DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and Tlr7

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_001277687.1	Gene:	Tlr7 / 170743	MGIID:	2176882	Length:	1053	Species:	Mus musculus

Alignment Length:	1101	Identity:	243/1101 - (22%)
Similarity:	424/1101 - (38%)	Gaps:	306/1101 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 IDGLCQCAPIMSEYEIICPANAENPTFRLTIQPKDYVQIMCNLTDTTDYQQLPKKLRIGEVDRVQ 103
            ||..|.|.|      ::..:.|...|.||.|:|..:    ..|:|          |:...:|..|
Mouse    97 IDLRCNCVP------VLLGSKANVCTKRLQIRPGSF----SGLSD----------LKALYLDGNQ 141

  Fly   104 MRRCMLPGHTPIASILDYLGIVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPAN 168
            :..  :|...|  |.|..|.:        |::|: .:||:::|..|..::............|.|
Mouse   142 LLE--IPQDLP--SSLHLLSL--------EANNI-FSITKENLTELVNIETLYLGQNCYYRNPCN 193

  Fly   169 L--------LTDMRNLSHLELR-ANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLK 224
            :        ...||||..|.|: .|:..:|:.|   ..||..:...:|.::::....|..:.:|:
Mouse   194 VSYSIEKDAFLVMRNLKVLSLKDNNVTAVPTTL---PPNLLELYLYNNIIKKIQENDFNNLNELQ 255

  Fly   225 QLNLWSN--QLHN-------------LTKHD--FEGATSVLGIDIHDNGIEQLPHDVFAHLTNVT 272
            .|:|..|  :.:|             |..||  |...|.:..:.:|.|.::.:|...|.::.|:.
Mouse   256 VLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQ 320

  Fly   273 DINLSAN-LFRSLPQGLFDHNKHLNEVRLMNNRVPL--------------ATLPSRLFANQPELQ 322
            :::||.| |.|.:.:..|.|        .:.|.|.|              .|||..| ::...|:
Mouse   321 ELDLSQNYLAREIEEAKFLH--------FLPNLVELDFSFNYELQVYHASITLPHSL-SSLENLK 376

  Fly   323 ILRLRA----ELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPD 383
            |||::.    ||::....:.....::..:.||.|.:|.....:.:|..||..:|||.|:::...:
Mouse   377 ILRVKGYVFKELKNSSLSVLHKLPRLEVLDLGTNFIKIADLNIFKHFENLKLIDLSVNKISPSEE 441

  Fly   384 SLFAHTTNLTDLRLEDNLLTGI---SGDIFSNLGNLVTLVMSRN-RLRTIDSRAFVSTNGLRHLH 444
            |        .::....|..|.:   ...:...|........:|: |.:..:..:|:..|...|::
Mouse   442 S--------REVGFCPNAQTSVDRHGPQVLEALHYFRYDEYARSCRFKNKEPPSFLPLNADCHIY 498

  Fly   445 -----LDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYND---WKNTMLQLRE 501
                 |..|:|...:|           |.|.::..|..|||..|:|....|.   |  .:.:||.
Mouse   499 GQTLDLSRNNIFFIKP-----------SDFQHLSFLKCLNLSGNTIGQTLNGSELW--PLRELRY 550

  Fly   502 LDLSYNNIS---SLGYEDLAFLSQNRLHVN--------MTH--NKIRRIALPEDVHLGEGYNNNL 553
            ||.|.|.:.   |..:|:|..|....|..|        :||  |..:::.|             |
Mouse   551 LDFSNNRLDLLYSTAFEELQSLEVLDLSSNSHYFQAEGITHMLNFTKKLRL-------------L 602

  Fly   554 VHVDLNDNPLVCDCT---------ILWFIQLVRGVH--------KPQYSRQFK---------LRT 592
            ..:.:|||.:....:         ||.|    ||.|        ..:|...||         :..
Mouse   603 DKLMMNDNDISTSASRTMESDSLRILEF----RGNHLDVLWRAGDNRYLDFFKNLFNLEVLDISR 663

  Fly   593 DRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTH 657
            :.|....|.|.||.|
Mouse   664 NSLNSLPPEVFEGMP-------------------------------------------------- 678

  Fly   658 VPRLPNLH--KN---------MQLME----LHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSI 707
             |.|.||.  ||         :||::    |.|.:|.|.::|.......:|:|:|.|..|.:..:
Mouse   679 -PNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQIRQL 742

  Fly   708 D----VDQLPTNLTHLDISWNHLQMLNAT-----VLGFLNRTMKWRSVKLSGNPWMCDCTAKPLL 763
            .    .|.|  .|.:||||.|.:|::..|     ||..|...:      |..|.::|:|.|...:
Mouse   743 TKYFLEDAL--QLRYLDISSNKIQVIQKTSFPENVLNNLEMLV------LHHNRFLCNCDAVWFV 799

  Fly   764 LFTQDNFERI------------GDRNEMMCVNAEMPTRMVELSTNDICPAEKGVFIALAVVIALT 816
            .:.......|            |.......::.::.|..::|:...:........:.|.||:..:
Mouse   800 WWVNHTDVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSVSISSVLFLMVVMTTS 864

  Fly   817 GLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDKKFDAFISYSHKDQSFIE---DYLV 878
            .|.......:||.::.:||.:.:..::            :..:||||.|..|:.:..|   ..||
Mouse   865 HLFFWDMWYIYYFWKAKIKGYQHLQSM------------ESCYDAFIVYDTKNSAVTEWVLQELV 917

  Fly   879 PQLEHGPQK-FQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSA 942
            .:||...:| |.||:.|||||.|..:.||:.:|:..|::|:.|::|.:.|:|..::.|..:|:..
Mouse   918 AKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFYLSHQRL 982

  Fly   943 LNEGRSRIIVIIYSDIGDVEK-LDE----ELKAYLKMNTYLKW-----GDPWFWDKLRFAL 993
            |:| :..:|::|:     :|| |.:    :|:..|..::.|:|     ..|:||..|:.||
Mouse   983 LDE-KVDVIILIF-----LEKPLQKSKFLQLRKRLCRSSVLEWPANPQAHPYFWQCLKNAL 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	16/61 (26%)
		leucine-rich repeat	176..198	CDD:275380	6/22 (27%)
		leucine-rich repeat	199..222	CDD:275380	3/22 (14%)
		LRR_RI	216..542	CDD:238064	86/386 (22%)
		LRR_8	221..281	CDD:290566	18/77 (23%)
		leucine-rich repeat	223..270	CDD:275380	14/63 (22%)
		leucine-rich repeat	271..294	CDD:275380	7/23 (30%)
		leucine-rich repeat	295..320	CDD:275380	7/38 (18%)
		leucine-rich repeat	321..343	CDD:275380	6/25 (24%)
		LRR_8	342..402	CDD:290566	13/59 (22%)
		leucine-rich repeat	344..367	CDD:275380	5/22 (23%)
		leucine-rich repeat	368..391	CDD:275380	6/22 (27%)
		LRR_8	390..450	CDD:290566	10/68 (15%)
		leucine-rich repeat	392..415	CDD:275380	3/25 (12%)
		leucine-rich repeat	416..439	CDD:275380	3/23 (13%)
		leucine-rich repeat	440..474	CDD:275380	7/38 (18%)
		leucine-rich repeat	475..498	CDD:275380	8/25 (32%)
		LRR_8	477..534	CDD:290566	22/72 (31%)
		leucine-rich repeat	499..520	CDD:275380	9/23 (39%)
		leucine-rich repeat	523..552	CDD:275380	6/38 (16%)
		LRRCT	561..619	CDD:214507	16/83 (19%)
		LRRNT	631..667	CDD:214470	4/37 (11%)
		leucine-rich repeat	664..693	CDD:275380	10/43 (23%)
		LRR_8	669..726	CDD:290566	20/64 (31%)
		leucine-rich repeat	694..715	CDD:275380	6/24 (25%)
		leucine-rich repeat	716..737	CDD:275380	10/25 (40%)
		LRRCT	751..800	CDD:214507	8/60 (13%)
		TIR	858..996	CDD:214587	49/150 (33%)
Tlr7	NP_001277687.1	PRK15370	<35..>246	CDD:185268	41/184 (22%)
		leucine-rich repeat	51..72	CDD:275380
		leucine-rich repeat	73..93	CDD:275380
		leucine-rich repeat	94..131	CDD:275380	12/43 (28%)
		leucine-rich repeat	132..155	CDD:275380	7/26 (27%)
		PLN00113	177..>789	CDD:215061	152/720 (21%)
		leucine-rich repeat	177..208	CDD:275380	3/30 (10%)
		leucine-rich repeat	209..229	CDD:275380	6/22 (27%)
		leucine-rich repeat	230..253	CDD:275380	3/22 (14%)
		leucine-rich repeat	254..294	CDD:275380	9/39 (23%)
		leucine-rich repeat	295..318	CDD:275380	4/22 (18%)
		leucine-rich repeat	319..344	CDD:275380	7/32 (22%)
		leucine-rich repeat	345..401	CDD:275380	12/56 (21%)
		leucine-rich repeat	402..425	CDD:275380	5/22 (23%)
		leucine-rich repeat	500..522	CDD:275380	6/32 (19%)
		leucine-rich repeat	523..547	CDD:275380	8/25 (32%)
		leucine-rich repeat	548..571	CDD:275380	9/22 (41%)
		leucine-rich repeat	572..601	CDD:275380	6/28 (21%)
		leucine-rich repeat	602..624	CDD:275380	4/21 (19%)
		leucine-rich repeat	625..655	CDD:275380	9/33 (27%)
		leucine-rich repeat	656..680	CDD:275380	6/74 (8%)
		leucine-rich repeat	681..704	CDD:275380	7/22 (32%)
		leucine-rich repeat	705..728	CDD:275380	5/22 (23%)
		leucine-rich repeat	753..778	CDD:275380	10/24 (42%)
		PCC	757..>841	CDD:188093	17/89 (19%)
		TIR	894..1039	CDD:214587	49/150 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780