DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6420 and wdr-20

DIOPT Version :9

Sequence 1:	NP_001287545.1	Gene:	CG6420 / 43218	FlyBaseID:	FBgn0039451	Length:	909	Species:	Drosophila melanogaster
Sequence 2:	NP_001370272.1	Gene:	wdr-20 / 179410	WormBaseID:	WBGene00007428	Length:	768	Species:	Caenorhabditis elegans

Alignment Length:	930	Identity:	270/930 - (29%)
Similarity:	380/930 - (40%)	Gaps:	303/930 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KDDLKTQFVTREGTYRLLTLSEYSRPNRVGYSSNQSSPQVRVSMVTLPSPAQGKLGSDVGVGTPV 74
            ::::|..|.||||.||.:..:|:|||..:        ||..     :|.          |:.:..
Worm    38 REEIKKNFETREGVYRSVPSAEFSRPRPL--------PQYH-----MPP----------GIASAA 79

  Fly    75 GGGTAGANTTT----TNGSSPGA-SPTGAAGASTAISNGGAGGDYSHSNHNSNSAGNNTVEARLG 134
            ....|.|.:|.    .||:.... ||...|..|:.         |.|..:..|           |
Worm    80 ASQIAAAGSTVRVSFLNGAEKSVESPEAVAPTSST---------YEHHKNEPN-----------G 124

  Fly   135 GGISMHSMMNGGVVDQNGVATNQVLGGDRICFNFGRDLYVYSFRGAKKGTEMSKPIDKKFYKGTN 199
            ..|.|        ||:        ...|:||||.|::|||:|:||.:..|::|:||||:.||||:
Worm   125 ARIDM--------VDE--------AQADKICFNVGKELYVFSYRGTQTETDLSRPIDKRVYKGTS 173

  Fly   200 PSCHDFNISSATPTGAPLLVGFTTGQIQLVSP--HVGPREVRKLFNEERLIDKTKVTCLKWLPNS 262
            |:.|.||..||......||:|||.||:|::.|  ........:|:||:|.|:||.|||::|||..
Worm   174 PTYHAFNQESAKNGSCQLLIGFTLGQLQIIDPLEKSSSSPFSRLYNEDRYIEKTSVTCIRWLPGD 238

  Fly   263 PHLFLAAHASGHLYLYNEELPCAAT-------APSYQPFKLGDGYTILTSKSKTTRNPLFKWVFS 320
            .::|||::.||:||:|::.:..|::       .|.:...|.||.:.|.|.|.|..|||:.:|...
Worm   239 SNIFLASYVSGNLYVYDQRISAASSNNNGSSQPPPWTIHKEGDKFAIHTWKGKVQRNPVTRWQIG 303

  Fly   321 TDNCCVNEFCFSPC-GSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCVCWSPDGKYIVVGG 384
            ..:  :::|.||.. |..:|.||.|||||:|:|...|||.:.:|||||.|.:.||||.|.|..||
Worm   304 EGS--IHQFSFSGSDGKMMATVSHDGFLRIFNYHAQELLAVMKSYFGGLLTLSWSPDAKLIATGG 366

  Fly   385 EDDLVTVWSLHERRVVARGQGHRSWVSVVAFDPY--TTSYTNWDGGDFSDDENQMNEYSHSREAR 447
            ||||:||:|:.|:|||.|||.|:||||.|.||||  ||.         .|.||.          .
Worm   367 EDDLLTVYSVAEKRVVCRGQAHKSWVSQVKFDPYLCTTE---------EDLENN----------G 412

  Fly   448 FSGDSTANGGFEGFDRNSTPV---HADRNGP-----------HSASFRS-DASSAEKLMSYRLGS 497
            .:..||.:...:.|...|.||   .||.|..           ..|||.: :.:.|...:.||:||
Worm   413 IAMTSTFDDVAKDFSIRSGPVPSTSADLNSGVMNATSTFSRCSLASFNTINGAPAGNSVRYRIGS 477

  Fly   498 VSQDTQICLWDITEDVLRHPLVLRQPANSERAYLNGGVDEEAEAEDGIKVIRPVAMSGQATGQQA 562
            |..||.:||||||||:|....: |:..||                   .:|.|:......|....
Worm   478 VGHDTFLCLWDITEDMLNQGNI-RRHRNS-------------------TIIAPMTTLEVQTNSLV 522

  Fly   563 ESGSCSPTREAAGGGTGNGAGEHSNSSSSKFSTANCTISSQSSPDDCDTEAATPASTSSNAGAGS 627
              |.....:|.:.||.|      .|:||...|..|
Worm   523 --GRLEDLQEVSPGGAG------VNASSDSQSITN------------------------------ 549

  Fly   628 VAGAGAVASTKQNNRNHGTGNSIKFPNCISATKSDSIDGGGGSGSGQRPSQTTSGYNSKTSNSSN 692
                           ||.|                           .||.:           ...
Worm   550 ---------------NHTT---------------------------PRPEK-----------QKK 561

  Fly   693 KSSNSGSGFSAFNSLTQRLSNFSFLSSSEKKGAGYEGSHSTAHRQHRKAMSMLKSYNQHNHTGGH 757
            |......|||.|.|                      ||.|..                .|..|||
Worm   562 KKFTKRLGFSKFTS----------------------GSSSAT----------------SNPVGGH 588

  Fly   758 NNHSQSNNSSSSNFGHSSTLDSNAAGAIGSSSTAHSFGSLKLSRSSHHSSLATAAHASGSAAGSG 822
            .                       .|.:.:.::.:|..|.|.:                  .|..
Worm   589 K-----------------------IGTLMNGASVNSESSKKQN------------------PGLI 612

  Fly   823 SGVSSFDPMQLIGTPACPRFDECPLLEPLVCKKIAHERLTALIFREDCFLTACQDGFIYTWARPG 887
            |.:|..:..:::|:..||...:.|::|||:|||::|:|||.|.|||||.:||||:|:|.||.|||
Worm   613 SQISCCNETRMLGSKFCPGIRDVPMIEPLMCKKVSHDRLTVLEFREDCVVTACQEGYICTWGRPG 677

  Fly   888 HATHATQHL-SPGQAAAPGG 906
            ........: |||.|:...|
Worm   678 RYQPKRDCINSPGTASPESG 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6420	NP_001287545.1	WD40	<193..509	CDD:225201	136/342 (40%)
		WD40 repeat	208..249	CDD:293791	15/42 (36%)
		WD40 repeat	284..330	CDD:293791	13/52 (25%)
		WD40	<297..417	CDD:295369	62/120 (52%)
		WD40 repeat	369..404	CDD:293791	21/34 (62%)
wdr-20	NP_001370272.1	WD40 repeat	229..266	CDD:293791	15/36 (42%)
		WD40	<304..407	CDD:421866	57/113 (50%)
		WD40 repeat	310..344	CDD:293791	17/33 (52%)
		WD40 repeat	350..385	CDD:293791	20/34 (59%)
		WD40 repeat	468..500	CDD:293791	16/32 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162199
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32684
Inparanoid	1	1.050	382	1.000	Inparanoid score	I1185
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49265
OrthoDB	1	1.010	-	-		D308422at33208
OrthoFinder	1	1.000	-	-		FOG0002009
OrthoInspector	1	1.000	-	-		oto17787
orthoMCL	1	0.900	-	-		OOG6_102737
Panther	1	1.100	-	-	LDO	PTHR14107
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R157
SonicParanoid	1	1.000	-	-		X1319
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.940