DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and tlr21

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	XP_002936443.3	Gene:	tlr21 / 100497009	XenbaseID:	XB-GENE-5956980	Length:	937	Species:	Xenopus tropicalis

Alignment Length:	1001	Identity:	249/1001 - (24%)
Similarity:	405/1001 - (40%)	Gaps:	290/1001 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 LTDMR-------------NLSHLELRANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMP 221
            |||::             |:|:    .||:.:....|..:..|.::....|:|:::..|.|..:.
Frog    43 LTDVKSAVGDLPSDVWYLNISY----NNIQTLHQGSFGHMPFLRTLRLNHNQLQRLDPGAFENLT 103

  Fly   222 KLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSAN---LFRS 283
            .|::|:|.||::.||:|..|.|..:|..:.:.||.:..:..:.|:||||:.::|||.|   .|..
Frog   104 MLEKLHLSSNKISNLSKEVFCGLQNVSWLFLDDNLLSSIHPEAFSHLTNLQNLNLSMNNLHNFEK 168

  Fly   284 LPQGLFDHNKHLNEVRLMNN---------RVP------------LATLPSR-------------- 313
            :.|.:....| ||.:.|.:|         |:|            ||||..:
Frog   169 VVQSIHPLQK-LNTLMLCSNQISSLNHTHRLPSTLRWLFLCKNQLATLDCQQDFFLNISWLDLSY 232

  Fly   314 ------------------------------LFANQPELQILRLRAELQSLPGD-------LFEHS 341
                                          :|...|.:.|.|:.....:|..|       .:...
Frog   233 NNIATSSLQTMDLRKVIYLNVAFNGNFDILIFIKNPTVPINRIDYSGLNLNNDSKLKTMCRYLKG 297

  Fly   342 TQITNISLGDNLLKTL-PATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTG- 404
            ..|..:.|..|.:||| ..||.:..:| .:||||.|||..|....|...||:.:|.:|.|||..
Frog   298 FNINTLYLSGNKIKTLNRGTLTDCPLN-KTLDLSRNRLKGLGCLEFMSKTNVENLIVEHNLLKEL 361

  Fly   405 ------------------------ISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHL 445
                                    :.|:.|....||.||.::.|.:..::..:|.....||.|.|
Frog   362 INCSKKSHFPRLRHISFRYNRIWIVKGNAFHFAPNLQTLYLNINNIVFLERYSFSGLGKLRELRL 426

  Fly   446 DHNDI-DLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNNI 509
            |:|.| ||.:           || |..:..|..||||||.:..:::.....:.:|..|||..|.|
Frog   427 DNNLITDLYE-----------NS-FANLTELRILNLRNNRVSVIFSKVFYNLGKLTTLDLGGNKI 479

  Fly   510 SSLGYEDLAFL-SQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFI 573
            :.|..:....| |.::|:::  .|:|:.|:.....|:    .:.|:.:||..|.|..:.|
Frog   480 TQLKNQSFYGLRSLSKLYLD--GNQIKEISRYVFSHV----ESTLLVLDLKSNHLRYNTT----- 533

  Fly   574 QLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTP------VRQIE----PQTLICPLDFSDDPRE 628
               |..:.| :....||...:|...||..|...|      ::.::    .|..|..|. ||...|
Frog   534 ---RETYSP-FLTLSKLYDLKLQAQQPYGLTAIPQGFFKGLKSLKALYLAQNRISSLS-SDAFNE 593

  Fly   629 RKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLP-----NLHKNMQLMELHLENNTL--LRLPSA 686
                    ....|| .:|..:|:.     :.|||     || ||:|:::  |||..|  :|:
Frog   594 --------LGQLTY-LSLAEDCNG-----IQRLPPGIFKNL-KNLQILD--LENICLQYMRM--- 638

  Fly   687 NTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGN 751
                 |..:||                |||..|.::.|.|..:|..|  |.|.| :.:.:.|...
Frog   639 -----EVFSSL----------------TNLKRLLLTKNALTHINIKV--FENMT-QLKYLDLRKC 679

  Fly   752 PWMCDCTAKPLLLFTQDNFERIGDRNEMMCVNAEM-------PTRMVELSTNDICPAEKGVFI-- 807
            |..|.|.                        |||:       |.::| |..|..|||.:..:.
Frog   680 PLSCTCN------------------------NAELQMWFKKGPVQIV-LPYNLTCPANENSYFHD 719

  Fly   808 ----ALAVVIALTGLLAGFTAAL--------YYKFQTEIKIWLYAHNLLL---W----FVTEEDL 853
                ...:.|.:....:.||:.|        |.||     .|:..:|..|   |    :.:|::|
Frog   720 FDTHVCDMEIKIKLFCSSFTSILLFIIIPIVYSKF-----YWMIKYNYFLFVAWLHERWKSEKEL 779

  Fly   854 DKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTI 918
               .|:|||:||:..|:.::...::|.||  ....:||:|.||:.:|..|.:||:.|:.:||:||
Frog   780 ---YKYDAFVSYNTHDEEWVYKIMLPVLE--TSALRLCLHHRDFQLGRDIIDNIVDSIHNSRKTI 839

  Fly   919 IVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDEELKAYLKM------NTY 977
            .|:|:::::|||..||.:.|.....:|.|..:::|:..:|.     |.||..|.:|      .||
Frog   840 CVVSRSYLQSEWCSLEMQLASYKLFDEMRDVLVLILLDNIP-----DRELSTYHRMRKLMLKKTY 899

  Fly   978 LKW-----GDPWFWDKLRFALPHRRP 998
            :.|     ....||.|::.|:..:||
Frog   900 ITWPTEPEAQQLFWAKVQEAVSGKRP 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	15/71 (21%)
		leucine-rich repeat	176..198	CDD:275380	4/21 (19%)
		leucine-rich repeat	199..222	CDD:275380	5/22 (23%)
		LRR_RI	216..542	CDD:238064	107/428 (25%)
		LRR_8	221..281	CDD:290566	22/62 (35%)
		leucine-rich repeat	223..270	CDD:275380	16/46 (35%)
		leucine-rich repeat	271..294	CDD:275380	6/25 (24%)
		leucine-rich repeat	295..320	CDD:275380	11/89 (12%)
		leucine-rich repeat	321..343	CDD:275380	4/28 (14%)
		LRR_8	342..402	CDD:290566	23/60 (38%)
		leucine-rich repeat	344..367	CDD:275380	8/23 (35%)
		leucine-rich repeat	368..391	CDD:275380	9/22 (41%)
		LRR_8	390..450	CDD:290566	21/84 (25%)
		leucine-rich repeat	392..415	CDD:275380	7/47 (15%)
		leucine-rich repeat	416..439	CDD:275380	5/22 (23%)
		leucine-rich repeat	440..474	CDD:275380	12/34 (35%)
		leucine-rich repeat	475..498	CDD:275380	7/22 (32%)
		LRR_8	477..534	CDD:290566	17/57 (30%)
		leucine-rich repeat	499..520	CDD:275380	7/20 (35%)
		leucine-rich repeat	523..552	CDD:275380	5/28 (18%)
		LRRCT	561..619	CDD:214507	14/67 (21%)
		LRRNT	631..667	CDD:214470	9/40 (23%)
		leucine-rich repeat	664..693	CDD:275380	9/30 (30%)
		LRR_8	669..726	CDD:290566	14/58 (24%)
		leucine-rich repeat	694..715	CDD:275380	2/20 (10%)
		leucine-rich repeat	716..737	CDD:275380	6/20 (30%)
		LRRCT	751..800	CDD:214507	10/55 (18%)
		TIR	858..996	CDD:214587	48/148 (32%)
tlr21	XP_002936443.3	PLN00113	<46..>528	CDD:215061	121/505 (24%)
		leucine-rich repeat	59..80	CDD:275380	5/24 (21%)
		leucine-rich repeat	81..104	CDD:275380	5/22 (23%)
		leucine-rich repeat	105..128	CDD:275380	10/22 (45%)
		leucine-rich repeat	129..152	CDD:275380	6/22 (27%)
		leucine-rich repeat	153..224	CDD:275380	17/71 (24%)
		leucine-rich repeat	225..299	CDD:275380	6/73 (8%)
		leucine-rich repeat	300..323	CDD:275380	8/22 (36%)
		leucine-rich repeat	348..363	CDD:275378	5/14 (36%)
		leucine-rich repeat	373..396	CDD:275380	2/22 (9%)
		inl_like_NEAT_1	<397..>652	CDD:411101	83/323 (26%)
		leucine-rich repeat	397..420	CDD:275380	5/22 (23%)
		leucine-rich repeat	421..444	CDD:275380	12/34 (35%)
		leucine-rich repeat	445..468	CDD:275380	7/22 (32%)
		leucine-rich repeat	469..492	CDD:275380	8/22 (36%)
		leucine-rich repeat	493..516	CDD:275380	5/28 (18%)
		leucine-rich repeat	518..572	CDD:275380	15/62 (24%)
		leucine-rich repeat	573..596	CDD:275380	6/31 (19%)
		leucine-rich repeat	597..622	CDD:275380	9/31 (29%)
		leucine-rich repeat	623..646	CDD:275380	9/48 (19%)
		leucine-rich repeat	647..668	CDD:275380	7/22 (32%)
		TIR	781..923	CDD:214587	48/148 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	1	1.000	-	-		mtm14092
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010