DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and Tlr2

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	XP_006501523.1	Gene:	Tlr2 / 24088	MGIID:	1346060	Length:	794	Species:	Mus musculus

Alignment Length:	949	Identity:	212/949 - (22%)
Similarity:	347/949 - (36%)	Gaps:	320/949 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 TRRLTHIPANLLTDMRNL----------SHLELRA------------NIEEMPSHLFDDLENLES 201
            :|..|.||:.|...|::|          .|.:|||            .|..:....|..|.:||.
Mouse    50 SRSFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLMLKSSRINTIEGDAFYSLGSLEH 114

  Fly   202 IEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFA 266
            ::...|.|..:....||.:..||.|||..|....|      |.||                 :|.
Mouse   115 LDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTL------GVTS-----------------LFP 156

  Fly   267 HLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILRLR-AEL 330
            :|||:..:.:.             :.:..:|:|    |:..|.|.|   .|:.|::.|.|| .:.
Mouse   157 NLTNLQTLRIG-------------NVETFSEIR----RIDFAGLTS---LNELEIKALSLRNYQS 201

  Fly   331 QSLPG--DLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLS----LDLSNNRLTHLPDS----- 384
            |||..  |: .|.|    :.|.::      |.|||...::||    |:|.:..|.....|
Mouse   202 QSLKSIRDI-HHLT----LHLSES------AFLLEIFADILSSVRYLELRDTNLARFQFSPLPVD 255

  Fly   385 --------------------------LFAHTTNLTDLRLEDNLLTGI------SGDIFSNLGNLV 417
                                      |..:...|:::..:|..|.|:      ..|:.|.||.:.
Mouse   256 EVSSPMKKLAFRGSVLTDESFNELLKLLRYILELSEVEFDDCTLNGLGDFNPSESDVVSELGKVE 320

  Fly   418 TLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRN 482
            |:.                   :|.||:.           ...|...:::.:..:..:..:.:.|
Mouse   321 TVT-------------------IRRLHIP-----------QFYLFYDLSTVYSLLEKVKRITVEN 355

  Fly   483 NSIIFVYNDWKNTMLQLRELDLSYN--------NISSLG-YEDL--AFLSQNRLHVNMTHNKIRR 536
            :.:..|...:...:..|..||||.|        |.:..| :..|  ..||||.|.   :..|...
Mouse   356 SKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLR---SMQKTGE 417

  Fly   537 IALPEDVHLGEGYNNNLVHVDLNDN---PLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCS 598
            |.|.         ..||..:|::.|   |:...|.  |          |:..|...
Mouse   418 ILLT---------LKNLTSLDISRNTFHPMPDSCQ--W----------PEKMRFLN--------- 452

  Fly   599 QPNVLEGTPVRQIE---PQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPR 660
                |..|.:|.::   ||||.. ||.|::                       |..|.:| .:||
Mouse   453 ----LSSTGIRVVKTCIPQTLEV-LDVSNN-----------------------NLDSFSL-FLPR 488

  Fly   661 LPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNH 725
                     |.||::..|.|..||.|:.  :..:..:.:..|.:::...|||.        |:..
Mouse   489 ---------LQELYISRNKLKTLPDASL--FPVLLVMKIRENAVSTFSKDQLG--------SFPK 534

  Fly   726 LQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDN---FERIGD-RNEMMCVNAEM 786
            |:.|.|                 ..|.::|.|   .||.||.:.   .:.:.| .:..:|   :.
Mouse   535 LETLEA-----------------GDNHFVCSC---ELLSFTMETPALAQILVDWPDSYLC---DS 576

  Fly   787 PTRMVELSTNDICPA---------EKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKI---WLY 839
            |.|:......|..|:         ..||..||.::|.|.|.|......|:|     :::   ||.
Mouse   577 PPRLHGHRLQDARPSVLECHQAALVSGVCCALLLLILLVGALCHHFHGLWY-----LRMMWAWLQ 636

  Fly   840 AHNLLLWFVTEEDLDKDKK-------FDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDW 897
            |..            |.||       :|||:|||.:|..::|:.:|.|||:....|:||:|:||:
Mouse   637 AKR------------KPKKAPCRDVCYDAFVSYSEQDSHWVENLMVQQLENSDPPFKLCLHKRDF 689

  Fly   898 LVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVE 962
            :.|..|.:||:.|:..|.:|:.|||:||::|||.:.|...:|....:|.....|:::...| :.:
Mouse   690 VPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDFSHFRLFDENNDAAILVLLEPI-ERK 753

  Fly   963 KLDE---ELKAYLKMNTYLKW-----GDPWFWDKLRFAL 993
            .:.:   :|:..:...|||:|     ....||..||.|:
Mouse   754 AIPQRFCKLRKIMNTKTYLEWPLDEGQQEVFWVNLRTAI 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	20/80 (25%)
		leucine-rich repeat	176..198	CDD:275380	8/43 (19%)
		leucine-rich repeat	199..222	CDD:275380	6/22 (27%)
		LRR_RI	216..542	CDD:238064	77/380 (20%)
		LRR_8	221..281	CDD:290566	14/59 (24%)
		leucine-rich repeat	223..270	CDD:275380	12/46 (26%)
		leucine-rich repeat	271..294	CDD:275380	0/22 (0%)
		leucine-rich repeat	295..320	CDD:275380	7/24 (29%)
		leucine-rich repeat	321..343	CDD:275380	8/24 (33%)
		LRR_8	342..402	CDD:290566	15/94 (16%)
		leucine-rich repeat	344..367	CDD:275380	5/22 (23%)
		leucine-rich repeat	368..391	CDD:275380	7/57 (12%)
		LRR_8	390..450	CDD:290566	12/65 (18%)
		leucine-rich repeat	392..415	CDD:275380	7/28 (25%)
		leucine-rich repeat	416..439	CDD:275380	1/22 (5%)
		leucine-rich repeat	440..474	CDD:275380	4/33 (12%)
		leucine-rich repeat	475..498	CDD:275380	2/22 (9%)
		LRR_8	477..534	CDD:290566	16/67 (24%)
		leucine-rich repeat	499..520	CDD:275380	9/31 (29%)
		leucine-rich repeat	523..552	CDD:275380	5/28 (18%)
		LRRCT	561..619	CDD:214507	13/63 (21%)
		LRRNT	631..667	CDD:214470	5/35 (14%)
		leucine-rich repeat	664..693	CDD:275380	8/28 (29%)
		LRR_8	669..726	CDD:290566	13/56 (23%)
		leucine-rich repeat	694..715	CDD:275380	4/20 (20%)
		leucine-rich repeat	716..737	CDD:275380	4/20 (20%)
		LRRCT	751..800	CDD:214507	12/52 (23%)
		TIR	858..996	CDD:214587	49/151 (32%)
Tlr2	XP_006501523.1	internalin_A	<58..>259	CDD:380193	58/254 (23%)
		leucine-rich repeat	65..87	CDD:275378	5/21 (24%)
		LRR_8	87..145	CDD:338972	14/57 (25%)
		leucine-rich repeat	88..111	CDD:275378	3/22 (14%)
		leucine-rich repeat	112..135	CDD:275378	6/22 (27%)
		leucine-rich repeat	136..160	CDD:275378	12/46 (26%)
		leucine-rich repeat	186..212	CDD:275380	9/26 (35%)
		leucine-rich repeat	213..233	CDD:275380	7/29 (24%)
		PRK15370	<350..>568	CDD:185268	66/318 (21%)
		leucine-rich repeat	372..398	CDD:275380	8/25 (32%)
		leucine-rich repeat	399..424	CDD:275380	9/36 (25%)
		leucine-rich repeat	448..468	CDD:275380	5/32 (16%)
		leucine-rich repeat	469..488	CDD:275380	7/43 (16%)
		leucine-rich repeat	489..510	CDD:275380	8/22 (36%)
		leucine-rich repeat	511..534	CDD:275380	5/30 (17%)
		TPKR_C2	543..596	CDD:387596	13/58 (22%)
		TIR	650..794	CDD:214587	48/144 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920