DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and Tlr2

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	XP_008759324.3	Gene:	Tlr2 / 310553	RGDID:	735138	Length:	831	Species:	Rattus norvegicus

Alignment Length:	966	Identity:	215/966 - (22%)
Similarity:	359/966 - (37%)	Gaps:	287/966 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 GHTPIASI-LDYLGIVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMR 174
            ||:..||: .|..|:...::..|.|...|:....:.||         .:..::|:|....|....
  Rat    68 GHSAQASLSCDAAGVCDGSSRSFTSIPSGLTANTKKLD---------LSFNKITYIGHGDLRACV 123

  Fly   175 NLSHLELRAN-IEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTK 238
            ||..|.|.:: |..:....|..|.:||.::..:|.|..:....|..:..||.|||..|....|
  Rat   124 NLRVLTLESSGINTIEGDAFYSLGSLEHLDLSNNHLSSLSSSWFRPLSSLKYLNLMGNPYRTL-- 186

  Fly   239 HDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNN 303
                |.||                 :|::|||:.::.:          |..|   ..:|:|
  Rat   187 ----GETS-----------------LFSNLTNLQNLRV----------GNVD---TFSEIR---- 213

  Fly   304 RVPLATLPSRLFANQPELQILRL----RAELQSLPGDLFEHSTQIT----------NISLGDNLL 354
            |:..|.|.|   .|:.|:|:|.|    ...|||: .|::..:..::          :|......|
  Rat   214 RIDFAGLTS---LNELEIQVLSLGNYESRSLQSI-RDIYHLTLHLSESAFLLGIFADILSSVRYL 274

  Fly   355 KTLPATLLEHQVNLLSLDLSNN-------RLTHLPD-------SLFAHTTNLTDLRLEDNLLTGI 405
            :.....|...|.:.||:|..|:       |...|.|       .|..:...|.::..:...|.|:
  Rat   275 ELRDTNLARFQFSELSVDEINSPMKKLAFRNADLTDKSFNELLKLLRYILELMEVEFDHCTLNGV 339

  Fly   406 ------SGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQ 464
                  ..|:...||.:.|:.                   :|.||:.           ...|...
  Rat   340 GNFNPSESDVVRELGKVETVT-------------------IRSLHIP-----------QFYLFYD 374

  Fly   465 INSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLS---------YNNISSLGYEDL--A 518
            :::.:..:..:..:.:.|:.:..|...:...:..|..||||         .|:....|:..|  .
  Rat   375 LSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACEGGWPSLQSL 439

  Fly   519 FLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDN---PLVCDCTILWFIQLVRGVH 580
            .||||.|      ..||:.|   ::.|   ...||..:|::.|   |:...|.  |
  Rat   440 VLSQNHL------RSIRKTA---EILL---TLKNLTALDISKNSFQPMPDSCQ--W--------- 481

  Fly   581 KPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKA 645
             |...|...|.:..:          ..|:...||||.. ||.|::
  Rat   482 -PGKMRFLNLSSTGI----------QAVKTCIPQTLEV-LDVSNN-------------------- 514

  Fly   646 LVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVD 710
               |..|.:| .:||         |.||::..|.|..||.|:.  :..:..:.:..|.:::...|
  Rat   515 ---NLDSFSL-FLPR---------LQELYISRNKLKTLPEASL--FPVLQVMKIRENAISTFSKD 564

  Fly   711 QLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFER--- 772
            ||.        |:..|:.|.|                 ..|.::|.|.....:|      ||
  Rat   565 QLG--------SFPKLETLEA-----------------GDNHFICSCELLSFIL------ERPAL 598

  Fly   773 ----IGDRNEMMCVNAEMPTRMVELSTNDICPA---------EKGVFIALAVVIALTGLLAGFTA 824
                :...:..:|   :.|.|:......|..|:         ..||..||.::|.|.|
  Rat   599 VHVLVDWPDSYLC---DSPPRLHGQRLQDARPSVLECHQAALVSGVCCALLLLILLLG------- 653

  Fly   825 ALYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDKK-------FDAFISYSHKDQSFIEDYLVPQLE 882
            ||.|.|.   .:| |...:..|...:.   |.||       :|||:|||.:|..::|:.:|.|||
  Rat   654 ALCYHFH---GLW-YLRMMWAWLRAKR---KPKKAPCRDLCYDAFVSYSEQDSYWVENLMVQQLE 711

  Fly   883 HGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGR 947
            :....|:||:|:||::.|..|.:||:.|:..|.:|:.|||:||::|||.:.|...:|....:|..
  Rat   712 NSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDFSHFRLFDENN 776

  Fly   948 SRIIVIIYSDIGDVEKLDE---ELKAYLKMNTYLKWGDPW-------FWDKLRFAL 993
            ...|:::...| :.:.:.:   :|:..:...|||:|  |.       ||..||.|:
  Rat   777 DAAILVLLEPI-EKKAIPQRFCKLRKIMNTKTYLEW--PLDEGQREVFWANLRTAI 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	18/59 (31%)
		leucine-rich repeat	176..198	CDD:275380	6/22 (27%)
		leucine-rich repeat	199..222	CDD:275380	5/22 (23%)
		LRR_RI	216..542	CDD:238064	73/370 (20%)
		LRR_8	221..281	CDD:290566	14/59 (24%)
		leucine-rich repeat	223..270	CDD:275380	12/46 (26%)
		leucine-rich repeat	271..294	CDD:275380	2/22 (9%)
		leucine-rich repeat	295..320	CDD:275380	7/24 (29%)
		leucine-rich repeat	321..343	CDD:275380	7/25 (28%)
		LRR_8	342..402	CDD:290566	13/83 (16%)
		leucine-rich repeat	344..367	CDD:275380	4/32 (13%)
		leucine-rich repeat	368..391	CDD:275380	8/36 (22%)
		LRR_8	390..450	CDD:290566	10/65 (15%)
		leucine-rich repeat	392..415	CDD:275380	5/28 (18%)
		leucine-rich repeat	416..439	CDD:275380	1/22 (5%)
		leucine-rich repeat	440..474	CDD:275380	4/33 (12%)
		leucine-rich repeat	475..498	CDD:275380	2/22 (9%)
		LRR_8	477..534	CDD:290566	15/67 (22%)
		leucine-rich repeat	499..520	CDD:275380	8/31 (26%)
		leucine-rich repeat	523..552	CDD:275380	6/28 (21%)
		LRRCT	561..619	CDD:214507	12/60 (20%)
		LRRNT	631..667	CDD:214470	5/35 (14%)
		leucine-rich repeat	664..693	CDD:275380	8/28 (29%)
		LRR_8	669..726	CDD:290566	13/56 (23%)
		leucine-rich repeat	694..715	CDD:275380	4/20 (20%)
		leucine-rich repeat	716..737	CDD:275380	4/20 (20%)
		LRRCT	751..800	CDD:214507	10/55 (18%)
		TIR	858..996	CDD:214587	50/153 (33%)
Tlr2	XP_008759324.3	leucine-rich repeat	101..124	CDD:275378	5/31 (16%)
		LRR_8	124..182	CDD:404697	17/57 (30%)
		leucine-rich repeat	125..148	CDD:275378	6/22 (27%)
		leucine-rich repeat	149..172	CDD:275378	5/22 (23%)
		leucine-rich repeat	173..197	CDD:275378	12/46 (26%)
		leucine-rich repeat	229..249	CDD:275380	7/20 (35%)
		leucine-rich repeat	250..270	CDD:275380	1/19 (5%)
		PRK15370	<387..>605	CDD:185268	64/318 (20%)
		leucine-rich repeat	409..435	CDD:275380	7/25 (28%)
		leucine-rich repeat	436..461	CDD:275380	10/36 (28%)
		leucine-rich repeat	462..484	CDD:275380	7/33 (21%)
		leucine-rich repeat	485..505	CDD:275380	4/29 (14%)
		leucine-rich repeat	506..525	CDD:275380	7/43 (16%)
		leucine-rich repeat	526..547	CDD:275380	8/22 (36%)
		leucine-rich repeat	548..571	CDD:275380	5/30 (17%)
		LRRCT	580..633	CDD:214507	11/61 (18%)
		TIR	687..831	CDD:214587	49/146 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920