DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and tlr8a

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	XP_001920594.5	Gene:	tlr8a / 403137	ZFINID:	ZDB-GENE-040219-13	Length:	1019	Species:	Danio rerio

Alignment Length:	1035	Identity:	230/1035 - (22%)
Similarity:	391/1035 - (37%)	Gaps:	282/1035 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 GIVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHLEL------ 181
            |:.|..|.:...|..|:.:.....|....|::......::|.|.......::|||.|.|
Zfish   105 GVFSNLTKLRVLDLNGIKLKYIPKDIPKNLEKLSLVENKITWINLTTFEHVKNLSVLYLSNNCYY 169

  Fly   182 ------RANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMP-KLKQLNLWSNQLHNLTKH 239
                  |..||:   .....|.||:.:....|.|.|:|.|    :| .|::|.|.||.|..:.:|
Zfish   170 WNPCSRRYRIEK---GSLSYLVNLKRLTLSFNNLTQVPIG----LPVSLERLELGSNSLTYIGEH 227

  Fly   240 DFEGATSVLGIDIHDN-----------------GIEQLPHDVFAHLTNVTDINLSANLFRSLPQG 287
            ||.|..::..:.|..|                 .||..| ..|:.|.|:..::|:.|..:|:...
Zfish   228 DFRGLFNLTVLKIQGNCPRCHTAPYPCIPCKNTSIEIHP-QAFSDLRNLHILHLAGNSIKSINPA 291

  Fly   288 LFDHNKHLNEVRLMNNRV---------------------------------PLATLPSRLFANQP 319
            .|.:..:|.::.|..|.:                                 ||..:.|..|||..
Zfish   292 WFANLSNLQQLFLSFNLLFSAITDPADTVFLGNLPLLTKLDLSYNFAFKTYPLTVVLSPGFANLT 356

  Fly   320 ELQILRLRA-ELQSLPGDLFEHSTQITNIS---LGDNLLKTLPATLLEHQVNLLSLDLSNNRLTH 380
            .|:.|.||. ..:.:..|.|:....:.:::   :|.|.:....:.:.:| |.||.  |:.|||..
Zfish   357 SLRSLHLRGLVFRKIQKDTFKSLFDLQHLNVLDVGVNFIVFATSYIFQH-VRLLY--LAENRLYP 418

  Fly   381 L-------------------------PDSLFAHTTNLTD---------LRLEDNLLTGISGDIFS 411
            :                         |...|....||..         |.|..|.|..||.:.|.
Zfish   419 VTVNGELSKATFVGSNHRSIMPLMAEPLDTFDAPKNLVKSECYNAGRVLDLSRNNLFLISPEQFD 483

  Fly   412 NLGNLVTLVMSRNRLRTI-DSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGL 475
            ..||:..|.:|||...|. :...|.|...|::|.|..|.:||           ..::.|..:..|
Zfish   484 TYGNISCLNLSRNGFSTAPNGSEFTSLPNLKYLDLSFNKVDL-----------AYDNAFRELQSL 537

  Fly   476 LTLNLRNNSIIFVYNDWKNTML------QLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKI 534
            ..|::..||..|......:.|:      .|:.|::|:|:|::|..:.::  |::...:....||:
Zfish   538 EVLDISYNSHYFTVAGVTHNMMFLQYLPSLKVLNMSFNSINTLTTKTMS--SKSLRELQFRGNKL 600

  Fly   535 RRIALPED---VHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYS--RQFKLRTDR 594
            .|:...:|   |.:.:.: .||:|:|:::|                .:.|..|:  .|..:...|
Zfish   601 GRMWRDKDNTYVMIFKNF-TNLIHLDISNN----------------SIGKIPYTVYTQLPITIQR 648

  Fly   595 LVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVP 659
            |..|. |.|...                                               |.|.:.
Zfish   649 LQMSH-NQLANI-----------------------------------------------NWTMLR 665

  Fly   660 RLPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLP--TNLTHLDIS 722
            |..||.      ||.|.:|.::.:.|..:....|:..|:|..|.::.:.:..|.  .||..||:|
Zfish   666 RFQNLR------ELILHDNNIIEIASNLSVDVPSLELLNLQHNRISKLAIGFLQGVVNLKELDLS 724

  Fly   723 WNHLQMLN-ATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMCVNAEM 786
            :|:|..:| :|.....:..|.|    |.|||:.|.|.....:|:..|             .|.::
Zfish   725 YNYLITVNQSTFPTESDLKMLW----LHGNPFHCTCNLLEFVLWILD-------------TNVKI 772

  Fly   787 PTRMVELSTNDICPAEKGV--------------------FIALAVVIALTGLLAGFTAALYYKFQ 831
            | |:|...|..:....||:                    ||:.|.:|..|  .|..|..|:|...
Zfish   773 P-RLVTGVTCTMPEERKGLAVIKFDIQECIDDQLAFVAYFISAACIICTT--FAAITMHLFYWDV 834

  Fly   832 TEIKIWLYAHNLLLWFVTEEDLDKDK-KFDAFISYSHKD---QSFIEDYLVPQLEHGPQKF-QLC 891
            :.:..:|.|.     |...:.|..:. .:||||:|..||   ..::.::|..|||...:.| .:|
Zfish   835 SYLYYYLKAR-----FTGYQQLSSESCIYDAFITYDTKDPQVSDWVLNHLRVQLEERSELFLPIC 894

  Fly   892 VHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYS 956
            :.||||:.|..:.:::.:|:.:||:|:.||::.::.|...:|....||:..|.|....|::::..
Zfish   895 LEERDWIPGSPVLDSLTQSIQNSRKTVFVLTEGYVNSGSFKLAVFLAHQRLLEENEDVIVLLLLE 959

  Fly   957 DIGDVEKLDE----ELKAYLKMNTYLKW-----GDPWFWDKLRFALPHRRPVGNIGNGAL 1007
            .:     |..    .|:..|...:.|:|     .:.|||..||.|:       .:.|.||
Zfish   960 PV-----LQHSHFVRLRRRLCARSILEWPHSSSAEAWFWQSLRNAI-------RVDNQAL 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	22/71 (31%)
		leucine-rich repeat	176..198	CDD:275380	8/33 (24%)
		leucine-rich repeat	199..222	CDD:275380	7/23 (30%)
		LRR_RI	216..542	CDD:238064	91/421 (22%)
		LRR_8	221..281	CDD:290566	21/77 (27%)
		leucine-rich repeat	223..270	CDD:275380	17/63 (27%)
		leucine-rich repeat	271..294	CDD:275380	4/22 (18%)
		leucine-rich repeat	295..320	CDD:275380	9/57 (16%)
		leucine-rich repeat	321..343	CDD:275380	6/22 (27%)
		LRR_8	342..402	CDD:290566	17/96 (18%)
		leucine-rich repeat	344..367	CDD:275380	3/25 (12%)
		leucine-rich repeat	368..391	CDD:275380	8/47 (17%)
		LRR_8	390..450	CDD:290566	22/69 (32%)
		leucine-rich repeat	392..415	CDD:275380	8/31 (26%)
		leucine-rich repeat	416..439	CDD:275380	7/23 (30%)
		leucine-rich repeat	440..474	CDD:275380	7/33 (21%)
		leucine-rich repeat	475..498	CDD:275380	6/28 (21%)
		LRR_8	477..534	CDD:290566	13/62 (21%)
		leucine-rich repeat	499..520	CDD:275380	6/20 (30%)
		leucine-rich repeat	523..552	CDD:275380	5/31 (16%)
		LRRCT	561..619	CDD:214507	9/59 (15%)
		LRRNT	631..667	CDD:214470	5/35 (14%)
		leucine-rich repeat	664..693	CDD:275380	6/28 (21%)
		LRR_8	669..726	CDD:290566	16/58 (28%)
		leucine-rich repeat	694..715	CDD:275380	4/22 (18%)
		leucine-rich repeat	716..737	CDD:275380	8/21 (38%)
		LRRCT	751..800	CDD:214507	11/48 (23%)
		TIR	858..996	CDD:214587	42/150 (28%)
tlr8a	XP_001920594.5	NEL	<15..>226	CDD:330839	32/127 (25%)
		leucine-rich repeat	62..112	CDD:275380	2/6 (33%)
		leucine-rich repeat	113..133	CDD:275380	3/19 (16%)
		LRR_8	133..200	CDD:316378	15/69 (22%)
		leucine-rich repeat	134..157	CDD:275380	3/22 (14%)
		leucine-rich repeat	158..189	CDD:275380	8/33 (24%)
		PLN00113	189..>702	CDD:331614	126/604 (21%)
		leucine-rich repeat	190..234	CDD:275380	17/47 (36%)
		leucine-rich repeat	235..274	CDD:275380	7/39 (18%)
		leucine-rich repeat	275..298	CDD:275380	4/22 (18%)
		leucine-rich repeat	299..327	CDD:275380	3/27 (11%)
		leucine-rich repeat	328..357	CDD:275380	6/28 (21%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	465..487	CDD:275380	7/21 (33%)
		leucine-rich repeat	488..512	CDD:275380	7/23 (30%)
		leucine-rich repeat	513..536	CDD:275380	7/33 (21%)
		leucine-rich repeat	537..566	CDD:275380	6/28 (21%)
		leucine-rich repeat	567..620	CDD:275380	12/55 (22%)
		leucine-rich repeat	621..645	CDD:275380	7/39 (18%)
		leucine-rich repeat	646..669	CDD:275380	8/70 (11%)
		leucine-rich repeat	670..693	CDD:275380	6/28 (21%)
		LRR_8	692..752	CDD:316378	19/63 (30%)
		leucine-rich repeat	694..717	CDD:275380	4/22 (18%)
		leucine-rich repeat	718..736	CDD:275380	7/17 (41%)
		TPKR_C2	750..>789	CDD:326558	11/52 (21%)
		TIR	858..1000	CDD:214587	41/146 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820