DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6420 and Wdr20

DIOPT Version :9

Sequence 1:	NP_001287545.1	Gene:	CG6420 / 43218	FlyBaseID:	FBgn0039451	Length:	909	Species:	Drosophila melanogaster
Sequence 2:	XP_006516266.1	Gene:	Wdr20 / 69641	MGIID:	1916891	Length:	584	Species:	Mus musculus

Alignment Length:	888	Identity:	312/888 - (35%)
Similarity:	389/888 - (43%)	Gaps:	327/888 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANQLDASVKDDLKTQFVTREGTYRLLTLSEYSRPNRVGYSSNQSSPQVRVSMVTLPSPAQGKLG 65
            ||.:......:::||||.||||.|:||..|||||||||.::|..|:| ||||.|.|.
Mouse     1 MATEGGGKEMNEIKTQFTTREGLYKLLQHSEYSRPNRVPFNSQGSNP-VRVSFVNLN-------- 56

  Fly    66 SDVGVGTPVGGGTAGANTTTTNGSSPGASPTGAAGASTAISNGGAGGDYSHSNHNSNSAGNNTVE 130

Mouse    57 ----------------------------------------------------------------- 56

  Fly   131 ARLGGGISMHSMMNGGVVDQNGVATNQVLGGDRICFNFGRDLYVYSFRGAKKGTEMSKPIDKKFY 195
                              ||:|       .|||:|||.||:||.|.::|.:|..::||||||:.|
Mouse    57 ------------------DQSG-------NGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIY 96

  Fly   196 KGTNPSCHDFNISSATPTGAPLLVGFTTGQIQLVSPHVGPREVRKLFNEERLIDKTKVTCLKWLP 260
            |||.|:|||||:.:||.....|||||:.||:||:.|.  .:|..|||||||||||::|||:||:|
Mouse    97 KGTQPTCHDFNLLTATAESVSLLVGFSAGQVQLIDPI--KKETSKLFNEERLIDKSRVTCVKWVP 159

  Fly   261 NSPHLFLAAHASGHLYLYNEELPCAATAPSYQPFKLGDGYTILTSKSKTTRNPLFKWVFSTDNCC 325
            .|..|||.||:||::||||.|..|..|||.||..|.|:.:.:.|.|||:|||||.||  :.....
Mouse   160 GSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKW--TVGEGA 222

  Fly   326 VNEFCFSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCVCWSPDGKYIVVGGEDDLVT 390
            :|||.|||.|..||.||||||||||::|::||.|..:|||||.|||||||||||||.||||||||
Mouse   223 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 287

  Fly   391 VWSLHERRVVARGQGHRSWVSVVAFDPYTTSYTNWDGGDFSDDENQMNEYSHSREARFSGDSTAN 455
            |||..:.||:|||.||:||||||||||||||....|..:||..:....:..|.
Mouse   288 VWSFLDCRVIARGHGHKSWVSVVAFDPYTTSVEESDPMEFSGSDEDFQDLLHF------------ 340

  Fly   456 GGFEGFDR-NSTPVHADRNGPHSASFRSDASSAEKLMSYRLGSVSQDTQICLWDITEDVLRHPLV 519
                |.|| |||.....:        |:...|....::||.|||.||||:||||:|||:| .|
Mouse   341 ----GRDRANSTQSRLSK--------RNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDIL-FP-- 390

  Fly   520 LRQPANSERAYLNGGVDEEAEAEDGIKVIRPVAMSGQATGQQAESGSCSPTREAAGGGTGNGAGE 584
             .||.:..|.:.|                                         ....|...||.
Mouse   391 -HQPLSRARTHTN-----------------------------------------VMNATSPPAGS 413

  Fly   585 HSNSSSSKFSTANCTISSQSSPDDCDTEAATPASTSSNAGAGSVAGAGAVASTKQNNRNHGTGNS 649
            :.||         .|....|.|.......:.|.|..|||
Mouse   414 NGNS---------VTTPGNSVPPPLPRSNSLPHSAVSNA-------------------------- 443

  Fly   650 IKFPNCISATKSDSIDGGGGSGSGQRPSQTTSGYNSKTSNSSNKSSNSGSGFSAFNSLTQRLSNF 714
                    |:|...:||...||                                       :|.|
Mouse   444 --------ASKGSVMDGAIASG---------------------------------------VSKF 461

  Fly   715 SFLSSSEKKGAGYEGSHSTAHRQHRKAMSMLKSYNQHNHTGGHNNHSQSNNSSSSNFGHSSTLDS 779
            :.||..::|    |..|...|::                     |||         .||.|
Mouse   462 ATLSLHDRK----ERHHEKDHKR---------------------NHS---------MGHIS---- 488

  Fly   780 NAAGAIGSSSTAHSFGSLKLSRSSHHSSLATAAHASGSAAGSGSGVSSFDPMQLIGTPACPRFDE 844
                                |:||...:|.|.|..              ||.:.:||..|||.::
Mouse   489 --------------------SKSSDKLNLVTKAKT--------------DPAKTLGTSLCPRMED 519

  Fly   845 CPLLEPLVCKKIAHERLTALIFREDCFLTACQDGFIYTWARPG 887
            .||||||:||||||||||.|:|.|||.:||||:|||.||||||
Mouse   520 VPLLEPLICKKIAHERLTVLVFLEDCIVTACQEGFICTWARPG 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6420	NP_001287545.1	WD40	<193..509	CDD:225201	169/316 (53%)
		WD40 repeat	208..249	CDD:293791	21/40 (53%)
		WD40 repeat	284..330	CDD:293791	21/45 (47%)
		WD40	<297..417	CDD:295369	79/119 (66%)
		WD40 repeat	369..404	CDD:293791	28/34 (82%)
Wdr20	XP_006516266.1	WD40	149..>314	CDD:392136	106/166 (64%)
		WD40 repeat	153..218	CDD:293791	37/66 (56%)
		WD40 repeat	223..259	CDD:293791	23/35 (66%)
		WD40 repeat	266..299	CDD:293791	26/32 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841957
Domainoid	1	1.000	238	1.000	Domainoid score	I2293
eggNOG	1	0.900	-	-		E2759_KOG2394
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32684
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1190
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49265
OrthoDB	1	1.010	-	-		D308422at33208
OrthoFinder	1	1.000	-	-		FOG0002009
OrthoInspector	1	1.000	-	-		otm43983
orthoMCL	1	0.900	-	-		OOG6_102737
Panther	1	1.100	-	-	O	PTHR14107
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R157
SonicParanoid	1	1.000	-	-		X1319
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800