DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and tlr6

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	XP_017950845.1	Gene:	tlr6 / 100493946	XenbaseID:	XB-GENE-492949	Length:	842	Species:	Xenopus tropicalis

Alignment Length:	803	Identity:	172/803 - (21%)
Similarity:	306/803 - (38%)	Gaps:	203/803 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 LQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTD 394
            |.::|.:|   |:..|.:.:..|.:.|:..:...:..:|..|:.|.|::.:|..|:|...|.|..
Frog    35 LFAVPKNL---SSLTTVLDISFNSIATMETSEFNYIFDLQVLNASYNKMKYLNSSIFKFNTQLQY 96

  Fly   395 LRLEDNLLTGISG-------------------DIFSNLGNLVTLV---MSRNRLRTIDSRAFVST 437
            |....|:|..|||                   .:.|..||:|.|.   :..:::...|      .
Frog    97 LDFSHNVLRNISGTFPSHIQHLDISFNNFQTLSVCSGFGNMVLLEYLGLGADQILKSD------F 155

  Fly   438 NGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHG-LLTLNLRNNSIIF--VYNDWKNTMLQL 499
            .|:.||||....|:|             ||...|.:| ||.||.:..::.|  :.|:.:..:|
Frog   156 EGIVHLHLKEVFIEL-------------NSLNDYENGSLLLLNTKKLTLDFGVLSNEDRYNVL-- 205

  Fly   500 RELDLSYNNISSLGYEDLAFLSQNRLHV-------NMTHN-KIRRIALPEDVHLGEGYNNNLVHV 556
                  ::.:::....:|:.|.:..:|:       |:..| |:..:.:.              ||
Frog   206 ------FDAVNTTSVLELSHLQRWNIHIDPKKYIFNIVQNSKVTDLTMR--------------HV 250

  Fly   557 DLNDNPLVCDCTILWFIQL------------------------------VRGVHKPQYSRQFKLR 591
            ::....:|.....:|...:                              |:||:...:  ||...
Frog   251 NVEWKMIVLALQYIWHSSVETLTFYDFSLKGLIAKTSFDYSNTSVKAVNVQGVNVGVF--QFDQS 313

  Fly   592 TDRLVCSQPNVLEGTPVRQIEPQTLICPL--------DFSDDPRERKCPRGCNCHVRTYDKALVI 648
            :...|.|..|: |...:.......::|||        |||.:.......:.|...:..  |.|.:
Frog   314 SVYRVFSNMNI-ENLTLNFASLLFMVCPLNSSTFQSIDFSHNALTDDLFKDCFTLINL--KRLKL 375

  Fly   649 NCHSGNLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLT-------- 705
              ....|..:.:|..:.:||..:|....::.||.....:....:::..|:||.|.||
Frog   376 --RKNKLEKIYKLSAMTENMPSLEYLDASHNLLAYDEEDCHWSQNIVELNLASNFLTASIFKCLP 438

  Fly   706 ---------SIDVDQLPTNLTHLD------ISWNHL-------QMLNATVLGFLNRTMKWRSVK- 747
                     |.|:..:|:.:||||      :|:|.|       .:.:.::||.....:.:.|::
Frog   439 ISIKILILESNDITHVPSGVTHLDDLVELNLSFNRLGDLPDCSNISSLSLLGVEGNQILYPSIES 503

  Fly   748 -----------LSGNPWMCDCTAKPLLLFTQDNFER------IGDRNEMMCVNAEMPTRMVELST 795
                       ...||:.|:|..:..:     |.|:      ||.....:|   :.|..:.....
Frog   504 IESCSRVKHISAGQNPFQCNCELRRFI-----NQEKEAPGTLIGWPEAYVC---KYPDHLRGTML 560

  Fly   796 NDICPAE--KGVFIALAVVI--------ALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTE 850
            .|...:|  ..|||.:.|:|        .:.||........:.|.     ||.|.........::
Frog   561 KDFYISEITCNVFILIPVIILPIIISIALIIGLCKYLDGPWFLKM-----IWQYTRTKQRTRTSK 620

  Fly   851 ---EDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVA 912
               :.|.:|..|:||||||..|.|::::..:|.:|......::|.|||:::.|..|.|||:..:.
Frog   621 QGYQSLQRDFDFNAFISYSEHDASWVKNIFLPSIERSNDCIRICQHERNFIPGKSIIENIINCIE 685

  Fly   913 DSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGD--VEKLDEELKAYLKMN 975
            .|.::|.:||.||::|||...|...||.....|....:|:|:...|..  :.....:||..:...
Frog   686 KSYKSIFILSPNFVQSEWCHYELYFAHHKLYTENNDNLILILLEPIPQYLIPSKYYKLKTLMAQR 750

  Fly   976 TYLKWGDP-----WFWDKLRFAL 993
            |||:|...     .||..||.|:
Frog   751 TYLEWPSEKSKHGLFWANLRAAI 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566
		leucine-rich repeat	176..198	CDD:275380
		leucine-rich repeat	199..222	CDD:275380
		LRR_RI	216..542	CDD:238064	52/244 (21%)
		LRR_8	221..281	CDD:290566
		leucine-rich repeat	223..270	CDD:275380
		leucine-rich repeat	271..294	CDD:275380
		leucine-rich repeat	295..320	CDD:275380
		leucine-rich repeat	321..343	CDD:275380	4/12 (33%)
		LRR_8	342..402	CDD:290566	14/59 (24%)
		leucine-rich repeat	344..367	CDD:275380	3/22 (14%)
		leucine-rich repeat	368..391	CDD:275380	7/22 (32%)
		LRR_8	390..450	CDD:290566	19/81 (23%)
		leucine-rich repeat	392..415	CDD:275380	8/41 (20%)
		leucine-rich repeat	416..439	CDD:275380	3/25 (12%)
		leucine-rich repeat	440..474	CDD:275380	9/33 (27%)
		leucine-rich repeat	475..498	CDD:275380	6/24 (25%)
		LRR_8	477..534	CDD:290566	10/66 (15%)
		leucine-rich repeat	499..520	CDD:275380	1/20 (5%)
		leucine-rich repeat	523..552	CDD:275380	4/36 (11%)
		LRRCT	561..619	CDD:214507	11/87 (13%)
		LRRNT	631..667	CDD:214470	5/35 (14%)
		leucine-rich repeat	664..693	CDD:275380	5/28 (18%)
		LRR_8	669..726	CDD:290566	18/79 (23%)
		leucine-rich repeat	694..715	CDD:275380	9/37 (24%)
		leucine-rich repeat	716..737	CDD:275380	9/33 (27%)
		LRRCT	751..800	CDD:214507	11/54 (20%)
		TIR	858..996	CDD:214587	47/143 (33%)
tlr6	XP_017950845.1	leucine-rich repeat	46..69	CDD:275378	3/22 (14%)
		LRR_8	70..125	CDD:404697	15/54 (28%)
		leucine-rich repeat	70..93	CDD:275378	7/22 (32%)
		leucine-rich repeat	94..114	CDD:275378	7/19 (37%)
		leucine-rich repeat	115..139	CDD:275378	3/23 (13%)
		LRR_RI	311..>478	CDD:423007	36/171 (21%)
		leucine-rich repeat	347..369	CDD:275380	4/21 (19%)
		leucine-rich repeat	370..395	CDD:275380	6/28 (21%)
		leucine-rich repeat	396..418	CDD:275380	3/21 (14%)
		leucine-rich repeat	419..440	CDD:275380	6/20 (30%)
		leucine-rich repeat	441..463	CDD:275380	6/21 (29%)
		leucine-rich repeat	464..485	CDD:275380	3/20 (15%)
		leucine-rich repeat	486..509	CDD:275380	3/22 (14%)
		LRRCT	518..570	CDD:214507	12/59 (20%)
		TIR	632..775	CDD:214587	47/142 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3846
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.070