DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6420 and wdr20

DIOPT Version :9

Sequence 1:	NP_001287545.1	Gene:	CG6420 / 43218	FlyBaseID:	FBgn0039451	Length:	909	Species:	Drosophila melanogaster
Sequence 2:	XP_012823778.1	Gene:	wdr20 / 496935	XenbaseID:	XB-GENE-5780752	Length:	586	Species:	Xenopus tropicalis

Alignment Length:	916	Identity:	323/916 - (35%)
Similarity:	406/916 - (44%)	Gaps:	337/916 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANQLDASVKDDLKTQFVTREGTYRLLTLSEYSRPNRVGYSSNQSSPQVRVSMVTLPSPAQGKLG 65
            ||.:......:::||||.||||.|:||:.|||||||||.::|..|:| |:||.|
Frog     1 MAAEGGGKEMNEIKTQFTTREGLYKLLSHSEYSRPNRVPFNSQGSNP-VKVSFV----------- 53

  Fly    66 SDVGVGTPVGGGTAGANTTTTNGSSPGASPTGAAGASTAISNGGAGGDYSHSNHNSNSAGNNTVE 130

Frog    54 ----------------------------------------------------------------- 53

  Fly   131 ARLGGGISMHSMMNGGVVDQNGVATNQVLGGDRICFNFGRDLYVYSFRGAKKGTEMSKPIDKKFY 195
                           .|.||:|       .|||||||.||:||.|.::|.:|..::||||||:.|
Frog    54 ---------------NVNDQSG-------NGDRICFNVGRELYFYIYKGVRKAADLSKPIDKRIY 96

  Fly   196 KGTNPSCHDFNISSATPTGAPLLVGFTTGQIQLVSPHVGPREVRKLFNEERLIDKTKVTCLKWLP 260
            |||.|:|||||..:||.....|||||:.||:||:.|.  .:|..|||||||||||::||.:||:|
Frog    97 KGTQPTCHDFNHLTATADSVSLLVGFSAGQVQLIDPI--KKETSKLFNEERLIDKSRVTSVKWVP 159

  Fly   261 NSPHLFLAAHASGHLYLYNEELPCAATAPSYQPFKLGDGYTILTSKSKTTRNPLFKWVFSTDNCC 325
            .|..|||.||:||::||||.|..|..|||.||..|.|:.:.:.|.|||:|||||.||  :.....
Frog   160 GSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKW--TVGEGA 222

  Fly   326 VNEFCFSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCVCWSPDGKYIVVGGEDDLVT 390
            :|||.|||.|..||.||||||||||::|::||.|..:|||||.|||||||||||||.||||||||
Frog   223 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 287

  Fly   391 VWSLHERRVVARGQGHRSWVSVVAFDPYTTSYTNWDGGDFSDDENQMNEY-------SHSREARF 448
            |||..:.||:||||||:||||||||||.|||....|..:||..:....|.       ::|.::|.
Frog   288 VWSFVDCRVIARGQGHKSWVSVVAFDPNTTSVEETDPMEFSGSDEDFQELISFGRDRANSTQSRL 352

  Fly   449 SGDSTANGGFEGFDRNSTPVHADRNGPHSASFRSDASSAEKLMSYRLGSVSQDTQICLWDITEDV 513
            |            .||||                  .|....::||.|||.||||:||||:|||:
Frog   353 S------------KRNST------------------DSRPVSVTYRFGSVGQDTQLCLWDLTEDI 387

  Fly   514 LRHPLVLRQPANSERAYLNGGVDEEAEAEDGIKVIRPVAMSGQATGQQAESGSCSPTREAAGGGT 578
            | .|   .||.:..|.:.|                   .|:  ||...|.||..:|      |..
Frog   388 L-FP---HQPLSRTRTHTN-------------------VMN--ATSPPAGSGGPNP------GSN 421

  Fly   579 GNGAGEHSNSSSSKFSTANCTISSQSSPDDCDTEAATPASTSSNAGAGSVAGAGAVASTKQNNRN 643
            ||                :.|....|.|.......:.|.|..||||:.|
Frog   422 GN----------------SITTPGNSIPPPLPRSNSLPHSAVSNAGSKS---------------- 454

  Fly   644 HGTGNSIKFPNCISATKSDSIDGGGGSGSGQRPSQTTSGYNSKTSNSSNKSSNSGSGFSAFNSLT 708
                               |:|....||
Frog   455 -------------------SVDSAIASG------------------------------------- 463

  Fly   709 QRLSNFSFLSSSEKKGAGYEGSHSTAHRQHRKAMSMLKSYNQHNHTGGHNNHSQSNNSSSSNFGH 773
              :|.|:.||..::|     ..|...|::                     |||         .||
Frog   464 --VSKFATLSLHDRK-----ERHDKDHKR---------------------NHS---------MGH 491

  Fly   774 SSTLDSNAAGAIGSSSTAHSFGSLKLSRSSHHSSLATAAHASGSAAGSGSGVSSFDPMQLIGTPA 838
            .|                        |:||...:|.|.              :..||.:.:|||.
Frog   492 IS------------------------SKSSDKLNLVTK--------------NKTDPAKTLGTPL 518

  Fly   839 CPRFDECPLLEPLVCKKIAHERLTALIFREDCFLTACQDGFIYTWARPGHATHATQHLSPGQAAA 903
            |||.::.||||||:||||||||||.|||.|||.:||||:|||.||||||.....:   |..||.:
Frog   519 CPRMEDVPLLEPLICKKIAHERLTVLIFLEDCIVTACQEGFICTWARPGKVGLLS---SQNQANS 580

  Fly   904 PGGTVI 909
            |.|||:
Frog   581 PSGTVV 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6420	NP_001287545.1	WD40	<193..509	CDD:225201	168/322 (52%)
		WD40 repeat	208..249	CDD:293791	21/40 (53%)
		WD40 repeat	284..330	CDD:293791	21/45 (47%)
		WD40	<297..417	CDD:295369	80/119 (67%)
		WD40 repeat	369..404	CDD:293791	28/34 (82%)
wdr20	XP_012823778.1	WD40 repeat	102..143	CDD:293791	21/42 (50%)
		WD40	149..>319	CDD:392136	110/171 (64%)
		WD40 repeat	153..218	CDD:293791	36/66 (55%)
		WD40 repeat	223..259	CDD:293791	23/35 (66%)
		WD40 repeat	266..301	CDD:293791	28/34 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	201	1.000	Domainoid score	I2973
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32684
Inparanoid	1	1.050	384	1.000	Inparanoid score	I1988
OMA	1	1.010	-	-		QHG49265
OrthoDB	1	1.010	-	-		D308422at33208
OrthoFinder	1	1.000	-	-		FOG0002009
OrthoInspector	1	1.000	-	-		oto104878
Panther	1	1.100	-	-	O	PTHR14107
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R157
SonicParanoid	1	1.000	-	-		X1319
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110