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Protein Alignment Tl and CD180

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_005573.2	Gene:	CD180 / 4064	HGNCID:	6726	Length:	661	Species:	Homo sapiens

Alignment Length:	586	Identity:	145/586 - (24%)
Similarity:	229/586 - (39%)	Gaps:	152/586 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 MNITRQHLDRL-------------HGLKRFRFTTRRLTHIPANLLTDMRNLSHLEL----RANIE 186
            ||:|...|.|.             |.|.....|...|..:....|...::|.||.|    .:|:|
Human    77 MNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLE 141

  Fly   187 EMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPK------LKQLNLWSNQLHNLTKHDFEGAT 245
            .:|.|   :||||||:..|||.:..:      |.||      ||.|:..:|.:|.:::.|.....
Human   142 FIPVH---NLENLESLYLGSNHISSI------KFPKDFPARNLKVLDFQNNAIHYISREDMRSLE 197

  Fly   246 SVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSA---NLFRSLPQGLFDHNKHLNEV--RLMNNRV 305
            ..:.:.::.||            .||..|.|.|   .:|:||.   |....:|:.:  .|.|:..
Human   198 QAINLSLNFNG------------NNVKGIELGAFDSTIFQSLN---FGGTPNLSVIFNGLQNSTT 247

  Fly   306 P---LAT--------LPSRLFANQPELQILRLRAE---LQSLPGDLFEHSTQITNISLGDNLLKT 356
            .   |.|        :.|.:.....|:.:..|..:   ...:....|:..||:..:.|....||.
Human   248 QSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKG 312

  Fly   357 LPATLLEHQVNLL-SLDLSNNRLTHLPDSLFAHTTNLTDLRLEDN---LLTGISGDIFSNLGNLV 417
            ||:.:  ..:||| .|.||.|....|.....|:..:||.|.:..|   |..|:.  ....||||.
Human   313 LPSGM--KGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVG--CLEKLGNLQ 373

  Fly   418 TLVMSRNRLRTID--SRAFVSTNGLRHLHLDHND-IDLQQ---------PLLDI-MLQTQIN--- 466
            ||.:|.|.:...|  |....:.:.|:.|:|.||: :.||.         .|||: ..:..||
Human   374 TLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQ 438

  Fly   467 SPFGYMHGLLTLNLRNNSIIFVYNDWKNTML-----QLRELDLSYNN------------------ 508
            |||..:|.|..|||     .:.:.|..|..|     .||.|:|..|:
Human   439 SPFQNLHFLQVLNL-----TYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSL 498

  Fly   509 ----ISSLG---YEDLAFLSQNRL-HVNMTHNKIRRIALPEDVHLGEGYNN------NLVH---- 555
                :||.|   .:..||.|..:: ||:::||.:...::....||...|.|      |::.
Human   499 EVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLL 563

  Fly   556 --------VDLNDNPLVCDCTILWFIQLVR-GVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQI 611
                    ::|:.|||.|.|:.:.|:...: .:||.:.|       :...|:.|..|.|..:..:
Human   564 PILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGS-------EETTCANPPSLRGVKLSDV 621

  Fly   612 E 612
            :
Human   622 K 622

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.