (30%)
		leucine-rich repeat	416..439	CDD:275380	4/25 (16%)
		leucine-rich repeat	440..474	CDD:275380	6/33 (18%)
		leucine-rich repeat	475..498	CDD:275380	4/22 (18%)
		LRR_8	477..534	CDD:290566	14/61 (23%)
		leucine-rich repeat	499..520	CDD:275380	8/25 (32%)
		leucine-rich repeat	523..552	CDD:275380	4/28 (14%)
		LRRCT	561..619	CDD:214507	10/57 (18%)
		LRRNT	631..667	CDD:214470	3/35 (9%)
		leucine-rich repeat	664..693	CDD:275380	3/28 (11%)
		LRR_8	669..726	CDD:290566	12/56 (21%)
		leucine-rich repeat	694..715	CDD:275380	5/20 (25%)
		leucine-rich repeat	716..737	CDD:275380	5/20 (25%)
		LRRCT	751..800	CDD:214507	3/25 (12%)
		TIR	858..996	CDD:214587
CG7800	NP_649770.1	leucine-rich repeat	46..64	CDD:275380	5/33 (15%)
		leucine-rich repeat	65..85	CDD:275380	10/34 (29%)
		LRR_8	87..147	CDD:290566	14/59 (24%)
		leucine-rich repeat	89..112	CDD:275380	4/22 (18%)
		leucine-rich repeat	113..136	CDD:275380	7/22 (32%)
		LRR_RI	<131..334	CDD:238064	71/304 (23%)
		leucine-rich repeat	137..160	CDD:275380	9/22 (41%)
		LRR_8	140..195	CDD:290566	20/103 (19%)
		leucine-rich repeat	161..184	CDD:275380	6/48 (13%)
		leucine-rich repeat	185..208	CDD:275380	7/45 (16%)
		leucine-rich repeat	209..246	CDD:275380	18/49 (37%)
		leucine-rich repeat	247..267	CDD:275380	4/19 (21%)
		leucine-rich repeat	268..292	CDD:275380	10/63 (16%)
		leucine-rich repeat	293..322	CDD:275380	9/28 (32%)
		leucine-rich repeat	395..406	CDD:275378	1/10 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453820
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930