DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and Toll-9

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster

Alignment Length:	1090	Identity:	219/1090 - (20%)
Similarity:	380/1090 - (34%)	Gaps:	349/1090 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 RDACSEMSI-DGLCQCAPIMSEYEIICPANAENPTFRLTIQPKDYVQIMCNLTDTTDYQQLPKKL 94
            |:|.:|.|| |||           ||.|.:|                    .|.:.:.:::.|
  Fly    21 REAYTEFSIQDGL-----------IIEPDSA--------------------TTSSEEAEEVSK-- 52

  Fly    95 RIGEVDRVQMRRCML-----PGHTPIASILDYLGIVSPTTLIFE------SDNLGMNITRQHLDR 148
                 :|..::..||     .|::.:      |.::....:.::      .|:......:.:||.
  Fly    53 -----ERTDLKSLMLKYESDDGNSCL------LDLIKDEVIWWQFPNGTLRDSTKKYAHKLYLDL 106

  Fly   149 LHG-------------LKR---------FRFTTRRLTHIPANLLTDMR-NLSHLELRAN------ 184
            .||             |.|         |......||..|...|..|| :|..|.||.|
  Fly   107 SHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSLRGNNFAELI 171

  Fly   185 ---------IEE--------MPSH-------------------LFDDLENL-ESIEFGSN----- 207
                     :.|        :|.|                   .|::..|: :||..|.|
  Fly   172 PDAEDFARFVNESRLEASNSVPHHCELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFI 236

  Fly   208 ------------KLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQL 260
                        ..:.:....|.|||:|.:|::.:..:..::|..|...:::..:.:.||.|..:
  Fly   237 KVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTI 301

  Fly   261 PHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILR 325
            .||.|.::..|..::||...|.:                               ::.|.:|..|.
  Fly   302 SHDTFYYVQGVQYLDLSFTNFLT-------------------------------YSYQLQLPTLE 335

  Fly   326 LRAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHT- 389
            :...|             |..:.:..|:.|.||        .|:.||||::::|......|||.
  Fly   336 MALSL-------------IYGLKIQQNVFKYLP--------ELIYLDLSHSKMTRNSAVAFAHLG 379

  Fly   390 TNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRN---RLRTIDSRAFVSTNGLRHLHLDHNDI- 450
            ..|..|.|....:..:|..||.|. .|..|.:|.|   ....||.......|.|::|:.:.::|
  Fly   380 DKLKFLSLCYTAIPMVSSTIFKNT-VLEGLDLSGNPYLSYNIIDDAFDGIANTLKYLYFERSNIK 443

  Fly   451 DLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNNISSLGYE 515
            ||:..              ..:..|..|.|..|:|..:......::..|..||||.|::.:  :.
  Fly   444 DLEWS--------------KSLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGN--WY 492

  Fly   516 DLAFLSQNRLHV-NMTHNKIRRIA--LPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVR 577
            ..||.:.:.|.| |:..|.|..::  :.:|.       ..|.::.|.||..:|||.:...:: |.
  Fly   493 RSAFHNNSALRVLNLRSNTINMLSNEMLKDF-------ERLDYLSLGDNDFICDCHLRAVVE-VA 549

  Fly   578 GVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTY 642
            ..:.......::|    |..||..|.|                                 .|.:.
  Fly   550 AANNKDADCSYRL----LNYSQNAVGE---------------------------------EVISL 577

  Fly   643 DKALVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTL-LRLPSANTPGYESVTSLHLAGNNLTS 706
            .::|:|:.......::|.|...:.|::  |.:..|:.: ||..|.:    ..|.....|
  Fly   578 AESLIIDRKLWQSRYIPWLQRSYSNIR--EFNRANHIIKLRFSSED----YMVAKCSAA------ 630

  Fly   707 IDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFE 771
                 .|.:|..||              |.|  |:|::.:....:.:.|......|.:
  Fly   631 -----QPYHLGDLD--------------GDL--TLKFQLLDYEASQYYCFNNTDQLQV------- 667

  Fly   772 RIGDRNEMMCVNAEMPTRMVELS--TNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEI 834
                 :|:.|....|.....||.  ||              .|||:.|.|.|   |....|...:
  Fly   668 -----DELNCQIRSMSDLAEELHHVTN--------------TVIAVMGSLVG---ACILGFIIYL 710

  Fly   835 KIW---LYAHNL----LLWFVTEEDLDK---------DKKFDAFISYSHKDQSFIEDYLVPQLEH 883
            |.|   .|..:|    ||...::|.::|         ...:|.||||...|::::.:.|:|.:|.
  Fly   711 KRWHIHYYYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEE 775

  Fly   884 GPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRS 948
             .....:|:||||:.:|..|.:||:..:..|...::::|..|:.|.|.:.|...|........:.
  Fly   776 -TGDVSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKE 839

  Fly   949 RIIVIIYSDIGDVEKLDEELKAYLKMNTYLKW-----GDPWFWDKLRFAL 993
            .:|::...|| ...|..:.|:..:.:.||:||     ....||.:|:.:|
  Fly   840 HLILVFLEDI-PRRKRPKTLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSL 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	21/119 (18%)
		leucine-rich repeat	176..198	CDD:275380	9/63 (14%)
		leucine-rich repeat	199..222	CDD:275380	7/40 (18%)
		LRR_RI	216..542	CDD:238064	73/333 (22%)
		LRR_8	221..281	CDD:290566	14/59 (24%)
		leucine-rich repeat	223..270	CDD:275380	10/46 (22%)
		leucine-rich repeat	271..294	CDD:275380	4/22 (18%)
		leucine-rich repeat	295..320	CDD:275380	1/24 (4%)
		leucine-rich repeat	321..343	CDD:275380	3/21 (14%)
		LRR_8	342..402	CDD:290566	17/60 (28%)
		leucine-rich repeat	344..367	CDD:275380	5/22 (23%)
		leucine-rich repeat	368..391	CDD:275380	9/23 (39%)
		LRR_8	390..450	CDD:290566	16/62 (26%)
		leucine-rich repeat	392..415	CDD:275380	7/22 (32%)
		leucine-rich repeat	416..439	CDD:275380	6/25 (24%)
		leucine-rich repeat	440..474	CDD:275380	5/34 (15%)
		leucine-rich repeat	475..498	CDD:275380	5/22 (23%)
		LRR_8	477..534	CDD:290566	16/57 (28%)
		leucine-rich repeat	499..520	CDD:275380	7/20 (35%)
		leucine-rich repeat	523..552	CDD:275380	6/31 (19%)
		LRRCT	561..619	CDD:214507	11/57 (19%)
		LRRNT	631..667	CDD:214470	5/35 (14%)
		leucine-rich repeat	664..693	CDD:275380	6/29 (21%)
		LRR_8	669..726	CDD:290566	11/57 (19%)
		leucine-rich repeat	694..715	CDD:275380	3/20 (15%)
		leucine-rich repeat	716..737	CDD:275380	4/20 (20%)
		LRRCT	751..800	CDD:214507	9/50 (18%)
		TIR	858..996	CDD:214587	38/141 (27%)
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	6/27 (22%)
		LRR_8	262..322	CDD:290566	14/59 (24%)
		leucine-rich repeat	264..287	CDD:275380	4/22 (18%)
		leucine-rich repeat	288..311	CDD:275380	6/22 (27%)
		leucine-rich repeat	312..356	CDD:275380	13/95 (14%)
		LRR_8	<344..387	CDD:290566	15/50 (30%)
		leucine-rich repeat	357..381	CDD:275380	9/23 (39%)
		leucine-rich repeat	382..397	CDD:275380	3/14 (21%)
		leucine-rich repeat	405..430	CDD:275380	6/24 (25%)
		LRR_8	431..488	CDD:290566	16/70 (23%)
		leucine-rich repeat	432..453	CDD:275380	5/34 (15%)
		LRR_RI	<449..536	CDD:238064	23/95 (24%)
		leucine-rich repeat	454..477	CDD:275380	5/22 (23%)
		LRR_8	477..536	CDD:290566	18/67 (27%)
		leucine-rich repeat	478..501	CDD:275380	8/24 (33%)
		leucine-rich repeat	502..525	CDD:275380	6/29 (21%)
		TIR	751..891	CDD:214587	38/140 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453685
Domainoid	1	1.000	44	1.000	Domainoid score	I4673
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3846
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	1	1.000	-	-		otm24216
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
	9	9.000