DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and tlr22

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_001122147.2	Gene:	tlr22 / 403135	ZFINID:	ZDB-GENE-040220-5	Length:	955	Species:	Danio rerio

Alignment Length:	1043	Identity:	228/1043 - (21%)
Similarity:	398/1043 - (38%)	Gaps:	297/1043 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 IVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANL-LTDMRNLSHLELRANIEE 187
            :|||.: .|...|..::.:::.:.....:..::.....:..:|.|. :.|:...|..:::  ||:
Zfish    24 MVSPCS-TFSLTNCTISSSQKDIKTQPKVLCYKMNFFTIPRVPNNTWILDISFNSFAQIQ--IED 85

  Fly   188 MPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDI 252
            :     :.|.||:.:...:||:.::..|.||.:..|..|||.||:|:.::.....|.|::|.:.:
Zfish    86 L-----NILLNLQYLNVSNNKISKIQDGAFGSLFNLTDLNLASNRLNAVSNGMLRGLTNLLVLRL 145

  Fly   253 HDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVR------------------ 299
            ..|.|..:....|:.|.::..:|||.|           |.:|:::|:
Zfish   146 DRNYISVIKESAFSTLHSLQVLNLSKN-----------HLRHIDDVKPVLASLYLEELYIGSNYF 199

  Fly   300 -------------------LMNNRVPLATLPSRLF---------------------------ANQ 318
                               |.|||.....|.:.:|                           |:.
Zfish   200 NVFNSSELSTKPLSLKRLDLSNNRFAAFQLTNNIFPTLNHLDLSYCGHNGTMAWNVTEKSYLASV 264

  Fly   319 PELQILRLRAELQSLPGDLFEHSTQITNISLGDN--LLKT---------------LPATLLEHQV 366
            ..|..:.:...:|:....|...:..:..|.|..|  |.||               |.||.::|..
Zfish   265 KTLYFMDVNMSIQTADNVLQSFNNTLNKIRLNGNVRLNKTSLLLSVCSPMLRVLRLIATKIKHLT 329

  Fly   367 N--------LLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSR 423
            |        |..|||..|.:::|..|:|.....|..|:|:.|.||.::.. |..|.:|..:.:||
Zfish   330 NHMFDPCSELSELDLGGNEISNLSQSMFRGFKQLKKLQLQINKLTRVTNS-FQILTSLEFIDLSR 393

  Fly   424 NRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFV 488
            |.:..:....|.:...::.|:|..|.|...:..|           |..:..|..|.|..|:::.:
Zfish   394 NHIHKLSCNDFANLTQVKTLYLYSNKISSIRSCL-----------FKDLKSLEVLRLGTNNLLKI 447

  Fly   489 YNDWKNTMLQLRELDLSYNNISSLGYEDLAFLSQ-NRLHVNMTHNKIRRIALPEDVHLGEGYN-- 550
            .:.:.|....|:||.||||.:|.:.......|.| |.|  ::..|:|..|         |||.
Zfish   448 DDVFSNGPYFLKELQLSYNKLSLIKSHTFGNLPQLNNL--SLEDNQISEI---------EGYAFG 501

  Fly   551 --NNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEP 613
              .||..:.|:.|.:                            |.:.:.:.|||..|.|..|
Zfish   502 GLENLTSLFLSSNKI----------------------------TGKTLTTHPNVFSGMPNLQ--- 535

  Fly   614 QTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMELHLENN 678
                 .||..           .|.....|||           ...|...:| ||::.:.|:.:..
Zfish   536 -----NLDLF-----------ANSISFAYDK-----------LKYPLFKDL-KNLRELSLYSQRR 572

  Fly   679 TLLRLPSANTPGYESVTSLHLAGNNLTSI----------------------DVDQLP-------T 714
            .:.:|||....|..|:...::...||..:                      :.|.:|       .
Zfish   573 GIGQLPSNLLEGLSSLQMFYIGNTNLNQLNPNLFNFTPQLWFLDLSKNALREDDAIPPELFHPIP 637

  Fly   715 NLTHLDISWNHLQMLNATVLGFLNRTMKWRS---------------------VKLSGNPWMCDCT 758
            |||.|.||...|:.||..:...||:....|:                     :.|..|.:.|||.
Zfish   638 NLTKLIISRTQLRSLNFLLGANLNKLSTLRASGNEIDSVNETLIKSLPRLAVLDLQNNTFTCDCN 702

  Fly   759 AKPLLLFTQDNFERIGDRNEMMCV------NAEMP-----TRMVELSTND-------ICPAEKGV 805
            ....:.:.:        :||...|      ....|     |.:.|.:|:.       ||
Zfish   703 NAFFIDWAK--------KNESTQVYYLSRYTCSYPRTLRGTSLAEFNTDSCTFNWDYIC------ 753

  Fly   806 FIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDK---KFDAFISYSH 867
            |:..::::.||.||:.....|.|:.       :|.:.|.|.|:.:...::..   ::||||||:.
Zfish   754 FVCSSILVILTLLLSFIWNFLRYQV-------VYTYYLFLAFLYDSRRNQSGQTFQYDAFISYNT 811

  Fly   868 KDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWAR 932
            .|::::.:.|:|:|| |.|.::||:|.||:..|..|.:||:..:..||:||.::::|::||.|..
Zfish   812 LDEAWVMEELIPKLE-GEQGWRLCLHHRDFEPGRPIIDNIVDGIYSSRKTICLITRNYLKSNWCS 875

  Fly   933 LEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLD--EELKAYLKMNTYLKWGDPW-----FWDKLR 990
            .|.:.|.....:|.:..:|::...|| ...:|.  ..|:..:|..||::|..|.     ||.||:
Zfish   876 SEVQVASFRLFDEQKDVLILVFLEDI-PTHQLSPYHRLRKLVKKRTYIRWPKPGEDNKIFWQKLK 939

  Fly   991 FAL 993
            .||
Zfish   940 MAL 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	17/58 (29%)
		leucine-rich repeat	176..198	CDD:275380	4/21 (19%)
		leucine-rich repeat	199..222	CDD:275380	6/22 (27%)
		LRR_RI	216..542	CDD:238064	91/415 (22%)
		LRR_8	221..281	CDD:290566	18/59 (31%)
		leucine-rich repeat	223..270	CDD:275380	14/46 (30%)
		leucine-rich repeat	271..294	CDD:275380	5/22 (23%)
		leucine-rich repeat	295..320	CDD:275380	8/88 (9%)
		leucine-rich repeat	321..343	CDD:275380	3/21 (14%)
		LRR_8	342..402	CDD:290566	23/84 (27%)
		leucine-rich repeat	344..367	CDD:275380	10/39 (26%)
		leucine-rich repeat	368..391	CDD:275380	8/22 (36%)
		LRR_8	390..450	CDD:290566	16/59 (27%)
		leucine-rich repeat	392..415	CDD:275380	8/22 (36%)
		leucine-rich repeat	416..439	CDD:275380	5/22 (23%)
		leucine-rich repeat	440..474	CDD:275380	6/33 (18%)
		leucine-rich repeat	475..498	CDD:275380	5/22 (23%)
		LRR_8	477..534	CDD:290566	17/57 (30%)
		leucine-rich repeat	499..520	CDD:275380	8/20 (40%)
		leucine-rich repeat	523..552	CDD:275380	8/32 (25%)
		LRRCT	561..619	CDD:214507	8/57 (14%)
		LRRNT	631..667	CDD:214470	6/35 (17%)
		leucine-rich repeat	664..693	CDD:275380	8/28 (29%)
		LRR_8	669..726	CDD:290566	16/85 (19%)
		leucine-rich repeat	694..715	CDD:275380	4/49 (8%)
		leucine-rich repeat	716..737	CDD:275380	8/20 (40%)
		LRRCT	751..800	CDD:214507	12/66 (18%)
		TIR	858..996	CDD:214587	49/143 (34%)
tlr22	NP_001122147.2	leucine-rich repeat	458..481	CDD:275380	9/22 (41%)
		LRR_RI	461..700	CDD:238064	61/308 (20%)
		LRR_8	480..544	CDD:290566	23/121 (19%)
		leucine-rich repeat	482..505	CDD:275380	8/33 (24%)
		leucine-rich repeat	506..533	CDD:275380	8/54 (15%)
		leucine-rich repeat	534..561	CDD:275380	9/57 (16%)
		LRR_8	560..622	CDD:290566	10/61 (16%)
		leucine-rich repeat	562..587	CDD:275380	5/24 (21%)
		leucine-rich repeat	588..606	CDD:275380	2/17 (12%)
		leucine-rich repeat	612..638	CDD:275380	2/25 (8%)
		LRR_8	637..695	CDD:290566	13/57 (23%)
		leucine-rich repeat	639..662	CDD:275380	9/22 (41%)
		leucine-rich repeat	663..686	CDD:275380	1/22 (5%)
		leucine-rich repeat	687..705	CDD:275380	5/17 (29%)
		TIR	802..945	CDD:214587	49/143 (34%)
		leucine-rich repeat	71..91	CDD:275380	5/26 (19%)
		LRR_8	91..150	CDD:290566	18/58 (31%)
		leucine-rich repeat	92..115	CDD:275380	6/22 (27%)
		leucine-rich repeat	116..139	CDD:275380	8/22 (36%)
		LRR_8	138..199	CDD:290566	13/71 (18%)
		leucine-rich repeat	140..163	CDD:275380	5/22 (23%)
		leucine-rich repeat	164..213	CDD:275380	7/59 (12%)
		leucine-rich repeat	214..338	CDD:275380	21/123 (17%)
		LRR_8	337..396	CDD:290566	20/59 (34%)
		leucine-rich repeat	339..362	CDD:275380	8/22 (36%)
		LRR_RI	<363..494	CDD:238064	38/144 (26%)
		leucine-rich repeat	363..385	CDD:275380	8/22 (36%)
		LRR_8	384..444	CDD:290566	15/70 (21%)
		leucine-rich repeat	386..409	CDD:275380	5/22 (23%)
		leucine-rich repeat	410..433	CDD:275380	6/33 (18%)
		LRR_8	432..492	CDD:290566	18/61 (30%)
		leucine-rich repeat	434..457	CDD:275380	5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	1	1.000	-	-		otm24216
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920