DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tl and cd180

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	XP_031762487.1	Gene:	cd180 / 100489673	XenbaseID:	XB-GENE-489949	Length:	571	Species:	Xenopus tropicalis

Alignment Length:	566	Identity:	129/566 - (22%)
Similarity:	219/566 - (38%)	Gaps:	168/566 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 IVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHLELRANIEEM 188
            :|:|.    :|...|:.||    :.::|...|.|...|         |..|| ||.:...:...:
Frog    29 VVTPV----QSTTPGLVIT----EVIYGTISFEFCFSR---------TFSRN-SHFQRAISAARL 75

  Fly   189 -PSHLFDDLENLE----SIEFGSNK-LRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSV 247
             |..|..:|.|::    .::|.|.| ||.:|               .|::.:.|.|
Frog    76 FPGPLALELINVKVDWAHVQFRSMKHLRPLP---------------VSHRQYCLVK--------- 116

  Fly   248 LGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRV------- 305
                 ..|.:..|.|..|..|..::.::|:......|.:.:|.:|.|||.:.|:.|.:
Frog   117 -----EINSLFALYHTTFMRLKCISPLDLTRCNINLLYEDVFQNNIHLNTLVLIGNPILYIAASA 176

  Fly   306 ---PLATLPSRLFANQPELQILRLRAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQV- 366
               |||.  ..||..|..|      ..:..:|   .||...:..:|.|:|.:.:|.   |.|..
Frog   177 FNGPLAL--KHLFLQQIPL------TNVTFIP---LEHLQHLETLSFGNNFISSLQ---LPHNFP 227

  Fly   367 --NLLSLDLSNN--RLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNR-- 425
              ||..||..:|  ::......:...:.||: |.|:.|.:..|..:.|.:: ||.:|.:..||
Frog   228 IKNLRVLDFQSNCXKILAADVEILKQSNNLS-LILKGNDIEYIEPNSFDSV-NLYSLDLKGNRGD 290

  Fly   426 -LRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQIN---SPFGYMHGLLT---LNL-RN 482
             ...:.|.||.....::.|.|....:: ..|||..:..:::|   |....:.||.:   ||: |.
Frog   291 LANLLSSTAFSCLTTIQRLDLTGTHVE-SLPLLKYLNLSRMNINASNENLLKGLESQTFLNMERP 354

  Fly   483 NSIIFVYNDWKNTMLQLRELDL--------------SYNNISSLGYEDL-----------AFLSQ 522
            .||..:|    |..||...|::              :::.::.|.||||           ||...
Frog   355 PSIWELY----NIFLQALHLEVLILLSCNLTAIEHRAFHKLAKLQYEDLRHNKITIFSSNAFRDL 415

  Fly   523 NRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVH-------VDLNDNPLVCDCTILWFIQLVRGVH 580
            :.:|:|...|.|..||            ::|:|       ::|:.||:.|.|
Frog   416 SHIHLNFASNMISDIA------------SHLLHNISGTSAINLSHNPIDCLC------------- 455

  Fly   581 KPQYSRQF----KLRTDRLV--CSQPNVLEGTPVRQIEPQTLICPL 620
               ::.||    |:..|:.:  |..|..:|||.:..::   |.|.|
Frog   456 ---FNFQFLXNEKIFEDKSITLCGSPKSIEGTTLSALQ---LSCGL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	15/64 (23%)
		leucine-rich repeat	176..198	CDD:275380	5/22 (23%)
		leucine-rich repeat	199..222	CDD:275380	6/27 (22%)
		LRR_RI	216..542	CDD:238064	85/375 (23%)
		LRR_8	221..281	CDD:290566	9/59 (15%)
		leucine-rich repeat	223..270	CDD:275380	8/46 (17%)
		leucine-rich repeat	271..294	CDD:275380	4/22 (18%)
		leucine-rich repeat	295..320	CDD:275380	10/34 (29%)
		leucine-rich repeat	321..343	CDD:275380	4/21 (19%)
		LRR_8	342..402	CDD:290566	16/64 (25%)
		leucine-rich repeat	344..367	CDD:275380	6/25 (24%)
		leucine-rich repeat	368..391	CDD:275380	4/24 (17%)
		LRR_8	390..450	CDD:290566	17/62 (27%)
		leucine-rich repeat	392..415	CDD:275380	6/22 (27%)
		leucine-rich repeat	416..439	CDD:275380	7/25 (28%)
		leucine-rich repeat	440..474	CDD:275380	7/36 (19%)
		leucine-rich repeat	475..498	CDD:275380	8/26 (31%)
		LRR_8	477..534	CDD:290566	20/85 (24%)
		leucine-rich repeat	499..520	CDD:275380	7/45 (16%)
		leucine-rich repeat	523..552	CDD:275380	6/28 (21%)
		LRRCT	561..619	CDD:214507	14/63 (22%)
		LRRNT	631..667	CDD:214470
		leucine-rich repeat	664..693	CDD:275380
		LRR_8	669..726	CDD:290566
		leucine-rich repeat	694..715	CDD:275380
		leucine-rich repeat	716..737	CDD:275380
		LRRCT	751..800	CDD:214507
		TIR	858..996	CDD:214587
cd180	XP_031762487.1	inl_like_NEAT_1	<71..>326	CDD:411101	68/300 (23%)
		leucine-rich repeat	138..158	CDD:275380	4/19 (21%)
		leucine-rich repeat	159..182	CDD:275380	5/22 (23%)
		leucine-rich repeat	183..206	CDD:275380	7/33 (21%)
		leucine-rich repeat	207..230	CDD:275380	6/25 (24%)
		leucine-rich repeat	231..256	CDD:275380	4/24 (17%)
		leucine-rich repeat	257..278	CDD:275380	6/22 (27%)
		leucine-rich repeat	279..305	CDD:275380	7/25 (28%)
		leucine-rich repeat	322..345	CDD:275380	5/22 (23%)
		LRR_8	369..427	CDD:404697	11/57 (19%)
		leucine-rich repeat	370..393	CDD:275380	1/22 (5%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..440	CDD:275380	8/33 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010