DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and Tlr13

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_991389.1	Gene:	Tlr13 / 279572	MGIID:	3045213	Length:	991	Species:	Mus musculus

Alignment Length:	1026	Identity:	244/1026 - (23%)
Similarity:	386/1026 - (37%)	Gaps:	282/1026 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 SDNLGMN-ITRQHLDRLHGL---KRFRFTTRRLTHIPANLLTDMRNLSHLELRAN-IEEMPSHLF 193
            ::..|.| .|:...|..|.|   |:....|..::.||       |..:||.|..| |:.:|...|
Mouse    66 AETYGFNKCTQYEFDIHHVLCIRKKITNLTEAISDIP-------RYTTHLNLTHNEIQVLPPWSF 123

  Fly   194 DDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIE 258
            .:|..|..:....|.:.::..|.|..:..|..|||..|::.:: .:.|||.:|:..:.:..|.|.
Mouse   124 TNLSALVDLRLEWNSIWKIDEGAFRGLENLTLLNLVENKIQSV-NNSFEGLSSLKTLLLSHNQIT 187

  Fly   259 QLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKH---LNEVRLMNNRVPLATLPSRLFANQPE 320
            .:..|.|..|..:..::||.|..... .|:.:..:|   |..:.|.||.:.......|...:...
Mouse   188 HIHKDAFTPLIKLKYLSLSRNNISDF-SGILEAVQHLPCLERLDLTNNSIMYLDHSPRSLVSLTH 251

  Fly   321 L-----QILRLRAELQSLPGDLFEHSTQITNISLGDN--------LLKTLP--------ATLL-- 362
            |     ::..|.....|||        .:||:|...|        .|||||        .|::
Mouse   252 LSFEGNKLRELNFSALSLP--------NLTNLSASRNGNKVIQNVYLKTLPQLKSLNLSGTVIKL 308

  Fly   363 -----EHQVNLLSLDLSNNRLTH------------------------------------------ 380
                 :|..||.::||||..|.|
Mouse   309 ENLSAKHLQNLRAMDLSNWELRHGHLDMKTVCHLLGNLPKLETLVFQKNVTNAEGIKQLAKCTRL 373

  Fly   381 -------------LPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSR 432
                         |.||.|....:|..|.|....|:.|:...:|:|.||.:|.:|.|:.::....
Mouse   374 LFLDLGQNSDLIYLNDSEFNALPSLQKLNLNKCQLSFINNRTWSSLQNLTSLDLSHNKFKSFPDF 438

  Fly   433 AFVSTNGLRHLHLDHNDID-------------------------------LQQPLLDIM------ 460
            ||.....|..|.|..|.|.                               .|.|.|:::
Mouse   439 AFSPLKHLEFLSLSRNPITELNNLAFSGLFALKELNLAACWIVTIDRYSFTQFPNLEVLDLGDNN 503

  Fly   461 LQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNNISSL------GYEDLAF 519
            ::|..:..|..:..|.:|.|.:|.:..:..:..:.:..||.|||.||::|..      |.|.|..
Mouse   504 IRTLNHGTFRPLKKLQSLILSHNCLKILEPNSFSGLTNLRSLDLMYNSLSYFHEHLFSGLEKLLI 568

  Fly   520 LSQNRLHVN-MTHNKIRRIALPEDVHLG-------EGYNNNLVHVDLNDNPLVCDCTILWFIQLV 576
            |   :|..| :|:...|.:..|..:.|.       ||..:.:..|..|            |.|
Mouse   569 L---KLGFNKITYETTRTLQYPPFIKLKSLKQLNLEGQRHGIQVVPSN------------FFQ-- 616

  Fly   577 RGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRT 641
             |:...|         :.|:...|:|.  ....|.:|...:..||.|.              .:.
Mouse   617 -GLGSLQ---------ELLLGKNPSVF--LDHHQFDPLINLTKLDISG--------------TKD 655

  Fly   642 YDKALVINCHSGNLTHVPRLPNLHKNMQLME-LHLENNTLLRLPSANTPGYESVTSLHLAGNNLT 705
            .|::|.:|.            :|.:|::.:: |.||||.|..|........:|:....|..|||.
Mouse   656 GDRSLYLNA------------SLFQNLKRLKILRLENNNLESLVPDMFSSLQSLQVFSLRFNNLK 708

  Fly   706 SIDVDQLPT--NLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWM----CDCTAKPLLL 764
            .|:...|..  :|...|:..|.|| .....|.|.|.:|....|.:   |::    |.......||
Mouse   709 VINQSHLKNLKSLMFFDVYGNKLQ-CTCDNLWFKNWSMNTEEVHI---PFLRSYPCQQPGSQSLL 769

  Fly   765 FTQDNFERIGDRNEMMCVNAEMPTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFT----AA 825
            .         |.::.|| |.::               .|..|:....::..|.:.:.|:    |:
Mouse   770 I---------DFDDAMC-NFDL---------------GKVYFLCSFSMVLSTMVFSWFSTKMIAS 809

  Fly   826 LYYKFQTEIKIWLY---AHNLLLWFVTEEDLDKDKKF--DAFISYSHKDQSFIEDYLVPQLEHGP 885
            |:|        .||   |..|..|..||      |||  |||:|:|..|::::...|||.||.|.
Mouse   810 LWY--------GLYICRAWYLTKWHKTE------KKFLYDAFVSFSATDEAWVYKELVPALEQGS 860

  Fly   886 Q-KFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSR 949
            | .|:||:|:||:..|..|.|||..::..||:|:.|:|.:::.|||.|||.:.|......|.:..
Mouse   861 QTTFKLCLHQRDFEPGIDIFENIQNAINTSRKTLCVVSNHYLHSEWCRLEVQLASMKMFYEHKDV 925

  Fly   950 IIVIIYSDIGDVEKLD--EELKAYLKMNTYLKWGD-----PWFWDKLRFAL 993
            ||:|...:|.:. ||.  ..|:..:...|::.|.|     |.||.::|.||
Mouse   926 IILIFLEEIPNY-KLSSYHRLRKLINKQTFITWPDSVHQQPLFWARIRNAL 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	18/59 (31%)
		leucine-rich repeat	176..198	CDD:275380	8/22 (36%)
		leucine-rich repeat	199..222	CDD:275380	4/22 (18%)
		LRR_RI	216..542	CDD:238064	98/455 (22%)
		LRR_8	221..281	CDD:290566	17/59 (29%)
		leucine-rich repeat	223..270	CDD:275380	14/46 (30%)
		leucine-rich repeat	271..294	CDD:275380	4/22 (18%)
		leucine-rich repeat	295..320	CDD:275380	5/24 (21%)
		leucine-rich repeat	321..343	CDD:275380	5/26 (19%)
		LRR_8	342..402	CDD:290566	26/137 (19%)
		leucine-rich repeat	344..367	CDD:275380	11/45 (24%)
		leucine-rich repeat	368..391	CDD:275380	11/77 (14%)
		LRR_8	390..450	CDD:290566	18/59 (31%)
		leucine-rich repeat	392..415	CDD:275380	7/22 (32%)
		leucine-rich repeat	416..439	CDD:275380	6/22 (27%)
		leucine-rich repeat	440..474	CDD:275380	10/70 (14%)
		leucine-rich repeat	475..498	CDD:275380	4/22 (18%)
		LRR_8	477..534	CDD:290566	18/63 (29%)
		leucine-rich repeat	499..520	CDD:275380	11/26 (42%)
		leucine-rich repeat	523..552	CDD:275380	8/36 (22%)
		LRRCT	561..619	CDD:214507	9/57 (16%)
		LRRNT	631..667	CDD:214470	4/35 (11%)
		leucine-rich repeat	664..693	CDD:275380	9/29 (31%)
		LRR_8	669..726	CDD:290566	17/59 (29%)
		leucine-rich repeat	694..715	CDD:275380	6/22 (27%)
		leucine-rich repeat	716..737	CDD:275380	6/20 (30%)
		LRRCT	751..800	CDD:214507	8/52 (15%)
		TIR	858..996	CDD:214587	55/146 (38%)
Tlr13	NP_991389.1	LRR 1	104..125		7/20 (35%)
		leucine-rich repeat	105..128	CDD:275380	8/22 (36%)
		LRR_8	106..163	CDD:290566	17/56 (30%)
		LRR 2	128..149		4/20 (20%)
		leucine-rich repeat	129..152	CDD:275380	4/22 (18%)
		LRR 3	152..174		8/22 (36%)
		leucine-rich repeat	153..175	CDD:275380	8/22 (36%)
		LRR 4	175..196		5/20 (25%)
		leucine-rich repeat	176..199	CDD:275380	5/22 (23%)
		LRR_8	183..236	CDD:290566	14/53 (26%)
		LRR_RI	<192..405	CDD:238064	44/221 (20%)
		LRR 5	199..220		4/21 (19%)
		leucine-rich repeat	200..225	CDD:275380	5/25 (20%)
		LRR 6	225..246		5/20 (25%)
		leucine-rich repeat	226..248	CDD:275380	5/21 (24%)
		LRR 7	248..268		2/19 (11%)
		leucine-rich repeat	249..271	CDD:275380	5/29 (17%)
		LRR 8	271..292		5/20 (25%)
		leucine-rich repeat	272..295	CDD:275380	8/22 (36%)
		LRR 9	295..315		1/19 (5%)
		leucine-rich repeat	296..319	CDD:275380	2/22 (9%)
		LRR 10	318..338		8/19 (42%)
		LRR 11	348..368		0/19 (0%)
		LRR 12	372..394		4/21 (19%)
		leucine-rich repeat	373..397	CDD:275380	4/23 (17%)
		LRR_8	396..456	CDD:290566	18/59 (31%)
		LRR 13	397..418		5/20 (25%)
		leucine-rich repeat	398..421	CDD:275380	7/22 (32%)
		LRR_4	420..463	CDD:289563	12/42 (29%)
		LRR 14	421..442		7/20 (35%)
		leucine-rich repeat	422..445	CDD:275380	6/22 (27%)
		LRR 15	445..466		5/20 (25%)
		leucine-rich repeat	446..469	CDD:275380	5/22 (23%)
		LRR 16	469..490		0/20 (0%)
		leucine-rich repeat	470..493	CDD:275380	1/22 (5%)
		LRR_8	492..552	CDD:290566	15/59 (25%)
		LRR 17	493..514		3/20 (15%)
		leucine-rich repeat	494..517	CDD:275380	3/22 (14%)
		LRR 18	517..538		4/20 (20%)
		leucine-rich repeat	518..541	CDD:275380	4/22 (18%)
		LRR_8	540..602	CDD:290566	18/64 (28%)
		LRR 19	541..562		8/20 (40%)
		leucine-rich repeat	542..565	CDD:275380	9/22 (41%)
		LRR 20	565..585		6/22 (27%)
		leucine-rich repeat	566..585	CDD:275380	6/21 (29%)
		LRR 21	594..617		6/37 (16%)
		LRR 22	620..641		5/31 (16%)
		LRR 23	644..665		6/46 (13%)
		LRR_8	671..731	CDD:290566	17/59 (29%)
		LRR 24	672..693		7/20 (35%)
		leucine-rich repeat	673..696	CDD:275380	7/22 (32%)
		LRR 25	696..716		6/19 (32%)
		leucine-rich repeat	697..718	CDD:275380	6/20 (30%)
		TIR	834..976	CDD:214587	53/143 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8923
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.910