DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and Tlr3

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_001344245.1	Gene:	Tlr3 / 142980	MGIID:	2156367	Length:	905	Species:	Mus musculus

Alignment Length:	995	Identity:	236/995 - (23%)
Similarity:	397/995 - (39%)	Gaps:	228/995 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 GIVSPTTLIFESDN---LGMNITR-QHLDRLHGLKRFRFTTRRLTHIPANLLTDMR--NLSHLEL 181
            |::|...|:..|.|   :..|:.. .||              :|||||.:|.:::.  ||:|.:|
Mouse    14 GLLSLWILLVSSTNQCTVRYNVADCSHL--------------KLTHIPDDLPSNITVLNLTHNQL 64

  Fly   182 RANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATS 246
            |    .:|...|.....|..::.|.|.:.::...:...:|.||.|||..|:|..::...|...|:
Mouse    65 R----RLPPTNFTRYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTN 125

  Fly   247 VLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLP 311
            :..:|:..|.|.::..:.|.:..|:..::||.|...|...|.....::|.|:.|..|::
Mouse   126 LTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLENLQELLLAKNKI------ 184

  Fly   312 SRLFANQPELQIL---RLR-AELQSLP------------GDLFE--------------------H 340
              |.....||:.|   .|| .:|.|.|            |.||.                    .
Mouse   185 --LALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEKLCWELS 247

  Fly   341 STQITNISLGDN-LLKTLPATLLEHQ-VNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLT 403
            :|.|.|:||.:| ||.|..:|....: .||..||||.|.|..:.:..|::..:|..|.||.|.:.
Mouse   248 NTSIQNLSLANNQLLATSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQ 312

  Fly   404 GISGDIFSNLGNLVTLVMSRNRLR---------TIDSRAFVSTNGLRHLHLDHNDIDLQQP---- 455
            .:|...|..|.||..|.:.|...:         .||..:|.....|.:|::|.|:|...:.
Mouse   313 RLSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFT 377

  Fly   456 -LLDI----------MLQTQINSPF-GYMHG-LLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYN 507
             |:.:          .|||..|..| ...|. ||||||..|.|..:.|...:.:.|||.|||..|
Mouse   378 GLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGTFSWLGQLRILDLGLN 442

  Fly   508 NI-SSLGYEDLAFLSQNRLHVNMTHNK-------------------IRRIALPEDVHLGEGYNNN 552
            .| ..|..::...| :|...:.:::||                   :||:||.
Mouse   443 EIEQKLSGQEWRGL-RNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVALK------------ 494

  Fly   553 LVHVDLNDNPL--VCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQT 615
              :||::.:|.  :.:.|||                  .|..:.:.....::|||....:|
Mouse   495 --NVDISPSPFRPLRNLTIL------------------DLSNNNIANINEDLLEGLENLEI---- 535

  Fly   616 LICPLDFSDDPR----ERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNM-QLMELHL 675
                |||..:..    :|..|.|....::......::|..|..|..:|  ..:.||: :|..::|
Mouse   536 ----LDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGLDEIP--VGVFKNLFELKSINL 594

  Fly   676 ENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLP---TNLTHLDISWNHLQMLNATVLGFL 737
            ..|.|.:|.........|:.||:|..|.:||::.|...   .||..||:.:|.......::..|:
Mouse   595 GLNNLNKLEPFIFDDQTSLRSLNLQKNLITSVEKDVFGPPFQNLNSLDMRFNPFDCTCESISWFV 659

  Fly   738 NRTMKW-----RSVKLSGNPWMCDCT----AKPLLLFTQDNFERIGDRNEMMCVNAEMPTRMVEL 793
            |    |     .::......::|:..    ..||.||...:           |.::.....:..:
Mouse   660 N----WINQTHTNISELSTHYLCNTPHHYYGFPLKLFDTSS-----------CKDSAPFELLFII 709

  Fly   794 STNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDKK 858
            ||:.:.     |||.:.::|.:.|....|             .|..:.:.:|.|...:...:..:
Mouse   710 STSMLL-----VFILVVLLIHIEGWRISF-------------YWNVSVHRILGFKEIDTQAEQFE 756

  Fly   859 FDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQ 923
            :.|:|.::|||:.::.::..| :|...|..:.|:.|||:..|....|.|:.|:..||:.|.|::.
Mouse   757 YTAYIIHAHKDRDWVWEHFSP-MEEQDQSLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITH 820

  Fly   924 NFIKSEWARLEFRAAH--RSALNEGRSRIIVIIYSDIGDVEKLDEEL---KAYLKMNTYLKWGDP 983
            :.:|....| .|:..|  :.|:.:....||:|...:|.|. ||:..|   :...|.:..|.|  |
Mouse   821 HLLKDPLCR-RFKVHHAVQQAIEQNLDSIILIFLQNIPDY-KLNHALCLRRGMFKSHCILNW--P 881

  Fly   984 -------WFWDKLRFALPHR 996
                   .|..||:.||..|
Mouse   882 VQKERINAFHHKLQVALGSR 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	17/60 (28%)
		leucine-rich repeat	176..198	CDD:275380	6/21 (29%)
		leucine-rich repeat	199..222	CDD:275380	3/22 (14%)
		LRR_RI	216..542	CDD:238064	108/409 (26%)
		LRR_8	221..281	CDD:290566	18/59 (31%)
		leucine-rich repeat	223..270	CDD:275380	13/46 (28%)
		leucine-rich repeat	271..294	CDD:275380	5/22 (23%)
		leucine-rich repeat	295..320	CDD:275380	5/24 (21%)
		leucine-rich repeat	321..343	CDD:275380	10/57 (18%)
		LRR_8	342..402	CDD:290566	24/61 (39%)
		leucine-rich repeat	344..367	CDD:275380	9/24 (38%)
		leucine-rich repeat	368..391	CDD:275380	8/22 (36%)
		LRR_8	390..450	CDD:290566	19/68 (28%)
		leucine-rich repeat	392..415	CDD:275380	8/22 (36%)
		leucine-rich repeat	416..439	CDD:275380	6/31 (19%)
		leucine-rich repeat	440..474	CDD:275380	11/49 (22%)
		leucine-rich repeat	475..498	CDD:275380	9/22 (41%)
		LRR_8	477..534	CDD:290566	20/76 (26%)
		leucine-rich repeat	499..520	CDD:275380	8/21 (38%)
		leucine-rich repeat	523..552	CDD:275380	7/47 (15%)
		LRRCT	561..619	CDD:214507	9/59 (15%)
		LRRNT	631..667	CDD:214470	6/35 (17%)
		leucine-rich repeat	664..693	CDD:275380	7/29 (24%)
		LRR_8	669..726	CDD:290566	18/59 (31%)
		leucine-rich repeat	694..715	CDD:275380	7/23 (30%)
		leucine-rich repeat	716..737	CDD:275380	4/20 (20%)
		LRRCT	751..800	CDD:214507	8/52 (15%)
		TIR	858..996	CDD:214587	42/149 (28%)
Tlr3	NP_001344245.1	leucine-rich repeat	37..53	CDD:275380	8/29 (28%)
		LRR 1	53..74		7/24 (29%)
		leucine-rich repeat	54..77	CDD:275380	7/26 (27%)
		PLN00113	70..>543	CDD:215061	126/521 (24%)
		LRR 2	77..98		3/20 (15%)
		leucine-rich repeat	78..101	CDD:275380	3/22 (14%)
		LRR 3	101..122		8/20 (40%)
		leucine-rich repeat	102..125	CDD:275380	8/22 (36%)
		LRR 4	125..146		4/20 (20%)
		leucine-rich repeat	126..149	CDD:275380	4/22 (18%)
		LRR 5	149..170		6/20 (30%)
		leucine-rich repeat	150..199	CDD:275380	13/56 (23%)
		LRR 6	173..196		7/30 (23%)
		LRR 7	199..220		5/20 (25%)
		leucine-rich repeat	200..250	CDD:275380	8/49 (16%)
		LRR 8	250..271		9/20 (45%)
		leucine-rich repeat	251..276	CDD:275380	9/24 (38%)
		LRR 9	276..297		9/20 (45%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR 10	300..321		7/20 (35%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		LRR 11	324..345		4/20 (20%)
		leucine-rich repeat	325..381	CDD:275380	12/55 (22%)
		LRR 12	357..378		5/20 (25%)
		LRR 13	381..401		4/19 (21%)
		leucine-rich repeat	382..433	CDD:275380	15/50 (30%)
		LRR 14	409..430		9/20 (45%)
		LRR 15	433..454		9/20 (45%)
		leucine-rich repeat	434..458	CDD:275380	9/24 (38%)
		LRR 16	458..479		3/20 (15%)
		leucine-rich repeat	459..482	CDD:275380	2/22 (9%)
		LRR 17	482..502		6/33 (18%)
		leucine-rich repeat	483..508	CDD:275380	7/38 (18%)
		PPP1R42	503..>649	CDD:411060	38/173 (22%)
		LRR 18	508..529		5/38 (13%)
		leucine-rich repeat	509..532	CDD:275380	7/40 (18%)
		LRR 19	532..553		5/28 (18%)
		leucine-rich repeat	533..564	CDD:275380	7/38 (18%)
		LRR 20	564..585		4/22 (18%)
		leucine-rich repeat	565..586	CDD:275380	5/22 (23%)
		LRR 21	588..609		5/20 (25%)
		leucine-rich repeat	589..610	CDD:275378	5/20 (25%)
		LRR 22	612..633		8/20 (40%)
		leucine-rich repeat	613..637	CDD:275380	7/23 (30%)
		LRRCT	646..698	CDD:214507	9/66 (14%)
		Tlr3_TMD	699..731	CDD:407816	7/36 (19%)
		TIR	756..901	CDD:214587	42/149 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880