DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tl and Tlr3

DIOPT Version :10

Sequence 1:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster
Sequence 2:NP_569054.2 Gene:Tlr3 / 142980 MGIID:2156367 Length:905 Species:Mus musculus


Alignment Length:995 Identity:236/995 - (23%)
Similarity:397/995 - (39%) Gaps:228/995 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   123 GIVSPTTLIFESDN---LGMNITR-QHLDRLHGLKRFRFTTRRLTHIPANLLTDMR--NLSHLEL 181
            |::|...|:..|.|   :..|:.. .||              :|||||.:|.:::.  ||:|.:|
Mouse    14 GLLSLWILLVSSTNQCTVRYNVADCSHL--------------KLTHIPDDLPSNITVLNLTHNQL 64

  Fly   182 RANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATS 246
            |    .:|...|.....|..::.|.|.:.::...:...:|.||.|||..|:|..::...|...|:
Mouse    65 R----RLPPTNFTRYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTN 125

  Fly   247 VLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLP 311
            :..:|:..|.|.::..:.|.:..|:..::||.|...|...|.....::|.|:.|..|::      
Mouse   126 LTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLENLQELLLAKNKI------ 184

  Fly   312 SRLFANQPELQIL---RLR-AELQSLP------------GDLFE--------------------H 340
              |.....||:.|   .|| .:|.|.|            |.||.                    .
Mouse   185 --LALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEKLCWELS 247

  Fly   341 STQITNISLGDN-LLKTLPATLLEHQ-VNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLT 403
            :|.|.|:||.:| ||.|..:|....: .||..||||.|.|..:.:..|::..:|..|.||.|.:.
Mouse   248 NTSIQNLSLANNQLLATSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQ 312

  Fly   404 GISGDIFSNLGNLVTLVMSRNRLR---------TIDSRAFVSTNGLRHLHLDHNDIDLQQP---- 455
            .:|...|..|.||..|.:.|...:         .||..:|.....|.:|::|.|:|...:.    
Mouse   313 RLSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFT 377

  Fly   456 -LLDI----------MLQTQINSPF-GYMHG-LLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYN 507
             |:.:          .|||..|..| ...|. ||||||..|.|..:.|...:.:.|||.|||..|
Mouse   378 GLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGTFSWLGQLRILDLGLN 442

  Fly   508 NI-SSLGYEDLAFLSQNRLHVNMTHNK-------------------IRRIALPEDVHLGEGYNNN 552
            .| ..|..::...| :|...:.:::||                   :||:||.            
Mouse   443 EIEQKLSGQEWRGL-RNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVALK------------ 494

  Fly   553 LVHVDLNDNPL--VCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQT 615
              :||::.:|.  :.:.|||                  .|..:.:.....::|||....:|    
Mouse   495 --NVDISPSPFRPLRNLTIL------------------DLSNNNIANINEDLLEGLENLEI---- 535

  Fly   616 LICPLDFSDDPR----ERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNM-QLMELHL 675
                |||..:..    :|..|.|....::......::|..|..|..:|  ..:.||: :|..::|
Mouse   536 ----LDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGLDEIP--VGVFKNLFELKSINL 594

  Fly   676 ENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLP---TNLTHLDISWNHLQMLNATVLGFL 737
            ..|.|.:|.........|:.||:|..|.:||::.|...   .||..||:.:|.......::..|:
Mouse   595 GLNNLNKLEPFIFDDQTSLRSLNLQKNLITSVEKDVFGPPFQNLNSLDMRFNPFDCTCESISWFV 659

  Fly   738 NRTMKW-----RSVKLSGNPWMCDCT----AKPLLLFTQDNFERIGDRNEMMCVNAEMPTRMVEL 793
            |    |     .::......::|:..    ..||.||...:           |.::.....:..:
Mouse   660 N----WINQTHTNISELSTHYLCNTPHHYYGFPLKLFDTSS-----------CKDSAPFELLFII 709

  Fly   794 STNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDKK 858
            ||:.:.     |||.:.::|.:.|....|             .|..:.:.:|.|...:...:..:
Mouse   710 STSMLL-----VFILVVLLIHIEGWRISF-------------YWNVSVHRILGFKEIDTQAEQFE 756

  Fly   859 FDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQ 923
            :.|:|.::|||:.::.::..| :|...|..:.|:.|||:..|....|.|:.|:..||:.|.|::.
Mouse   757 YTAYIIHAHKDRDWVWEHFSP-MEEQDQSLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITH 820

  Fly   924 NFIKSEWARLEFRAAH--RSALNEGRSRIIVIIYSDIGDVEKLDEEL---KAYLKMNTYLKWGDP 983
            :.:|....| .|:..|  :.|:.:....||:|...:|.|. ||:..|   :...|.:..|.|  |
Mouse   821 HLLKDPLCR-RFKVHHAVQQAIEQNLDSIILIFLQNIPDY-KLNHALCLRRGMFKSHCILNW--P 881

  Fly   984 -------WFWDKLRFALPHR 996
                   .|..||:.||..|
Mouse   882 VQKERINAFHHKLQVALGSR 901

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TlNP_001262995.1 LRR_8 174..233 CDD:404697 17/60 (28%)
leucine-rich repeat 176..198 CDD:275380 6/21 (29%)
leucine-rich repeat 199..222 CDD:275380 3/22 (14%)
LRR 222..576 CDD:443914 113/439 (26%)
leucine-rich repeat 223..270 CDD:275380 13/46 (28%)
leucine-rich repeat 271..294 CDD:275380 5/22 (23%)
leucine-rich repeat 295..320 CDD:275380 5/24 (21%)
leucine-rich repeat 321..343 CDD:275380 10/57 (18%)
leucine-rich repeat 344..367 CDD:275380 9/24 (38%)
leucine-rich repeat 368..391 CDD:275380 8/22 (36%)
leucine-rich repeat 392..415 CDD:275380 8/22 (36%)
leucine-rich repeat 416..439 CDD:275380 6/31 (19%)
leucine-rich repeat 440..474 CDD:275380 11/49 (22%)
leucine-rich repeat 475..498 CDD:275380 9/22 (41%)
leucine-rich repeat 499..520 CDD:275380 8/21 (38%)
leucine-rich repeat 523..552 CDD:275380 7/47 (15%)
LRRCT 561..619 CDD:214507 9/59 (15%)
LRRNT 631..667 CDD:214470 6/35 (17%)
PPP1R42 <660..752 CDD:455733 23/100 (23%)
leucine-rich repeat 664..693 CDD:275380 7/29 (24%)
leucine-rich repeat 694..715 CDD:275380 7/23 (30%)
leucine-rich repeat 716..737 CDD:275380 4/20 (20%)
LRRCT 751..800 CDD:214507 8/52 (15%)
TIR 858..996 CDD:214587 42/149 (28%)
Tlr3NP_569054.2 LRR 3 101..122 8/20 (40%)
leucine-rich repeat 102..125 CDD:275380 8/22 (36%)
LRR 4 125..146 4/20 (20%)
leucine-rich repeat 126..149 CDD:275380 4/22 (18%)
LRR 5 149..170 6/20 (30%)
leucine-rich repeat 150..199 CDD:275380 13/56 (23%)
LRR 6 173..196 7/30 (23%)
LRR 7 199..220 5/20 (25%)
leucine-rich repeat 200..250 CDD:275380 8/49 (16%)
LRR 8 250..271 9/20 (45%)
leucine-rich repeat 251..276 CDD:275380 9/24 (38%)
LRR 9 276..297 9/20 (45%)
leucine-rich repeat 277..300 CDD:275380 8/22 (36%)
LRR 10 300..321 7/20 (35%)
leucine-rich repeat 301..324 CDD:275380 8/22 (36%)
LRR 11 324..345 4/20 (20%)
leucine-rich repeat 325..381 CDD:275380 12/55 (22%)
LRR 12 357..378 5/20 (25%)
LRR 13 381..401 4/19 (21%)
leucine-rich repeat 382..433 CDD:275380 15/50 (30%)
LRR 14 409..430 9/20 (45%)
LRR 15 433..454 9/20 (45%)
leucine-rich repeat 434..458 CDD:275380 9/24 (38%)
LRR 16 458..479 3/20 (15%)
leucine-rich repeat 459..482 CDD:275380 2/22 (9%)
LRR 17 482..502 6/33 (18%)
leucine-rich repeat 483..508 CDD:275380 7/38 (18%)
PPP1R42 503..>649 CDD:455733 38/173 (22%)
LRR 18 508..529 5/38 (13%)
leucine-rich repeat 509..532 CDD:275380 7/40 (18%)
LRR 19 532..553 5/28 (18%)
leucine-rich repeat 533..564 CDD:275380 7/38 (18%)
LRR 20 564..585 4/22 (18%)
leucine-rich repeat 565..586 CDD:275380 5/22 (23%)
LRR 21 588..609 5/20 (25%)
leucine-rich repeat 589..610 CDD:275378 5/20 (25%)
LRR 22 612..633 8/20 (40%)
leucine-rich repeat 613..637 CDD:275380 7/23 (30%)
LRRCT 646..698 CDD:214507 9/66 (14%)
Tlr3_TMD 699..731 CDD:465595 7/36 (19%)
TIR 756..901 CDD:214587 42/149 (28%)
leucine-rich repeat 37..53 CDD:275380 8/29 (28%)
LRR 1 53..74 7/24 (29%)
leucine-rich repeat 54..77 CDD:275380 7/26 (27%)
PLN00113 70..>543 CDD:215061 126/521 (24%)
LRR 2 77..98 3/20 (15%)
leucine-rich repeat 78..101 CDD:275380 3/22 (14%)

Return to query results.
Submit another query.