Protein Alignment CG6420 and Dmwd

DIOPT Version :10

• Sequence 1: NP_651499.2
• Gene: CG6420 / 43218
• FlyBaseID: FBgn0039451
• Length: 909
• Species: Drosophila melanogaster
• Sequence 2: NP_034188.2
• Gene: Dmwd / 13401
• MGIID: 94907
• Length: 665
• Species: Mus musculus
• Alignment Length: 927
• Identity: 320/927 - (34%)
• Similarity: 398/927 - (42%)
• Gaps: 311/927 - (33%)

  Fly    12 DLKTQFVTREGTYRLLTLSEYSRPNRVGYSSNQSSPQVRVSMVTLPSPAQGKLGSDVGVGTPVGG 76
            ::|:||.||||.|:||.          |.::.:|.|    :....|:|.|
Mouse    21 EIKSQFRTREGFYKLLP----------GDATRRSGP----TSAQTPAPPQ--------------- 56

  Fly    77 GTAGANTTTTNGSSPGASPTGAAGASTAISNGGAGGDYSHSNHNSNSAGNNTVEARLGGGISMHS 141
                          |...|.|.|.|    |..||.|..|.........|......||       |
Mouse    57 --------------PTQPPPGPAAA----SGPGAAGPASSPPPAGPGPGPALPAVRL-------S 96

  Fly   142 MMNGGVVDQNG----VATNQVLGGDRICFNFGRDLYVY---SFRGAKKGTEMSKPIDKKFYKGTN 199
            ::..|..|..|    ..:....||||:|||.||:||.|   ...|:::..:::|||||:.||||.
Mouse    97 LVRLGDPDGAGEPPSTPSGLGAGGDRVCFNLGRELYFYPGCCRSGSQRSIDLNKPIDKRIYKGTQ 161

  Fly   200 PSCHDFNISSATPTGAPLLVGFTTGQIQLVSPHVGPREVRKLFNEERLIDKTKVTCLKWLPNSPH 264
            |:|||||..:|......|||||:.||:|.:.  :..::..|||||||||||||||.|||||.|..
Mouse   162 PTCHDFNQFTAATETISLLVGFSAGQVQYLD--LIKKDTSKLFNEERLIDKTKVTYLKWLPESES 224

  Fly   265 LFLAAHASGHLYLYNEELPCAATAPSYQPFKLGDGYTILTSKSKTTRNPLFKWVFSTDNCCVNEF 329
            ||||:||||||||||...||.:|.|.|...|.|:|:.:..:|||..||||.||......  :|||
Mouse   225 LFLASHASGHLYLYNVSHPCTSTPPQYSLLKQGEGFAVYAAKSKAPRNPLAKWAVGEGP--LNEF 287

  Fly   330 CFSPCGSHLAVVSQDGFLRVFHYDTMELLGIARSYFGGFLCVCWSPDGKYIVVGGEDDLVTVWSL 394
            .|||.|.|||.|||||.|||||:|:|.|.|:.:|||||.|||||||||:|:|.|||||||||||.
Mouse   288 AFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSF 352

  Fly   395 HERRVVARGQGHRSWVSVVAFDPYTTSYTNWDGGDFSDDENQMNEYSHSREARFSGDSTANGGFE 459
            .|.||||||.||:|||:.||||||||                        .|..:..::|:|...
Mouse   353 TEGRVVARGHGHKSWVNAVAFDPYTT------------------------RAEEAASASADGDPS 393

  Fly   460 GFDRNSTPVHADRNGPHSASFRSDASSAEKLMSYRLGSVSQDTQICLWDITEDVLR-HPLVLRQP 523
            |.:.......:|...|.|...::.:      ::||.||..||||.||||:|||||. ||.:.|
Mouse   394 GEEEEPEVTSSDTGAPVSPLPKAGS------ITYRFGSAGQDTQFCLWDLTEDVLSPHPSLAR-- 450

  Fly   524 ANSERAYLNGGVDEEAEAEDGIKVIRPVAMSGQATGQQAESGSCSPTREAAGGGTGNGAGEHSNS 588
                                                          ||...|
Mouse   451 ----------------------------------------------TRTLPG------------- 456

  Fly   589 SSSKFSTANCTISSQSSPDDCDTEAAT-PASTSSNAGAGSVAGAGAVASTKQNNRNHGTGNSIKF 652
                                  |..|| |||.||.||.   .|||.:.      |:....||:..
Mouse   457 ----------------------TPGATPPASGSSRAGE---TGAGPLP------RSLSRSNSLPH 490

  Fly   653 PNCISATKSDSIDGGGGSGSGQRPSQTTSGYNSKTSNSSNKSSNSGSGFSAFNSLTQRLSNFSFL 717
            |            .|||...|  ||               .|...|..||        :..|:.|
Mouse   491 P------------AGGGKAGG--PS---------------ASMEPGIPFS--------IGRFATL 518

  Fly   718 SSSEKKGAGYEGSHSTAHRQHRKAMSMLKSYNQHNHTGGHNNHSQSNNSSSSNFGHSSTLDSNAA 782
            :..|::..|.|..|              |.|           ||..|.|...:.|:||
Mouse   519 TLQERRDRGAEKEH--------------KRY-----------HSLGNISRGGSGGNSS------- 551

  Fly   783 GAIGSSSTAHSFGSLKLSRSSHHSSLATAAHASGSAAGSGSGVSSFDPMQLIGTPACPRFDECPL 847
                         :.|||..:..|.|                    ||.:::||..|||..|.||
Mouse   552 -------------NDKLSGPAPRSRL--------------------DPAKVLGTALCPRIHEVPL 583

  Fly   848 LEPLVCKKIAHERLTALIFREDCFLTACQDGFIYTWARPGHA-THATQHLSPGQA---------- 901
            ||||||||||.||||.|:|.|||.:||||:|.|.||||||.| |........|||
Mouse   584 LEPLVCKKIAQERLTVLLFLEDCIITACQEGLICTWARPGKAFTDEETEAQAGQASWPRSPSKSV 648

  Fly   902 ---------AAPGGTVI 909
                     ::|.|||:
Mouse   649 VEGISSQPGSSPSGTVV 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6420	NP_651499.2	WD40 repeat	208..249	CDD:293791	17/40 (43%)
		WD40 repeat	284..330	CDD:293791	18/45 (40%)
		WD40	<298..417	CDD:441893	76/118 (64%)
		WD40 repeat	369..404	CDD:293791	28/34 (82%)
Dmwd	NP_034188.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..91		27/116 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..119		3/18 (17%)
		WD 1. /evidence=ECO:0000255	208..248		29/39 (74%)
		WD40 repeat	214..254	CDD:293791	26/39 (67%)
		WD40 repeat	259..319	CDD:293791	34/61 (56%)
		WD40	<273..375	CDD:441893	70/103 (68%)
		WD 2. /evidence=ECO:0000255	279..318		23/40 (58%)
		WD 3. /evidence=ECO:0000255	321..360		31/38 (82%)
		WD40 repeat	327..360	CDD:293791	26/32 (81%)
		WD 4. /evidence=ECO:0000255	363..445		37/111 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..413		7/32 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..506		29/180 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	524..564		16/84 (19%)
		WD 5. /evidence=ECO:0000255	592..629		25/36 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	628..665		6/36 (17%)