DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6420 and Wdr20rt

DIOPT Version :9

Sequence 1:	NP_001287545.1	Gene:	CG6420 / 43218	FlyBaseID:	FBgn0039451	Length:	909	Species:	Drosophila melanogaster
Sequence 2:	NP_081890.1	Gene:	Wdr20rt / 70948	MGIID:	1918198	Length:	567	Species:	Mus musculus

Alignment Length:	888	Identity:	302/888 - (34%)
Similarity:	383/888 - (43%)	Gaps:	329/888 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANQLDASVKDDLKTQFVTREGTYRLLTLSEYSRPNRVGYSSNQSSPQVRVSMVTLPSPAQGKLG 65
            ||.:......:::||.|.||||.||||..|||||||||.::|..|:| ||||.|.|.
Mouse     1 MATEGRGKETNEIKTHFTTREGLYRLLPHSEYSRPNRVPFNSQGSNP-VRVSFVNLN-------- 56

  Fly    66 SDVGVGTPVGGGTAGANTTTTNGSSPGASPTGAAGASTAISNGGAGGDYSHSNHNSNSAGNNTVE 130

Mouse    57 ----------------------------------------------------------------- 56

  Fly   131 ARLGGGISMHSMMNGGVVDQNGVATNQVLGGDRICFNFGRDLYVYSFRGAKKGTEMSKPIDKKFY 195
                              ||.|       .|:|:||:.||:||||.::|.:|..::||||||:.|
Mouse    57 ------------------DQTG-------NGNRLCFSVGRELYVYIYKGVRKAADLSKPIDKRIY 96

  Fly   196 KGTNPSCHDFNISSATPTGAPLLVGFTTGQIQLVSPHVGPREVRKLFNEERLIDKTKVTCLKWLP 260
            |||.|:|||||..:||.....|||||:.||:||:.|.  .:|..|||||||||||::|||:||:|
Mouse    97 KGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPI--KKETSKLFNEERLIDKSRVTCVKWVP 159

  Fly   261 NSPHLFLAAHASGHLYLYNEELPCAATAPSYQPFKLGDGYTILTSKSKTTRNPLFKWVFSTDNCC 325
            .|..|||.||:||::|.||.|.....|||.||..|.|:.:.:...|||:||:  .||  :.....
Mouse   160 GSDSLFLVAHSSGNMYSYNVEHTYGTTAPHYQLLKQGESFAVHNCKSKSTRD--LKW--TVGEGA 220

  Fly   326 VNEFCFSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCVCWSPDGKYIVVGGEDDLVT 390
            :|||.|||.|..||.||||||||||::|:.||.|..:|||||.||:||||||||||.||||||||
Mouse   221 LNEFAFSPDGKFLACVSQDGFLRVFNFDSAELHGTMKSYFGGLLCLCWSPDGKYIVTGGEDDLVT 285

  Fly   391 VWSLHERRVVARGQGHRSWVSVVAFDPYTTSYTNWDGGDFSDDENQMNEYSHSREARFSGDSTAN 455
            |||..:.||:|||:||:||||||||||||||....|..:|||.:....:..|.
Mouse   286 VWSFLDCRVIARGRGHKSWVSVVAFDPYTTSVEESDPMEFSDSDKNFQDLLHF------------ 338

  Fly   456 GGFEGFDR-NSTPVHADRNGPHSASFRSDASSAEKLMSYRLGSVSQDTQICLWDITEDVLRHPLV 519
                |.|| |||.....:        ::...|....::||.|||.||||:||||:|||:| .|
Mouse   339 ----GRDRANSTQSRLSK--------QNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDIL-FP-- 388

  Fly   520 LRQPANSERAYLNGGVDEEAEAEDGIKVIRPVAMSGQATGQQAESGSCSPTREAAGGGTGNGAGE 584
             .||.:..||:.|                                         ....||..||
Mouse   389 -HQPLSRARAHAN-----------------------------------------VMNATGLPAG- 410

  Fly   585 HSNSSSSKFSTANCTISSQSSPDDCDTEAATPASTSSNAGAGSVAGAGAVASTKQNNRNHGTGNS 649
             ||.|:       .|....|.|.......:.|.|..|||
Mouse   411 -SNGSA-------VTTPGNSVPPPLPRSNSLPHSAVSNA-------------------------- 441

  Fly   650 IKFPNCISATKSDSIDGGGGSGSGQRPSQTTSGYNSKTSNSSNKSSNSGSGFSAFNSLTQRLSNF 714
                    |:|...:||                                       ::|..:|.|
Mouse   442 --------ASKGSVMDG---------------------------------------AITSGVSKF 459

  Fly   715 SFLSSSEKKGAGYEGSHSTAHRQHRKAMSMLKSYNQHNHTGGHNNHSQSNNSSSSNFGHSSTLDS 779
            :.||..::|           .|.|.|...              .|||         .||.|:..|
Mouse   460 ALLSLHDRK-----------ERHHEKDRK--------------RNHS---------MGHISSKSS 490

  Fly   780 NAAGAIGSSSTAHSFGSLKLSRSSHHSSLATAAHASGSAAGSGSGVSSFDPMQLIGTPACPRFDE 844
            :....:..:.|                                      ||.:.:||..|||.::
Mouse   491 DKLNLVNKAKT--------------------------------------DPAKTLGTSLCPRMED 517

  Fly   845 CPLLEPLVCKKIAHERLTALIFREDCFLTACQDGFIYTWARPG 887
            .||||||:||||||||||.|:|.|||.:||||:|||.||||||
Mouse   518 VPLLEPLICKKIAHERLTVLVFLEDCIVTACQEGFICTWARPG 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6420	NP_001287545.1	WD40	<193..509	CDD:225201	162/316 (51%)
		WD40 repeat	208..249	CDD:293791	21/40 (53%)
		WD40 repeat	284..330	CDD:293791	16/45 (36%)
		WD40	<297..417	CDD:295369	74/119 (62%)
		WD40 repeat	369..404	CDD:293791	27/34 (79%)
Wdr20rt	NP_081890.1	WD40 repeat	102..143	CDD:293791	21/42 (50%)
		WD40	<122..295	CDD:225201	102/178 (57%)
		WD 1	147..187		21/39 (54%)
		WD40	149..>317	CDD:295369	104/171 (61%)
		WD40 repeat	153..204	CDD:293791	24/50 (48%)
		WD40 repeat	209..257	CDD:293791	27/51 (53%)
		WD 2	216..257		23/40 (58%)
		WD 3	258..297		30/38 (79%)
		WD40 repeat	264..299	CDD:293791	27/34 (79%)
		WD 4	345..389		21/55 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..441		11/41 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..493		11/58 (19%)
		WD 5	529..566		25/32 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841959
Domainoid	1	1.000	238	1.000	Domainoid score	I2293
eggNOG	1	0.900	-	-		E2759_KOG2394
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1190
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49265
OrthoDB	1	1.010	-	-		D308422at33208
OrthoFinder	1	1.000	-	-		FOG0002009
OrthoInspector	1	1.000	-	-		otm43983
orthoMCL	1	0.900	-	-		OOG6_102737
Panther	1	1.100	-	-	O	PTHR14107
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R157
SonicParanoid	1	1.000	-	-		X1319
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.890