DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tl and Toll-6

DIOPT Version :10

Sequence 1:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster
Sequence 2:NP_524081.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster


Alignment Length:1356 Identity:313/1356 - (23%)
Similarity:508/1356 - (37%) Gaps:424/1356 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 DACSEMSIDGLCQCAPIMSEYEIIC---PANAENPTFRLTIQPKDY---VQIMCNLTDTTDYQQL 90
            |.|..|...||.|     .|..:.|   ..|:|..|...::.|.::   :.|:||       .::
  Fly    79 DDCHFMPAAGLDQ-----PEIALTCNLRTVNSEFDTTNFSVIPAEHTIALHILCN-------DEI 131

  Fly    91 PKKLRIGEVDRVQMRRCMLPGHTPIASILDYLGIVSPTTLIFESDNLGMNITRQHLDRLHGLKRF 155
            ..|.|:                    ....:..:|....|..:...|| .:.||.||   ||::.
  Fly   132 MAKSRL--------------------EAQSFAHLVRLQQLSIQYCKLG-RLGRQVLD---GLEQL 172

  Fly   156 RFTTRRLTHIPANLLTDMRNLSHLELRANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKM 220
            |..|.| ||   |:|....|.          |:.:..|.....||.::..||.:..:|..||..:
  Fly   173 RNLTLR-TH---NILWPALNF----------EIEADAFSVTRRLERLDLSSNNIWSLPDNIFCTL 223

  Fly   221 PKLKQLNLWSNQLHNL--------TKHDFEGATSVLG---------------------------- 249
            .:|..||:..|:|.::        :|....|:|....                            
  Fly   224 SELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHND 288

  Fly   250 -----------------IDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLF-DHNKHLN 296
                             :.:::|||..:.....:.|.|:..:|||:|...:||..|| :..|.:.
  Fly   289 FVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQ 353

  Fly   297 EVRLMNNRVPLATLPSRLFAN-------------------------------------------Q 318
            ||.|.||.:  :.|..:||:|                                           :
  Fly   354 EVYLQNNSI--SVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLE 416

  Fly   319 PE-------LQILRLR-----------------------------------------AELQSLPG 335
            ||       ||||.||                                         ..|.||..
  Fly   417 PEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDN 481

  Fly   336 --------DLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNL 392
                    |.|.:.:.:.:::|..|.|||:|.. |.:..:|.::||..|.:|.:.||.|....||
  Fly   482 NALIGVHPDAFRNCSALQDLNLNGNQLKTVPLA-LRNMRHLRTVDLGENMITVMEDSAFKGLGNL 545

  Fly   393 TDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLL 457
            ..|||..|.|..|:...|.:|.||..|.::|||:..::..||..|:.::.:.||.|:::      
  Fly   546 YGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELN------ 604

  Fly   458 DIMLQTQINSPFGYMHGLLTLNLRNNSI-IFVYN------DW----KNTM------------LQL 499
                  .||..|..|..||.||:.:|.: .|.|.      .|    ||.:            |:|
  Fly   605 ------DINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKL 663

  Fly   500 RELDLSYNNISSLGYE------DLAFLSQNRL-----HVNMTHNKIRRIALPEDVHLGEGYNNNL 553
            :.||:|:|.:..:|..      :|.||:.|.:     ...|....:.|:.|         |.|.:
  Fly   664 QTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDL---------YANQI 719

  Fly   554 VHVDLND-------------------NPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQ 599
            ..:|:..                   ||..|||.|.| :|.:..:...||.|...|.|  :.|..
  Fly   720 TTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDW-LQKINHITSRQYPRIMDLET--IYCKL 781

  Fly   600 PNVLEGT--PVRQIEPQTLICP-----------LDFSDDPRERKCPRGCNC-HVRTYDKALVINC 650
            .|..|..  |:.:.||:..:|.           .:|.....|..||..|.| |.:|: ...::.|
  Fly   782 LNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTW-STNIVEC 845

  Fly   651 HSGNLTHVP-RLPNLHKNMQLMELHLENNTLLRLPS-------------ANT-----------PG 690
            .....:.:| |:|     |...||:::.|..:.|..             ||.           .|
  Fly   846 SGAAYSEMPRRVP-----MDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSG 905

  Fly   691 YESVTSLHLAGNNLTSIDVDQLPT--NLTHLDISWNHL--------QMLNATVLGFL--NRTMKW 743
            .:.:..|||..|::.|::.::...  ||..|.:..|.:        |||....:..|  ||.|.:
  Fly   906 LKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHF 970

  Fly   744 RSVKLSGNP-----------WMCDCTAKPLLLFTQ---DNFERIGDRNEMMCV--NAEMPTRMVE 792
            ...:||.||           |.|:|..  |..|..   .:.|:|.|.:.:.|:  ||   |.::.
  Fly   971 EVWQLSANPYLVEISLADNQWSCECGY--LARFRNYLGQSSEKIIDASRVSCIYNNA---TSVLR 1030

  Fly   793 LSTNDICPAEKGV----------------FIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAH 841
            ......|....||                .:|....:|..||:.|.     :.::.|:|||.::.
  Fly  1031 EKNGTKCTLRDGVAHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGL-----FCYRHELKIWAHST 1090

  Fly   842 NLLLWFVTE-----EDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEH--GPQKFQLCVHERDWLV 899
            |.|:.|..:     :.|||::..||:.:||.:|:.|:...|...||:  |   ::||:|.||..:
  Fly  1091 NCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLENDIG---YRLCLHYRDVNI 1152

  Fly   900 GGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNE---GRSRIIVIIYSDIGDV 961
            ..:|.:.::.:...:::.::|||:||:.:||:|.|:    :|||:|   .|.|::.|:|.|:.. 
  Fly  1153 NAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEY----KSALHELVKRRKRVVFILYGDLPQ- 1212

  Fly   962 EKLDEELKAYLKMNTYLKWGDPWFWDKLRFALPHRRPVGNIGNGALIKTALKGSTDDKLELIKPS 1026
            ..:|.:::.||:.:|.::|.|..||.|||.|||.....|| .|..::...|.|.|        ||
  Fly  1213 RDIDMDMRHYLRTSTCIEWDDKKFWQKLRLALPLPNGRGN-NNKRVVSGCLSGRT--------PS 1268

  Fly  1027 PVTPPLTTPPAEATKNPLVAQLNGVTPHQAIMIAN-GKNGLTNLYTPNGKSHGNGH 1081
                    ....||.:...|...||.|..:...|: |.|....:........|.|:
  Fly  1269 --------VNMYATSHEYQAGNGGVIPPPSARYADCGSNNYATINECAAAGGGRGY 1316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TlNP_001262995.1 LRR_8 174..233 CDD:404697 14/58 (24%)
leucine-rich repeat 176..198 CDD:275380 2/21 (10%)
leucine-rich repeat 199..222 CDD:275380 7/22 (32%)
LRR 222..576 CDD:443914 120/559 (21%)
leucine-rich repeat 223..270 CDD:275380 12/99 (12%)
leucine-rich repeat 271..294 CDD:275380 8/23 (35%)
leucine-rich repeat 295..320 CDD:275380 9/67 (13%)
leucine-rich repeat 321..343 CDD:275380 11/70 (16%)
leucine-rich repeat 344..367 CDD:275380 7/22 (32%)
leucine-rich repeat 368..391 CDD:275380 8/22 (36%)
leucine-rich repeat 392..415 CDD:275380 9/22 (41%)
leucine-rich repeat 416..439 CDD:275380 8/22 (36%)
leucine-rich repeat 440..474 CDD:275380 7/33 (21%)
leucine-rich repeat 475..498 CDD:275380 10/45 (22%)
leucine-rich repeat 499..520 CDD:275380 7/26 (27%)
leucine-rich repeat 523..552 CDD:275380 5/33 (15%)
LRRCT 561..619 CDD:214507 19/59 (32%)
LRRNT 631..667 CDD:214470 10/37 (27%)
PPP1R42 <660..752 CDD:455733 28/127 (22%)
leucine-rich repeat 664..693 CDD:275380 8/52 (15%)
leucine-rich repeat 694..715 CDD:275380 5/22 (23%)
leucine-rich repeat 716..737 CDD:275380 6/28 (21%)
LRRCT 751..800 CDD:214507 14/64 (22%)
TIR 858..996 CDD:214587 48/142 (34%)
Toll-6NP_524081.1 PPP1R42 <135..>242 CDD:455733 33/144 (23%)
leucine-rich repeat 148..171 CDD:275380 9/26 (35%)
leucine-rich repeat 172..201 CDD:275380 10/42 (24%)
LRR_8 200..>246 CDD:404697 12/45 (27%)
leucine-rich repeat 202..278 CDD:275380 15/75 (20%)
leucine-rich repeat 229..249 CDD:275380 4/19 (21%)
leucine-rich repeat 279..302 CDD:275380 0/22 (0%)
LRR 299..654 CDD:443914 87/369 (24%)
leucine-rich repeat 303..326 CDD:275380 4/22 (18%)
leucine-rich repeat 327..350 CDD:275380 8/22 (36%)
leucine-rich repeat 352..375 CDD:275380 9/24 (38%)
leucine-rich repeat 376..401 CDD:275380 0/24 (0%)
leucine-rich repeat 402..425 CDD:275380 2/22 (9%)
leucine-rich repeat 426..449 CDD:275380 6/22 (27%)
leucine-rich repeat 450..473 CDD:275380 0/22 (0%)
leucine-rich repeat 474..497 CDD:275380 5/22 (23%)
leucine-rich repeat 498..518 CDD:275380 7/20 (35%)
leucine-rich repeat 521..544 CDD:275380 8/22 (36%)
leucine-rich repeat 545..566 CDD:275380 8/20 (40%)
leucine-rich repeat 569..592 CDD:275380 8/22 (36%)
leucine-rich repeat 593..615 CDD:275380 7/33 (21%)
leucine-rich repeat 616..637 CDD:275380 7/20 (35%)
leucine-rich repeat 638..662 CDD:275380 3/23 (13%)
LRR_8 662..719 CDD:404697 15/65 (23%)
leucine-rich repeat 663..684 CDD:275380 6/20 (30%)
leucine-rich repeat 685..708 CDD:275380 5/22 (23%)
leucine-rich repeat 709..728 CDD:275380 5/27 (19%)
LRR <863..>990 CDD:443914 27/126 (21%)
leucine-rich repeat 885..908 CDD:275380 3/22 (14%)
leucine-rich repeat 909..932 CDD:275380 5/22 (23%)
leucine-rich repeat 933..956 CDD:275380 6/22 (27%)
TIR 1114..1247 CDD:214587 48/140 (34%)

Return to query results.
Submit another query.