DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and Tlr8

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_573475.2	Gene:	Tlr8 / 170744	MGIID:	2176887	Length:	1032	Species:	Mus musculus

Alignment Length:	1029	Identity:	232/1029 - (22%)
Similarity:	392/1029 - (38%)	Gaps:	294/1029 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 ESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHLELRANIEEMPSHLFDDLE 197
            |:.| |||||...|..|..|........:|..|||.|...::.||.::  .||.::..:....|.
Mouse   105 ENKN-GMNITEGALLSLRNLTVLLLEDNQLYTIPAGLPESLKELSLIQ--NNIFQVTKNNTFGLR 166

  Fly   198 NLESIEFG------SNKLRQMPRGIFGKMPKLKQLNLWSNQLH---------------------N 235
            |||.:..|      .|:..::..|.|..:..||.|:|..|.|.                     |
Mouse   167 NLERLYLGWNCYFKCNQTFKVEDGAFKNLIHLKVLSLSFNNLFYVPPKLPSSLRKLFLSNAKIMN 231

  Fly   236 LTKHDFEGATSVLGIDIHDN--------------------GIEQLPHDVFAHLTNVTDINLSANL 280
            :|:.||:|..::..:|:..|                    .|..|   .|..||.:..:|||:..
Mouse   232 ITQEDFKGLENLTLLDLSGNCPRCYNAPFPCTPCKENSSIHIHPL---AFQSLTQLLYLNLSSTS 293

  Fly   281 FRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILRLRAELQSLPGDLFEHSTQIT 345
            .|::|...|::..:|.|:.|..|.:.............|.||||.|....|      ::...|..
Mouse   294 LRTIPSTWFENLSNLKELHLEFNYLVQEIASGAFLTKLPSLQILDLSFNFQ------YKEYLQFI 352

  Fly   346 NISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIF 410
            |||...:.|::|...   |....:..:|......|| .||    .||..:.|..|.:..|....|
Mouse   353 NISSNFSKLRSLKKL---HLRGYVFRELKKKHFEHL-QSL----PNLATINLGINFIEKIDFKAF 409

  Fly   411 SNLGNLVTLVMSRNRLRTI-DSRAFVS-TNGLR------------HLHLDHNDIDLQQP------ 455
            .|...|..:.:|.||:.:: |...:.| .|.||            |::..|:...|.:|
Mouse   410 QNFSKLDVIYLSGNRIASVLDGTDYSSWRNRLRKPLSTDDDEFDPHVNFYHSTKPLIKPQCTAYG 474

  Fly   456 -LLDIML--------------------------QTQI--NSPFGYMHGLLTLNLRNNSIIFVYND 491
             .||:.|                          .||:  .:.|..|..:..|:|.||.:.|..|:
Mouse   475 KALDLSLNNIFIIGKSQFEGFQDIACLNLSFNANTQVFNGTEFSSMPHIKYLDLTNNRLDFDDNN 539

  Fly   492 WKNTMLQLRELDLSYN----NISSLGYEDLAFLSQNRLH---VNMTHN---------KIRRIALP 540
            ..:.:..|..||||:|    :|:.:.:. |.|: ||.::   :|::||         :::.|:|.
Mouse   540 AFSDLHDLEVLDLSHNAHYFSIAGVTHR-LGFI-QNLINLRVLNLSHNGIYTLTEESELKSISLK 602

  Fly   541 EDVHLGEGYN-----------------NNLVHVDLNDNPLVCDCTILWFIQLVRG--VHKPQYSR 586
            |.|..|...:                 .||:.:||:.|.|.         |:..|  ::.||..:
Mouse   603 ELVFSGNRLDRLWNANDGKYWSIFKSLQNLIRLDLSYNNLQ---------QIPNGAFLNLPQSLQ 658

  Fly   587 QFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCH 651
            :.             ::.|..:|..
Mouse   659 EL-------------LISGNKLRFF---------------------------------------- 670

  Fly   652 SGNLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPT-- 714
              |.|.:...|:||.      |.|..|.|..||:..:....|:.:|.|:.|:.:     .||:
Mouse   671 --NWTLLQYFPHLHL------LDLSRNELYFLPNCLSKFAHSLETLLLSHNHFS-----HLPSGF 722

  Fly   715 -----NLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIG 774
                 ||.|||:|:|.::|:|.:.|....:| ....::|.||.:.|.|.......:..:|
Mouse   723 LSEARNLVHLDLSFNTIKMINKSSLQTKMKT-NLSILELHGNYFDCTCDISDFRSWLDEN----- 781

  Fly   775 DRNEMMCVNAEMPTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAAL--YYKFQTEIKIW 837
                   :|..:|..:..:.:|......|.:     :.:.||..::..|||:  :..|.|...:.
Mouse   782 -------LNITIPKLVNVICSNPGDQKSKSI-----MSLDLTTCVSDTTAAVLFFLTFLTTSMVM 834

  Fly   838 LYA--HNLL---LWFVTEEDLDKDKK----------FDAFISYSHKDQSFIEDYLVPQLEHGPQK 887
            |.|  |:|.   :||:......|.|.          :||:|||..||.| :.|:::.:|.:..::
Mouse   835 LAALVHHLFYWDVWFIYHMCSAKLKGYRTSSTSQTFYDAYISYDTKDAS-VTDWVINELRYHLEE 898

  Fly   888 FQ-----LCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGR 947
            .:     ||:.||||..|..|.:|:|:|:..|::||.||::.:.||...:..|..|.:..::|..
Mouse   899 SEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTAFYLALQRLMDENM 963

  Fly   948 SRIIVIIYSDIGDVEKLDEELKAYLKM------NTYLKW-----GDPWFWDKLR 990
            ..||.|:...:       .:...||::      ::.|:|     .:..||..|:
Mouse   964 DVIIFILLEPV-------LQYSQYLRLRQRICKSSILQWPNNPKAENLFWQSLK 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	17/64 (27%)
		leucine-rich repeat	176..198	CDD:275380	5/21 (24%)
		leucine-rich repeat	199..222	CDD:275380	6/28 (21%)
		LRR_RI	216..542	CDD:238064	97/431 (23%)
		LRR_8	221..281	CDD:290566	21/100 (21%)
		leucine-rich repeat	223..270	CDD:275380	17/87 (20%)
		leucine-rich repeat	271..294	CDD:275380	6/22 (27%)
		leucine-rich repeat	295..320	CDD:275380	4/24 (17%)
		leucine-rich repeat	321..343	CDD:275380	6/21 (29%)
		LRR_8	342..402	CDD:290566	16/59 (27%)
		leucine-rich repeat	344..367	CDD:275380	6/22 (27%)
		leucine-rich repeat	368..391	CDD:275380	5/22 (23%)
		LRR_8	390..450	CDD:290566	18/73 (25%)
		leucine-rich repeat	392..415	CDD:275380	6/22 (27%)
		leucine-rich repeat	416..439	CDD:275380	6/24 (25%)
		leucine-rich repeat	440..474	CDD:275380	13/80 (16%)
		leucine-rich repeat	475..498	CDD:275380	6/22 (27%)
		LRR_8	477..534	CDD:290566	20/72 (28%)
		leucine-rich repeat	499..520	CDD:275380	8/24 (33%)
		leucine-rich repeat	523..552	CDD:275380	9/57 (16%)
		LRRCT	561..619	CDD:214507	8/59 (14%)
		LRRNT	631..667	CDD:214470	5/35 (14%)
		leucine-rich repeat	664..693	CDD:275380	8/28 (29%)
		LRR_8	669..726	CDD:290566	19/63 (30%)
		leucine-rich repeat	694..715	CDD:275380	5/27 (19%)
		leucine-rich repeat	716..737	CDD:275380	9/20 (45%)
		LRRCT	751..800	CDD:214507	7/48 (15%)
		TIR	858..996	CDD:214587	41/159 (26%)
Tlr8	NP_573475.2	LRR_RI	32..252	CDD:238064	39/149 (26%)
		LRR 1	41..61
		LRR 2	62..85
		LRR_8	65..133	CDD:290566	10/28 (36%)
		leucine-rich repeat	65..88	CDD:275380
		LRR 3	87..109		2/4 (50%)
		leucine-rich repeat	89..122	CDD:275380	9/17 (53%)
		LRR 4	120..143		7/22 (32%)
		leucine-rich repeat	123..143	CDD:275380	6/19 (32%)
		leucine-rich repeat	144..167	CDD:275380	5/24 (21%)
		LRR 5	145..165		4/21 (19%)
		LRR_8	166..251	CDD:290566	19/84 (23%)
		LRR 6	166..194		7/27 (26%)
		leucine-rich repeat	168..197	CDD:275380	6/28 (21%)
		LRR 7	195..218		6/22 (27%)
		leucine-rich repeat	198..218	CDD:275380	6/19 (32%)
		leucine-rich repeat	219..242	CDD:275380	5/22 (23%)
		LRR 8	220..239		4/18 (22%)
		LRR 9	240..267		2/26 (8%)
		leucine-rich repeat	243..283	CDD:275380	6/42 (14%)
		LRR_RI	<277..>428	CDD:238064	43/164 (26%)
		LRR 10	281..304		8/22 (36%)
		LRR_8	282..342	CDD:290566	17/59 (29%)
		leucine-rich repeat	284..307	CDD:275380	6/22 (27%)
		LRR 11	306..329		4/22 (18%)
		leucine-rich repeat	308..327	CDD:275380	4/18 (22%)
		LRR 12	331..360		11/34 (32%)
		leucine-rich repeat	334..363	CDD:275380	11/34 (32%)
		LRR 13	361..384		4/25 (16%)
		LRR_8	362..425	CDD:290566	17/70 (24%)
		leucine-rich repeat	364..390	CDD:275380	7/33 (21%)
		LRR 14	388..411		7/26 (27%)
		leucine-rich repeat	391..414	CDD:275380	6/22 (27%)
		LRR 15	413..436		5/22 (23%)
		leucine-rich repeat	465..497	CDD:275380	5/31 (16%)
		LRR 16	471..494		3/22 (14%)
		LRR_8	475..533	CDD:290566	11/57 (19%)
		leucine-rich repeat	501..522	CDD:275380	4/20 (20%)
		LRR 17	520..543		7/22 (32%)
		LRR_8	521..587	CDD:290566	20/67 (30%)
		leucine-rich repeat	523..546	CDD:275380	6/22 (27%)
		LRR 18	545..572		9/28 (32%)
		LRR_RI	546..765	CDD:238064	62/296 (21%)
		leucine-rich repeat	547..576	CDD:275380	11/30 (37%)
		LRR 19	574..598		3/23 (13%)
		leucine-rich repeat	577..600	CDD:275380	3/22 (14%)
		LRR_8	600..667	CDD:290566	15/88 (17%)
		LRR 20	600..621		4/20 (20%)
		leucine-rich repeat	601..631	CDD:275380	4/29 (14%)
		LRR 21	629..652		8/31 (26%)
		leucine-rich repeat	632..656	CDD:275380	8/32 (25%)
		LRR 22	654..677		6/77 (8%)
		leucine-rich repeat	657..680	CDD:275380	4/77 (5%)
		LRR 23	678..701		9/28 (32%)
		LRR_8	679..737	CDD:290566	21/68 (31%)
		leucine-rich repeat	681..704	CDD:275380	8/28 (29%)
		LRR 24	702..725		6/27 (22%)
		leucine-rich repeat	705..728	CDD:275380	5/27 (19%)
		LRR 25	727..749		10/21 (48%)
		leucine-rich repeat	729..748	CDD:275380	8/18 (44%)
		LRR 26	752..776		6/24 (25%)
		TIR	871..1007	CDD:214587	39/143 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820