DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tl and CG6749

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	610	Identity:	140/610 - (22%)
Similarity:	227/610 - (37%)	Gaps:	184/610 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ILQLLQW---PGSEASFGRDACSEMSIDGLCQCAPIMSEYEIICPANAE--------NPTFRLTI 69
            :|.||.|   .|.....|.|.|..:..... ||:.:.|..::: ...||        |....|.:
  Fly     8 VLPLLLWLLCMGFPILHGADLCQPIGWRNF-QCSEVASLQDLV-DLGAENWHTLAIRNVQTELEV 70

  Fly    70 QPKDYVQIMCNLTD------------TTDYQQLPKKLRIGEVDRVQMRRCMLPGHTPIASILDYL 122
            ...:....:.||.|            |..:..||           .:|:..|.|          .
  Fly    71 GSGENADHLANLLDLDLTGAAPINVHTNGFSILP-----------NLRQLNLSG----------C 114

  Fly   123 GIVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMR-----NLSHLELR 182
            |:|              :|...|......|:|..|:..::..:..:...::|     |.||..|:
  Fly   115 GLV--------------DIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALK 165

  Fly   183 -ANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATS 246
             .::..||.        |..:|.|.|:|   ....||..|:|::|.|..|||..|..:.|.|...
  Fly   166 QCDLPHMPL--------LNRLELGHNRL---VNATFGVCPQLQELILNDNQLIQLDVNAFRGLHG 219

  Fly   247 VLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLF----DHNKHLNEVRLMNNRVPL 307
            :|.:.:..|.:..:..:.|..|..:..:|||.|...:|...:|    :...||.::.|..||:.|
  Fly   220 LLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRL 284

  Fly   308 ATLPSRLFANQPELQILRLRAELQSLPGDLFEHSTQITNIS------LG---------DNLLKTL 357
                  ||.||     .|:.|.||.|  |:..:|  |.::|      ||         :.:|:..
  Fly   285 ------LFDNQ-----FRVLARLQML--DVSRNS--IASLSPAHFVGLGSLRKLYLQYNAILEIK 334

  Fly   358 PATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTT--NLTDLRLEDNLLTGISGDIFSNLGNLVTLV 420
            |||... .:||.:||||.|.|..|.:.:|...|  .:..|.|..|.:..:....||:|..|..|.
  Fly   335 PATFAA-LLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLK 398

  Fly   421 MSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSI 485
            :..|.|:::|.|.|.....|:.|||.||  .|::..||::
  Fly   399 LGHNELKSLDVRMFAPMRRLQKLHLGHN--LLEEINLDVL------------------------- 436

  Fly   486 IFVYNDWKNTMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGYN 550
                    .::..::|:.:..|.        |.||::    ||::...::|:|:       ||
  Fly   437 --------ESLSSVQEILVDNNR--------LTFLAK----VNVSFPNLKRVAI-------EG-- 472

  Fly   551 NNLVHVDLNDNPLVCDCTILWFIQL 575
                      ||..|.|    |::|
  Fly   473 ----------NPWQCPC----FVKL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	19/64 (30%)
		leucine-rich repeat	176..198	CDD:275380	5/22 (23%)
		leucine-rich repeat	199..222	CDD:275380	7/22 (32%)
		LRR_RI	216..542	CDD:238064	89/346 (26%)
		LRR_8	221..281	CDD:290566	18/59 (31%)
		leucine-rich repeat	223..270	CDD:275380	13/46 (28%)
		leucine-rich repeat	271..294	CDD:275380	6/26 (23%)
		leucine-rich repeat	295..320	CDD:275380	9/24 (38%)
		leucine-rich repeat	321..343	CDD:275380	7/21 (33%)
		LRR_8	342..402	CDD:290566	22/76 (29%)
		leucine-rich repeat	344..367	CDD:275380	8/37 (22%)
		leucine-rich repeat	368..391	CDD:275380	10/24 (42%)
		LRR_8	390..450	CDD:290566	20/61 (33%)
		leucine-rich repeat	392..415	CDD:275380	6/22 (27%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..474	CDD:275380	9/33 (27%)
		leucine-rich repeat	475..498	CDD:275380	0/22 (0%)
		LRR_8	477..534	CDD:290566	7/56 (13%)
		leucine-rich repeat	499..520	CDD:275380	3/20 (15%)
		leucine-rich repeat	523..552	CDD:275380	6/28 (21%)
		LRRCT	561..619	CDD:214507	6/15 (40%)
		LRRNT	631..667	CDD:214470
		leucine-rich repeat	664..693	CDD:275380
		LRR_8	669..726	CDD:290566
		leucine-rich repeat	694..715	CDD:275380
		leucine-rich repeat	716..737	CDD:275380
		LRRCT	751..800	CDD:214507
		TIR	858..996	CDD:214587
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	44/198 (22%)
		LRR_8	104..164	CDD:290566	15/94 (16%)
		leucine-rich repeat	106..129	CDD:275380	7/46 (15%)
		leucine-rich repeat	130..153	CDD:275380	3/22 (14%)
		leucine-rich repeat	154..195	CDD:275380	13/51 (25%)
		LRR_RI	194..455	CDD:238064	81/319 (25%)
		LRR_8	194..254	CDD:290566	18/59 (31%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		leucine-rich repeat	220..243	CDD:275380	4/22 (18%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR_8	271..330	CDD:290566	21/73 (29%)
		leucine-rich repeat	272..295	CDD:275380	10/33 (30%)
		leucine-rich repeat	296..319	CDD:275380	8/26 (31%)
		LRR_8	319..380	CDD:290566	18/61 (30%)
		leucine-rich repeat	320..343	CDD:275380	4/23 (17%)
		leucine-rich repeat	344..369	CDD:275380	10/24 (42%)
		LRR_8	368..428	CDD:290566	19/61 (31%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	9/57 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453578
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840