DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tl and Tlr4

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_067272.1	Gene:	Tlr4 / 21898	MGIID:	96824	Length:	835	Species:	Mus musculus

Alignment Length:	812	Identity:	190/812 - (23%)
Similarity:	326/812 - (40%)	Gaps:	232/812 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 NNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNG 439
            :.:|:.:||.:.:.|.|:.   |..|.|..:....|||...|..|.:||..:.||:.:|:...:.
Mouse    41 DQKLSKVPDDIPSSTKNID---LSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHH 102

  Fly   440 LRHLHLDHNDIDLQQP-------LLD--IMLQTQINS----PFGYMHGLLTLNLRNNSIIFVYN- 490
            |.:|.|..|.|....|       .|:  :.::|::.|    |.|.:..|..||:.:|   |:::
Mouse   103 LSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHN---FIHSC 164

  Fly   491 ---DWKNTMLQLRELDLSYNNISSLGYEDLAFLSQN---RLHVNMTHNKIRRIALPEDVHLGEGY 549
               .:.:.:..|..:|||||.|.::...||.||.:|   .|.::|:.|       |.|....:.:
Mouse   165 KLPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRENPQVNLSLDMSLN-------PIDFIQDQAF 222

  Fly   550 NNNLVHV-----DLNDNPLVCDCTILWFIQLVRGVHKPQ-YSRQFKLRTDRLVCSQPNVLEGTPV 608
            ....:|.     :.|.:.::..|     :|.:.|:|..: ...:||...: |...:|:::||...
Mouse   223 QGIKLHELTLRGNFNSSNIMKTC-----LQNLAGLHVHRLILGEFKDERN-LEIFEPSIMEGLCD 281

  Fly   609 RQIEPQTLICPLDFSDDPRERKC--------------------PRG--------CNCHVRTYD-- 643
            ..|:...|....|||||..:..|                    |:.        ..|.::.:.
Mouse   282 VTIDEFRLTYTNDFSDDIVKFHCLANVSAMSLAGVSIKYLEDVPKHFKWQSLSIIRCQLKQFPTL 346

  Fly   644 -----KALVINCHSGNLTH----VPRLPNL------------------------HKNM------- 668
                 |:|.:..:.|:::.    :|.|..|                        |.::
Mouse   347 DLPFLKSLTLTMNKGSISFKKVALPSLSYLDLSRNALSFSGCCSYSDLGTNSLRHLDLSFNGAII 411

  Fly   669 ---------QLMELHLENNTLLRLPS-----------------ANTP--------GYESVTSLHL 699
                     :|..|..:::||.|:..                 .||.        |..|:.:|.:
Mouse   412 MSANFMGLEELQHLDFQHSTLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKM 476

  Fly   700 AGNNL---TSIDVDQLPTNLTHLD--------ISW------NHLQMLN----------------- 730
            |||:.   |..:|....||||.||        |||      :.||:||
Mouse   477 AGNSFKDNTLSNVFANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQL 541

  Fly   731 ---ATVLGFLNRTMKWRSV-----------KLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMC 781
               :|:....||....:.:           .|:.|...|.|..:..|.:.::..:.:.:..:|.|
Mouse   542 YSLSTLDCSFNRIETSKGILQHFPKSLAFFNLTNNSVACICEHQKFLQWVKEQKQFLVNVEQMTC 606

  Fly   782 VN-AEMPTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLL 845
            .. .||.|.:|....|..|...|.: |:::||   :.::....|.|.|.|        |.|.:|:
Mouse   607 ATPVEMNTSLVLDFNNSTCYMYKTI-ISVSVV---SVIVVSTVAFLIYHF--------YFHLILI 659

  Fly   846 ----WFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPEN 906
                .:...|.:     :|||:.||.:::.::.:.||..||.|..:|.||:|.||::.|..|..|
Mouse   660 AGCKKYSRGESI-----YDAFVIYSSQNEDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAAN 719

  Fly   907 IMR-SVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEK--LDEEL 968
            |:: ....||:.|:|:|::||:|.|...|:..|........||.||.|:   :..|||  |.:::
Mouse   720 IIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIV---LEKVEKSLLRQQV 781

  Fly   969 KAY--LKMNTYLKWGD-PW----FWDKLRFAL 993
            :.|  |..||||:|.| |.    ||.:|:.||
Mouse   782 ELYRLLSRNTYLEWEDNPLGRHIFWRRLKNAL 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566
		leucine-rich repeat	176..198	CDD:275380
		leucine-rich repeat	199..222	CDD:275380
		LRR_RI	216..542	CDD:238064	50/186 (27%)
		LRR_8	221..281	CDD:290566
		leucine-rich repeat	223..270	CDD:275380
		leucine-rich repeat	271..294	CDD:275380
		leucine-rich repeat	295..320	CDD:275380
		leucine-rich repeat	321..343	CDD:275380
		LRR_8	342..402	CDD:290566	7/26 (27%)
		leucine-rich repeat	344..367	CDD:275380
		leucine-rich repeat	368..391	CDD:275380	4/15 (27%)
		LRR_8	390..450	CDD:290566	18/59 (31%)
		leucine-rich repeat	392..415	CDD:275380	6/22 (27%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..474	CDD:275380	11/46 (24%)
		leucine-rich repeat	475..498	CDD:275380	5/26 (19%)
		LRR_8	477..534	CDD:290566	19/63 (30%)
		leucine-rich repeat	499..520	CDD:275380	9/20 (45%)
		leucine-rich repeat	523..552	CDD:275380	6/31 (19%)
		LRRCT	561..619	CDD:214507	12/58 (21%)
		LRRNT	631..667	CDD:214470	10/98 (10%)
		leucine-rich repeat	664..693	CDD:275380	10/93 (11%)
		LRR_8	669..726	CDD:290566	24/98 (24%)
		leucine-rich repeat	694..715	CDD:275380	6/23 (26%)
		leucine-rich repeat	716..737	CDD:275380	12/54 (22%)
		LRRCT	751..800	CDD:214507	11/49 (22%)
		TIR	858..996	CDD:214587	54/146 (37%)
Tlr4	NP_067272.1	LRR_8	53..113	CDD:290566	19/62 (31%)
		LRR 1	54..75		6/23 (26%)
		leucine-rich repeat	58..78	CDD:275380	6/22 (27%)
		LRR 2	78..99		7/20 (35%)
		leucine-rich repeat	79..102	CDD:275380	7/22 (32%)
		LRR 3	102..123		6/20 (30%)
		leucine-rich repeat	103..126	CDD:275380	6/22 (27%)
		LRR 4	126..147		4/20 (20%)
		leucine-rich repeat	127..150	CDD:275380	5/22 (23%)
		LRR_8	150..214	CDD:290566	20/73 (27%)
		LRR 5	150..171		5/23 (22%)
		leucine-rich repeat	151..175	CDD:275380	5/26 (19%)
		LRR 6	175..198		10/22 (45%)
		leucine-rich repeat	176..204	CDD:275380	12/27 (44%)
		LRR 7	204..224		5/26 (19%)
		leucine-rich repeat	205..226	CDD:275380	5/27 (19%)
		LRR 8	226..247		3/25 (12%)
		LRR 9	248..269		4/21 (19%)
		LRR 10	329..349		1/19 (5%)
		leucine-rich repeat	331..350	CDD:275380	1/18 (6%)
		LRR 11	350..370		3/19 (16%)
		leucine-rich repeat	351..372	CDD:275380	3/20 (15%)
		LRR_RI	<369..555	CDD:238064	35/185 (19%)
		LRR 12	372..392		2/19 (11%)
		leucine-rich repeat	373..398	CDD:275380	2/24 (8%)
		LRR 13	398..420		1/21 (5%)
		leucine-rich repeat	399..421	CDD:275380	1/21 (5%)
		LRR 14	421..442		5/20 (25%)
		leucine-rich repeat	422..446	CDD:275380	5/23 (22%)
		LRR 15	446..467		2/20 (10%)
		leucine-rich repeat	447..470	CDD:275380	3/22 (14%)
		LRR 16	470..490		6/19 (32%)
		leucine-rich repeat	471..495	CDD:275380	6/23 (26%)
		LRR_8	494..554	CDD:290566	15/59 (25%)
		LRR 17	495..516		8/20 (40%)
		leucine-rich repeat	496..519	CDD:275380	7/22 (32%)
		LRR 18	519..540		4/20 (20%)
		leucine-rich repeat	520..543	CDD:275380	4/22 (18%)
		LRR 19	543..564		3/20 (15%)
		Interaction with SCIMP. /evidence=ECO:0000269\|PubMed:28098138	670..835		54/152 (36%)
		TIR	672..813	CDD:214587	52/143 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920