DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and Tlr7

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	XP_017457568.1	Gene:	Tlr7 / 317468	RGDID:	1563357	Length:	1068	Species:	Rattus norvegicus

Alignment Length:	1067	Identity:	242/1067 - (22%)
Similarity:	435/1067 - (40%)	Gaps:	267/1067 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 PTTLIFESDN--LGMNITRQHLDRL-HGLKRFRFTTRRLT----HIPANLLTDMRNLSHLE---L 181
            |..:..:|.|  :.::.|.:||..: .|:..   .|..||    |||:........|.|||   |
  Rat    53 PCDVSLDSTNTHVIVDCTDKHLTEIPEGIPT---NTTNLTLTINHIPSISPDSFHRLKHLEELDL 114

  Fly   182 RAN----------------IEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWS 230
            |.|                ::..|.. |..|.:|:|:....|:|.::|:.:   ...|:.|:|.:
  Rat   115 RCNCVPILLGSKANVCTKRLQIRPGS-FSGLSDLKSLYLDGNQLLEIPQDL---PSSLQLLSLEA 175

  Fly   231 NQLHNLTKHDFEGATSVLGIDIHDNGIEQLP--------HDVFAHLTNVTDINLSANLFRSLPQG 287
            |.:.::||.:.....::..:.:..|...:.|        .|.|..:.|:..::|..|...::|..
  Rat   176 NNIFSITKENLSELVNIESLYLGQNCYYRNPCNVSYSIEKDAFLVMKNLKVLSLKDNNVTAVPTI 240

  Fly   288 L-------------------FDHNKHLNEVRLMN-------------------NRVPLATLPSRL 314
            |                   .|.|| |:::::::                   |..|| .:....
  Rat   241 LPPNLLELYLYNNIIKRIQEHDFNK-LSQLQVLDLSGNCPRCYNVPYPCTPCENNSPL-QIHDNA 303

  Fly   315 FANQPELQILRLRA-ELQSLPGDLFEHSTQITNISLGDNLL--KTLPATLLEHQVNLLSLDLSNN 376
            |.:..||::|||.: .||.:|.:.|::.:.:..:.|..|.|  :...|..|....||:.||||.|
  Rat   304 FDSLTELKVLRLHSNSLQHVPAEWFKNMSNLQELDLSQNYLAREIEEAKFLNSLPNLVQLDLSFN 368

  Fly   377 ---RLTH----LPDSLFAHTTNLTDLR-----------LEDNLLTGISGDIFSNLGNLVTLVMSR 423
               ::.|    ||.||    ::||.|:           |:|:.|:     :..||.||..|.:..
  Rat   369 YELQVYHASITLPHSL----SSLTKLKNLYIKGYVFKELKDSSLS-----VLHNLSNLEVLDLGT 424

  Fly   424 NRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIML----QTQINSPFGYMHGLLTLNLRNNS 484
            |.::..|...|.....|:.:.|..|.|...:...::.|    ||.::     .||...|...:
  Rat   425 NFIKIADLNIFQQFENLKFIDLSVNKISPSEESREVGLCPNAQTSVD-----WHGPQVLEALH-- 482

  Fly   485 IIFVYNDW------KN----TMLQL--------RELDLSYNNISSL---GYEDLAF-----LSQN 523
             .|.|:::      ||    |.|.|        :.||||.|||..:   .::.|:|     ||.|
  Rat   483 -YFRYDEYARSCRFKNKEPPTFLPLNADCHTYGKTLDLSRNNIFFIKPSDFKHLSFLKCLNLSGN 546

  Fly   524 RLHVNMTHNKIRRIALPEDVHLGEGYNN--------------NLVHVDLNDNPLVCDCTILWFIQ 574
            .:...:..::::.:   .::...:..||              ||..:||:.|.        .:.|
  Rat   547 AIGQTLNGSELQPL---RELRYLDFSNNRLDLLYSTAFEELQNLEILDLSSNS--------HYFQ 600

  Fly   575 LVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHV 639
            .....|...:::  |||....:....|.:..:..|.:|.::|.. |:|..:..:.....|.|.::
  Rat   601 AEGITHMLNFTK--KLRHLEKLMMNDNDISTSASRTMESESLRV-LEFRGNHLDVLWRDGDNRYL 662

  Fly   640 RTYDKAL---VINCHSGNLTHVP------RLPN-----LHKN---------MQLMELHLEN---- 677
            ..:...|   .::....:|..||      ..||     |.||         :||:: ||:|
  Rat   663 DFFKNLLNLEELDISRNSLNSVPPGVFEGMPPNLTTLSLAKNGLRSFSWGRLQLLK-HLKNLDLS 726

  Fly   678 -NTLLRLPSANTPGYESVTSLHLAGNNLTSID----VDQLPTNLTHLDISWNHLQMLNAT----- 732
             |.|..:|:......:|:|.|.|..|.:..:.    .|.|  .|.:||||.|.:|::..|
  Rat   727 HNQLTTVPARLANCSKSLTKLILNHNQIRQLTKYFLEDAL--QLRYLDISSNKIQVIQKTSFPEN 789

  Fly   733 VLGFLNRTMKWRSVKLSGNPWMCDCTAKPLL------------LFTQDNFERIGDRNEMMCVNAE 785
            ||..||..:      |..|.::|:|.|...:            |.|.......|.......::.:
  Rat   790 VLNNLNMLL------LHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCAGPGAHKGQSVISLD 848

  Fly   786 MPTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTE 850
            :.|..::|:...:........:.|.:|:..:.|.......:||.::.:||.:.:..::
  Rat   849 LYTCELDLTNLILFSVSISSVLFLMIVMTTSHLFFWDMWYIYYFWKAKIKGYQHLQSM------- 906

  Fly   851 EDLDKDKKFDAFISYSHKDQSFIE---DYLVPQLEHGPQK-FQLCVHERDWLVGGHIPENIMRSV 911
                 :..:||||.|..|:.:..|   ..||.:||...:| |.||:.|||||.|..:.||:.:|:
  Rat   907 -----ESCYDAFIVYDTKNSAVTEWVLQELVVKLEDPREKHFNLCLEERDWLPGQPVLENLSQSI 966

  Fly   912 ADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEK-LDE----ELKAY 971
            ..||:|:.|::|.:.|:|..::.|..:|:..::| :..:|::|:     :|| |.:    :|:..
  Rat   967 QLSRKTVFVMTQKYAKTESFKMAFYLSHQRLMDE-KVDVIILIF-----LEKPLQKSKFLQLRKR 1025

  Fly   972 LKMNTYLKW-----GDPWFWDKLRFAL 993
            |..::.|:|     ..|:||..|:.||
  Rat  1026 LCSSSVLEWPTNPQAHPYFWQCLKNAL 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	19/77 (25%)
		leucine-rich repeat	176..198	CDD:275380	10/40 (25%)
		leucine-rich repeat	199..222	CDD:275380	5/22 (23%)
		LRR_RI	216..542	CDD:238064	92/422 (22%)
		LRR_8	221..281	CDD:290566	13/67 (19%)
		leucine-rich repeat	223..270	CDD:275380	10/54 (19%)
		leucine-rich repeat	271..294	CDD:275380	6/41 (15%)
		leucine-rich repeat	295..320	CDD:275380	5/43 (12%)
		leucine-rich repeat	321..343	CDD:275380	8/22 (36%)
		LRR_8	342..402	CDD:290566	22/79 (28%)
		leucine-rich repeat	344..367	CDD:275380	5/24 (21%)
		leucine-rich repeat	368..391	CDD:275380	11/29 (38%)
		LRR_8	390..450	CDD:290566	17/70 (24%)
		leucine-rich repeat	392..415	CDD:275380	8/33 (24%)
		leucine-rich repeat	416..439	CDD:275380	5/22 (23%)
		leucine-rich repeat	440..474	CDD:275380	7/37 (19%)
		leucine-rich repeat	475..498	CDD:275380	6/32 (19%)
		LRR_8	477..534	CDD:290566	20/82 (24%)
		leucine-rich repeat	499..520	CDD:275380	10/36 (28%)
		leucine-rich repeat	523..552	CDD:275380	3/42 (7%)
		LRRCT	561..619	CDD:214507	10/57 (18%)
		LRRNT	631..667	CDD:214470	9/49 (18%)
		leucine-rich repeat	664..693	CDD:275380	11/42 (26%)
		LRR_8	669..726	CDD:290566	21/65 (32%)
		leucine-rich repeat	694..715	CDD:275380	6/24 (25%)
		leucine-rich repeat	716..737	CDD:275380	10/25 (40%)
		LRRCT	751..800	CDD:214507	9/60 (15%)
		TIR	858..996	CDD:214587	49/150 (33%)
Tlr7	XP_017457568.1	leucine-rich repeat	66..87	CDD:275380	5/23 (22%)
		LRR_8	93..157	CDD:290566	16/64 (25%)
		leucine-rich repeat	109..146	CDD:275380	8/37 (22%)
		leucine-rich repeat	147..191	CDD:275380	11/46 (24%)
		leucine-rich repeat	192..223	CDD:275380	4/30 (13%)
		LRR_8	222..277	CDD:290566	9/55 (16%)
		LRR_RI	223..472	CDD:238064	60/264 (23%)
		leucine-rich repeat	224..244	CDD:275380	4/19 (21%)
		leucine-rich repeat	245..268	CDD:275380	4/23 (17%)
		leucine-rich repeat	269..309	CDD:275380	4/40 (10%)
		LRR_8	308..368	CDD:290566	20/59 (34%)
		leucine-rich repeat	310..333	CDD:275380	8/22 (36%)
		leucine-rich repeat	334..359	CDD:275380	5/24 (21%)
		leucine-rich repeat	370..389	CDD:275380	6/22 (27%)
		leucine-rich repeat	390..416	CDD:275380	6/30 (20%)
		leucine-rich repeat	417..440	CDD:275380	5/22 (23%)
		LRR_8	515..573	CDD:290566	14/60 (23%)
		leucine-rich repeat	515..537	CDD:275380	8/21 (38%)
		LRR_RI	532..778	CDD:238064	55/262 (21%)
		leucine-rich repeat	538..562	CDD:275380	3/26 (12%)
		LRR_8	561..627	CDD:290566	13/75 (17%)
		leucine-rich repeat	563..586	CDD:275380	2/22 (9%)
		leucine-rich repeat	587..616	CDD:275380	8/38 (21%)
		leucine-rich repeat	617..639	CDD:275380	3/21 (14%)
		LRR_8	639..706	CDD:290566	14/67 (21%)
		leucine-rich repeat	640..670	CDD:275380	5/30 (17%)
		leucine-rich repeat	671..695	CDD:275380	3/23 (13%)
		LRR_8	694..754	CDD:290566	18/60 (30%)
		leucine-rich repeat	696..719	CDD:275380	5/23 (22%)
		leucine-rich repeat	720..743	CDD:275380	5/22 (23%)
		leucine-rich repeat	768..786	CDD:275380	8/17 (47%)
		TIR	909..1054	CDD:214587	49/150 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.780