DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Yif1 and YIF1A

DIOPT Version :9

Sequence 1:	NP_651498.1	Gene:	Yif1 / 43217	FlyBaseID:	FBgn0039450	Length:	402	Species:	Drosophila melanogaster
Sequence 2:	NP_065203.2	Gene:	YIF1A / 10897	HGNCID:	16688	Length:	293	Species:	Homo sapiens

Alignment Length:	304	Identity:	122/304 - (40%)
Similarity:	184/304 - (60%)	Gaps:	29/304 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 GYG-YGAPPPQQAAGPP------TYGIGAPQPVA-PPTGQYPQFA---MFQQPIVQDMAMQYGQK 149
            ||| :|:....:||..|      |.|..:.||.. |.||....|:   :...|:. ::||.||..
Human     6 GYGAHGSKHRARAAPDPPPLFDDTSGGYSSQPGGYPATGADVAFSVNHLLGDPMA-NVAMAYGSS 69

  Fly   150 LADQGKQIMENQFEKWVPVAKLKYYFAVDNAYVGRKLRLLFFPYMHKDWSLRYDQEHPVQPRYDV 214
            :|..||.::..:..::|.|:||||:||||.|||.:||.||.|||.|::|.::|.::.|:.||.|:
Human    70 IASHGKDMVHKELHRFVSVSKLKYFFAVDTAYVAKKLGLLVFPYTHQNWEVQYSRDAPLPPRQDL 134

  Fly   215 NAPDLYLPTMGYITYVIVAGLLLGMQKRFSPEQLGIQASSAMAYSIFELVIYSLALYVMNVKTSL 279
            ||||||:|||.:||||::||:.||:|||||||.||:.||:|:.:.:.|::...|.||:..|::.|
Human   135 NAPDLYIPTMAFITYVLLAGMALGIQKRFSPEVLGLCASTALVWVVMEVLALLLGLYLATVRSDL 199

  Fly   280 KTLDLLAFTGYKYVNIVVCLMVSTLFFKSGYYIALAYTSFSFGFFMLRTLRTKLLQDNSPAAPSG 344
            .|..|||::|||||.:::.::...||...|||:|||:||.:..:|::|:|||..|..:|...|.
Human   200 STFHLLAYSGYKYVGMILSVLTGLLFGSDGYYVALAWTSSALMYFIVRSLRTAALGPDSMGGPV- 263

  Fly   345 AINYDPYGNPQQFDYSGGKKRKLYFLFMIVAGQALFAFLLSKHL 388
                     |:|       :.:||......|.|.|..:.|:.||
Human   264 ---------PRQ-------RLQLYLTLGAAAFQPLIIYWLTFHL 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Yif1	NP_651498.1	YIF1	142..383	CDD:281822	103/240 (43%)
YIF1A	NP_065203.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		9/26 (35%)
YIF1A	NP_065203.2	YIF1	57..287	CDD:309122	104/247 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152362
Domainoid	1	1.000	235	1.000	Domainoid score	I2373
eggNOG	1	0.900	-	-		E1_COG5197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3264
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55435
OrthoDB	1	1.010	-	-		D1256839at2759
OrthoFinder	1	1.000	-	-		FOG0002277
OrthoInspector	1	1.000	-	-		otm41325
orthoMCL	1	0.900	-	-		OOG6_101876
Panther	1	1.100	-	-	O	PTHR14083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1884
SonicParanoid	1	1.000	-	-		X1506
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800