DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and Tlr12

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_991392.1	Gene:	Tlr12 / 384059	MGIID:	3045221	Length:	906	Species:	Mus musculus

Alignment Length:	988	Identity:	202/988 - (20%)
Similarity:	347/988 - (35%)	Gaps:	312/988 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 LGMNITR------QHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHLEL-------RANIEEM 188
            |.:::|:      :.|.:|..|..|....||...:|.:..:|:.:|..|.:       :|.|...
Mouse    99 LSLHLTQLLPGALRGLGQLQSLSFFDSPLRRSLFLPPDAFSDLISLQRLHISGPCLDKKAGIRLP 163

  Fly   189 P------------------SHLFDDLE---------NLESIEFGSN-KLRQ-MPRGIFGKMPKLK 224
            |                  :.:|.||.         .|:.::..|| ||:. .|..:.|...::.
Mouse   164 PGLQWLGVTLSCIQDVGELAGMFPDLVQGSSSRVSWTLQKLDLSSNWKLKMASPGSLQGLQVEIL 228

  Fly   225 QLN------LWSNQLHNLTKHDF---EGATSVL-----------GIDIHDNGIEQLPHDVFAHLT 269
            .|.      :|...| .|.|.|.   :.||:.|           |:.:.::.|..:..:..|...
Mouse   229 DLTRTPLDAVWLKGL-GLQKLDVLYAQTATAELAAEAVAHFELQGLIVKESKIGSISQEALASCH 292

  Fly   270 NVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILRLRAELQSLP 334
            ::..:.||:.....||.|.......|..:.|..|::..|.|                   ..:..
Mouse   293 SLKTLGLSSTGLTKLPPGFLTAMPRLQRLELSGNQLQSAVL-------------------CMNET 338

  Fly   335 GDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLED 399
            ||:                            ..|.:||||.|||..||.:.|:...:|.:|.|..
Mouse   339 GDV----------------------------SGLTTLDLSGNRLRILPPAAFSCLPHLRELLLRY 375

  Fly   400 NLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDI-MLQT 463
            |.|..:.|.:|..|..|.||.:..|.|                |||..|.:.....|..: :|.|
Mouse   376 NQLLSLEGYLFQELQQLETLKLDGNPL----------------LHLGKNWLAALPALTTLSLLDT 424

  Fly   464 QIN-SP---FGYMHGLLTLNLR-----NNSIIFVYNDWKNTMLQLRELDLS-------------- 505
            ||. ||   |.....|.||:|:     ..:::|:       .:.|..|:|.
Mouse   425 QIRMSPEPGFWGAKNLHTLSLKLPALPAPAVLFL-------PMYLTSLELHIASGTTEHWTLSPA 482

  Fly   506 -YNNISSL----GYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVC 565
             :.::.:|    |...|...|||...|.....|:..:....|....:|.:|
Mouse   483 IFPSLETLTISGGGLKLKLGSQNASGVFPALQKLSLLKNSLDAFCSQGTSN-------------- 533

  Fly   566 DCTILWFIQLVRGVHKPQYSRQFKLRTDRL----VCSQPNVLEGTP-VRQIEPQTLICPLDFSDD 625
              ..||.:.              ||::.|:    ..|:|.::.|.| :|:::..:|
Mouse   534 --LFLWQLP--------------KLQSLRVWGAGNSSRPCLITGLPSLRELKLASL--------- 573

  Fly   626 PRERKCPRGCNCHVRTYD----KALVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTL----LR 682
             :....||.........|    :|||::..............|| ::|::.|..|.:.:    ||
Mouse   574 -QSITQPRSVQLEELVGDLPQLQALVLSSTGLKSLSAAAFQRLH-SLQVLVLEYEKDLMLQDSLR 636

  Fly   683 LPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVK 747
            ..|...|.|     :::..:||.           .|...:|.
Mouse   637 EYSPQMPHY-----IYILESNLA-----------CHCANAWM----------------------- 662

  Fly   748 LSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMCVNAEMPTRMVELSTNDICP--AEKGVFIA-- 808
               .||:...|  ...::.:||  |:....:.:.....:|:.:.     |.||  .|..:|:|
Mouse   663 ---EPWVKRST--KTYIYIRDN--RLCPGQDRLSARGSLPSFLW-----DHCPQTLELKLFLASS 715

  Fly   809 --LAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDL----DKDKK--FDAFISY 865
              :.::|||..|.....:.:.| .|...::||            :.|    ||.|:  ||.|:|:
Mouse   716 ALVFMLIALPLLQEARNSWIPY-LQALFRVWL------------QGLRGKGDKGKRFLFDVFVSH 767

  Fly   866 SHKDQSFIEDYLVPQLE---HGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIK 927
            ..:||.::.:.|:|.||   ......:||:.|||:..|..:.:|::.|:..||.|:.|||...:.
Mouse   768 CRQDQGWVIEELLPALEGFLPAGLGLRLCLPERDFEPGKDVVDNVVDSMLSSRTTLCVLSGQALC 832

  Fly   928 SEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLD-EELKAYLKMNTYLKWGD--PW----- 984
            :...|||.|.|....|......::::::     :|.:. .:|..|.::...|:.||  .|
Mouse   833 NPRCRLELRLATSLLLAAPSPPVLLLVF-----LEPISRHQLPGYHRLARLLRRGDYCLWPEEEE 892

  Fly   985 ----FWDKLRFAL 993
                ||..||..|
Mouse   893 RKSGFWTWLRSRL 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	17/100 (17%)
		leucine-rich repeat	176..198	CDD:275380	8/55 (15%)
		leucine-rich repeat	199..222	CDD:275380	7/24 (29%)
		LRR_RI	216..542	CDD:238064	77/374 (21%)
		LRR_8	221..281	CDD:290566	14/79 (18%)
		leucine-rich repeat	223..270	CDD:275380	12/66 (18%)
		leucine-rich repeat	271..294	CDD:275380	5/22 (23%)
		leucine-rich repeat	295..320	CDD:275380	5/24 (21%)
		leucine-rich repeat	321..343	CDD:275380	2/21 (10%)
		LRR_8	342..402	CDD:290566	15/59 (25%)
		leucine-rich repeat	344..367	CDD:275380	0/22 (0%)
		leucine-rich repeat	368..391	CDD:275380	11/22 (50%)
		LRR_8	390..450	CDD:290566	17/59 (29%)
		leucine-rich repeat	392..415	CDD:275380	8/22 (36%)
		leucine-rich repeat	416..439	CDD:275380	5/22 (23%)
		leucine-rich repeat	440..474	CDD:275380	12/38 (32%)
		leucine-rich repeat	475..498	CDD:275380	5/27 (19%)
		LRR_8	477..534	CDD:290566	14/80 (18%)
		leucine-rich repeat	499..520	CDD:275380	6/39 (15%)
		leucine-rich repeat	523..552	CDD:275380	5/28 (18%)
		LRRCT	561..619	CDD:214507	11/62 (18%)
		LRRNT	631..667	CDD:214470	8/39 (21%)
		leucine-rich repeat	664..693	CDD:275380	10/32 (31%)
		LRR_8	669..726	CDD:290566	12/60 (20%)
		leucine-rich repeat	694..715	CDD:275380	2/20 (10%)
		leucine-rich repeat	716..737	CDD:275380	2/20 (10%)
		LRRCT	751..800	CDD:214507	8/48 (17%)
		TIR	858..996	CDD:214587	42/153 (27%)
Tlr12	NP_991392.1	LRR 1	91..114		2/14 (14%)
		leucine-rich repeat	94..116	CDD:275380	3/16 (19%)
		LRR 2	115..140		6/24 (25%)
		leucine-rich repeat	117..143	CDD:275380	7/25 (28%)
		LRR 3	142..170		5/27 (19%)
		leucine-rich repeat	144..191	CDD:275380	8/46 (17%)
		LRR 4	198..222		6/23 (26%)
		leucine-rich repeat	201..224	CDD:275380	7/22 (32%)
		LRR 5	224..247		4/23 (17%)
		leucine-rich repeat	225..247	CDD:275380	4/22 (18%)
		leucine-rich repeat	248..293	CDD:275380	7/44 (16%)
		LRR 6	267..290		2/22 (9%)
		LRR_8	269..328	CDD:290566	11/58 (19%)
		LRR 7	291..314		5/22 (23%)
		leucine-rich repeat	294..317	CDD:275380	5/22 (23%)
		LRR 8	316..338		5/40 (13%)
		leucine-rich repeat	318..343	CDD:275380	7/71 (10%)
		LRR 9	341..364		11/50 (22%)
		LRR_8	342..402	CDD:290566	23/59 (39%)
		leucine-rich repeat	344..367	CDD:275380	11/22 (50%)
		LRR_RI	364..625	CDD:238064	65/324 (20%)
		LRR 10	366..388		7/21 (33%)
		leucine-rich repeat	368..391	CDD:275380	8/22 (36%)
		LRR 11	389..412		10/38 (26%)
		leucine-rich repeat	392..415	CDD:275380	9/38 (24%)
		LRR 12	414..436		8/21 (38%)
		leucine-rich repeat	416..436	CDD:275380	8/19 (42%)
		leucine-rich repeat	440..512	CDD:275380	15/78 (19%)
		LRR 13	462..484		3/21 (14%)
		LRR 14	485..508		6/22 (27%)
		LRR 15	510..533		3/22 (14%)
		leucine-rich repeat	513..564	CDD:275380	12/80 (15%)
		LRR 16	562..586		5/33 (15%)
		leucine-rich repeat	565..593	CDD:275380	5/37 (14%)
		LRR 17	591..614		3/22 (14%)
		leucine-rich repeat	594..617	CDD:275380	5/23 (22%)
		TIR	761..902	CDD:214587	39/145 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920