DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and tlr14.3

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	XP_004920451.1	Gene:	tlr14.3 / 100485201	XenbaseID:	XB-GENE-5909728	Length:	835	Species:	Xenopus tropicalis

Alignment Length:	897	Identity:	197/897 - (21%)
Similarity:	333/897 - (37%)	Gaps:	264/897 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 MPK-----LKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSAN 279
            :||     |.:|:|..|:|.::...||...|.:..:::..|.|..:....||....:|::.|..|
Frog    47 VPKDLPTTLVELDLSYNRLSHIQFDDFASFTHLRALNLSYNNISAIETGSFASNVLLTNLTLFNN 111

  Fly   280 LFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILRLRAELQS--LPGDLFEHST 342
            ....:|..||:..:.|..:.:.||....|||.:. |:....|:.|.:...|.|  |.||.    .
Frog   112 SLTEMPSALFEPLRFLQFLDISNNFYNCATLGAE-FSMLENLRNLSIGGPLVSKVLKGDF----A 171

  Fly   343 QITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDN------L 401
            .|.||||....|||: ::|..::....| ||:...|             ..|:.|:.|      :
Frog   172 PIKNISLQRFSLKTM-SSLWLYEKGAFS-DLNTQSL-------------WLDIALDTNPQALPRM 221

  Fly   402 LTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQIN 466
            |..::|..||:|           |.|.:....:.:           :.:|:...|.||.::
Frog   222 LKDLAGKAFSSL-----------RFRNLFEFTYYT-----------DAMDVFFGLADIFIK---- 260

  Fly   467 SPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNNISSLGYEDLAF---LSQNRLHVN 528
                             .:.|....:...:|:|...::..:||..|....:.|   ||.||..:.
Frog   261 -----------------ELTFYRGKFNENLLRLTLKNVEKSNIQDLFLLSIDFARSLSTNRTDIR 308

  Fly   529 MTHNKIRRIAL-----PEDVHLGEGYN--NNLVHVDL---NDNPLVCDCTILWFIQLVRGVHKPQ 583
            :....:||:.:     |:.:.....:.  |.:.|:|:   |.|.:.||.   | .|:|.
Frog   309 INDLALRRLVIKDVTNPDILRFDWTFTWFNKVSHLDIINVNFNFVPCDA---W-SQMVN------ 363

  Fly   584 YSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVI 648
             ..:..:..:||:.|  |:           ..|:|  .:|:
Frog   364 -VERLDISNNRLLAS--NL-----------YNLLC--QYSE------------------------ 388

  Fly   649 NCHSGNLTHVPRLPNLH------KNM--------------QLMELHLENNTLLRLPSAN--TPGY 691
                        |||||      .||              :|..|.|.:|.|..|....  ||
Frog   389 ------------LPNLHTFIASDNNMRSLYTLSLLTLTWPKLATLDLTSNYLGALDEVCTWTP-- 439

  Fly   692 ESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGN----- 751
             .:|.|.|..|.|.......||..:.|||:|.:.|:.|:   :.:.||..|.:.:.||.|
Frog   440 -QITKLILKDNTLKVGVFKCLPVTVEHLDMSNSLLERLD---MDYFNRATKLKVLILSQNKLKFI 500

  Fly   752 --PWMC-------------------------------------DCTAKPLLLFTQDNFER---IG 774
              .|.|                                     .||......||:...||   :.
Frog   501 SRDWKCPNLQVLGLEGNSFSVIDKGSFKDLPELRRLTAGDNPYHCTCDLYAFFTETLTERRVSLA 565

  Fly   775 DRNEMMCVNAEMPTRMVELSTNDICP--AEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIW 837
            |..|.  .|...|..:::.......|  .|..|.:.:|:.::.|.::......|.::|...
Frog   566 DWPEE--YNCYHPPHLLDTKVEFYNPGRVECDVRLVVAISVSTTAVVVMLCMLLCWRFDVP---- 624

  Fly   838 LYAHNLLLWFV--------------TEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKF 888
                    |::              :..| .:|..:.|||||||.|..::...|:.:||.....:
Frog   625 --------WYLRTTCSIVQSKYRSRSFHD-SRDYNYHAFISYSHSDADWVRGELLYRLESCSPPY 680

  Fly   889 QLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVI 953
            ::|:||||:|.|..|.:||:.::..||:.|.|||:||:.|||...|...||:.|:......:|::
Frog   681 RVCIHERDFLPGRWIIDNIIENIESSRKIIFVLSRNFVNSEWCNYELYFAHQRAIGHAFEDVILV 745

  Fly   954 IYSDI--GDVEKLDEELKAYLKMNTYLKWGDP-----WFWDKLRFALPHRRP 998
            :...:  .|:.|..::|:..::..|||:|...     :||.:|:..|....|
Frog   746 VKEKVTMEDLPKRFQKLRKMMRTKTYLEWPSEQNRQHFFWIQLKSILGKANP 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	6/17 (35%)
		leucine-rich repeat	176..198	CDD:275380
		leucine-rich repeat	199..222	CDD:275380	0/1 (0%)
		LRR_RI	216..542	CDD:238064	75/342 (22%)
		LRR_8	221..281	CDD:290566	17/64 (27%)
		leucine-rich repeat	223..270	CDD:275380	12/46 (26%)
		leucine-rich repeat	271..294	CDD:275380	6/22 (27%)
		leucine-rich repeat	295..320	CDD:275380	7/24 (29%)
		leucine-rich repeat	321..343	CDD:275380	7/23 (30%)
		LRR_8	342..402	CDD:290566	16/65 (25%)
		leucine-rich repeat	344..367	CDD:275380	9/22 (41%)
		leucine-rich repeat	368..391	CDD:275380	4/22 (18%)
		LRR_8	390..450	CDD:290566	10/65 (15%)
		leucine-rich repeat	392..415	CDD:275380	8/28 (29%)
		leucine-rich repeat	416..439	CDD:275380	2/22 (9%)
		leucine-rich repeat	440..474	CDD:275380	4/33 (12%)
		leucine-rich repeat	475..498	CDD:275380	1/22 (5%)
		LRR_8	477..534	CDD:290566	11/59 (19%)
		leucine-rich repeat	499..520	CDD:275380	5/23 (22%)
		leucine-rich repeat	523..552	CDD:275380	5/35 (14%)
		LRRCT	561..619	CDD:214507	11/57 (19%)
		LRRNT	631..667	CDD:214470	5/41 (12%)
		leucine-rich repeat	664..693	CDD:275380	12/50 (24%)
		LRR_8	669..726	CDD:290566	19/58 (33%)
		leucine-rich repeat	694..715	CDD:275380	7/20 (35%)
		leucine-rich repeat	716..737	CDD:275380	6/20 (30%)
		LRRCT	751..800	CDD:214507	13/95 (14%)
		TIR	858..996	CDD:214587	48/144 (33%)
tlr14.3	XP_004920451.1	LRR_8	54..113	CDD:338972	15/58 (26%)
		leucine-rich repeat	55..78	CDD:275378	7/22 (32%)
		leucine-rich repeat	79..102	CDD:275378	4/22 (18%)
		leucine-rich repeat	103..126	CDD:275378	6/22 (27%)
		leucine-rich repeat	127..151	CDD:275378	7/24 (29%)
		leucine-rich repeat	364..391	CDD:275380	8/77 (10%)
		leucine-rich repeat	392..417	CDD:275380	4/24 (17%)
		leucine-rich repeat	418..440	CDD:275380	8/24 (33%)
		leucine-rich repeat	441..462	CDD:275378	7/20 (35%)
		LRR_8	462..519	CDD:338972	14/59 (24%)
		leucine-rich repeat	463..486	CDD:275378	8/25 (32%)
		leucine-rich repeat	487..508	CDD:275378	5/20 (25%)
		leucine-rich repeat	509..532	CDD:275378	0/22 (0%)
		leucine-rich repeat	533..545	CDD:275378	0/11 (0%)
		TIR	651..788	CDD:214587	46/136 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3846
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.070