Protein Alignment Tl and LOC3289806

DIOPT Version :10

• Sequence 1: NP_001262995.1
• Gene: Tl / 43222
• FlyBaseID: FBgn0262473
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: XP_061499828.1
• Gene: LOC3289806 / 3289806
• VectorBaseID: AGAMI1_003467
• Length: 1094
• Species: Anopheles gambiae
• Alignment Length: 1137
• Identity: 360/1137 - (31%)
• Similarity: 557/1137 - (48%)
• Gaps: 157/1137 - (13%)

  Fly    10 LALLVIILQLLQWPGSEASFGRDACSEMSIDGLCQCAPIMSEYEIICPANAENPTFRLTIQPKDY 74
            |:|||::...:.        |.|...|...|       ::|:.:  ||  ..|....|...|:.
Mosquito    46 LSLLVLLTAQVS--------GNDCTVEKHSD-------LVSKAK--CP--GFNVQLTLHTNPRQ- 90

  Fly    75 VQIMCNLTDTTDYQQLP--KKLRIGEVDRVQMRRCMLP-GHTPIASILDYLGI------VSPTTL 130
            :::.|  :|..|:|.|.  :.|...:.:.:..:.|.|| |:   .|::|.|..      :|....
Mosquito    91 LEVTC--SDKPDFQLLKNIQNLPNFKFEELAYQNCPLPVGN---QSLVDLLSAFLDRTQLSSIRR 150

  Fly   131 IFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHL-----ELRANIEEM-- 188
            :|..||.          :|.|  :.....:....:||..:..|:|.|.:     ||...::.:
Mosquito   151 LFFVDNA----------KLSG--QVTLDPQLFADLPALQVLSMKNSSRMPLDNPELFKYLQSLTW 203

  Fly   189 ------------PSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDF 241
                        ...|...|..|.::|...|:|..:|..:...:|.|..|.|:.|:|..:  ..|
Mosquito   204 IDLREGDGGSRNSKVLLHTLTQLTTLELTENELTTLPTELITDLPSLGSLTLYHNKLERI--EQF 266

  Fly   242 EGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVP 306
            ....::..:|:..|.::.|..|||..|.|:|.:.|::|...|||.||...|..|...|..|....
Mosquito   267 ADLPNLTSLDLTYNELDTLQEDVFYKLPNLTHLFLNSNKLTSLPSGLLKRNTKLIVFRADNQHGS 331

  Fly   307 LATLPSRLFANQPELQILRL-RAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLS 370
            ...|...|||....|:.:.: ..:|.:||..||..::::|.:.:.||.|::||..||.|...|..
Mosquito   332 GLVLGDELFAGLTMLEDVSVSNCKLTTLPEGLFTAASKLTKLDVSDNKLQSLPENLLRHSSILKE 396

  Fly   371 LDLSNNRLTH-LPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAF 434
            |.|.:|.|.: |||:|...|..|..|.|..|.||.:|..:..:..:|..|.:..|:|..||..||
Mosquito   397 LYLQHNELINMLPDTLLQSTNKLRILNLGHNKLTTLSKYLLDSKNSLEELHLEYNQLYMIDRDAF 461

  Fly   435 VS-TNGLRHLHLDHNDIDLQQPLLDI---------MLQTQINSPFGYMHGLLTLNLRNNSIIFVY 489
            :| ...|:.|:|.||.:.|.....|:         :.||    ||..:..|..|:|..|:||.::
Mosquito   462 ISQAQSLKMLNLSHNQVALHVNGTDVFYLDGKTYYISQT----PFYILAQLTDLDLSYNAIIKIF 522

  Fly   490 NDWKNTMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLV 554
            .|:|..|..|:.||||:|.|.::..:|.:|||.....||:..|:|......:...  ..::|..:
Mosquito   523 GDFKGFMGNLQSLDLSHNLIMNISDKDFSFLSPKIEKVNLESNRITMFTFNDSKK--STFSNRSI 585

  Fly   555 H----VDLNDNPLVCDC---TILWFIQ---------LVRGVHKPQYSRQFKLRTDRLVCSQPNVL 603
            :    :.|.||.|.|||   :::.::|         .::|:|                |:||..|
Mosquito   586 NTPRQILLADNSLNCDCISSSLVTYLQDQLNAGKFVPLKGLH----------------CAQPPEL 634

  Fly   604 EGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVP--RLPNL-H 665
            .|...:.:..:.|:|.:|.|..    .||..|.|:.|..|:..::||.:.|||.||  :.|:: .
Mosquito   635 LGRKPQDLSLEDLLCKIDVSSG----FCPTECKCYKRAVDQGAIVNCTAANLTRVPVIKSPSIVG 695

  Fly   666 KNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLN 730
            :||  :||:||.|.:..|.:.. .|:.::..|::|.|:.|::..|.||..|..||:|.|.|..::
Mosquito   696 RNM--IELYLEQNMIKELSNVG-EGWNTIRRLNIANNSFTTLPGDSLPEQLELLDVSGNQLTEVD 757

  Fly   731 ATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMCVNAEMPTRMVELST 795
            |..:..||.| ..|::.||.|||.|.| ..|||.|..||..||...:.:.|.:.: |.....|
Mosquito   758 AAFIIKLNHT-ALRNISLSANPWDCHC-ENPLLAFAVDNAARITGYSTLQCSDGQ-PINSATL-- 817

  Fly   796 NDIC--PAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDKK 858
            ||:|  |.....:|:.||.:.|...|....  ||.|:..|||:||:.||||.|.||||.:|.||:
Mosquito   818 NDLCAWPTTLKFYISAAVSLVLAACLLAIW--LYMKYSLEIKVWLFKHNLLQWLVTEEQIDMDKR 880

  Fly   859 FDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQ 923
            :||||||||||:.|:.|.|:|:||.....|::|.|.||::.|..|...|.::|.|||||||:||.
Mosquito   881 YDAFISYSHKDEEFVTDQLLPRLESEELNFKICWHVRDFMPGEMIATQITKAVEDSRRTIIILSL 945

  Fly   924 NFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDEELKAYLKMNTYLKWGDPWFWDK 988
            |:::|.|.::||..|:..:|.:.|:|:|.|||.||||:::||.||:||||.|||::|.|||||||
Mosquito   946 NYLESVWGQMEFNTAYLQSLEDKRNRVIPIIYQDIGDIDQLDPELRAYLKTNTYVRWDDPWFWDK 1010

  Fly   989 LRFALPH-RRPVGNIGNGALIKTALKGSTDDKLELIK-PSPVTPPL--TTPPAEATKNPLVAQLN 1049
            |.:|:|| |||     .|......::.::.|||.|:| |:.:||..  ||||.|..:..:.
Mosquito  1011 LHYAMPHKRRP-----KGVQATDNMRMASVDKLNLLKAPAIMTPASSETTPPVEHAEKGIA---- 1066

  Fly  1050 GVTPHQAIMIANGKNGLTNLYTP----NGKSH 1077
                |...:...|....|:...|    ||.|:
Mosquito  1067 ----HDGPLGCYGDPSKTSTMPPFIISNGMSN 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:404697	16/77 (21%)
		leucine-rich repeat	176..198	CDD:275380	5/40 (13%)
		leucine-rich repeat	199..222	CDD:275380	5/22 (23%)
		LRR	222..576	CDD:443914	115/381 (30%)
		leucine-rich repeat	223..270	CDD:275380	13/46 (28%)
		leucine-rich repeat	271..294	CDD:275380	9/22 (41%)
		leucine-rich repeat	295..320	CDD:275380	7/24 (29%)
		leucine-rich repeat	321..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..367	CDD:275380	9/22 (41%)
		leucine-rich repeat	368..391	CDD:275380	10/23 (43%)
		leucine-rich repeat	392..415	CDD:275380	7/22 (32%)
		leucine-rich repeat	416..439	CDD:275380	9/23 (39%)
		leucine-rich repeat	440..474	CDD:275380	11/42 (26%)
		leucine-rich repeat	475..498	CDD:275380	9/22 (41%)
		leucine-rich repeat	499..520	CDD:275380	8/20 (40%)
		leucine-rich repeat	523..552	CDD:275380	4/28 (14%)
		LRRCT	561..619	CDD:214507	14/69 (20%)
		LRRNT	631..667	CDD:214470	14/38 (37%)
		PPP1R42	<660..752	CDD:455733	30/92 (33%)
		leucine-rich repeat	664..693	CDD:275380	9/29 (31%)
		leucine-rich repeat	694..715	CDD:275380	7/20 (35%)
		leucine-rich repeat	716..737	CDD:275380	7/20 (35%)
		LRRCT	751..800	CDD:214507	19/50 (38%)
		TIR	858..996	CDD:214587	74/138 (54%)
LOC3289806	XP_061499828.1	None