DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and tlr1

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_001124065.1	Gene:	tlr1 / 403127	ZFINID:	ZDB-GENE-040220-1	Length:	795	Species:	Danio rerio

Alignment Length:	944	Identity:	198/944 - (20%)
Similarity:	333/944 - (35%)	Gaps:	321/944 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 NIEEMPSHLFDDLE-NLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSV 247
            |:..:|    |||: :.|.::...|.::.:....|...|:|:.|||..|.|.|:.:..|....::
Zfish    36 NLSSVP----DDLKPSTEDLDLSLNHIQSLNCRDFNTTPRLRFLNLSWNILENIDRDTFTSTPAL 96

  Fly   248 LGIDIHDNGIEQLPHDVF-AHLTNVTDINLSANLFRSLPQGL----------------------F 289
            ..:|:..||::.|....: .||..:..::||:|.|.::..|.                      |
Zfish    97 EMLDLSHNGLQNLSEQPYLLHLGCLELLDLSSNRFSAMALGEEFSMLKRLQWLGLSAKSISIQDF 161

  Fly   290 DHNKHLN---------------------------EVRLMNNRVPLATLPSRLFANQPE------- 320
            .|..:|.                           .:.|.:..|.:| :.:.:||...|
Zfish   162 THISNLTLRTLFINADGLLTYEGNSLDDVHAEKAVIALSSTNVDIA-IANDVFARFKEVEFTKVD 225

  Fly   321 -----LQILRLRAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSL--------- 371
                 :|.:|.||.::::       ..:|:|:......|.:...|:|...:..|||
Zfish   226 GKMEVVQQMRSRALMRTV-------RLEISNVKTTWEFLTSSVNTILSSTIRELSLTDLTLTEMK 283

  Fly   372 DLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVS 436
            |.:|...||:.:|......::|....:..:|.    |.|.|       ..:|....|.....|::
Zfish   284 DGANQSSTHILESFSTKRASVTTFIFDQKMLY----DFFIN-------TPARKVSLTESPIIFMT 337

  Fly   437 TNGL--RHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQL 499
            ..|.  :...||.:|..|.:.:..:..:|:.    |.:..|..|.||.|:           :..|
Zfish   338 CPGTISKIQELDLSDCALTEKIFSVNPETEC----GTLVNLTRLVLRGNN-----------LKHL 387

  Fly   500 RELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLV 564
            ..|....|.:.||.|.|   ||||.|  ..:.|:.|....|           .::||||:.|..
Zfish   388 SPLTSRINLMDSLQYID---LSQNTL--TYSENQGRCFWPP-----------RVLHVDLSRNGF- 435

  Fly   565 CDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRER 629
                                        |.:|.
Zfish   436 ----------------------------DEVVF-------------------------------- 440

  Fly   630 KC-PRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGYES 693
            || |          |...|:|.....::.||  .::|....|..:.|..|.||.||:..:  :.|
Zfish   441 KCLP----------DSVQVLNLRHNRVSTVP--ADIHTFDTLQVIDLTFNRLLDLPTCRS--FPS 491

  Fly   694 VTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDC- 757
            :..|.:..|::.|    .:|.:|.    :..|||.|:                 ||.||::|.|
Zfish   492 LQKLLIRSNSIHS----PVPGSLK----TCQHLQDLD-----------------LSHNPFICTCA 531

  Fly   758 --------------TAKPLLLFTQDNFERIGDRNEMMCVNAEMPTR-------MVELSTNDICPA 801
                          |.|..|....|.:.         |...|..:.       :.|:|.|
Zfish   532 LRDFASLINAQGIKTFKSTLKHWPDGYR---------CSYPESWSNSTLEDFYLPEISCN----- 582

  Fly   802 EKGVFIALAVVIALTGLLAG-------------------FTAALYYKFQTEIKIWLYAHNLLLWF 847
              ...:|:.::|....|:..                   :|.|.:|...:::|
Zfish   583 --AWILAITILIPTISLIVAVSLLCNRLDIPWYVRMMWKWTRAKHYSITSQLK------------ 633

  Fly   848 VTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVA 912
              |||::: ..|.||:|||.|:..:::...:|:|| |....::|.||||::.|..:.:||:|.:.
Zfish   634 --EEDVER-LHFHAFVSYSQKNAGWVKSQFLPKLE-GDCGLRMCHHERDFIPGKTVVQNILRCIE 694

  Fly   913 DSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLD--------EELK 969
            .|||.:.|||.:|::|||...|...|:...|..|...|::|:      :|.|.        .:||
Zfish   695 QSRRCVFVLSSHFVQSEWCHYELYFANHQKLTRGMDSILLIL------LEPLPLYLIPSKYYQLK 753

  Fly   970 AYLKMNTYLKW-----GDPWFWDKLRFALPHRRP 998
            ..:...|||:|     ....||..||.||....|
Zfish   754 TMMSRRTYLEWPQEGAKQKLFWANLRAALQAELP 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	14/49 (29%)
		leucine-rich repeat	176..198	CDD:275380	5/14 (36%)
		leucine-rich repeat	199..222	CDD:275380	3/22 (14%)
		LRR_RI	216..542	CDD:238064	82/398 (21%)
		LRR_8	221..281	CDD:290566	18/60 (30%)
		leucine-rich repeat	223..270	CDD:275380	14/47 (30%)
		leucine-rich repeat	271..294	CDD:275380	7/44 (16%)
		leucine-rich repeat	295..320	CDD:275380	6/51 (12%)
		leucine-rich repeat	321..343	CDD:275380	4/21 (19%)
		LRR_8	342..402	CDD:290566	14/68 (21%)
		leucine-rich repeat	344..367	CDD:275380	5/22 (23%)
		leucine-rich repeat	368..391	CDD:275380	8/31 (26%)
		LRR_8	390..450	CDD:290566	11/61 (18%)
		leucine-rich repeat	392..415	CDD:275380	5/22 (23%)
		leucine-rich repeat	416..439	CDD:275380	3/22 (14%)
		leucine-rich repeat	440..474	CDD:275380	6/35 (17%)
		leucine-rich repeat	475..498	CDD:275380	5/22 (23%)
		LRR_8	477..534	CDD:290566	17/56 (30%)
		leucine-rich repeat	499..520	CDD:275380	7/20 (35%)
		leucine-rich repeat	523..552	CDD:275380	5/28 (18%)
		LRRCT	561..619	CDD:214507	3/57 (5%)
		LRRNT	631..667	CDD:214470	8/36 (22%)
		leucine-rich repeat	664..693	CDD:275380	8/28 (29%)
		LRR_8	669..726	CDD:290566	13/56 (23%)
		leucine-rich repeat	694..715	CDD:275380	4/20 (20%)
		leucine-rich repeat	716..737	CDD:275380	5/20 (25%)
		LRRCT	751..800	CDD:214507	13/70 (19%)
		TIR	858..996	CDD:214587	50/150 (33%)
tlr1	NP_001124065.1	LRR_8	46..106	CDD:290566	14/59 (24%)
		leucine-rich repeat	48..71	CDD:275380	3/22 (14%)
		leucine-rich repeat	72..95	CDD:275380	8/22 (36%)
		leucine-rich repeat	109..145	CDD:275380	8/35 (23%)
		leucine-rich repeat	146..166	CDD:275380	2/19 (11%)
		leucine-rich repeat	346..373	CDD:275380	6/30 (20%)
		LRR_8	373..457	CDD:290566	33/181 (18%)
		leucine-rich repeat	374..399	CDD:275380	8/35 (23%)
		leucine-rich repeat	400..425	CDD:275380	11/40 (28%)
		leucine-rich repeat	426..446	CDD:275380	10/90 (11%)
		leucine-rich repeat	447..469	CDD:275380	5/23 (22%)
		LRR_8	469..526	CDD:290566	20/83 (24%)
		leucine-rich repeat	470..491	CDD:275380	7/22 (32%)
		leucine-rich repeat	492..515	CDD:275380	5/30 (17%)
		TPKR_C2	524..>565	CDD:301599	9/49 (18%)
		TIR	642..783	CDD:214587	49/147 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020