Protein Alignment Tl and LOC1270739

DIOPT Version :10

• Sequence 1: NP_001262995.1
• Gene: Tl / 43222
• FlyBaseID: FBgn0262473
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: XP_309458.5
• Gene: LOC1270739 / 1270739
• VectorBaseID: AGAMI1_013532
• Length: 1347
• Species: Anopheles gambiae
• Alignment Length: 1160
• Identity: 268/1160 - (23%)
• Similarity: 471/1160 - (40%)
• Gaps: 312/1160 - (26%)

  Fly   139 MNITRQHLDRLH--------------------GLKRFRFTTRRLTHIPANLLTDMRNLSHLELRA 183
            :|:||..|..:.                    ||:....:...|..:|.|.|:.:|:||.|.|:.
Mosquito   197 LNLTRNRLTDVSQLGFSDWGNGPTAPGKACNTGLEVLDLSHNDLLALPDNGLSSLRSLSVLMLQD 261

  Fly   184 N-IEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQL-------------- 233
            | :..:....|..|.:|:.:...||||..:|...|....:|:|:.|.:|.|
Mosquito   262 NLLTALADRSFVGLGSLKVLNMSSNKLVALPPETFQSTRELRQIYLQNNSLSVLAPGMLEGLDRL 326

  Fly   234 ------HN------LTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQ 286
                  ||      :.::.|.|...::.::|..|.:.::...||..|.::..:||.||...|:..
Mosquito   327 EILDLSHNELTSEWVKRNTFAGMKRLVVLEIAHNALTKIDRHVFRELYSLQILNLEANQIESIAD 391

  Fly   287 GLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQIL-RLRAE---LQSLPGDLFEHSTQITNI 347
            ..|...|:|..:.|.:||  |..:....|:   ||.:| :|..|   ::|:.|...|:.|.:.::
Mosquito   392 NAFSDLKNLVALTLSHNR--LKRIEQHHFS---ELYVLNQLYVESNLIESMHGRALENLTNLNDL 451

  Fly   348 SLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSN 412
            :|.||.|..:|..|.:.:. |.||||..||::.:.::.|.....|..|||.:|.:|.||.|.|..
Mosquito   452 NLNDNRLTEIPEGLGKLRF-LKSLDLGKNRISAVSNASFEGLEQLLGLRLVENRITNISRDAFVT 515

  Fly   413 LGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLT 477
            |.:|..|.::.|::|.||..||.|...:|.:.||:|:::            .|:..|..:..|:.
Mosquito   516 LSSLHVLNLASNQIRHIDQSAFSSNPTIRAIRLDNNELE------------DISGVFTSLPALVF 568

  Fly   478 LNLRNNSI-IFVYNDWKNTMLQLRELDLSYNNISSLG-YEDLAFLSQNRLHVNMTHNKIRRI--- 537
            ||:.:|.| :|   |:.:..:.|..||:..|||:.|| |.||     |.|.:.|......|:
Mosquito   569 LNVSDNQIRLF---DYSHFPVSLEWLDMHQNNITELGNYYDL-----NNLQIKMLDVSFNRLTSV 625

  Fly   538 ---ALPEDV-----------HLGEG-------------YNNNLVHVD------------------ 557
               .:|:.:           .:..|             |.|.|..::
Mosquito   626 DAKCIPDSIETLFLNNNALEEVAAGTFLSKRSLEKVVLYGNYLRKLEIGALALTRVADDREVPAF 690

  Fly   558 -LNDNPLVCDCTILWFIQLVRGVHKPQYSRQFK--LRTDRLVCSQPNVLEGT--PVRQIEPQTLI 617
             |.|||:.||||:.|    ::|::|..:.||..  :..|.::|:..:....:  |:..:.|...:
Mosquito   691 YLGDNPIHCDCTMEW----LQGINKLAHLRQHPRVMDLDTVLCTMEHERGASIRPLMDLRPHDFL 751

  Fly   618 CP-----------LDFSDDPRERKCPRGCNC-HVRTYDKALVINCHSGNLTHVPRLPNLHKNMQL 670
            |.           .:|.....:..||..|:| |..|: ||.:::|.|.:.|.||.    |..|..
Mosquito   752 CRYETHCFATCHCCEFDACDCKMTCPDRCSCYHDHTW-KANIVDCGSADYTEVPE----HIPMDA 811

  Fly   671 MELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSI---------------------------D 708
            ..::|:.|.|.:|.|....|.:.:..|:|.|:|:..:                           :
Mosquito   812 STIYLDGNELRQLASHQFIGKKKLEVLYLNGSNIRDVHNRTFNGIPSLRVLHLENNYINELRGFE 876

  Fly   709 VDQLPTNLTHLDISWNHLQMLNATV---LGFL-------NRTMKWR---------------SVKL 748
            .||| |||..|.:..|.:..:....   |.||       ||..::|               .|.|
Mosquito   877 FDQL-TNLNELYLDHNAIAYVGERTFESLRFLEVVSLSDNRISEFRPWQAFAAAGETGSLARVAL 940

  Fly   749 SGNPWMCDCTA----KPLLLFTQDNFERIGDRNEMMCVNAEMPTRMVELSTNDICPAEK--GVF- 806
            .||.|.|||.:    :..:.....|||    ...|:|.::.:....:.     .|.:.:  |||
Mosquito   941 DGNRWRCDCESLRRMQRWIRTVSGNFE----LQRMICADSRVVADAIA-----SCDSRQGGGVFG 996

  Fly   807 ---------------------------------IALAVVIALTGLLAGFTAALYYKFQTEIKIWL 838
                                             :..|:::|:.|  .....||...|:.::::|.
Mosquito   997 AGAEVGEVDGDGPPAVHRTVLLGHGLIGGGYVPLLAAILVAIIG--TALIVALACVFRQDVRLWA 1059

  Fly   839 YA-HNLLLWFVTE-------EDLDKDKKFDAFISYSHKDQSFIEDYLVPQLE-HGPQKFQLCVHE 894
            :| :.:.|  |.:       ::.|.|:.:|.::.:|..|..|:...|..:|: ||   :.:|.|.
Mosquito  1060 HARYGVRL--VKDPIIVGGRKEPDSDRLYDCYLVHSVHDSDFVGRLLGAELQLHG---YSVCQHH 1119

  Fly   895 RDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALN-----EGRSRIIVII 954
            ||...|..:.:::..:...:|:.::|:|.||:::||::.:||.|.:|.:.     ..|.:|::::
Mosquito  1120 RDVHPGAFLADSLQSAADSARKLLLVVSMNFLQTEWSQPQFRVALQSVIESIRPAHRRHKIVLVL 1184

  Fly   955 YSDIGDVEKLDEELKAYLKMNTYLKWGDPWFWDKLRFALPHRRPVGNIGNGALIKTALKGSTDDK 1019
            .:.: ::..:|..:...::..|...||:..||||||:|||.           :.|..:.....|
Mosquito  1185 TAPV-EIVAMDPIMHLLIRTCTVACWGERKFWDKLRYALPD-----------VPKDRVPAKLGD- 1236

  Fly  1020 LELIKPSPVTPPLTTPPAEATKNPLVAQLNGVTPHQAIMIANGKNGLTNLYTPNG 1074
                        :|..||.....|....|     .|...|:.|:.|      |||
Mosquito  1237 ------------ITRSPANLRYTPAPTSL-----EQWCKISPGETG------PNG 1268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:404697	19/59 (32%)
		leucine-rich repeat	176..198	CDD:275380	7/22 (32%)
		leucine-rich repeat	199..222	CDD:275380	7/22 (32%)
		LRR	222..576	CDD:443914	112/434 (26%)
		leucine-rich repeat	223..270	CDD:275380	14/72 (19%)
		leucine-rich repeat	271..294	CDD:275380	6/22 (27%)
		leucine-rich repeat	295..320	CDD:275380	6/24 (25%)
		leucine-rich repeat	321..343	CDD:275380	7/25 (28%)
		leucine-rich repeat	344..367	CDD:275380	6/22 (27%)
		leucine-rich repeat	368..391	CDD:275380	8/22 (36%)
		leucine-rich repeat	392..415	CDD:275380	11/22 (50%)
		leucine-rich repeat	416..439	CDD:275380	9/22 (41%)
		leucine-rich repeat	440..474	CDD:275380	6/33 (18%)
		leucine-rich repeat	475..498	CDD:275380	7/23 (30%)
		leucine-rich repeat	499..520	CDD:275380	11/21 (52%)
		leucine-rich repeat	523..552	CDD:275380	7/58 (12%)
		LRRCT	561..619	CDD:214507	15/61 (25%)
		LRRNT	631..667	CDD:214470	14/36 (39%)
		PPP1R42	<660..752	CDD:455733	29/143 (20%)
		leucine-rich repeat	664..693	CDD:275380	8/28 (29%)
		leucine-rich repeat	694..715	CDD:275380	7/47 (15%)
		leucine-rich repeat	716..737	CDD:275380	4/23 (17%)
		LRRCT	751..800	CDD:214507	10/52 (19%)
		TIR	858..996	CDD:214587	39/143 (27%)
LOC1270739	XP_309458.5	None