Protein Alignment CG6420 and DMWD

DIOPT Version :10

• Sequence 1: NP_651499.2
• Gene: CG6420 / 43218
• FlyBaseID: FBgn0039451
• Length: 909
• Species: Drosophila melanogaster
• Sequence 2: NP_004934.1
• Gene: DMWD / 1762
• HGNCID: 2936
• Length: 674
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 68/332 - (20%)
• Similarity: 127/332 - (38%)
• Gaps: 93/332 - (28%)

  Fly    57 LTAEQMYSVLE--FGAPDRKQTVADNYRRLMERLATDSTVNVANKIY-VMQNYAVKGAFNAIATG 118
            ||:.::.::.:  .|:.:....|.|...||.         |..:|.: |:.:|.:.  :..:.||
Human   751 LTSYELITIDQAILGSIEWACLVVDEAHRLK---------NNQSKFFRVLNSYKID--YKLLLTG 804

  Fly   119 S-FRSEAES----VNFAESAAAAKKINGWVEEKTN-------NKIKDLISPDALDELSRMVLVNA 171
            : .::..|.    :||. :......:.|::||..:       .|:.||:.|..|..|...|..|.
Human   805 TPLQNNLEELFHLLNFL-TPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNM 868

  Fly   172 VHFKGTWTYQFDPSLTRPF-PFWLSETESRDVPMMNIKKHFAF---NNFEELGFSALELTYGGSD 232
                        |:.|... ...||:.:         ||::.|   .|||     ||....||:.
Human   869 ------------PAKTELIVRVELSQMQ---------KKYYKFILTRNFE-----ALNSKGGGNQ 907

  Fly   233 MTMMLLLPNER--------MGLAALEEKLPTL--------NLAELAGKMHKQEVEVFLPKFKIEF 281
            ::::.::.:.:        ..:||:|  .|.|        :|.:.:||:  ..::..|.|.:.|.
Human   908 VSLLNIMMDLKKCCNHPYLFPVAAVE--APVLPNGSYDGSSLVKSSGKL--MLLQKMLKKLRDEG 968

  Fly   282 TRDLNEDLQALGMERMFSDSAEFPDLLE---QNEPMKVSKVVHKAFIEVNEEGTEAAAATAMIAV 343
            .|.|           :||...:..||||   :.|..|..::.......:.:|..:...|..  |.
Human   969 HRVL-----------IFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPG--AQ 1020

  Fly   344 SFCMIIS 350
            .||.::|
Human  1021 QFCFLLS 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6420	NP_651499.2	WD40 repeat	208..249	CDD:293791	11/51 (22%)
		WD40 repeat	284..330	CDD:293791	9/48 (19%)
		WD40	<298..417	CDD:441893	14/56 (25%)
		WD40 repeat	369..404	CDD:293791
DMWD	NP_004934.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..92
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	103..122
		WD 1. /evidence=ECO:0000255	211..251
		WD40 repeat	217..282	CDD:293791
		WD40	<276..378	CDD:441893
		WD 2. /evidence=ECO:0000255	282..321
		WD40 repeat	287..322	CDD:293791
		WD 3. /evidence=ECO:0000255	324..363
		WD40 repeat	330..363	CDD:293791
		WD 4. /evidence=ECO:0000255	366..409
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	384..419
		WD 5. /evidence=ECO:0000255	413..453
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	456..516
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..573
		WD 6. /evidence=ECO:0000255	601..638
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..674