DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and MstProx

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster

Alignment Length:	1111	Identity:	253/1111 - (22%)
Similarity:	433/1111 - (38%)	Gaps:	340/1111 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LTIQPKDYVQI----MCNLT--------------DTTDYQQLPKKLRIGEVD------------- 100
            ||| |.||.:.    :||.|              .|.:|..:   :|.|.::
  Fly     5 LTI-PDDYCETYCGGICNDTVASKTCDREAYDYIATNEYHLI---MRDGHLEVNWKIPDPNIFII 65

  Fly   101 -------RVQMRRCMLPGHT-PIASILDY---LGIVSPTTLIFESDNLGMNITRQHLDRLHGLKR 154
                   |:::...::...: ||.:: ||   ||:.:.|.  ||:......:..:.:..::|.|.
  Fly    66 SPISKENRLKLNELIVSDTSYPIRAV-DYLRQLGVETVTR--FENQINSFKVIERDVHYINGPKS 127

  Fly   155 FRFTTRRLTHIP-----ANLLTDMRNLSHLELRA--NIEE----MPSHLFDDLENLESIEFGSNK 208
            .:...:...::.     .|..||  |::.:.:.|  .:|.    :.:.:|:...:|.|:.|...:
  Fly   128 LKIIIQSNLYLNEIIEYINKTTD--NVNEIIINAYKTVENQQIALDNLIFNGKSHLRSLTFIGFQ 190

  Fly   209 LRQMPRGIFGKMPKLKQLNLWSNQLHNLT-KHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVT 272
            :..:....|.:...||::.|.:..:.||| ....:.:...|.:|| ||.::      ..:.||.:
  Fly   191 IENLSTKPFAQFINLKRMVLTNCTVRNLTFLRTLQKSLEHLELDI-DNEVD------LKYFTNFS 248

  Fly   273 DINLSANLFRSLPQ----GLFDHNKHLNEVRLMNNRVPLATLPSRLF-----------ANQPELQ 322
            .:.. ..:...:|.    .|...:|:.|.:|.:|. :....|...|:           :|...||
  Fly   249 SLKF-MKVRNYIPNKNFTALICTHKNCNFIRGING-LECPKLCQCLYIIDDLELNIDCSNLGLLQ 311

  Fly   323 ILRLRAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLT-----HLP 382
            |..|  .:.|..|         ..::..:|.|..||...|.....:..||:|.||||     |||
  Fly   312 IPPL--PIPSYGG---------VKLNFSNNSLSQLPTMTLPGYKLVKRLDVSRNRLTNLSINHLP 365

  Fly   383 DSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDH 447
            ..|             |.|  .:|.:...|:||.|.     ..|||:.  .|..|.....:|.|
  Fly   366 AKL-------------DYL--DVSFNEIINMGNDVI-----KYLRTVP--IFKQTGNQWTIHCD- 407

  Fly   448 NDIDLQQPLLD--------IMLQTQINSPFGYMHGLLTL-------------------------- 478
                 .:|||:        |.:::....|. ::|.|..|
  Fly   408 -----DKPLLNFFRHLKLIIRMKSAEMKPM-FLHSLTELPKGFLKFLGKHFIWLGVRKQEYYLIN 466

  Fly   479 -------------NLRNNSIIFVYNDWKNTMLQL--RELDLSY---------------------- 506
                         ||.....|:.|.:|.:..|..  ||.||.|
  Fly   467 EEQLLQSMHRKLNNLNTIMSIYKYMEWLHRKLIFVNREYDLFYIRQMAAPCPHKCECCYSRDSLI 531

  Fly   507 ------------------NNISSLGYEDLAFLSQNRLHVNMTHNKIRRIA---LPEDVHLGEGYN 550
                              .|...:|.::::  |...||  ::.|.|..|.   ||:::...:...
  Fly   532 LKIDCRNKFVYNFPDIVARNSRLMGKQNMS--SPMELH--LSKNNISNITIAMLPKELRFLDLRF 592

  Fly   551 NNLVHVD---------------LNDNPLVCDCTILWFIQLVRGVHKP-QYSRQFKLRTDRLVCSQ 599
            ||||.:|               |:.||..|||.....:.::|. |:| :|....|.      |:
  Fly   593 NNLVTLDDKVLSYLKKNSIKTKLSGNPWNCDCKSRSVLSILRD-HEPLEYDVTLKR------CN- 649

  Fly   600 PNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYD-KALVINCHSGNLTHVPRLPN 663
                             |.|.|         ||..|.|.:.... .:.:::|....|..:|.|.:
  Fly   650 -----------------ISPTD---------CPDVCVCCLDNLTWPSFIVDCRGEGLLQMPSLSS 688

  Fly   664 LHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQM 728
                                         .||.:.|..||||::.    ..|.:.::
  Fly   689 -----------------------------RVTYVDLRNNNLTALS----QKNRSSIE-------- 712

  Fly   729 LNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMCVNAEMPTRMVEL 793
                     ||::|   :.|..|||.|.|.....:.|.:.....|.|..|:.|.|.|   ::|.:
  Fly   713 ---------NRSLK---LHLLDNPWSCSCNDIEKINFMKSVSSSIVDFTEIKCSNGE---KLVSI 762

  Fly   794 STNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDKK 858
            :.:.:||::...::|||:.:..|.:...|   |.: |:..:.:|.|.|.:.|....:.:|||||:
  Fly   763 NQHIVCPSDLFYYLALAISLVATIIALNF---LIW-FRQPVLVWFYEHGVCLSLSAKRELDKDKR 823

  Fly   859 FDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQ 923
            ||||::::|||::.:|:: |.:||.|..:||||.:.||||.|..||:.|.:|:.||||.|:::::
  Fly   824 FDAFLAFTHKDEALLEEF-VDRLERGRPRFQLCFYLRDWLAGESIPDCIGQSIKDSRRIIVLMTE 887

  Fly   924 NFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDEELKAYLKMNTYLKWGDPWFWDK 988
            ||:.|.|.|||||.|..:...:...|:||::|.::.:.:.||.||:.|:..||||:...|.||:|
  Fly   888 NFMNSTWGRLEFRLALHATSRDRCKRLIVVLYPNVKNFDSLDSELRTYMAFNTYLERSHPNFWNK 952

  Fly   989 LRFALP 994
            |.:::|
  Fly   953 LIYSMP 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	11/64 (17%)
		leucine-rich repeat	176..198	CDD:275380	3/27 (11%)
		leucine-rich repeat	199..222	CDD:275380	4/22 (18%)
		LRR_RI	216..542	CDD:238064	88/438 (20%)
		LRR_8	221..281	CDD:290566	13/60 (22%)
		leucine-rich repeat	223..270	CDD:275380	11/47 (23%)
		leucine-rich repeat	271..294	CDD:275380	2/26 (8%)
		leucine-rich repeat	295..320	CDD:275380	6/35 (17%)
		leucine-rich repeat	321..343	CDD:275380	6/21 (29%)
		LRR_8	342..402	CDD:290566	17/64 (27%)
		leucine-rich repeat	344..367	CDD:275380	5/22 (23%)
		leucine-rich repeat	368..391	CDD:275380	11/27 (41%)
		LRR_8	390..450	CDD:290566	14/59 (24%)
		leucine-rich repeat	392..415	CDD:275380	4/22 (18%)
		leucine-rich repeat	416..439	CDD:275380	6/22 (27%)
		leucine-rich repeat	440..474	CDD:275380	7/41 (17%)
		leucine-rich repeat	475..498	CDD:275380	7/61 (11%)
		LRR_8	477..534	CDD:290566	18/137 (13%)
		leucine-rich repeat	499..520	CDD:275380	7/62 (11%)
		leucine-rich repeat	523..552	CDD:275380	7/31 (23%)
		LRRCT	561..619	CDD:214507	12/58 (21%)
		LRRNT	631..667	CDD:214470	8/36 (22%)
		leucine-rich repeat	664..693	CDD:275380	0/28 (0%)
		LRR_8	669..726	CDD:290566	8/56 (14%)
		leucine-rich repeat	694..715	CDD:275380	7/20 (35%)
		leucine-rich repeat	716..737	CDD:275380	0/20 (0%)
		LRRCT	751..800	CDD:214507	13/48 (27%)
		TIR	858..996	CDD:214587	59/137 (43%)
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378	5/19 (26%)
		leucine-rich repeat	346..367	CDD:275378	10/20 (50%)
		leucine-rich repeat	563..583	CDD:275378	6/21 (29%)
		leucine-rich repeat	585..610	CDD:275378	5/24 (21%)
		leucine-rich repeat	611..622	CDD:275378	3/10 (30%)
		TIR	823..960	CDD:214587	59/137 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I4673
eggNOG	1	0.900	-	-		E2759_KOG4641
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920