DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and ltl

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_001261524.1	Gene:	ltl / 38845	FlyBaseID:	FBgn0268063	Length:	817	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	130/554 - (23%)
Similarity:	226/554 - (40%)	Gaps:	167/554 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 NLGMNITRQHLDRLH---------GLKRFRFTTRRLTHIPANLLTDMRNLSHLELRAN-IEEMPS 190
            |:.:.||...||.|.         .|.:.|.....|..:|......:.|:::|.:..| ::|:|.
  Fly    62 NIDLKITHSQLDDLEMRSFTDMNFNLYKLRMQWNSLKSLPEVPFRGLSNVTYLSIGDNDLDEIPK 126

  Fly   191 HLFDDLENLESIEFGSNKLRQMP----RGI-----------------FGKMPK-LKQLNLWSNQL 233
            |....:.:|.:::.|..|:|.:.    |||                 .|..|| |..|:|..|||
  Fly   127 HALSHMPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLLILHLGRNQL 191

  Fly   234 HNL--TKHD-------FEGATSVLGID-------------IHDNGIEQLPHDVFAHLTNVTDINL 276
            .:|  :.||       |..|.::..:|             .|:|.:|:||.:: |.:.::..:::
  Fly   192 ESLNGSLHDLHNLESLFINANNITSLDDELPDGGQLRLLMAHNNRLERLPANM-AGMHSLETVHI 255

  Fly   277 SANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILRLRAELQSLPGDLFEHS 341
            ..|..||     ||        |::.|.|.|:             :::....||:.|..|.|...
  Fly   256 HCNQLRS-----FD--------RVLRNAVNLS-------------EVMADNNELEYLAQDEFASC 294

  Fly   342 TQITNISLGDNLLKTLPATLLE----------------------HQV-NLLSLDLSNNRLTH-LP 382
            :::..:.:|.|.:|:|.::||.                      |.: :|.:|.||:||:.. ||
  Fly   295 SKVETLQMGCNHIKSLNSSLLPILKLKNANFSFNDIEEFSMAELHGLRSLKTLQLSSNRIQRLLP 359

  Fly   383 DSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDH 447
            |........|.:|.|::|.:..::|.: :.||||..|.::.|||.                ||..
  Fly   360 DPRGVQELMLVNLDLDNNRIDSLNGAL-AGLGNLRILNLAGNRLE----------------HLQV 407

  Fly   448 NDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTML-QLRELDLSYNNISS 511
            .|       .|.|::..|            |:|..|.:..: ...:.|:| .|:.|.::||||:.
  Fly   408 GD-------FDGMIRLDI------------LDLTGNQLAEL-KPLEMTLLPSLKILKVAYNNITK 452

  Fly   512 L--GYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNL---VHVDLNDNPLVCDCTILW 571
            |  .::.|..|.|    .|:|:|:|..|: .|.|......|:|:   :.:.|:|||::||..:..
  Fly   453 LEQDFKGLPVLCQ----ANLTNNQISTIS-SELVTNTRCKNHNVPGKLEIHLDDNPIMCDVGLNE 512

  Fly   572 FIQL-------VRGVHKPQYSRQFKLRTDRLVCS 598
            ..:|       :||       |......|:.||:
  Fly   513 LCRLMAVQEARIRG-------RSQCFENDQEVCT 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	20/81 (25%)
		leucine-rich repeat	176..198	CDD:275380	5/22 (23%)
		leucine-rich repeat	199..222	CDD:275380	8/43 (19%)
		LRR_RI	216..542	CDD:238064	91/392 (23%)
		LRR_8	221..281	CDD:290566	21/82 (26%)
		leucine-rich repeat	223..270	CDD:275380	18/68 (26%)
		leucine-rich repeat	271..294	CDD:275380	5/22 (23%)
		leucine-rich repeat	295..320	CDD:275380	4/24 (17%)
		leucine-rich repeat	321..343	CDD:275380	5/21 (24%)
		LRR_8	342..402	CDD:290566	20/83 (24%)
		leucine-rich repeat	344..367	CDD:275380	7/45 (16%)
		leucine-rich repeat	368..391	CDD:275380	9/23 (39%)
		LRR_8	390..450	CDD:290566	15/59 (25%)
		leucine-rich repeat	392..415	CDD:275380	6/22 (27%)
		leucine-rich repeat	416..439	CDD:275380	5/22 (23%)
		leucine-rich repeat	440..474	CDD:275380	6/33 (18%)
		leucine-rich repeat	475..498	CDD:275380	5/23 (22%)
		LRR_8	477..534	CDD:290566	18/59 (31%)
		leucine-rich repeat	499..520	CDD:275380	8/22 (36%)
		leucine-rich repeat	523..552	CDD:275380	8/28 (29%)
		LRRCT	561..619	CDD:214507	11/45 (24%)
		LRRNT	631..667	CDD:214470
		leucine-rich repeat	664..693	CDD:275380
		LRR_8	669..726	CDD:290566
		leucine-rich repeat	694..715	CDD:275380
		leucine-rich repeat	716..737	CDD:275380
		LRRCT	751..800	CDD:214507
		TIR	858..996	CDD:214587
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380	5/20 (25%)
		LRR_8	86..145	CDD:290566	12/58 (21%)
		leucine-rich repeat	87..110	CDD:275380	4/22 (18%)
		leucine-rich repeat	111..134	CDD:275380	5/22 (23%)
		leucine-rich repeat	135..158	CDD:275380	7/22 (32%)
		LRR_8	158..214	CDD:290566	14/55 (25%)
		leucine-rich repeat	159..180	CDD:275380	2/20 (10%)
		leucine-rich repeat	181..203	CDD:275380	9/21 (43%)
		leucine-rich repeat	204..226	CDD:275380	3/21 (14%)
		LRR_RI	226..451	CDD:238064	65/288 (23%)
		leucine-rich repeat	227..249	CDD:275380	6/22 (27%)
		leucine-rich repeat	250..272	CDD:275380	7/34 (21%)
		leucine-rich repeat	273..296	CDD:275380	6/35 (17%)
		leucine-rich repeat	297..315	CDD:275380	4/17 (24%)
		LRR_8	319..402	CDD:290566	21/83 (25%)
		leucine-rich repeat	320..335	CDD:275378	0/14 (0%)
		leucine-rich repeat	344..366	CDD:275380	9/21 (43%)
		leucine-rich repeat	367..391	CDD:275380	6/24 (25%)
		LRR_8	369..426	CDD:290566	22/92 (24%)
		leucine-rich repeat	392..415	CDD:275380	10/45 (22%)
		leucine-rich repeat	416..439	CDD:275380	6/35 (17%)
		LRR_8	438..>479	CDD:290566	15/45 (33%)
		leucine-rich repeat	440..462	CDD:275380	8/21 (38%)
		leucine-rich repeat	463..483	CDD:275380	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453823
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930