DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tl and Tlr3

DIOPT Version :9

Sequence 1:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster
Sequence 2:NP_942086.2 Gene:Tlr3 / 364594 RGDID:735171 Length:905 Species:Rattus norvegicus


Alignment Length:997 Identity:241/997 - (24%)
Similarity:393/997 - (39%) Gaps:222/997 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 ILDYLGIVSPTTLIFESDN---LGMNITR-QHLDRLHGLKRFRFTTRRLTHIPANLLTDMR--NL 176
            |..:.|::|...|:..|.|   :..|:.. .||              :|||||.:|.:::.  ||
  Rat     9 IYSFGGLLSLWILVVSSTNQCTVRYNVADCSHL--------------KLTHIPDDLPSNITVLNL 59

  Fly   177 SHLELRANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDF 241
            :|.:||.    :|...|.....|..::.|.|.:.::...:...:|.||.|||..|:|..::...|
  Rat    60 THNQLRG----LPPANFTRYSQLALLDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTF 120

  Fly   242 EGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVP 306
            ...|::..:.:..|.|.::..:.|.:..::..::||.|...|...|.....::|.|:.|..|::.
  Rat   121 AFCTNLTELHLMSNSIRKIKSNPFKNQKSLIKLDLSRNGLSSTKLGTGVQLENLQELLLAKNKIF 185

  Fly   307 LATLPSRLFANQPELQILRLRAELQSLP------------GDLFE-------------------- 339
            ........|.....||    :.:|.|.|            |.||.                    
  Rat   186 ALRSEELDFLGNSSLQ----KLDLSSNPLKEFSPGCFHAIGKLFVLLLNNAQLNLNLTEKLCWEL 246

  Fly   340 HSTQITNISLGDN-LLKTLPATLLE-HQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLL 402
            .:|.|.|:||.:| ||.|..:|... .|.||.|||||.|.|.::.:..|:...:|..|.||.|.:
  Rat   247 SNTSIQNLSLANNQLLATSNSTFSGLKQTNLTSLDLSYNSLRYVGNDAFSWLPHLKYLSLEYNNI 311

  Fly   403 TGISGDIFSNLGNLVTLVMSRNRLR---------TIDSRAFVSTNGLRHLHLDHNDID------- 451
            ..::...|..|.||..|.:.|...:         .||..:|.....|.||::|.|.|.       
  Rat   312 QSLTPHSFRGLSNLRYLSLKRAFTKQSVALASHPNIDDFSFQWLKCLEHLNMDDNTIPGIKSNTF 376

  Fly   452 ---LQQPLLDIM-----LQTQINSPF-GYMHG-LLTLNLRNNSIIFVYNDWKNTMLQLRELDLSY 506
               :....|.:.     |||..|..| ...|. ||||||..|.|..:.:...:.:.|||.|||..
  Rat   377 TGLVSLKYLSLSKTFTGLQTLTNETFVSLTHSPLLTLNLTKNHISKIASGTFSWLGQLRILDLGL 441

  Fly   507 NNIS---------SLGYEDLAFLSQNRLHVNMTHNK-----------IRRIALPEDVHLGEGYNN 551
            |.|.         .||.....:||.|: ::.:|...           :||:||..          
  Rat   442 NEIEQELTGQEWRGLGNIFEIYLSYNK-YLQLTSKSFTLVPSLQRLMLRRVALKS---------- 495

  Fly   552 NLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQ-FKLRTDRLVCSQPNVLEGTPVRQIEPQT 615
                ||::.:|.                 :|.|:.. ..|..:.:.....::|||....:|    
  Rat   496 ----VDISPSPF-----------------RPLYNLTILDLSNNNIANLNEDLLEGLENLEI---- 535

  Fly   616 LICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTL 680
                |||..           |...|.:..|    ...|.:..:..|.:||      .|:||:|.|
  Rat   536 ----LDFQH-----------NNLARLWKHA----NPGGPVNFLKGLSHLH------ILNLESNGL 575

  Fly   681 LRLPSANTPGYESVTSLHLAGNNLT----SIDVDQLPTNLTHLDISWNHLQMLNATVLG--FLNR 739
            ..:|.........:.|::|..|||.    ||..||  |:|..|::..|.:..:..:|.|  |.| 
  Rat   576 DEIPVKVFKNLFELKSINLGLNNLNTLLPSIFDDQ--TSLRSLNLQKNLITSVEKSVFGPAFHN- 637

  Fly   740 TMKWRSVKLSGNPWMCDCTAKPLLLF------TQDNFERIGDRNEMMCVNAE----MPTRMVELS 794
               ..|:.:|.||:  |||.:.:..|      |..|...:.  ...:|...:    :|.::.:.|
  Rat   638 ---LNSLDMSFNPF--DCTCESIAWFVTWLNQTHTNIPELS--THYLCNTPQRYHGLPVKLFDTS 695

  Fly   795 T-NDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQ-TEIKI-WLYAHNLLLWFVTEEDLDKD 856
            : .|..|.:      |..:|..:.||....|.|...|: ..|.. |..:.:.:|.|...:...:.
  Rat   696 SCKDSAPFQ------LLFIINTSTLLTFILAVLLIHFEGWRISFYWNVSVHRILGFKEIDAQGEQ 754

  Fly   857 KKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVL 921
            .::.|:|.::.||:.::.::..| :|...|..:.|:.|||:..|....|.|:.|:..||:.|.|:
  Rat   755 FEYTAYIIHAQKDRDWVWEHFSP-MEEQDQSLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVI 818

  Fly   922 SQNFIKSEWARLEFRAAH--RSALNEGRSRIIVIIYSDIGDVEKLDEEL---KAYLKMNTYLKWG 981
            :.:.:|....| .|:..|  :.|:.:....||:|...:|.|. ||:..|   :...|.:..|.| 
  Rat   819 THHLLKDPLCR-RFKVHHAVQQAIEQNLDSIILIFLQNIPDY-KLNHALCLRRGMFKSHCILNW- 880

  Fly   982 DP-------WFWDKLRFALPHR 996
             |       .|..||:.||..|
  Rat   881 -PIQKERINAFHHKLQVALGSR 901

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TlNP_001262995.1 LRR_8 174..233 CDD:290566 17/60 (28%)
leucine-rich repeat 176..198 CDD:275380 6/21 (29%)
leucine-rich repeat 199..222 CDD:275380 3/22 (14%)
LRR_RI 216..542 CDD:238064 105/405 (26%)
LRR_8 221..281 CDD:290566 16/59 (27%)
leucine-rich repeat 223..270 CDD:275380 12/46 (26%)
leucine-rich repeat 271..294 CDD:275380 5/22 (23%)
leucine-rich repeat 295..320 CDD:275380 5/24 (21%)
leucine-rich repeat 321..343 CDD:275380 8/53 (15%)
LRR_8 342..402 CDD:290566 26/61 (43%)
leucine-rich repeat 344..367 CDD:275380 10/24 (42%)
leucine-rich repeat 368..391 CDD:275380 9/22 (41%)
LRR_8 390..450 CDD:290566 19/68 (28%)
leucine-rich repeat 392..415 CDD:275380 7/22 (32%)
leucine-rich repeat 416..439 CDD:275380 6/31 (19%)
leucine-rich repeat 440..474 CDD:275380 12/49 (24%)
leucine-rich repeat 475..498 CDD:275380 8/22 (36%)
LRR_8 477..534 CDD:290566 20/76 (26%)
leucine-rich repeat 499..520 CDD:275380 9/29 (31%)
leucine-rich repeat 523..552 CDD:275380 6/39 (15%)
LRRCT 561..619 CDD:214507 8/58 (14%)
LRRNT 631..667 CDD:214470 7/35 (20%)
leucine-rich repeat 664..693 CDD:275380 8/28 (29%)
LRR_8 669..726 CDD:290566 19/60 (32%)
leucine-rich repeat 694..715 CDD:275380 9/24 (38%)
leucine-rich repeat 716..737 CDD:275380 5/22 (23%)
LRRCT 751..800 CDD:214507 12/59 (20%)
TIR 858..996 CDD:214587 41/149 (28%)
Tlr3NP_942086.2 leucine-rich repeat 37..53 CDD:275380 8/29 (28%)
leucine-rich repeat 54..77 CDD:275380 7/26 (27%)
PLN00113 66..>646 CDD:215061 155/654 (24%)
leucine-rich repeat 78..101 CDD:275380 3/22 (14%)
leucine-rich repeat 102..125 CDD:275380 8/22 (36%)
leucine-rich repeat 126..149 CDD:275380 3/22 (14%)
leucine-rich repeat 150..199 CDD:275380 10/48 (21%)
leucine-rich repeat 200..250 CDD:275380 8/53 (15%)
leucine-rich repeat 251..276 CDD:275380 10/24 (42%)
leucine-rich repeat 277..300 CDD:275380 9/22 (41%)
leucine-rich repeat 301..322 CDD:275380 6/20 (30%)
leucine-rich repeat 325..381 CDD:275380 12/55 (22%)
leucine-rich repeat 382..407 CDD:275380 6/24 (25%)
leucine-rich repeat 410..433 CDD:275380 8/22 (36%)
leucine-rich repeat 434..458 CDD:275380 8/23 (35%)
leucine-rich repeat 459..482 CDD:275380 4/23 (17%)
leucine-rich repeat 483..508 CDD:275380 8/55 (15%)
leucine-rich repeat 509..532 CDD:275380 4/22 (18%)
leucine-rich repeat 533..564 CDD:275380 9/53 (17%)
leucine-rich repeat 565..586 CDD:275380 8/26 (31%)
leucine-rich repeat 589..612 CDD:275380 9/24 (38%)
leucine-rich repeat 613..631 CDD:275380 3/17 (18%)
LRRCT 646..698 CDD:214507 11/55 (20%)
Tlr3_TMD 699..731 CDD:407816 9/37 (24%)
TIR 756..901 CDD:214587 41/149 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24365
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
54.880

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