DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and tlr7

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	XP_021334735.1	Gene:	tlr7 / 100534776	ZFINID:	ZDB-GENE-040219-11	Length:	1036	Species:	Danio rerio

Alignment Length:	1172	Identity:	245/1172 - (20%)
Similarity:	440/1172 - (37%)	Gaps:	376/1172 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ASELALLVIILQLLQW-PGS---EASFGRDACSEMSIDGLCQCAP-IMSEYEIICPANAENPTFR 66
            ||.::|||    ..:| |.|   :.|...:. :|:|:|    |.. .::|..:..|.|..|.|..
Zfish    10 ASFISLLV----AAEWYPKSLKCDVSLASNG-TEVSVD----CTERSLTEVPLGIPTNTTNLTLT 65

  Fly    67 LTIQPKDYVQIMCNLTDTTDYQQ----LPKKLRIGEVDRVQMRRCMLPGHTPIASILDYLGIVSP 127
            :...|........||.:.|:...    :|  :::|..|||    |
Zfish    66 INHIPHVMNNSFDNLHNITEIDLRCNCVP--VKVGPKDRV----C-------------------- 104

  Fly   128 TTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANL---------------------LT 171
                    :..::|......:|..||.......:|:.||..|                     ||
Zfish   105 --------SQSVSIDNGTFWKLKNLKSLYLDGNQLSSIPKGLPANIVLLSLEINSIYSILQENLT 161

  Fly   172 DMRNLSHLELRAN------------IEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMP-KL 223
            ::.|:..|.|..|            ||:   ..|..|:.:..:...||.|..:|    .::| .|
Zfish   162 ELTNIRTLYLGQNCYFRNPCNQSYYIEK---DAFMLLDKMTLLSLKSNNLSYIP----NQLPSSL 219

  Fly   224 KQLNLWSNQLHNLTKHDFEGATSVLGID------------------------------------- 251
            |:|.|::|.:..:|::||...|.:..:|
Zfish   220 KELYLYNNNIEKITENDFCNLTELEVLDLSGNCPRCYNAPFPCIPCPNNAPLQIHPNSFKTLRNL 284

  Fly   252 ----IHDNGIEQLPHDVFAHLTNVTDINLSANLF------RSLPQGLFDHNKHLNEVRLMNNRVP 306
                :|.|.:..:|.:.|..|.::|.::||:|..      .|.|..|    ..|.|:.|..| ..
Zfish   285 KTLRLHSNSLTNIPPEWFQSLADLTLLDLSSNFLAKEITCTSFPSLL----PKLEELDLSFN-YE 344

  Fly   307 LATLPSRL-----FANQPELQILRLRA----ELQSLPGDLFEHSTQITNISLGDNLLKTLPATLL 362
            |...|:.|     |:....|::||:|.    ||:........:.|.:..:.||.|.:|....::|
Zfish   345 LQVYPASLSLSESFSQLKSLRVLRIRGYVFQELKLQDIQPLTNLTYLEFLDLGTNFIKIAQLSIL 409

  Fly   363 EHQVNLLSLDLSNNRLTHLPDSLFA-------------------HTTNLTDL------------R 396
            ::..|...::||:|:::...:..|:                   |...:.|:            :
Zfish   410 KNLKNFKIINLSDNKISVPSEGEFSFSNHREAYYGSPMSQGAQYHNGEVKDMHYFLYDEFARSCK 474

  Fly   397 LEDNLL------------TGISGDI-----------FSNLGNLVTLVMSRNRL-RTIDSRAFVST 437
            .:|..|            .|.:.||           |.|||.|..|.:|.|.: ::::...||..
Zfish   475 YKDKELWIPSPFNNDCSSFGKTLDISRNNIFFLHSKFLNLGELRCLNLSGNAMSQSLNGSEFVQL 539

  Fly   438 NGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYN------DWKNTM 496
            ..|::|....|.:||..|           |.|..:..|:.|::..||..||..      ::...:
Zfish   540 TNLQYLDFTDNRLDLMYP-----------SAFQELSNLVVLDISRNSHYFVAEGLTHMLNFTENL 593

  Fly   497 LQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNN--NLVHVDLN 559
            .:||:|.::.|.||:....::.  |....|:....|::..:....|......:.|  :|..:|::
Zfish   594 SKLRKLIMNDNQISTSTNTEMK--SYKLEHLEFKGNRLDMLWRDGDTRYVNYFKNLMSLKTLDIS 656

  Fly   560 DNPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSD 624
            .|.|.       ||.||                         |.:|.|       ..:..|..:|
Zfish   657 RNNLN-------FIPLV-------------------------VFQGLP-------NTLTKLYITD 682

  Fly   625 DPRERKCPRGCNCHVRTYDKALVINCHSGN-LTHVPR-LPNLHKNMQLMELHLENNTLLRLPSAN 687
            :..:.....|.     .|.|:|::...:|| ||.||. |.|..|::|  .|.|..|.:::|....
Zfish   683 NKLKLFKWEGL-----VYLKSLLLLDLTGNLLTEVPSCLSNYTKSIQ--TLVLSKNKIVKLSPNF 740

  Fly   688 TPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNP 752
            .....|:..|.|:.|::..||....|.|:.      :|||.|      :||..|
Zfish   741 LKDAFSLKILDLSYNSIQFIDESSFPENVI------DHLQTL------YLNNNM----------- 782

  Fly   753 WMCDCTAKPLLLF---TQDNFERIGDRNEMMCVNAEMPTRMVELSTNDICPAEKG---VFI---- 807
            ::|.|.|..|:.:   |..|..|:.  :::.|.:..               |:||   :|:
Zfish   783 FVCSCNATWLVRWINRTSVNIPRLA--SDVTCASPS---------------AQKGQSVIFLNLQA 830

  Fly   808 ----ALAVVIALTGLLAGFTAALYYKFQTE-----IKIWLYAHNLL--LWFVTEEDLDKDK---- 857
                :|::::.:              |||.     :.:.:.:|..|  :|::....|.|.|
Zfish   831 CQHNSLSIILCI--------------FQTTLILTILTLTISSHLFLWDVWYIYHFCLAKLKGYRR 881

  Fly   858 ------KFDAFISYSHKDQSFIEDYLVPQL-----EHGPQKFQLCVHERDWLVGGHIPENIMRSV 911
                  .:|||:.|...|.: ::::::.:|     :.|..:..||:.||||:.|..:.||:.:|:
Zfish   882 LSSNSAVYDAFVIYDTTDPA-VQEWVMQELRVHLEDKGDPRMNLCLEERDWVPGCPLIENLSQSI 945

  Fly   912 ADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDEELKAYLKMNT 976
            ..|:||:.:|::.:|:|...|..|..||:..::| |:.:||:|:     :|::....| ||::..
Zfish   946 QLSQRTVFILTERYIRSGSFRTAFYLAHQRLMDE-RNDVIVLIF-----LERMPCHSK-YLRLRK 1003

  Fly   977 YL 978
            .|
Zfish  1004 RL 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	18/71 (25%)
		leucine-rich repeat	176..198	CDD:275380	7/33 (21%)
		leucine-rich repeat	199..222	CDD:275380	5/23 (22%)
		LRR_RI	216..542	CDD:238064	88/443 (20%)
		LRR_8	221..281	CDD:290566	20/101 (20%)
		leucine-rich repeat	223..270	CDD:275380	15/87 (17%)
		leucine-rich repeat	271..294	CDD:275380	7/28 (25%)
		leucine-rich repeat	295..320	CDD:275380	8/29 (28%)
		leucine-rich repeat	321..343	CDD:275380	6/25 (24%)
		LRR_8	342..402	CDD:290566	14/90 (16%)
		leucine-rich repeat	344..367	CDD:275380	5/22 (23%)
		leucine-rich repeat	368..391	CDD:275380	5/41 (12%)
		LRR_8	390..450	CDD:290566	19/95 (20%)
		leucine-rich repeat	392..415	CDD:275380	9/57 (16%)
		leucine-rich repeat	416..439	CDD:275380	6/23 (26%)
		leucine-rich repeat	440..474	CDD:275380	8/33 (24%)
		leucine-rich repeat	475..498	CDD:275380	6/28 (21%)
		LRR_8	477..534	CDD:290566	14/62 (23%)
		leucine-rich repeat	499..520	CDD:275380	6/20 (30%)
		leucine-rich repeat	523..552	CDD:275380	4/30 (13%)
		LRRCT	561..619	CDD:214507	9/57 (16%)
		LRRNT	631..667	CDD:214470	12/37 (32%)
		leucine-rich repeat	664..693	CDD:275380	6/28 (21%)
		LRR_8	669..726	CDD:290566	13/56 (23%)
		leucine-rich repeat	694..715	CDD:275380	6/20 (30%)
		leucine-rich repeat	716..737	CDD:275380	4/20 (20%)
		LRRCT	751..800	CDD:214507	8/51 (16%)
		TIR	858..996	CDD:214587	37/126 (29%)
tlr7	XP_021334735.1	LRR_8	67..131	CDD:316378	14/97 (14%)
		leucine-rich repeat	83..120	CDD:275380	9/70 (13%)
		PLN00113	107..>574	CDD:331614	97/489 (20%)
		leucine-rich repeat	121..165	CDD:275380	8/43 (19%)
		leucine-rich repeat	142..157	CDD:275380	0/14 (0%)
		leucine-rich repeat	166..197	CDD:275380	7/33 (21%)
		leucine-rich repeat	199..218	CDD:275380	5/22 (23%)
		leucine-rich repeat	219..242	CDD:275380	8/22 (36%)
		leucine-rich repeat	243..283	CDD:275380	1/39 (3%)
		leucine-rich repeat	284..307	CDD:275380	5/22 (23%)
		leucine-rich repeat	308..333	CDD:275380	7/28 (25%)
		leucine-rich repeat	334..363	CDD:275380	8/29 (28%)
		leucine-rich repeat	364..390	CDD:275380	6/25 (24%)
		leucine-rich repeat	391..414	CDD:275380	5/22 (23%)
		leucine-rich repeat	415..434	CDD:275380	3/18 (17%)
		leucine-rich repeat	495..516	CDD:275380	5/20 (25%)
		leucine-rich repeat	517..541	CDD:275380	6/23 (26%)
		leucine-rich repeat	542..565	CDD:275380	8/33 (24%)
		leucine-rich repeat	566..595	CDD:275380	6/28 (21%)
		leucine-rich repeat	596..616	CDD:275380	6/21 (29%)
		leucine-rich repeat	619..649	CDD:275380	4/29 (14%)
		LRR_8	<644..685	CDD:316378	14/79 (18%)
		leucine-rich repeat	650..673	CDD:275380	11/61 (18%)
		leucine-rich repeat	675..722	CDD:275380	14/51 (27%)
		LRR_8	722..781	CDD:316378	19/72 (26%)
		leucine-rich repeat	723..746	CDD:275380	5/24 (21%)
		leucine-rich repeat	747..765	CDD:275380	5/17 (29%)
		PCC	751..>828	CDD:188093	25/116 (22%)
		TIR	889..>993	CDD:214587	33/110 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010