DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and tlr19.1

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_001352353.1	Gene:	tlr19.1 / 403134	ZFINID:	ZDB-GENE-040220-3	Length:	958	Species:	Danio rerio

Alignment Length:	1048	Identity:	233/1048 - (22%)
Similarity:	390/1048 - (37%)	Gaps:	312/1048 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 LGMNITRQHLDRL---------HGLKRFRFTTRRLTHIP----------ANLLTDMRNLSHLELR 182
            ||::|....|.|:         |.||:..:|...| |.|          .:|.||:..:. .|:|
Zfish    19 LGLSICNVVLTRITKRCITIEEHLLKQMPWTPHCL-HYPGKGPYANCNITDLSTDLSQVG-FEVR 81

  Fly   183 -----ANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLN-LWSNQLHNLTKHD- 240
                 .:|..:|:..|..|.:||.:.....:|.::..|.|..:|.||.|: |:|::|:.|.:.|
Zfish    82 TLCVFGDITSIPAKAFSHLPSLEVLHIDGIRLERVQAGAFEGLPNLKYLSMLFSDELYRLVRIDN 146

  Fly   241 --------------------------FEGATSVLGIDI--------------HDNGIEQLPHDVF 265
                                      |:...|::.:||              ..||:.:|.|
Zfish   147 RSFAGLNNLEELSLTGLMLLNGSSGIFDPLVSLIRLDIVRTCAQDLGEIFCCISNGMTRLRH--- 208

  Fly   266 AHLTNVTDINLSANLFRSLPQG----------------LFDHN---------------------- 292
               .||.|..:|....:..|.|                |..:|
Zfish   209 ---LNVEDSEISTIENKGCPGGSMTWPLTALSGVQNLYLIGNNIKYIQANSLIIFQNLSSLFLEF 270

  Fly   293 --KHLNEV-------------------RLMNNRVPLATLPSRLFANQPEL---QILRLRAELQSL 333
              |.|..:                   :...|...|..|.|.|::....|   .|.||.||
Zfish   271 EGKSLGSIWESGVGKVNDLTLKGKVLKKYSTNFKDLCHLVSSLYSQSLSLVYTSIDRLTAE---- 331

  Fly   334 PGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTT--NLTDLR 396
              ||.:..|::|.:.:.::.:..|.......::.:.:|.::..:||..|....|::|  :||.|.
Zfish   332 --DLKDCGTKLTKLLIQNSKIDNLDFRFWTSKLEMQALQMAYMKLTDAPFCFVANSTMWSLTSLD 394

  Fly   397 LEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIML 461
            |..|.:|.|.||.|:.:..|..|.:|:|.::|:...||.....|:.|.||.|.|          .
Zfish   395 LTGNSITNIEGDQFACMPFLEQLYLSQNAIKTLQLHAFRGLPRLKILQLDSNKI----------W 449

  Fly   462 QTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLREL-DLSYNNISSLGYEDLAFLSQNRL 525
            |...|. |..:..|..|.:.:|.|..:..   .|....||| :||:..:..: ||         |
Zfish   450 QLSAND-FKNLRALEVLLINDNIIETIET---GTFWDQRELCELSFGRLEYV-YE---------L 500

  Fly   526 HV-NMTHN---KIRRIALPEDVHLGEGY-------NNNLVHVDLNDNPL---VCDCTILWFIQLV 576
            |: |:...   |::|:::  |.|.|...       .|....::||...|   .||..:|..:
Zfish   501 HLENIFFEFPPKLQRLSI--DAHYGTNIYIGNASPPNGTFALELNGERLGFVGCDSDVLMAV--- 560

  Fly   577 RGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRT 641
                     |:.|:.....:|.               .:.:.|...:.:..|
Zfish   561 ---------RELKVNCTYFLCK---------------DSFMAPYFLNLESLE------------- 588

  Fly   642 YDKALVINCHSGNLTHVP----RLPNLH--KNMQLMELHLENNTLLRLPSANTPGYES--VTSLH 698
                     .||.....|    .:.|||  |:::|..|:..|.|..|....|....::  |.:.|
Zfish   589 ---------ISGGAERAPLNYATINNLHHLKHLKLARLNFPNYTESRSAFWNLTQLQTLVVVNCH 644

  Fly   699 LA------GNNLTSIDVDQL----PTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPW 753
            |:      ..:|||:.:.:|    |..||  |..:..|.:|.|.:|..::......      |.|
Zfish   645 LSFLTKSMFRDLTSLQLLRLYSDSPLILT--DGVFGVLPVLKAFILDRVDFQCSCE------NGW 701

  Fly   754 M---CDCTAKPLLLFTQDNFERIGDRNEMMCV----NAEMPTRMVELSTND---ICPAEKGVFIA 808
            :   .|.|.|..:::.|          :..||    .......|.:|...|   ||      ::|
Zfish   702 LLDWADSTEKVQVIYLQ----------KQQCVWHYQKLNFLATMEKLCQTDAQYIC------YVA 750

  Fly   809 LAVVIALTGLLAGFTAALYYKFQ--------TEIKIWLYAHNLLLWFVTEEDLDKD------KKF 859
            .|..|:|.     .:||:.|:|.        ..:|.|:.......|......::.|      .::
Zfish   751 TASSISLL-----LSAAVGYQFARWPSLVLFLRLKGWMERRFGRRWNRRRRRMEDDYGEIEEMQY 810

  Fly   860 DAFISYSHKDQSFIEDYLVPQL-EHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQ 923
            |||:|:..:|::::...:..:| |.|..:.:||:|.||:.||..|.:||..|:.:|:.|:.::|:
Zfish   811 DAFVSFCSQDEAWVLGEMASRLEEQGNPRLRLCLHNRDFEVGKDIMDNITDSIHNSQCTVCLISR 875

  Fly   924 NFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVE-KLDEELKAYLKMNTYLKW----GD- 982
            .:::|:|..||.|.|....|.|.:.|:|:|....|...| .....|...::..|||.|    ||
Zfish   876 RYLRSDWCGLEMRVATHRQLEEQKHRLILIFLQHISPFELSAFHRLAKLVRSRTYLDWPEEEGDR 940

  Fly   983 PWFWDKLR 990
            ..|||:||
Zfish   941 EHFWDRLR 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	17/64 (27%)
		leucine-rich repeat	176..198	CDD:275380	6/26 (23%)
		leucine-rich repeat	199..222	CDD:275380	5/22 (23%)
		LRR_RI	216..542	CDD:238064	93/436 (21%)
		LRR_8	221..281	CDD:290566	21/101 (21%)
		leucine-rich repeat	223..270	CDD:275380	16/88 (18%)
		leucine-rich repeat	271..294	CDD:275380	7/62 (11%)
		leucine-rich repeat	295..320	CDD:275380	6/43 (14%)
		leucine-rich repeat	321..343	CDD:275380	8/24 (33%)
		LRR_8	342..402	CDD:290566	14/61 (23%)
		leucine-rich repeat	344..367	CDD:275380	2/22 (9%)
		leucine-rich repeat	368..391	CDD:275380	6/24 (25%)
		LRR_8	390..450	CDD:290566	23/61 (38%)
		leucine-rich repeat	392..415	CDD:275380	10/22 (45%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..474	CDD:275380	9/33 (27%)
		leucine-rich repeat	475..498	CDD:275380	5/22 (23%)
		LRR_8	477..534	CDD:290566	14/61 (23%)
		leucine-rich repeat	499..520	CDD:275380	7/21 (33%)
		leucine-rich repeat	523..552	CDD:275380	8/39 (21%)
		LRRCT	561..619	CDD:214507	7/60 (12%)
		LRRNT	631..667	CDD:214470	6/41 (15%)
		leucine-rich repeat	664..693	CDD:275380	9/30 (30%)
		LRR_8	669..726	CDD:290566	17/68 (25%)
		leucine-rich repeat	694..715	CDD:275380	8/30 (27%)
		leucine-rich repeat	716..737	CDD:275380	7/20 (35%)
		LRRCT	751..800	CDD:214507	12/58 (21%)
		TIR	858..996	CDD:214587	47/140 (34%)
tlr19.1	NP_001352353.1	LRR_8	101..162	CDD:316378	14/60 (23%)
		leucine-rich repeat	103..126	CDD:275380	5/22 (23%)
		leucine-rich repeat	127..154	CDD:275380	8/26 (31%)
		leucine-rich repeat	155..178	CDD:275380	1/22 (5%)
		leucine-rich repeat	179..238	CDD:275380	12/64 (19%)
		leucine-rich repeat	207..219	CDD:275378	5/17 (29%)
		leucine-rich repeat	239..265	CDD:275380	2/25 (8%)
		leucine-rich repeat	340..363	CDD:275380	2/22 (9%)
		leucine-rich repeat	364..389	CDD:275380	6/24 (25%)
		LRR_8	389..448	CDD:316378	22/58 (38%)
		leucine-rich repeat	390..413	CDD:275378	10/22 (45%)
		leucine-rich repeat	414..437	CDD:275378	7/22 (32%)
		LRR_8	436..>482	CDD:316378	14/59 (24%)
		leucine-rich repeat	438..461	CDD:275378	9/33 (27%)
		leucine-rich repeat	462..485	CDD:275378	5/25 (20%)
		leucine-rich repeat	540..562	CDD:275380	6/33 (18%)
		leucine-rich repeat	563..608	CDD:275380	9/81 (11%)
		leucine-rich repeat	609..634	CDD:275380	7/24 (29%)
		leucine-rich repeat	635..658	CDD:275380	4/22 (18%)
		TIR	809..952	CDD:214587	47/140 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010