DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tl and Tlr12

DIOPT Version :10

Sequence 1:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster
Sequence 2:NP_001102152.1 Gene:Tlr12 / 362604 RGDID:1559145 Length:904 Species:Rattus norvegicus


Alignment Length:875 Identity:182/875 - (20%)
Similarity:304/875 - (34%) Gaps:296/875 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 SHLEL------RANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHN 235
            :|.||      |:.|..:.........:||::......|.::|.|....||:|::|||..|||.:
  Rat   267 AHFELQGLNVDRSKIGNISQEALASCHSLETLSLSDTGLTKLPPGFLAAMPRLRRLNLAGNQLQS 331

  Fly   236 LTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRL 300
            ..            :.:::.|      ||    :.::.::||.|..|.||...|....||.|:.|
  Rat   332 TM------------LCMNETG------DV----SGLSTLDLSGNGLRILPPATFSCLPHLRELLL 374

  Fly   301 MNNRVPLATLPSRLFANQPELQILRL-RAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEH 364
            .:|:  |.:|....|.:..:|:.|:| |..|                ::||.|.|..|||     
  Rat   375 QDNQ--LLSLEGHPFQDLQQLETLKLDRNPL----------------LNLGKNCLAALPA----- 416

  Fly   365 QVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTI 429
               |.:|.|.:.::.|.||:.|....:|..|.|.   |..:|.....:|...:|           
  Rat   417 ---LTTLSLLDTQILHSPDAGFWGARSLHTLHLS---LPPLSAPAVLSLPMYLT----------- 464

  Fly   430 DSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKN 494
             |.....|.||:|..|..|..    |.|:.:   .||.     .| |.|.::|.|.:|.      
  Rat   465 -SLELHVTPGLKHWTLSPNIF----PFLETL---TING-----RG-LKLGVQNASEVFP------ 509

  Fly   495 TMLQLRELDLSYNNISSLGYEDLA--FLSQ----NRLHV-------------------NMTHNKI 534
               .|:.|.|..|::.:...:|.:  ||.|    ..|.|                   .:....:
  Rat   510 ---ALQHLFLLQNSLDAFCSQDASSIFLWQLPKLQSLKVWGAGSNSRPCLITGLPSLQELKLESL 571

  Fly   535 RRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQL----VRGVHKPQYSRQFKLRTDRL 595
            :.|..|..|.|.|               ||.|...|..:||    ::.:....:.|...|:...|
  Rat   572 QSITQPRSVQLEE---------------LVGDLPQLQALQLSSTGLKSLSAAAFRRLHSLQALVL 621

  Fly   596 VCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPR 660
            ...:..||:.: :|:..||                .||    :|......|...|.:.       
  Rat   622 DSEKDLVLQDS-LREYSPQ----------------MPR----YVYILQSKLACQCANA------- 658

  Fly   661 LPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNH 725
                     .|||.::.:|              .|.:|:...:|...:| ::|...:.:...|:|
  Rat   659 ---------WMELWVKQST--------------KTYVHIRDGHLCPGEV-RVPARDSLISFLWDH 699

  Fly   726 LQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMCVNAEMPTRM 790
                                         |..|.: |.||...:                     
  Rat   700 -----------------------------CPQTLE-LKLFLASS--------------------- 713

  Fly   791 VELSTNDICPAEKGVFIALAVVIALTGLLAG-------FTAALYYKFQTEIKIWLYAHNLLLWFV 848
                             ||.:::.:..||.|       :..||:       :|||..      ..
  Rat   714 -----------------ALVLLLIVLPLLQGARNTWIPYLRALF-------RIWLQG------LR 748

  Fly   849 TEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLE---HGPQKFQLCVHERDWLVGGHIPENIMRS 910
            .:.:..|...||.|:|:..:||.::.:.|:|.||   ......:||:.|||:..|..:.:|::.|
  Rat   749 GQGNAGKRFLFDVFVSHCRQDQGWVLEELLPALEGFLPAGLGLRLCLPERDFEPGKDVVDNVVDS 813

  Fly   911 VADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLD-EELKAYLKM 974
            :..||.|:.|||...:.:....||.|.|....|......::::::     :|.:. .:|.:|.::
  Rat   814 MVSSRVTLCVLSGPALCNPRCCLELRLATSLLLAAPSPPVLLLVF-----LEPISRHQLPSYHRL 873

  Fly   975 NTYLKWGD--PW---------FWDKLRFAL 993
            ...|:.||  .|         ||..||..|
  Rat   874 ARLLRRGDYCLWPEEEERKGGFWTWLRSRL 903

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TlNP_001262995.1 LRR_8 174..233 CDD:404697 17/61 (28%)
leucine-rich repeat 176..198 CDD:275380 5/26 (19%)
leucine-rich repeat 199..222 CDD:275380 6/22 (27%)
LRR 222..576 CDD:443914 89/383 (23%)
leucine-rich repeat 223..270 CDD:275380 10/46 (22%)
leucine-rich repeat 271..294 CDD:275380 7/22 (32%)
leucine-rich repeat 295..320 CDD:275380 7/24 (29%)
leucine-rich repeat 321..343 CDD:275380 5/22 (23%)
leucine-rich repeat 344..367 CDD:275380 7/22 (32%)
leucine-rich repeat 368..391 CDD:275380 7/22 (32%)
leucine-rich repeat 392..415 CDD:275380 6/22 (27%)
leucine-rich repeat 416..439 CDD:275380 3/22 (14%)
leucine-rich repeat 440..474 CDD:275380 8/33 (24%)
leucine-rich repeat 475..498 CDD:275380 5/22 (23%)
leucine-rich repeat 499..520 CDD:275380 5/22 (23%)
leucine-rich repeat 523..552 CDD:275380 7/47 (15%)
LRRCT 561..619 CDD:214507 14/61 (23%)
LRRNT 631..667 CDD:214470 5/35 (14%)
PPP1R42 <660..752 CDD:455733 11/91 (12%)
leucine-rich repeat 664..693 CDD:275380 4/28 (14%)
leucine-rich repeat 694..715 CDD:275380 5/20 (25%)
leucine-rich repeat 716..737 CDD:275380 2/20 (10%)
LRRCT 751..800 CDD:214507 5/48 (10%)
TIR 858..996 CDD:214587 41/151 (27%)
Tlr12NP_001102152.1 leucine-rich repeat 71..93 CDD:275380
leucine-rich repeat 94..116 CDD:275380
leucine-rich repeat 117..144 CDD:275380
LRR <202..516 CDD:443914 82/333 (25%)
leucine-rich repeat 202..225 CDD:275380
leucine-rich repeat 226..270 CDD:275380 1/2 (50%)
leucine-rich repeat 271..294 CDD:275380 3/22 (14%)
leucine-rich repeat 295..318 CDD:275380 6/22 (27%)
leucine-rich repeat 319..344 CDD:275380 10/46 (22%)
leucine-rich repeat 345..368 CDD:275380 7/22 (32%)
leucine-rich repeat 369..392 CDD:275380 7/24 (29%)
PPP1R42 390..645 CDD:455733 74/351 (21%)
leucine-rich repeat 393..416 CDD:275380 10/38 (26%)
leucine-rich repeat 417..437 CDD:275380 7/19 (37%)
leucine-rich repeat 441..510 CDD:275380 24/105 (23%)
leucine-rich repeat 511..562 CDD:275380 10/50 (20%)
leucine-rich repeat 563..591 CDD:275380 8/42 (19%)
leucine-rich repeat 592..615 CDD:275380 4/22 (18%)
TIR 759..900 CDD:214587 38/145 (26%)
Blue background indicates that the domain is not in the aligned region.

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