DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6420 and Dmwd

DIOPT Version :9

Sequence 1:	NP_001287545.1	Gene:	CG6420 / 43218	FlyBaseID:	FBgn0039451	Length:	909	Species:	Drosophila melanogaster
Sequence 2:	XP_008757259.1	Gene:	Dmwd / 680252	RGDID:	1594179	Length:	665	Species:	Rattus norvegicus

Alignment Length:	927	Identity:	321/927 - (34%)
Similarity:	400/927 - (43%)	Gaps:	311/927 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DLKTQFVTREGTYRLLTLSEYSRPNRVGYSSNQSSPQVRVSMVTLPSPAQGKLGSDVGVGTPVGG 76
            ::|:||.||||.|:||.          |.::.:|.|    :....|:|.|
  Rat    21 EIKSQFRTREGFYKLLP----------GDATRRSGP----TSAQTPAPPQ--------------- 56

  Fly    77 GTAGANTTTTNGSSPGASPTGAAGASTAISNGGAGGDYSHSNHNSNSAGNNTVEARLGGGISMHS 141
                          |...|.|.|.|    |..||.|..|.........|......||       |
  Rat    57 --------------PTQPPPGPASA----SGPGAAGPASSPPPAGPGPGPALPAVRL-------S 96

  Fly   142 MMNGGVVDQNG----VATNQVLGGDRICFNFGRDLYVY---SFRGAKKGTEMSKPIDKKFYKGTN 199
            ::..|..|..|    ..:....||||:|||.||:||.|   ..||:::..:::|||||:.||||.
  Rat    97 LVRLGDPDGTGEPPSTPSGLGAGGDRVCFNLGRELYFYPGCCRRGSQRSIDLNKPIDKRIYKGTQ 161

  Fly   200 PSCHDFNISSATPTGAPLLVGFTTGQIQLVSPHVGPREVRKLFNEERLIDKTKVTCLKWLPNSPH 264
            |:|||||..:|......|||||:.||:|.:.  :..::..|||||||||||||||.|||||.|..
  Rat   162 PTCHDFNQFTAATETISLLVGFSAGQVQYLD--LIKKDTSKLFNEERLIDKTKVTYLKWLPESES 224

  Fly   265 LFLAAHASGHLYLYNEELPCAATAPSYQPFKLGDGYTILTSKSKTTRNPLFKWVFSTDNCCVNEF 329
            ||||:||||||||||...|||:|.|.|...|.|:|:.:..:|||..||||.||......  :|||
  Rat   225 LFLASHASGHLYLYNVSHPCASTPPQYSLLKQGEGFAVYAAKSKAPRNPLAKWAVGEGP--LNEF 287

  Fly   330 CFSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCVCWSPDGKYIVVGGEDDLVTVWSL 394
            .|||.|.|||.|||||.|||||:|:|.|.|:.:|||||.|||||||||:|:|.|||||||||||.
  Rat   288 AFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSF 352

  Fly   395 HERRVVARGQGHRSWVSVVAFDPYTTSYTNWDGGDFSDDENQMNEYSHSREARFSGDSTANGGFE 459
            .|.||||||.||:|||:.||||||||                    .....|..|||...:|..|
  Rat   353 TEGRVVARGHGHKSWVNAVAFDPYTT--------------------RAEETASASGDGDPSGEEE 397

  Fly   460 GFDRNSTPVHADRNGPHSASFRSDASSAEKLMSYRLGSVSQDTQICLWDITEDVLR-HPLVLRQP 523
            ..:..|    :|...|.|...::.:      ::||.||..||||.||||:|||||. ||.:.|
  Rat   398 EPEATS----SDTGAPVSPLPKAGS------VTYRFGSAGQDTQFCLWDLTEDVLSPHPPLAR-- 450

  Fly   524 ANSERAYLNGGVDEEAEAEDGIKVIRPVAMSGQATGQQAESGSCSPTREAAGGGTGNGAGEHSNS 588
                                                          ||...|
  Rat   451 ----------------------------------------------TRTLPG------------- 456

  Fly   589 SSSKFSTANCTISSQSSPDDCDTEAAT-PASTSSNAGAGSVAGAGAVASTKQNNRNHGTGNSIKF 652
                                  |..|| |||..|.||.   .|||.:.      |:....||:..
  Rat   457 ----------------------TPGATPPASGGSRAGE---TGAGPLP------RSLSRSNSLPH 490

  Fly   653 PNCISATKSDSIDGGGGSGSGQRPSQTTSGYNSKTSNSSNKSSNSGSGFSAFNSLTQRLSNFSFL 717
            |            .|||...|  ||               .|...|..||        :..|:.|
  Rat   491 P------------AGGGKAGG--PS---------------VSMEPGVPFS--------IGRFATL 518

  Fly   718 SSSEKKGAGYEGSHSTAHRQHRKAMSMLKSYNQHNHTGGHNNHSQSNNSSSSNFGHSSTLDSNAA 782
            :..|::..|.|..|              |.|           ||..|.|...:.|:||
  Rat   519 TLQERRDRGAEKEH--------------KRY-----------HSLGNISRGGSGGNSS------- 551

  Fly   783 GAIGSSSTAHSFGSLKLSRSSHHSSLATAAHASGSAAGSGSGVSSFDPMQLIGTPACPRFDECPL 847
                         :.||:..:..|.|                    ||.:::||..|||..|.||
  Rat   552 -------------NDKLNGPAPRSRL--------------------DPAKVLGTALCPRIHEVPL 583

  Fly   848 LEPLVCKKIAHERLTALIFREDCFLTACQDGFIYTWARPGHA-------THA------------- 892
            ||||||||||.||||.|:|.|||.:||||:|.:.||||||.|       |.|
  Rat   584 LEPLVCKKIAQERLTVLLFLEDCIITACQEGLVCTWARPGKAFTDEETETQAGEASWPRSPSKSV 648

  Fly   893 TQHLSPGQAAAPGGTVI 909
            .:.:|....::|.|||:
  Rat   649 VEGISSQPGSSPSGTVV 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6420	NP_001287545.1	WD40	<193..509	CDD:225201	164/315 (52%)
		WD40 repeat	208..249	CDD:293791	17/40 (43%)
		WD40 repeat	284..330	CDD:293791	19/45 (42%)
		WD40	<297..417	CDD:295369	77/119 (65%)
		WD40 repeat	369..404	CDD:293791	28/34 (82%)
Dmwd	XP_008757259.1	WD40 repeat	214..279	CDD:293791	39/64 (61%)
		WD40	<281..>375	CDD:421866	66/95 (69%)
		WD40 repeat	284..319	CDD:293791	24/34 (71%)
		WD40 repeat	327..360	CDD:293791	26/32 (81%)
		WD40 repeat	368..403	CDD:293791	15/54 (28%)
		WD40 repeat	410..455	CDD:293791	23/98 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345352
Domainoid	1	1.000	202	1.000	Domainoid score	I2894
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	466	1.000	Inparanoid score	I1473
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D308422at33208
OrthoFinder	1	1.000	-	-		FOG0002009
OrthoInspector	1	1.000	-	-		otm46073
orthoMCL	1	0.900	-	-		OOG6_102737
Panther	1	1.100	-	-	LDO	PTHR14107
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1319
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.860