DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and Tlr6

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_997487.1	Gene:	Tlr6 / 305353	RGDID:	1303030	Length:	806	Species:	Rattus norvegicus

Alignment Length:	972	Identity:	212/972 - (21%)
Similarity:	351/972 - (36%)	Gaps:	324/972 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 FTTRRLTHIPANLLTDMRNLSHLELRAN-IEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKM 220
            ::.:.|||:|.:|....::||   |..| |.::.......|..|..:....|::|::..|:|...
  Rat    49 YSNKNLTHVPKDLSPSTKSLS---LSQNSISDLQMSDISFLSELRVLRLSHNRIRRLDFGVFLLN 110

  Fly   221 PKLKQLNLWSNQLHNLT-------KHDFEGATSVLGIDIHDNGIEQLP-HDVFAHLTNVTDINLS 277
            ..|:.|::..|||.|::       ||          :|:..|..|.|| :..|.:|..::.:.||
  Rat   111 RDLEYLDVSHNQLQNISCCPMVNLKH----------LDLSFNDFEVLPVYKEFGNLRKLSFLGLS 165

  Fly   278 ANLFRSLPQGLFDHNKHLNEVRL------------------MNNRVPLATLPSRLFANQPELQIL 324
            |..||.|......| .||:.|.|                  ..|.:.|...|:.||:.|..:.:.
  Rat   166 AAKFRQLDLLPISH-LHLSCVLLDLVNYQIKDGETESLQVPNTNVLHLVFHPNSLFSVQVNISVN 229

  Fly   325 RLRAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHT 389
            .|        |.|     |::||.|.|.              |..||.:..:.||..|..|
  Rat   230 AL--------GCL-----QLSNIKLNDE--------------NCQSLIIFLSELTRGPTLL---- 263

  Fly   390 TNLTDLRLEDN------LLTGI--SGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLD 446
             |||...:|.|      ||..:  ....:.|:.|| |:..|.:|    ::..:|.| .|:.|.::
  Rat   264 -NLTLQHIETNWKCFVRLLQFLWPRPVEYLNIYNL-TITESISR----ETFIYVET-VLKSLKIE 321

  Fly   447 H--NDIDL--QQPL------LDIMLQTQINSPFGYM------------------------HGLLT 477
            |  |.:.|  :..|      ::|.:.|..::||.:|                        .|..|
  Rat   322 HVTNQVFLFVKDALYSVFAEMNIRMLTLSDTPFIHMVCPEFPSTFAFLNFTQNVFTDSIFQGCST 386

  Fly   478 LNLRNNSIIFVYNDWKN---------TMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNK 533
            |. |..::|...|..||         ||..|..||:|.|:::|..|
  Rat   387 LK-RLETLILQRNGLKNLFKVALMTKTMSSLETLDVSLNSLNSHVY------------------- 431

  Fly   534 IRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCS 598
                                            |.|..|                  ..:.|::..
  Rat   432 --------------------------------DRTCAW------------------AESIRVLNL 446

  Fly   599 QPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPN 663
            ..|||..:..|.:.|                              |..|::.|:..:..:|:  :
  Rat   447 SSNVLSDSVFRCLPP------------------------------KVKVLDLHNNRIVSIPK--D 479

  Fly   664 LHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQM 728
            :.....|.||::.:|.|..||...  .:.|::.|.:..|:::....|
  Rat   480 VTHLQALQELNVASNFLTDLPGCG--AFSSLSVLVIDHNSVSHPSSD------------------ 524

  Fly   729 LNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMM------CVNAEMP 787
                   |.......||:....||:.|.|..:..:       :.||..:..:      ....:.|
  Rat   525 -------FFQSCQNIRSITAGNNPFRCTCELREFV-------KNIGQASREVVEGWPDSYRCDYP 575

  Fly   788 TRMVELSTNDI------CPAEKGVFIALAVVIALTGLL---AGFTAALYYKFQTEIK-IWLY--- 839
            ..:......|.      |..     |.|.|.|..|.||   .|.:..||:.....:: :|.:
  Rat   576 DSIKGTPLQDFHMSPLSCDT-----ILLTVTIGATLLLLAAIGASLCLYFDLPWYLRMLWQWTQT 635

  Fly   840 ---AHNLLLWFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGG 901
               |.|:.|     |:|.::.:|.||:|||..|.:::::.|:|.||  ....::|:|||:::.|.
  Rat   636 RHRARNIPL-----EELQRNLQFHAFVSYSEHDSAWVKNELLPNLE--KDDIRVCLHERNFVPGK 693

  Fly   902 HIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDI--GDVEKL 964
            .|.|||:..:..|.::|.|||.:||:|||...|...||.:..:||...:|:|:...|  .::...
  Rat   694 SIVENIIHFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPIQQNNIPSR 758

  Fly   965 DEELKAYLKMNTYLKWGDP-------WFWDKLRFALPHRRPVGNIGNGALIKTALKGSTDDK 1019
            ..:|:|.:...|||:|  |       .||..||.:.             ::|.||....|.|
  Rat   759 YHKLRALMAQRTYLEW--PIEKGKRGLFWANLRASF-------------IMKLALVNENDVK 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	14/59 (24%)
		leucine-rich repeat	176..198	CDD:275380	6/22 (27%)
		leucine-rich repeat	199..222	CDD:275380	5/22 (23%)
		LRR_RI	216..542	CDD:238064	91/402 (23%)
		LRR_8	221..281	CDD:290566	18/67 (27%)
		leucine-rich repeat	223..270	CDD:275380	15/54 (28%)
		leucine-rich repeat	271..294	CDD:275380	7/22 (32%)
		leucine-rich repeat	295..320	CDD:275380	9/42 (21%)
		leucine-rich repeat	321..343	CDD:275380	3/21 (14%)
		LRR_8	342..402	CDD:290566	17/65 (26%)
		leucine-rich repeat	344..367	CDD:275380	4/22 (18%)
		leucine-rich repeat	368..391	CDD:275380	6/22 (27%)
		LRR_8	390..450	CDD:290566	19/69 (28%)
		leucine-rich repeat	392..415	CDD:275380	7/30 (23%)
		leucine-rich repeat	416..439	CDD:275380	6/22 (27%)
		leucine-rich repeat	440..474	CDD:275380	11/67 (16%)
		leucine-rich repeat	475..498	CDD:275380	9/31 (29%)
		LRR_8	477..534	CDD:290566	16/65 (25%)
		leucine-rich repeat	499..520	CDD:275380	7/20 (35%)
		leucine-rich repeat	523..552	CDD:275380	0/28 (0%)
		LRRCT	561..619	CDD:214507	9/57 (16%)
		LRRNT	631..667	CDD:214470	4/35 (11%)
		leucine-rich repeat	664..693	CDD:275380	7/28 (25%)
		LRR_8	669..726	CDD:290566	11/56 (20%)
		leucine-rich repeat	694..715	CDD:275380	3/20 (15%)
		leucine-rich repeat	716..737	CDD:275380	0/20 (0%)
		LRRCT	751..800	CDD:214507	8/60 (13%)
		TIR	858..996	CDD:214587	49/146 (34%)
Tlr6	NP_997487.1	leucine-rich repeat	46..64	CDD:275380	5/14 (36%)
		leucine-rich repeat	65..88	CDD:275378	6/25 (24%)
		LRR_8	87..144	CDD:290566	15/66 (23%)
		leucine-rich repeat	89..112	CDD:275378	5/22 (23%)
		leucine-rich repeat	113..133	CDD:275378	6/19 (32%)
		leucine-rich repeat	134..158	CDD:275378	9/33 (27%)
		leucine-rich repeat	369..385	CDD:275380	1/15 (7%)
		LRR_RI	<380..>500	CDD:238064	35/221 (16%)
		LRR_8	388..451	CDD:290566	19/132 (14%)
		leucine-rich repeat	390..415	CDD:275380	6/24 (25%)
		leucine-rich repeat	416..440	CDD:275380	10/92 (11%)
		leucine-rich repeat	441..462	CDD:275380	6/50 (12%)
		LRR_8	461..516	CDD:290566	14/88 (16%)
		leucine-rich repeat	463..485	CDD:275380	3/23 (13%)
		leucine-rich repeat	486..508	CDD:275380	7/23 (30%)
		leucine-rich repeat	510..531	CDD:275380	4/45 (9%)
		LRRCT	540..594	CDD:214507	8/60 (13%)
		TIR	652..791	CDD:214587	49/142 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920