DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and Tlr1

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	XP_038947853.1	Gene:	Tlr1 / 305354	RGDID:	1309975	Length:	808	Species:	Rattus norvegicus

Alignment Length:	891	Identity:	201/891 - (22%)
Similarity:	341/891 - (38%)	Gaps:	209/891 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 LTHIPANLLTDMRNLSHLELRANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQL 226
            ||.:|.:|......|.  ..:.||.|:.:.....|..|.......|:|:.:...:|....:|:.|
  Rat    52 LTRVPKDLPLQTTTLD--VSQNNISELQTSDILLLSKLRVFIMSYNRLQYLNISVFKFNTELEYL 114

  Fly   227 NLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDH 291
            :|..|:|..::.|    ||:            .|.|           ::||.|.|.:||
  Rat   115 DLSHNELRLISCH----ATA------------DLKH-----------LDLSFNAFDALP------ 146

  Fly   292 NKHLNEVRLMNNRVPLATLPSRLFANQPELQILRLR-AELQSLPGDLFEHSTQITNIS-----LG 350
                               ..:.|.|..:||.|.|. :::|:....|..|    .|||     ||
  Rat   147 -------------------ICKEFGNLSQLQFLGLSGSQIQNSSVQLIAH----LNISKVLLVLG 188

  Fly   351 DNLLKTLPATLLEH-QVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLG 414
            |...:......|:| ....|.:...:.|..|.          |.|:        .:|..|...|.
  Rat   189 DTYGEKEDPKCLQHISTETLHIVFPSKREFHF----------LLDM--------SVSTAISLELS 235

  Fly   415 NLVTLVMSRN---------RLRTIDSRAFVSTNGLRHLHLDHNDIDLQQ--PLLDIMLQTQINSP 468
            |:..::..:|         |||        .|..|.:|.|::.|.....  .:|.::..|.:.|
  Rat   236 NIKCVLEDKNCSYFLGTLERLR--------KTQRLSNLTLNNVDTTWNSFINILQLVWHTPVKS- 291

  Fly   469 FGYMHGLLT--LNLRNNSIIFVYNDWKNTMLQLREL-----DLSYNNISSLGYEDLAFLSQNRLH 526
            |...:..|.  .|.|.    |.|:|.....|.:.::     ....:||.|:      |.:.|...
  Rat   292 FSISNVKLKGHFNFRR----FHYSDTSLRALSIHQVVTDVFSFPQSNIYSI------FSNMNIQS 346

  Fly   527 VNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVC----DCTILWFIQLVRGVHKPQYSRQ 587
            ..::..::..:..|:.:       :..:::|..||.|..    ||..|
  Rat   347 FTVSGTRMVHMLCPDQI-------SPFLYLDFTDNLLTDIVFEDCRNL----------------- 387

  Fly   588 FKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHS 652
            .:|:|..|..:|...||...:..:| .|.:..||.|.:.. |....|..|  ......||:|..|
  Rat   388 IRLKTLSLQKNQLKTLENIILMSME-MTSLQKLDISQNSL-RYSDAGSPC--SWTQSLLVLNLSS 448

  Fly   653 GNLT-HVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNL 716
            ..|| .|.|.  |...:::::||  ||.::.: |.:....:::..|::|.|.||.:......::|
  Rat   449 NMLTDSVFRC--LPPKVKVLDLH--NNRIVSI-SKDVTHLQALQELNVASNFLTDLPGCGAFSSL 508

  Fly   717 THLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMM- 780
            :.|.|..|.:...::   .|.......||:....||:.|.|..:..:       :.||..:..:
  Rat   509 SVLVIDHNSVSHPSS---DFFQSCQNIRSITAGNNPFRCTCELREFV-------KNIGQASREVV 563

  Fly   781 -----CVNAEMPTRMVELSTNDI------CPAEKGVFIALAVVIALTGLL---AGFTAALYYKFQ 831
                 ....:.|..:......|.      |..     |.|.|.|..|.||   .|.:..||:...
  Rat   564 EGWPDSYRCDYPDSIKGTPLQDFHMSPLSCDT-----ILLTVTIGATLLLLAAIGASLCLYFDLP 623

  Fly   832 TEIK-IWLY------AHNLLLWFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQ 889
            ..:: :|.:      |.|:.|     |:|.::.:|.||:|||..|.:::::.|:|.||  ....:
  Rat   624 WYLRMLWQWTQTRHRARNIPL-----EELQRNLQFHAFVSYSGHDSAWVKNELLPNLE--KDDIR 681

  Fly   890 LCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVII 954
            :|:|||:::.|..|.|||:..:..|.::|.|||.:||:|||...|...||.:..:||...:|:|:
  Rat   682 VCLHERNFVPGKSIVENIIHFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILIL 746

  Fly   955 YSDIG--DVEKLDEELKAYLKMNTYLKWGDP-----WFWDKLRFAL 993
            ...|.  .:.....:||..:...|||:|...     .||..||.::
  Rat   747 LEPIPQYSIPTNYHKLKTLMARRTYLEWPTEKSKHGLFWANLRASI 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	13/58 (22%)
		leucine-rich repeat	176..198	CDD:275380	5/21 (24%)
		leucine-rich repeat	199..222	CDD:275380	4/22 (18%)
		LRR_RI	216..542	CDD:238064	69/350 (20%)
		LRR_8	221..281	CDD:290566	13/59 (22%)
		leucine-rich repeat	223..270	CDD:275380	10/46 (22%)
		leucine-rich repeat	271..294	CDD:275380	6/22 (27%)
		leucine-rich repeat	295..320	CDD:275380	2/24 (8%)
		leucine-rich repeat	321..343	CDD:275380	7/22 (32%)
		LRR_8	342..402	CDD:290566	13/65 (20%)
		leucine-rich repeat	344..367	CDD:275380	8/28 (29%)
		leucine-rich repeat	368..391	CDD:275380	3/22 (14%)
		LRR_8	390..450	CDD:290566	14/68 (21%)
		leucine-rich repeat	392..415	CDD:275380	5/22 (23%)
		leucine-rich repeat	416..439	CDD:275380	5/31 (16%)
		leucine-rich repeat	440..474	CDD:275380	8/35 (23%)
		leucine-rich repeat	475..498	CDD:275380	6/24 (25%)
		LRR_8	477..534	CDD:290566	11/63 (17%)
		leucine-rich repeat	499..520	CDD:275380	3/25 (12%)
		leucine-rich repeat	523..552	CDD:275380	2/28 (7%)
		LRRCT	561..619	CDD:214507	13/61 (21%)
		LRRNT	631..667	CDD:214470	11/36 (31%)
		leucine-rich repeat	664..693	CDD:275380	6/28 (21%)
		LRR_8	669..726	CDD:290566	14/56 (25%)
		leucine-rich repeat	694..715	CDD:275380	5/20 (25%)
		leucine-rich repeat	716..737	CDD:275380	4/20 (20%)
		LRRCT	751..800	CDD:214507	8/60 (13%)
		TIR	858..996	CDD:214587	48/143 (34%)
Tlr1	XP_038947853.1	PRK15370	<51..>146	CDD:185268	27/122 (22%)
		leucine-rich repeat	63..86	CDD:275378	5/24 (21%)
		leucine-rich repeat	87..110	CDD:275378	4/22 (18%)
		leucine-rich repeat	111..125	CDD:275378	5/13 (38%)
		leucine-rich repeat	132..156	CDD:275378	10/59 (17%)
		leucine-rich repeat	157..169	CDD:275378	4/11 (36%)
		PRK15370	<313..>500	CDD:185268	47/225 (21%)
		leucine-rich repeat	368..389	CDD:275380	7/37 (19%)
		leucine-rich repeat	390..415	CDD:275380	7/25 (28%)
		leucine-rich repeat	416..440	CDD:275380	6/26 (23%)
		leucine-rich repeat	441..462	CDD:275380	9/22 (41%)
		leucine-rich repeat	463..485	CDD:275380	5/24 (21%)
		leucine-rich repeat	486..507	CDD:275380	5/20 (25%)
		leucine-rich repeat	508..531	CDD:275380	5/25 (20%)
		LRRCT	540..594	CDD:214507	8/60 (13%)
		TIR	652..795	CDD:214587	48/143 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020