Protein Alignment Tl and CG6749

DIOPT Version :10

• Sequence 1: NP_001262995.1
• Gene: Tl / 43222
• FlyBaseID: FBgn0262473
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: NP_648354.1
• Gene: CG6749 / 39144
• FlyBaseID: FBgn0036040
• Length: 552
• Species: Drosophila melanogaster
• Alignment Length: 610
• Identity: 140/610 - (22%)
• Similarity: 227/610 - (37%)
• Gaps: 184/610 - (30%)

  Fly    16 ILQLLQW---PGSEASFGRDACSEMSIDGLCQCAPIMSEYEIICPANAE--------NPTFRLTI 69
            :|.||.|   .|.....|.|.|..:..... ||:.:.|..::: ...||        |....|.:
  Fly     8 VLPLLLWLLCMGFPILHGADLCQPIGWRNF-QCSEVASLQDLV-DLGAENWHTLAIRNVQTELEV 70

  Fly    70 QPKDYVQIMCNLTD------------TTDYQQLPKKLRIGEVDRVQMRRCMLPGHTPIASILDYL 122
            ...:....:.||.|            |..:..||           .:|:..|.|          .
  Fly    71 GSGENADHLANLLDLDLTGAAPINVHTNGFSILP-----------NLRQLNLSG----------C 114

  Fly   123 GIVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMR-----NLSHLELR 182
            |:|              :|...|......|:|..|:..::..:..:...::|     |.||..|:
  Fly   115 GLV--------------DIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALK 165

  Fly   183 -ANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATS 246
             .::..||.        |..:|.|.|:|   ....||..|:|::|.|..|||..|..:.|.|...
  Fly   166 QCDLPHMPL--------LNRLELGHNRL---VNATFGVCPQLQELILNDNQLIQLDVNAFRGLHG 219

  Fly   247 VLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLF----DHNKHLNEVRLMNNRVPL 307
            :|.:.:..|.:..:..:.|..|..:..:|||.|...:|...:|    :...||.::.|..||:.|
  Fly   220 LLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRL 284

  Fly   308 ATLPSRLFANQPELQILRLRAELQSLPGDLFEHSTQITNIS------LG---------DNLLKTL 357
                  ||.||     .|:.|.||.|  |:..:|  |.::|      ||         :.:|:..
  Fly   285 ------LFDNQ-----FRVLARLQML--DVSRNS--IASLSPAHFVGLGSLRKLYLQYNAILEIK 334

  Fly   358 PATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTT--NLTDLRLEDNLLTGISGDIFSNLGNLVTLV 420
            |||... .:||.:||||.|.|..|.:.:|...|  .:..|.|..|.:..:....||:|..|..|.
  Fly   335 PATFAA-LLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLK 398

  Fly   421 MSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSI 485
            :..|.|:::|.|.|.....|:.|||.||  .|::..||::
  Fly   399 LGHNELKSLDVRMFAPMRRLQKLHLGHN--LLEEINLDVL------------------------- 436

  Fly   486 IFVYNDWKNTMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGYN 550
                    .::..::|:.:..|.        |.||::    ||::...::|:|:       ||
  Fly   437 --------ESLSSVQEILVDNNR--------LTFLAK----VNVSFPNLKRVAI-------EG-- 472

  Fly   551 NNLVHVDLNDNPLVCDCTILWFIQL 575
                      ||..|.|    |::|
  Fly   473 ----------NPWQCPC----FVKL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:404697	19/64 (30%)
		leucine-rich repeat	176..198	CDD:275380	5/22 (23%)
		leucine-rich repeat	199..222	CDD:275380	7/22 (32%)
		LRR	222..576	CDD:443914	94/375 (25%)
		leucine-rich repeat	223..270	CDD:275380	13/46 (28%)
		leucine-rich repeat	271..294	CDD:275380	6/26 (23%)
		leucine-rich repeat	295..320	CDD:275380	9/24 (38%)
		leucine-rich repeat	321..343	CDD:275380	7/21 (33%)
		leucine-rich repeat	344..367	CDD:275380	8/37 (22%)
		leucine-rich repeat	368..391	CDD:275380	10/24 (42%)
		leucine-rich repeat	392..415	CDD:275380	6/22 (27%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..474	CDD:275380	9/33 (27%)
		leucine-rich repeat	475..498	CDD:275380	0/22 (0%)
		leucine-rich repeat	499..520	CDD:275380	3/20 (15%)
		leucine-rich repeat	523..552	CDD:275380	6/28 (21%)
		LRRCT	561..619	CDD:214507	6/15 (40%)
		LRRNT	631..667	CDD:214470
		PPP1R42	<660..752	CDD:455733
		leucine-rich repeat	664..693	CDD:275380
		leucine-rich repeat	694..715	CDD:275380
		leucine-rich repeat	716..737	CDD:275380
		LRRCT	751..800	CDD:214507
		TIR	858..996	CDD:214587
CG6749	NP_648354.1	LRR_8	104..164	CDD:404697	15/94 (16%)
		leucine-rich repeat	106..129	CDD:275380	7/46 (15%)
		leucine-rich repeat	130..153	CDD:275380	3/22 (14%)
		leucine-rich repeat	154..195	CDD:275380	13/51 (25%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		LRR	199..>452	CDD:443914	78/311 (25%)
		leucine-rich repeat	220..243	CDD:275380	4/22 (18%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		leucine-rich repeat	272..295	CDD:275380	10/33 (30%)
		leucine-rich repeat	296..319	CDD:275380	8/26 (31%)
		leucine-rich repeat	320..343	CDD:275380	4/23 (17%)
		leucine-rich repeat	344..369	CDD:275380	10/24 (42%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	9/57 (16%)