DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and kek5

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster

Alignment Length:	610	Identity:	120/610 - (19%)
Similarity:	214/610 - (35%)	Gaps:	176/610 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 ESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDF--EGATSVLGIDIHDNGIEQLPH 262
            :|.:..:..|.::|:.:..:|   :.|:...||:..|.:.:|  .|..:|..|.:.:..|:::..
  Fly    55 KSADCKNKALTKIPQDMSNEM---QVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHR 116

  Fly   263 DVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILRLR 327
            :.|..|..:.:::||.|..|.|..|.|...:.|..|.:.||
  Fly   117 EAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVIINNN------------------------ 157

  Fly   328 AELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNL 392
             |::.||..||.:.:.::.|...:|.|:.:...:....:.|.::.|..|||:||....|.....|
  Fly   158 -EIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKL 221

  Fly   393 TDLRLEDNLLT-----------GISGDIFSN----------LGNLVTLVMSRN---RLRTIDS-R 432
            ..|.|:.|...           .||..:::.          .|.|.:.|.|.|   |.|.:.| |
  Fly   222 MHLSLQGNAWNCSCELQDFRDFAISKRLYTPPTDCQEPPQLRGKLWSEVPSENFACRPRILGSVR 286

  Fly   433 AFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTML 497
            :|:..|        |::|.|...:        :.||            |.| :.:|||  |..:.
  Fly   287 SFIEAN--------HDNISLPCRI--------VGSP------------RPN-VTWVYN--KRPLQ 320

  Fly   498 Q-------LRELDLSYNNISSLGYEDLAFL----SQNRLHVNMTHNKIRR------IALPED--- 542
            |       |..::......|.:...:|..:    |....:..:..|:..|      :.:..|
  Fly   321 QYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLLVSGDYAG 385

  Fly   543 -VHLGEGYNNNLV---HVDLNDNPLVCDC---TILWFIQLVRGVHKPQYSRQFK--------LRT 592
             |...:|.....:   .:|...|..:..|   |.|..:.||..:....|.|:.|        :..
  Fly   386 AVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSG 450

  Fly   593 DRLVCSQ------PNVLEGT--------------PVRQIEPQTLICPLDFSDDPRERK------- 630
            |.|:.|:      .::|||:              ||.:...:|.|..:|..||..|.|
  Fly   451 DGLISSKMDKTHNGSMLEGSVIMEMQKSLLNEVNPVEKPPRRTDIESVDGGDDVLEIKKTLLDDT 515

  Fly   631 ----------------------CPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMEL 673
                                  .||..:.:|   |.|...:.....|....|:|....:||..:.
  Fly   516 VYVANHSRDEEAVSVAMSDTTTTPRSRHTYV---DDAYANSLPPDLLAFPARVPPTSPSMQSSQS 577

  Fly   674 HLENNTLLRL---PSANTPGYESVT 695
            ::.:..:..:   ||..:|.|..:|
  Fly   578 NIPDQVIYGIRSPPSLTSPVYTHMT 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	6/32 (19%)
		leucine-rich repeat	176..198	CDD:275380
		leucine-rich repeat	199..222	CDD:275380	4/21 (19%)
		LRR_RI	216..542	CDD:238064	74/369 (20%)
		LRR_8	221..281	CDD:290566	14/61 (23%)
		leucine-rich repeat	223..270	CDD:275380	11/48 (23%)
		leucine-rich repeat	271..294	CDD:275380	7/22 (32%)
		leucine-rich repeat	295..320	CDD:275380	4/24 (17%)
		leucine-rich repeat	321..343	CDD:275380	5/21 (24%)
		LRR_8	342..402	CDD:290566	15/59 (25%)
		leucine-rich repeat	344..367	CDD:275380	3/22 (14%)
		leucine-rich repeat	368..391	CDD:275380	8/22 (36%)
		LRR_8	390..450	CDD:290566	18/84 (21%)
		leucine-rich repeat	392..415	CDD:275380	6/43 (14%)
		leucine-rich repeat	416..439	CDD:275380	9/26 (35%)
		leucine-rich repeat	440..474	CDD:275380	5/33 (15%)
		leucine-rich repeat	475..498	CDD:275380	6/22 (27%)
		LRR_8	477..534	CDD:290566	12/67 (18%)
		leucine-rich repeat	499..520	CDD:275380	3/20 (15%)
		leucine-rich repeat	523..552	CDD:275380	5/38 (13%)
		LRRCT	561..619	CDD:214507	19/88 (22%)
		LRRNT	631..667	CDD:214470	8/35 (23%)
		leucine-rich repeat	664..693	CDD:275380	6/31 (19%)
		LRR_8	669..726	CDD:290566	6/30 (20%)
		leucine-rich repeat	694..715	CDD:275380	1/2 (50%)
		leucine-rich repeat	716..737	CDD:275380
		LRRCT	751..800	CDD:214507
		TIR	858..996	CDD:214587
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	23/108 (21%)
		leucine-rich repeat	76..100	CDD:275380	6/23 (26%)
		LRR_8	99..159	CDD:290566	16/84 (19%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		LRR_8	148..207	CDD:290566	15/83 (18%)
		leucine-rich repeat	149..172	CDD:275380	9/47 (19%)
		leucine-rich repeat	173..196	CDD:275380	3/22 (14%)
		LRR_8	197..>229	CDD:290566	11/31 (35%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		LRRCT	229..277	CDD:214507	8/47 (17%)
		Ig	296..376	CDD:143165	17/102 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453730
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840