Protein Alignment Tl and CG4950

DIOPT Version :10

• Sequence 1: NP_001262995.1
• Gene: Tl / 43222
• FlyBaseID: FBgn0262473
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: NP_648855.2
• Gene: CG4950 / 39783
• FlyBaseID: FBgn0036587
• Length: 574
• Species: Drosophila melanogaster
• Alignment Length: 486
• Identity: 118/486 - (24%)
• Similarity: 208/486 - (42%)
• Gaps: 81/486 - (16%)

  Fly   166 PANLLTDMRNLSHLELRANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWS 230
            |.|::..|:     ...:.:..||.|||:....|::::..:..:.::.|..|.....|..|||..
  Fly    68 PGNMVKFMK-----FYESTLLYMPFHLFETFPYLKTLDVSNTNILELTRNAFSAASNLTYLNLAY 127

  Fly   231 NQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHL 295
            |.|.::....|.||..::.:|:..|.|..|..:.|..|..::.|.|:.||.:.|...:|..|::|
  Fly   128 NNLTSIQTSVFIGANVLMRLDLSYNEISSLSVNAFCGLHTISQIYLTGNLLKELHNDIFKDNEYL 192

  Fly   296 NEVRLMNNRVPLATLPSRLFANQPELQILRL-RAELQSLPGDLFEHSTQITNISLGDNLLKTLPA 359
            .:|....|.  |.::...:|.|...::.:.| ...|..:..|.|..:..:.|:.|..|.||....
  Fly   193 EKVSFEGNL--LTSIQPEVFRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKNFQL 255

  Fly   360 TLLEHQVNLL-SLDLSNNRLTHLPDSLFAHTTNLTD-LRLEDNLLTGISGDIFSNLG-NLVTLVM 421
            |    :.|:: .|.|.||.||:|       |.|.|. :|...|.::    ::|.:.. ::.||.:
  Fly   256 T----EKNIVHQLHLDNNYLTNL-------TINATRFVRASHNQIS----ELFLHQSLHIETLDL 305

  Fly   422 SRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSII 486
            |.|:|.:|.:    .||....|:||.:|    .|:..:.:.|     |..:..|..||||...|.
  Fly   306 SANKLSSISN----ITNITHMLYLDVSD----NPIGPLNIST-----FSQLKRLRGLNLRGTGIR 357

  Fly   487 FVYNDWKNTMLQLRELDLSYNNISSL--------------------GYEDL--------AF---- 519
            .:.....:....|.|||||:||::.|                    |..:|        ||
  Fly   358 ELKFGMFSKQKYLEELDLSFNNLTILNLDMFVPYLTNLKKFLIDGNGLTELQGNRTFSEAFPQLQ 422

  Fly   520 ---LSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHK 581
               :|:||.:.:..|:.:...:|||.|.|....:.|     |::.|.:.|.:.:...|.|  |:.
  Fly   423 KLGVSRNRFNCSYLHHLLIPPSLPESVVLNIEPDTN-----LDETPHIRDVSCISQSQEV--VNA 480

  Fly   582 PQYSRQFKLRTDRLVCSQPNVLEGTPVRQIE 612
            ...:.:.||.:...:.|:...:.|:..:.:|
  Fly   481 SFTAEESKLESQIQMLSKQLDIVGSHSKNLE 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:404697	13/58 (22%)
		leucine-rich repeat	176..198	CDD:275380	5/21 (24%)
		leucine-rich repeat	199..222	CDD:275380	3/22 (14%)
		LRR	222..576	CDD:443914	100/392 (26%)
		leucine-rich repeat	223..270	CDD:275380	15/46 (33%)
		leucine-rich repeat	271..294	CDD:275380	7/22 (32%)
		leucine-rich repeat	295..320	CDD:275380	6/24 (25%)
		leucine-rich repeat	321..343	CDD:275380	4/22 (18%)
		leucine-rich repeat	344..367	CDD:275380	6/22 (27%)
		leucine-rich repeat	368..391	CDD:275380	8/23 (35%)
		leucine-rich repeat	392..415	CDD:275380	4/24 (17%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..474	CDD:275380	7/33 (21%)
		leucine-rich repeat	475..498	CDD:275380	6/22 (27%)
		leucine-rich repeat	499..520	CDD:275380	13/55 (24%)
		leucine-rich repeat	523..552	CDD:275380	8/28 (29%)
		LRRCT	561..619	CDD:214507	10/52 (19%)
		LRRNT	631..667	CDD:214470
		PPP1R42	<660..752	CDD:455733
		leucine-rich repeat	664..693	CDD:275380
		leucine-rich repeat	694..715	CDD:275380
		leucine-rich repeat	716..737	CDD:275380
		LRRCT	751..800	CDD:214507
		TIR	858..996	CDD:214587
CG4950	NP_648855.2	LRR	96..411	CDD:443914	87/344 (25%)
		leucine-rich repeat	96..119	CDD:275380	3/22 (14%)
		leucine-rich repeat	120..143	CDD:275380	9/22 (41%)
		leucine-rich repeat	144..167	CDD:275380	6/22 (27%)
		leucine-rich repeat	168..191	CDD:275380	7/22 (32%)
		leucine-rich repeat	192..215	CDD:275380	6/24 (25%)
		leucine-rich repeat	216..239	CDD:275380	4/22 (18%)
		leucine-rich repeat	240..299	CDD:275380	20/73 (27%)
		leucine-rich repeat	300..321	CDD:275380	8/24 (33%)
		leucine-rich repeat	322..345	CDD:275380	7/31 (23%)
		leucine-rich repeat	346..365	CDD:275380	6/18 (33%)
		leucine-rich repeat	370..394	CDD:275380	9/23 (39%)
		leucine-rich repeat	395..420	CDD:275380	4/24 (17%)