DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tl and NRROS

DIOPT Version :10

Sequence 1:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster
Sequence 2:NP_940967.1 Gene:NRROS / 375387 HGNCID:24613 Length:692 Species:Homo sapiens


Alignment Length:755 Identity:164/755 - (21%)
Similarity:247/755 - (32%) Gaps:276/755 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 LTHIPANLLTDMRNLSHLELRAN-IEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQ 225
            |..:|::|....|.|:   |.|| ::.:.:|.......|||:...|..|.::.||.|.:...|:.
Human    48 LASVPSSLPPHARMLT---LDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRS 109

  Fly   226 LNLWSN-----------QLH---NLTKHDFEG--------------ATSVLGIDIHDNGIEQLPH 262
            |.|..|           .||   .|.:.|..|              .:|:..:.:..|.|.:|..
Human   110 LVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDD 174

  Fly   263 DVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILRLR 327
            .||..|..:.:::|..|....:..|.||....|..:.|..|.:|...          :..:.|||
Human   175 SVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIV----------DFGLTRLR 229

  Fly   328 AELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNL 392
                            :.|:|.  |:|:...||..|....|.:||||:|:|...|  |....:.|
Human   230 ----------------VLNVSY--NVLEWFLATGGEAAFELETLDLSHNQLLFFP--LLPQYSKL 274

  Fly   393 TDLRLEDNLLTGISGDIFS----------------NLGNLVTLVMSRNRLRTIDSRAFVSTN--G 439
            ..|.|.||.: |...|:::                |:.|:.|:.:...         |.|::  .
Human   275 RTLLLRDNNM-GFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEE---------FSSSDLAD 329

  Fly   440 LRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDL 504
            ||.|.:..|..   |.|.|..|:.        |..|..|||..|.::.::.........|.||||
Human   330 LRFLDMSQNQF---QYLPDGFLRK--------MPSLSHLNLHQNCLMTLHIREHEPPGALTELDL 383

  Fly   505 SYNNISS----------LGYEDLAFLSQNRL---------------HVNMTHNKIRRIALP---- 540
            |:|.:|.          ||...|..||.|:|               .::|:||:|....||    
Human   384 SHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASD 448

  Fly   541 ---------------------EDVHLG-------EGYNNNLVHVDLNDNPLVCDCTILWFIQLVR 577
                                 |...||       :|  .:|.::||:.|         |      
Human   449 RVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQG--TSLTYLDLSSN---------W------ 496

  Fly   578 GVHKPQYSRQFKLRTDRLVCSQPNVLEGT--PVRQIEPQTLI------------CPLDFSDDPRE 628
                                   .||.|:  |::.:.|...:            ..||||.....
Human   497 -----------------------GVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNL 538

  Fly   629 RKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGYES 693
            |......||                 ||..||...   ::.|..|.|..|:|..||       :.
Human   539 RDLDLSGNC-----------------LTTFPRFGG---SLALETLDLRRNSLTALP-------QK 576

  Fly   694 VTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQ------------------MLNATVL-GFLNR 739
            ..|..|: ..|.:|.:.|.|.:...:| .|..||                  ::..|.| |.:.|
Human   577 AVSEQLS-RGLRTIYLSQNPYDCCGVD-GWGALQHGQTVADWAMVTCNLSSKIIRVTELPGGVPR 639

  Fly   740 TMKWRSVKL----------SGNPWMCDCTA------KPLL 763
            ..||..:.|          |....:..||.      ||||
Human   640 DCKWERLDLGLLYLVLILPSCLTLLVACTVIVLTFKKPLL 679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TlNP_001262995.1 LRR_8 174..233 CDD:404697 18/70 (26%)
leucine-rich repeat 176..198 CDD:275380 5/22 (23%)
leucine-rich repeat 199..222 CDD:275380 8/22 (36%)
LRR 222..576 CDD:443914 100/456 (22%)
leucine-rich repeat 223..270 CDD:275380 16/74 (22%)
leucine-rich repeat 271..294 CDD:275380 5/22 (23%)
leucine-rich repeat 295..320 CDD:275380 4/24 (17%)
leucine-rich repeat 321..343 CDD:275380 3/21 (14%)
leucine-rich repeat 344..367 CDD:275380 7/22 (32%)
leucine-rich repeat 368..391 CDD:275380 9/22 (41%)
leucine-rich repeat 392..415 CDD:275380 8/38 (21%)
leucine-rich repeat 416..439 CDD:275380 3/24 (13%)
leucine-rich repeat 440..474 CDD:275380 9/33 (27%)
leucine-rich repeat 475..498 CDD:275380 5/22 (23%)
leucine-rich repeat 499..520 CDD:275380 11/30 (37%)
leucine-rich repeat 523..552 CDD:275380 12/75 (16%)
LRRCT 561..619 CDD:214507 7/71 (10%)
LRRNT 631..667 CDD:214470 6/35 (17%)
PPP1R42 <660..752 CDD:455733 26/120 (22%)
leucine-rich repeat 664..693 CDD:275380 7/28 (25%)
leucine-rich repeat 694..715 CDD:275380 6/20 (30%)
leucine-rich repeat 716..737 CDD:275380 7/39 (18%)
LRRCT 751..800 CDD:214507 6/19 (32%)
TIR 858..996 CDD:214587
NRROSNP_940967.1 leucine-rich repeat 42..61 CDD:275380 3/12 (25%)
LRR 1. /evidence=ECO:0000255 58..79 6/23 (26%)
leucine-rich repeat 62..82 CDD:275380 5/22 (23%)
LRR 2. /evidence=ECO:0000255 82..103 8/20 (40%)
leucine-rich repeat 83..106 CDD:275380 8/22 (36%)
LRR <106..414 CDD:443914 84/358 (23%)
LRR 3. /evidence=ECO:0000255 106..127 4/20 (20%)
leucine-rich repeat 107..133 CDD:275380 6/25 (24%)
LRR 4. /evidence=ECO:0000255 133..155 3/21 (14%)
leucine-rich repeat 134..158 CDD:275380 3/23 (13%)
LRR 5. /evidence=ECO:0000255 158..179 6/20 (30%)
leucine-rich repeat 159..182 CDD:275380 6/22 (27%)
LRR 6. /evidence=ECO:0000255 182..203 4/20 (20%)
leucine-rich repeat 183..206 CDD:275380 5/22 (23%)
LRR 7. /evidence=ECO:0000255 206..227 4/30 (13%)
leucine-rich repeat 207..227 CDD:275380 4/29 (14%)
leucine-rich repeat 228..251 CDD:275380 9/40 (23%)
LRR 8. /evidence=ECO:0000255 228..239 5/28 (18%)
LRR 9. /evidence=ECO:0000255 251..272 9/22 (41%)
leucine-rich repeat 252..273 CDD:275380 9/22 (41%)
LRR 10. /evidence=ECO:0000255 273..294 7/21 (33%)
LRR 293..>595 CDD:443914 77/389 (20%)
LRR 11. /evidence=ECO:0000255 329..350 8/23 (35%)
leucine-rich repeat 330..353 CDD:275380 9/33 (27%)
LRR 12. /evidence=ECO:0000255 353..374 5/20 (25%)
leucine-rich repeat 354..377 CDD:275380 5/22 (23%)
LRR 13. /evidence=ECO:0000255 377..398 8/20 (40%)
leucine-rich repeat 378..403 CDD:275380 9/24 (38%)
LRR 14. /evidence=ECO:0000255 403..424 5/20 (25%)
leucine-rich repeat 404..427 CDD:275380 5/22 (23%)
LRR 15. /evidence=ECO:0000255 427..447 6/19 (32%)
leucine-rich repeat 428..463 CDD:275380 6/34 (18%)
LRR 16. /evidence=ECO:0000255 463..484 3/20 (15%)
leucine-rich repeat 464..486 CDD:275380 4/23 (17%)
LRR 17. /evidence=ECO:0000255 486..507 9/58 (16%)
leucine-rich repeat 487..512 CDD:275380 9/62 (15%)
LRR 18. /evidence=ECO:0000255 512..534 3/21 (14%)
leucine-rich repeat 513..537 CDD:275380 4/23 (17%)
LRR 19. /evidence=ECO:0000255 537..558 7/40 (18%)
leucine-rich repeat 538..559 CDD:275380 7/40 (18%)
LRR 20. /evidence=ECO:0000255 559..580 7/27 (26%)
LRR 21. /evidence=ECO:0000255 585..594 2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

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